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Gene Gene information from NCBI Gene database.
Entrez ID 55856
Gene name Acyl-CoA thioesterase 13
Gene symbol ACOT13
Synonyms (NCBI Gene)
HT012PNAS-27THEM2
Chromosome 6
Chromosome location 6p22.3
Summary This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. Th
miRNA miRNA information provided by mirtarbase database.
447 Show/Hide all (447)
miRTarBase ID miRNA Experiments Reference
MIRT689918 hsa-miR-6732-3p HITS-CLIP 23313552
MIRT689917 hsa-miR-10a-5p HITS-CLIP 23313552
MIRT689916 hsa-miR-10b-5p HITS-CLIP 23313552
MIRT689915 hsa-miR-6849-3p HITS-CLIP 23313552
MIRT689914 hsa-miR-3190-5p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20 Show/Hide all (20)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183, 32814053
GO:0005634 Component Nucleus HDA 21630459
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0005739 Component Mitochondrion HTP 34800366
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615652 20999 ENSG00000112304
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NPJ3
Protein name Acyl-coenzyme A thioesterase 13 (Acyl-CoA thioesterase 13) (EC 3.1.2.-) (Hotdog-fold thioesterase superfamily member 2) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Thioesterase superfamily member 2) (THEM2) [Cleaved into: Acyl-coenzyme A thioesterase 13, N-te
Protein function Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18)
PDB 2F0X , 2H4U , 3F5O
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03061 4HBT 52 → 129 Thioesterase superfamily Domain
Sequence
MTSMTQSLREVIKAMTKARNFERVLGKITLVSAAPGKVICEMKVEEEHTNAIGTLHGGLT
ATLVDNISTMALLCTERGAPGVSVDMNITYMSPAKLGEDIVITAHVLKQGKTLAFTSVDL
TNKATGKLI
AQGRHTKHLGN
Sequence length 140
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Mitochondrial Fatty Acid Beta-Oxidation