ABHD14B (abhydrolase domain containing 14B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84836
• Gene name: Abhydrolase domain containing 14B
• Gene symbol: ABHD14B
• Synonyms (NCBI Gene): CIB, HEL-S-299
• Chromosome: 3
• Chromosome location: 3p21.2

miRNA Show/Hide all (113)

miRTarBase ID	miRNA	Experiments	Reference
MIRT036529	hsa-miR-1226-3p	CLASH	23622248
MIRT036529	hsa-miR-1226-3p	CLASH	23622248
MIRT482615	hsa-miR-2278	PAR-CLIP	23592263
MIRT482613	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT482614	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT482612	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT482611	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT482610	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT482609	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT482608	hsa-miR-4533	PAR-CLIP	23592263
MIRT482607	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT482606	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT482605	hsa-miR-4271	PAR-CLIP	23592263
MIRT482604	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT482603	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT482601	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT482602	hsa-miR-575	PAR-CLIP	23592263
MIRT482600	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT482599	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT482598	hsa-miR-6086	PAR-CLIP	23592263
MIRT482597	hsa-miR-1289	PAR-CLIP	23592263
MIRT482596	hsa-miR-1294	PAR-CLIP	23592263
MIRT482595	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT482594	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT482593	hsa-miR-1258	PAR-CLIP	23592263
MIRT482592	hsa-miR-4266	PAR-CLIP	23592263
MIRT482615	hsa-miR-2278	PAR-CLIP	23592263
MIRT482613	hsa-miR-6510-5p	PAR-CLIP	23592263
MIRT482614	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT482612	hsa-miR-6501-3p	PAR-CLIP	23592263
MIRT482611	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT482610	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT482609	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT482608	hsa-miR-4533	PAR-CLIP	23592263
MIRT482607	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT482606	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT482605	hsa-miR-4271	PAR-CLIP	23592263
MIRT482604	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT482603	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT482601	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT482602	hsa-miR-575	PAR-CLIP	23592263
MIRT482600	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT482599	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT482598	hsa-miR-6086	PAR-CLIP	23592263
MIRT482597	hsa-miR-1289	PAR-CLIP	23592263
MIRT482596	hsa-miR-1294	PAR-CLIP	23592263
MIRT482595	hsa-miR-19a-3p	PAR-CLIP	23592263
MIRT482594	hsa-miR-19b-3p	PAR-CLIP	23592263
MIRT482593	hsa-miR-1258	PAR-CLIP	23592263
MIRT482592	hsa-miR-4266	PAR-CLIP	23592263
MIRT759606	hsa-miR-1200	CLIP-seq
MIRT759607	hsa-miR-1252	CLIP-seq
MIRT759608	hsa-miR-1291	CLIP-seq
MIRT759609	hsa-miR-1909	CLIP-seq
MIRT759610	hsa-miR-204	CLIP-seq
MIRT759611	hsa-miR-211	CLIP-seq
MIRT759612	hsa-miR-2110	CLIP-seq
MIRT759613	hsa-miR-3147	CLIP-seq
MIRT759614	hsa-miR-3173-3p	CLIP-seq
MIRT759615	hsa-miR-3202	CLIP-seq
MIRT759616	hsa-miR-328	CLIP-seq
MIRT759617	hsa-miR-3689d	CLIP-seq
MIRT759618	hsa-miR-4287	CLIP-seq
MIRT759619	hsa-miR-4290	CLIP-seq
MIRT759620	hsa-miR-4314	CLIP-seq
MIRT759621	hsa-miR-4324	CLIP-seq
MIRT759622	hsa-miR-4326	CLIP-seq
MIRT759623	hsa-miR-4425	CLIP-seq
MIRT759624	hsa-miR-4455	CLIP-seq
MIRT759625	hsa-miR-4476	CLIP-seq
MIRT759626	hsa-miR-4667-5p	CLIP-seq
MIRT759627	hsa-miR-4685-3p	CLIP-seq
MIRT759628	hsa-miR-4693-3p	CLIP-seq
MIRT759629	hsa-miR-4700-5p	CLIP-seq
MIRT759630	hsa-miR-4795-5p	CLIP-seq
MIRT759631	hsa-miR-491-5p	CLIP-seq
MIRT759632	hsa-miR-502-5p	CLIP-seq
MIRT759633	hsa-miR-544b	CLIP-seq
MIRT759634	hsa-miR-609	CLIP-seq
MIRT759635	hsa-miR-637	CLIP-seq
MIRT759636	hsa-miR-663b	CLIP-seq
MIRT1923882	hsa-miR-3657	CLIP-seq
MIRT1923883	hsa-miR-3691-3p	CLIP-seq
MIRT1923884	hsa-miR-4669	CLIP-seq
MIRT1923885	hsa-miR-649	CLIP-seq
MIRT2165371	hsa-miR-298	CLIP-seq
MIRT2165372	hsa-miR-3127-5p	CLIP-seq
MIRT2165373	hsa-miR-3176	CLIP-seq
MIRT2165374	hsa-miR-34c-3p	CLIP-seq
MIRT2165375	hsa-miR-3678-3p	CLIP-seq
MIRT2165376	hsa-miR-3918	CLIP-seq
MIRT2165377	hsa-miR-3922-3p	CLIP-seq
MIRT2165378	hsa-miR-4446-3p	CLIP-seq
MIRT2165379	hsa-miR-4492	CLIP-seq
MIRT2165380	hsa-miR-4498	CLIP-seq
MIRT2165381	hsa-miR-4761-3p	CLIP-seq
MIRT2165382	hsa-miR-5096	CLIP-seq
MIRT2165383	hsa-miR-762	CLIP-seq
MIRT2165384	hsa-miR-2276	CLIP-seq
MIRT2165385	hsa-miR-4514	CLIP-seq
MIRT2165386	hsa-miR-4692	CLIP-seq
MIRT2165387	hsa-miR-940	CLIP-seq
MIRT2467376	hsa-miR-3192	CLIP-seq
MIRT2467377	hsa-miR-4684-3p	CLIP-seq
MIRT2467378	hsa-miR-661	CLIP-seq
MIRT2674068	hsa-miR-1253	CLIP-seq
MIRT2674069	hsa-miR-185	CLIP-seq
MIRT2467376	hsa-miR-3192	CLIP-seq
MIRT2674070	hsa-miR-4306	CLIP-seq
MIRT2674071	hsa-miR-4644	CLIP-seq
MIRT2467377	hsa-miR-4684-3p	CLIP-seq
MIRT2674072	hsa-miR-4696	CLIP-seq
MIRT2467378	hsa-miR-661	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14672934
GO:0005634	Component	Nucleus	IDA	14672934
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	14672934
GO:0005829	Component	Cytosol	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0016787	Function	Hydrolase activity	IBA
GO:0016787	Function	Hydrolase activity	IDA	14672934
GO:0016787	Function	Hydrolase activity	TAS
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	14672934
GO:0050427	Process	3'-phosphoadenosine 5'-phosphosulfate metabolic process	TAS
GO:0061733	Function	Protein-lysine-acetyltransferase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145

Other IDs

• MIM: 621040
• HGNC: 28235
• e!Ensembl: ENSG00000114779

Protein

• UniProt ID: Q96IU4
• Protein name: Putative protein-lysine deacylase ABHD14B (EC 2.3.1.-) (Alpha/beta hydrolase domain-containing protein 14B) (Abhydrolase domain-containing protein 14B) (CCG1-interacting factor B)
• Protein function: Acts as an atypical protein-lysine deacetylase in vitro (PubMed:31478652). Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues (PubMed:31478652). Additional e
• PDB: 1IMJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12697	Abhydrolase_6	35 → 140	Alpha/beta hydrolase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous (PubMed:14672934). Detected in spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocyte, heart, placenta, lung, liver, skeletal muscle, pancreas and kidney (PubMed:14672934). {ECO:0000269|P
• Sequence:

  MAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFSSETWQNLGTLHRLAQA
  GYRAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALELGPPVVISPSLSGMYSLPF
  LTAPGSQLPGFVPVAPICTDKINAANYASVKTPALIVYGDQDPMGQTSFEHLKQLPNHRV
  LIMKGAGHPCYLDKPEEWHTGLLDFLQGLQ

• Sequence length: 210

Pathways

Reactome Pathway:

Cytosolic sulfonation of small molecules

Related Genes

No strongly related genes found yet for ABHD14B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to ABHD14B.