ABHD3 (abhydrolase domain containing 3, phospholipase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 171586
• Gene name: Abhydrolase domain containing 3, phospholipase
• Gene symbol: ABHD3
• Synonyms (NCBI Gene): LABH3
• Chromosome: 18
• Chromosome location: 18q11.2
• Summary: This gene encodes a protein containing an alpha/beta hydrolase fold, which is a catalytic domain found in a very wide range of enzymes. The function of this protein has not been determined. [provided by RefSeq, Jul 2008]

miRNA Show/Hide all (12)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024138	hsa-miR-221-3p	Sequencing	20371350
MIRT759993	hsa-miR-4325	CLIP-seq
MIRT759994	hsa-miR-4684-3p	CLIP-seq
MIRT759995	hsa-miR-511	CLIP-seq
MIRT759996	hsa-miR-561	CLIP-seq
MIRT1924121	hsa-miR-4328	CLIP-seq
MIRT2165426	hsa-miR-1	CLIP-seq
MIRT2165427	hsa-miR-1273g	CLIP-seq
MIRT2165428	hsa-miR-1324	CLIP-seq
MIRT2165429	hsa-miR-206	CLIP-seq
MIRT2165430	hsa-miR-4698	CLIP-seq
MIRT2165431	hsa-miR-613	CLIP-seq

Gene ontology (GO) Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004623	Function	Phospholipase A2 activity	IBA
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0004623	Function	Phospholipase A2 activity	IMP	21926997
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006656	Process	Phosphatidylcholine biosynthetic process	TAS
GO:0008126	Function	Acetylesterase activity	IBA
GO:0008970	Function	Phospholipase A1 activity	IBA
GO:0008970	Function	Phospholipase A1 activity	IEA
GO:0008970	Function	Phospholipase A1 activity	IMP	21926997
GO:0008970	Function	Phospholipase A1 activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046470	Process	Phosphatidylcholine metabolic process	IBA
GO:0046470	Process	Phosphatidylcholine metabolic process	IEA
GO:0046470	Process	Phosphatidylcholine metabolic process	IMP	21926997
GO:0047372	Function	Monoacylglycerol lipase activity	IBA
GO:0051792	Process	Medium-chain fatty acid biosynthetic process	IBA
GO:0051793	Process	Medium-chain fatty acid catabolic process	IBA
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA

Other IDs

• MIM: 612197
• HGNC: 18718
• e!Ensembl: ENSG00000158201

Protein

• UniProt ID: Q8WU67
• Protein name: Phospholipase ABHD3 (EC 3.1.1.32) (EC 3.1.1.4) (Abhydrolase domain-containing protein 3)
• Protein function: Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In para
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00561	Abhydrolase_1	140 → 382	alpha/beta hydrolase fold	Domain

• Sequence:

  MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAYAFYYLSSIAKKPQLVT
  GGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSKPPVQYRNELIKTADGGQI
  SLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHMIHLSEELGYRCVVFNNRGVA
  GENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAGVSMGGMLLLNYLGKIGSKTPLM
  AAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQSSVNKHRHMFVKQVDMDHVMKAKS
  IREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSVGIPVLCLNSVDDVFSPSHAIPIETAK
  QNPNVALVLTSYGGHIGFLEGIWPRQSTYMDRVFKQFVQAMVEHGHELS

• Sequence length: 409

Pathways

Reactome Pathway:

Synthesis of PC

Related Genes

No strongly related genes found yet for ABHD3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ABHD3.