Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9991
Gene name	Polypyrimidine tract binding protein 3
Gene symbol	PTBP3
Synonyms (NCBI Gene)	ROD1
Chromosome	9
Chromosome location	9q32
Summary	The protein encoded by this gene binds RNA and is a regulator of cell differentiation. The encoded protein preferentially binds to poly(G) and poly(U) sequences in vitro. Several transcript variants encoding different isoforms have been found for this gen

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Show/Hide all (152)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022729	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT024160	hsa-miR-221-3p	Sequencing	20371350
MIRT030890	hsa-miR-21-5p	Microarray	18591254
MIRT048115	hsa-miR-197-3p	CLASH	23622248
MIRT047996	hsa-miR-30c-5p	CLASH	23622248
MIRT042966	hsa-miR-324-3p	CLASH	23622248
MIRT041782	hsa-miR-484	CLASH	23622248
MIRT036365	hsa-miR-1229-3p	CLASH	23622248
MIRT054186	hsa-miR-210-3p	MicroarrayqRT-PCRWestern blot	23024754
MIRT722100	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT722099	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT722098	hsa-miR-607	HITS-CLIP	19536157
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT630581	hsa-miR-4496	HITS-CLIP	19536157
MIRT630580	hsa-miR-1323	HITS-CLIP	19536157
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT323959	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT323960	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT630578	hsa-miR-4268	HITS-CLIP	19536157
MIRT630577	hsa-miR-4448	HITS-CLIP	19536157
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT106872	hsa-miR-181d-5p	HITS-CLIP	23824327
MIRT106868	hsa-miR-181a-5p	HITS-CLIP	23824327
MIRT106870	hsa-miR-181c-5p	HITS-CLIP	23824327
MIRT106869	hsa-miR-181b-5p	HITS-CLIP	23824327
MIRT106875	hsa-miR-4262	HITS-CLIP	23824327
MIRT666783	hsa-miR-8485	HITS-CLIP	23824327
MIRT666782	hsa-miR-603	HITS-CLIP	23824327
MIRT666781	hsa-miR-3941	HITS-CLIP	23824327
MIRT666780	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566243	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566242	hsa-miR-3714	PAR-CLIP	20371350
MIRT566241	hsa-miR-3910	PAR-CLIP	20371350
MIRT566240	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT566239	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566238	hsa-miR-4672	PAR-CLIP	20371350
MIRT555177	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555176	hsa-miR-4728-3p	PAR-CLIP	21572407
MIRT555175	hsa-miR-8060	PAR-CLIP	21572407
MIRT555174	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT555173	hsa-miR-891b	PAR-CLIP	21572407
MIRT555172	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT555171	hsa-miR-548v	PAR-CLIP	21572407
MIRT024160	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT555170	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT106878	hsa-miR-7154-5p	PAR-CLIP	21572407
MIRT555169	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT555168	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT534943	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534942	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534941	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534940	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534939	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534938	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534937	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT364362	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT393731	hsa-miR-3613-3p	PAR-CLIP	22012620
MIRT735604	hsa-miR-29a-3p	qRT-PCR	32117452
MIRT722100	hsa-miR-6715b-3p	HITS-CLIP	19536157
MIRT722099	hsa-miR-29b-2-5p	HITS-CLIP	19536157
MIRT722098	hsa-miR-607	HITS-CLIP	19536157
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	19536157
MIRT630581	hsa-miR-4496	HITS-CLIP	19536157
MIRT630580	hsa-miR-1323	HITS-CLIP	19536157
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	19536157
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT323959	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT323960	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT630578	hsa-miR-4268	HITS-CLIP	19536157
MIRT630577	hsa-miR-4448	HITS-CLIP	19536157
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	19536157
MIRT106872	hsa-miR-181d-5p	HITS-CLIP	23824327
MIRT106868	hsa-miR-181a-5p	HITS-CLIP	23824327
MIRT106870	hsa-miR-181c-5p	HITS-CLIP	23824327
MIRT106869	hsa-miR-181b-5p	HITS-CLIP	23824327
MIRT106875	hsa-miR-4262	HITS-CLIP	23824327
MIRT666783	hsa-miR-8485	HITS-CLIP	23824327
MIRT666782	hsa-miR-603	HITS-CLIP	23824327
MIRT666781	hsa-miR-3941	HITS-CLIP	23824327
MIRT666780	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT630582	hsa-miR-6835-3p	HITS-CLIP	23824327
MIRT630581	hsa-miR-4496	HITS-CLIP	23824327
MIRT630580	hsa-miR-1323	HITS-CLIP	23824327
MIRT630579	hsa-miR-548o-3p	HITS-CLIP	23824327
MIRT323962	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT323959	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT323960	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT630578	hsa-miR-4268	HITS-CLIP	23824327
MIRT630577	hsa-miR-4448	HITS-CLIP	23824327
MIRT630576	hsa-miR-6772-3p	HITS-CLIP	23824327
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT022729	hsa-miR-124-3p	PAR-CLIP	20371350
MIRT566243	hsa-miR-506-3p	PAR-CLIP	20371350
MIRT566242	hsa-miR-3714	PAR-CLIP	20371350
MIRT566241	hsa-miR-3910	PAR-CLIP	20371350
MIRT566240	hsa-miR-6768-5p	PAR-CLIP	20371350
MIRT566239	hsa-miR-5582-5p	PAR-CLIP	20371350
MIRT566238	hsa-miR-4672	PAR-CLIP	20371350
MIRT555177	hsa-miR-4712-3p	PAR-CLIP	21572407
MIRT555176	hsa-miR-4728-3p	PAR-CLIP	21572407
MIRT555175	hsa-miR-8060	PAR-CLIP	21572407
MIRT555174	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT555173	hsa-miR-891b	PAR-CLIP	21572407
MIRT555172	hsa-miR-187-5p	PAR-CLIP	21572407
MIRT555171	hsa-miR-548v	PAR-CLIP	21572407
MIRT024160	hsa-miR-221-3p	PAR-CLIP	21572407
MIRT555170	hsa-miR-222-3p	PAR-CLIP	21572407
MIRT106878	hsa-miR-7154-5p	PAR-CLIP	21572407
MIRT555169	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT555168	hsa-miR-5089-3p	PAR-CLIP	21572407
MIRT534943	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT534942	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT534941	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT534940	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT534939	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT534938	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT534937	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT364362	hsa-miR-205-3p	PAR-CLIP	22012620
MIRT393731	hsa-miR-3613-3p	PAR-CLIP	22012620

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	10207106
GO:0003729	Function	MRNA binding	IBA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0009653	Process	Anatomical structure morphogenesis	TAS	10207106
GO:0030154	Process	Cell differentiation	IEA
GO:0033119	Process	Negative regulation of RNA splicing	IDA	18335065
GO:0033119	Process	Negative regulation of RNA splicing	IEA
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0043484	Process	Regulation of RNA splicing	IBA
GO:0045595	Process	Regulation of cell differentiation	IEA

MIM	HGNC	e!Ensembl
607527	10253	ENSG00000119314

O95758

Protein name

Polypyrimidine tract-binding protein 3 (Regulator of differentiation 1) (Rod1)

Protein function

RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentia

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF11835	RRM_8	171 → 258	RRM-like domain	Domain
PF13893	RRM_5	329 → 454		Domain
PF13893	RRM_5	472 → 552		Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in several hematopoietic cell lines examined. {ECO:0000269|PubMed:10207106}.

Sequence

MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRV
LHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPH
LRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSP
VLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALD
GQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGI
ISSPYAGAAGFAPAIGFPQATGLSVPAVPGALGPLTITSSAVTGRMAIPGASGIPGNSVL
LVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRL
YGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLS
NIPPSVTVDDLKNLFIEAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGEN
HHLRVSFSKSTI

Sequence length

552

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANTIPHOSPHOLIPID SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (18)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	29187406, 30013660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	24618292	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37633911	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31291975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31291975	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	35136024	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	26443314		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	26443314	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	26443314		★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Heart disease	Pubtator	29146485	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30068940		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29187406, 30013660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28222070, 29752441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29187406, 30013660, 30068940		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	25119103, 30013660, 31291975		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	30634466	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28222070, 29752441		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28222070	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

PTBP3 (polypyrimidine tract binding protein 3)