Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9948
Gene name	WD repeat domain 1
Gene symbol	WDR1
Synonyms (NCBI Gene)	AIP1HEL-S-52NORI-1PFITS
Chromosome	4
Chromosome location	4p16.1
Summary	This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019985	hsa-miR-375	Microarray	20215506
MIRT028095	hsa-miR-93-5p	Sequencing	20371350
MIRT049572	hsa-miR-92a-3p	CLASH	23622248
MIRT039865	hsa-miR-615-3p	CLASH	23622248
MIRT036948	hsa-miR-877-3p	CLASH	23622248
MIRT036411	hsa-miR-1226-3p	CLASH	23622248
MIRT452510	hsa-miR-3121-3p	PAR-CLIP	23592263
MIRT163905	hsa-miR-5680	PAR-CLIP	23592263
MIRT452509	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT452507	hsa-miR-3123	PAR-CLIP	23592263
MIRT452508	hsa-miR-3976	PAR-CLIP	23592263
MIRT163869	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT452506	hsa-miR-3178	PAR-CLIP	23592263
MIRT439293	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT439291	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439293	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT726109	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT726108	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028095	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT726106	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT726107	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT726105	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT439291	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439290	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT732721	hsa-miR-1250-5p	Luciferase reporter assayqRT-PCRWestern blotting	34044822
MIRT452510	hsa-miR-3121-3p	PAR-CLIP	23592263
MIRT163905	hsa-miR-5680	PAR-CLIP	23592263
MIRT452509	hsa-miR-3925-5p	PAR-CLIP	23592263
MIRT452507	hsa-miR-3123	PAR-CLIP	23592263
MIRT452508	hsa-miR-3976	PAR-CLIP	23592263
MIRT163869	hsa-miR-539-5p	PAR-CLIP	23592263
MIRT452506	hsa-miR-3178	PAR-CLIP	23592263
MIRT1489742	hsa-miR-2355-3p	CLIP-seq
MIRT1489743	hsa-miR-3121-5p	CLIP-seq
MIRT1489744	hsa-miR-3164	CLIP-seq
MIRT1489745	hsa-miR-4646-3p	CLIP-seq
MIRT1489746	hsa-miR-526b	CLIP-seq
MIRT1489747	hsa-miR-617	CLIP-seq
MIRT1489748	hsa-miR-676	CLIP-seq
MIRT1489749	hsa-miR-141	CLIP-seq
MIRT1489750	hsa-miR-200a	CLIP-seq
MIRT1489751	hsa-miR-30a	CLIP-seq
MIRT1489752	hsa-miR-30b	CLIP-seq
MIRT1489753	hsa-miR-30c	CLIP-seq
MIRT1489754	hsa-miR-30d	CLIP-seq
MIRT1489755	hsa-miR-30e	CLIP-seq
MIRT1489756	hsa-miR-3660	CLIP-seq
MIRT1489757	hsa-miR-4526	CLIP-seq
MIRT1489758	hsa-miR-4709-5p	CLIP-seq
MIRT1489759	hsa-miR-4742-5p	CLIP-seq
MIRT1922478	hsa-miR-3545-3p	CLIP-seq
MIRT1922479	hsa-miR-3938	CLIP-seq
MIRT1922480	hsa-miR-448	CLIP-seq
MIRT1922481	hsa-miR-4539	CLIP-seq
MIRT1922482	hsa-miR-628-5p	CLIP-seq
MIRT1922483	hsa-miR-642a	CLIP-seq
MIRT2147682	hsa-miR-1	CLIP-seq
MIRT2147683	hsa-miR-1299	CLIP-seq
MIRT2147684	hsa-miR-206	CLIP-seq
MIRT2147685	hsa-miR-2117	CLIP-seq
MIRT2147686	hsa-miR-3157-5p	CLIP-seq
MIRT2147687	hsa-miR-3673	CLIP-seq
MIRT2147688	hsa-miR-4273	CLIP-seq
MIRT2147689	hsa-miR-4445	CLIP-seq
MIRT2147690	hsa-miR-4677-5p	CLIP-seq
MIRT2147691	hsa-miR-4691-3p	CLIP-seq
MIRT2147692	hsa-miR-4728-5p	CLIP-seq
MIRT2147693	hsa-miR-544	CLIP-seq
MIRT2147694	hsa-miR-613	CLIP-seq
MIRT2147695	hsa-miR-875-3p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2368024	hsa-miR-1180	CLIP-seq
MIRT2368025	hsa-miR-1197	CLIP-seq
MIRT2368026	hsa-miR-1229	CLIP-seq
MIRT2368027	hsa-miR-125a-5p	CLIP-seq
MIRT2368028	hsa-miR-125b	CLIP-seq
MIRT1489749	hsa-miR-141	CLIP-seq
MIRT2368029	hsa-miR-147	CLIP-seq
MIRT2368030	hsa-miR-149	CLIP-seq
MIRT2368031	hsa-miR-150	CLIP-seq
MIRT2368032	hsa-miR-1587	CLIP-seq
MIRT2368033	hsa-miR-1908	CLIP-seq
MIRT2368034	hsa-miR-19a	CLIP-seq
MIRT2368035	hsa-miR-19b	CLIP-seq
MIRT1489750	hsa-miR-200a	CLIP-seq
MIRT2368036	hsa-miR-2114	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2368038	hsa-miR-3064-5p	CLIP-seq
MIRT1489751	hsa-miR-30a	CLIP-seq
MIRT1489752	hsa-miR-30b	CLIP-seq
MIRT1489753	hsa-miR-30c	CLIP-seq
MIRT1489754	hsa-miR-30d	CLIP-seq
MIRT1489755	hsa-miR-30e	CLIP-seq
MIRT2368039	hsa-miR-3147	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2368041	hsa-miR-320a	CLIP-seq
MIRT2368042	hsa-miR-320b	CLIP-seq
MIRT2368043	hsa-miR-320c	CLIP-seq
MIRT2368044	hsa-miR-320d	CLIP-seq
MIRT1922478	hsa-miR-3545-3p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2368045	hsa-miR-3657	CLIP-seq
MIRT1489756	hsa-miR-3660	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2368047	hsa-miR-3923	CLIP-seq
MIRT1922479	hsa-miR-3938	CLIP-seq
MIRT2368048	hsa-miR-3942-3p	CLIP-seq
MIRT2368049	hsa-miR-421	CLIP-seq
MIRT2368050	hsa-miR-4319	CLIP-seq
MIRT2368051	hsa-miR-4429	CLIP-seq
MIRT2368052	hsa-miR-4436a	CLIP-seq
MIRT2368053	hsa-miR-4462	CLIP-seq
MIRT1922480	hsa-miR-448	CLIP-seq
MIRT2368054	hsa-miR-4492	CLIP-seq
MIRT2368055	hsa-miR-4498	CLIP-seq
MIRT2368056	hsa-miR-4509	CLIP-seq
MIRT2368057	hsa-miR-4520a-3p	CLIP-seq
MIRT2368058	hsa-miR-4520b-3p	CLIP-seq
MIRT1489757	hsa-miR-4526	CLIP-seq
MIRT1922481	hsa-miR-4539	CLIP-seq
MIRT2368059	hsa-miR-4656	CLIP-seq
MIRT2368060	hsa-miR-4669	CLIP-seq
MIRT2368061	hsa-miR-4674	CLIP-seq
MIRT2368062	hsa-miR-4675	CLIP-seq
MIRT2368063	hsa-miR-4685-5p	CLIP-seq
MIRT2368064	hsa-miR-4693-5p	CLIP-seq
MIRT2368065	hsa-miR-4705	CLIP-seq
MIRT1489758	hsa-miR-4709-5p	CLIP-seq
MIRT2368066	hsa-miR-4732-3p	CLIP-seq
MIRT2368067	hsa-miR-4741	CLIP-seq
MIRT1489759	hsa-miR-4742-5p	CLIP-seq
MIRT2368068	hsa-miR-4744	CLIP-seq
MIRT2368069	hsa-miR-4746-5p	CLIP-seq
MIRT2368070	hsa-miR-4794	CLIP-seq
MIRT2368071	hsa-miR-4799-5p	CLIP-seq
MIRT2368072	hsa-miR-520a-5p	CLIP-seq
MIRT2368073	hsa-miR-521	CLIP-seq
MIRT2368074	hsa-miR-525-5p	CLIP-seq
MIRT2368075	hsa-miR-548ac	CLIP-seq
MIRT2368076	hsa-miR-548ae	CLIP-seq
MIRT2368077	hsa-miR-548aj	CLIP-seq
MIRT2368078	hsa-miR-548am	CLIP-seq
MIRT2368079	hsa-miR-548d-3p	CLIP-seq
MIRT2368080	hsa-miR-548g	CLIP-seq
MIRT2368081	hsa-miR-548x	CLIP-seq
MIRT2368082	hsa-miR-548z	CLIP-seq
MIRT2368083	hsa-miR-554	CLIP-seq
MIRT2368084	hsa-miR-618	CLIP-seq
MIRT1922482	hsa-miR-628-5p	CLIP-seq
MIRT2368085	hsa-miR-629	CLIP-seq
MIRT1922483	hsa-miR-642a	CLIP-seq
MIRT2368086	hsa-miR-659	CLIP-seq
MIRT2368087	hsa-miR-663	CLIP-seq
MIRT2368088	hsa-miR-670	CLIP-seq
MIRT2368089	hsa-miR-762	CLIP-seq
MIRT2368090	hsa-miR-890	CLIP-seq
MIRT2368091	hsa-miR-942	CLIP-seq
MIRT2368025	hsa-miR-1197	CLIP-seq
MIRT2147685	hsa-miR-2117	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2147686	hsa-miR-3157-5p	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2368049	hsa-miR-421	CLIP-seq
MIRT2147688	hsa-miR-4273	CLIP-seq
MIRT2368052	hsa-miR-4436a	CLIP-seq
MIRT2147690	hsa-miR-4677-5p	CLIP-seq
MIRT2147691	hsa-miR-4691-3p	CLIP-seq
MIRT2368029	hsa-miR-147	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2368063	hsa-miR-4685-5p	CLIP-seq
MIRT2434708	hsa-miR-494	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2368024	hsa-miR-1180	CLIP-seq
MIRT2661548	hsa-miR-1184	CLIP-seq
MIRT2661549	hsa-miR-1205	CLIP-seq
MIRT2661550	hsa-miR-1225-3p	CLIP-seq
MIRT2368026	hsa-miR-1229	CLIP-seq
MIRT2661551	hsa-miR-1233	CLIP-seq
MIRT2368027	hsa-miR-125a-5p	CLIP-seq
MIRT2368028	hsa-miR-125b	CLIP-seq
MIRT2661552	hsa-miR-1321	CLIP-seq
MIRT2368029	hsa-miR-147	CLIP-seq
MIRT2368033	hsa-miR-1908	CLIP-seq
MIRT2661553	hsa-miR-1976	CLIP-seq
MIRT2368036	hsa-miR-2114	CLIP-seq
MIRT2661554	hsa-miR-218	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2661555	hsa-miR-296-5p	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2661556	hsa-miR-3162-5p	CLIP-seq
MIRT2661557	hsa-miR-3174	CLIP-seq
MIRT2661558	hsa-miR-323-3p	CLIP-seq
MIRT2661559	hsa-miR-342-5p	CLIP-seq
MIRT1922478	hsa-miR-3545-3p	CLIP-seq
MIRT2661560	hsa-miR-3612	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2661561	hsa-miR-3622b-5p	CLIP-seq
MIRT2661562	hsa-miR-3648	CLIP-seq
MIRT2368045	hsa-miR-3657	CLIP-seq
MIRT1489756	hsa-miR-3660	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2661563	hsa-miR-3689d	CLIP-seq
MIRT2661564	hsa-miR-3714	CLIP-seq
MIRT2661565	hsa-miR-377	CLIP-seq
MIRT2368047	hsa-miR-3923	CLIP-seq
MIRT1922479	hsa-miR-3938	CLIP-seq
MIRT2661566	hsa-miR-3943	CLIP-seq
MIRT2661567	hsa-miR-3960	CLIP-seq
MIRT2368049	hsa-miR-421	CLIP-seq
MIRT2661568	hsa-miR-4253	CLIP-seq
MIRT2661569	hsa-miR-4283	CLIP-seq
MIRT2661570	hsa-miR-4290	CLIP-seq
MIRT2368050	hsa-miR-4319	CLIP-seq
MIRT2661571	hsa-miR-4443	CLIP-seq
MIRT2661572	hsa-miR-4447	CLIP-seq
MIRT2661573	hsa-miR-4457	CLIP-seq
MIRT2661574	hsa-miR-4472	CLIP-seq
MIRT1922480	hsa-miR-448	CLIP-seq
MIRT2661575	hsa-miR-4488	CLIP-seq
MIRT2661576	hsa-miR-4493	CLIP-seq
MIRT2661577	hsa-miR-4514	CLIP-seq
MIRT1489757	hsa-miR-4526	CLIP-seq
MIRT1922481	hsa-miR-4539	CLIP-seq
MIRT2661578	hsa-miR-4640-5p	CLIP-seq
MIRT2661579	hsa-miR-4651	CLIP-seq
MIRT2661580	hsa-miR-4662a-3p	CLIP-seq
MIRT2661581	hsa-miR-4664-5p	CLIP-seq
MIRT2661582	hsa-miR-4667-3p	CLIP-seq
MIRT2368060	hsa-miR-4669	CLIP-seq
MIRT2368063	hsa-miR-4685-5p	CLIP-seq
MIRT2147691	hsa-miR-4691-3p	CLIP-seq
MIRT2661583	hsa-miR-4692	CLIP-seq
MIRT2661584	hsa-miR-4697-5p	CLIP-seq
MIRT2661585	hsa-miR-4704-5p	CLIP-seq
MIRT2661586	hsa-miR-4707-5p	CLIP-seq
MIRT1489758	hsa-miR-4709-5p	CLIP-seq
MIRT2661587	hsa-miR-4722-3p	CLIP-seq
MIRT2661588	hsa-miR-4726-5p	CLIP-seq
MIRT2368066	hsa-miR-4732-3p	CLIP-seq
MIRT2661589	hsa-miR-4739	CLIP-seq
MIRT1489759	hsa-miR-4742-5p	CLIP-seq
MIRT2368069	hsa-miR-4746-5p	CLIP-seq
MIRT2661590	hsa-miR-4756-5p	CLIP-seq
MIRT2661591	hsa-miR-4761-5p	CLIP-seq
MIRT2434708	hsa-miR-494	CLIP-seq
MIRT2661592	hsa-miR-516b	CLIP-seq
MIRT2368072	hsa-miR-520a-5p	CLIP-seq
MIRT2368074	hsa-miR-525-5p	CLIP-seq
MIRT2661593	hsa-miR-539	CLIP-seq
MIRT2661594	hsa-miR-541	CLIP-seq
MIRT2147693	hsa-miR-544	CLIP-seq
MIRT2368083	hsa-miR-554	CLIP-seq
MIRT2661595	hsa-miR-572	CLIP-seq
MIRT2661596	hsa-miR-581	CLIP-seq
MIRT2661597	hsa-miR-603	CLIP-seq
MIRT2661598	hsa-miR-608	CLIP-seq
MIRT2368084	hsa-miR-618	CLIP-seq
MIRT2661599	hsa-miR-624	CLIP-seq
MIRT1922482	hsa-miR-628-5p	CLIP-seq
MIRT2661600	hsa-miR-636	CLIP-seq
MIRT1922483	hsa-miR-642a	CLIP-seq
MIRT2661601	hsa-miR-650	CLIP-seq
MIRT2661602	hsa-miR-654-5p	CLIP-seq
MIRT2368087	hsa-miR-663	CLIP-seq
MIRT2368088	hsa-miR-670	CLIP-seq
MIRT2661603	hsa-miR-744	CLIP-seq
MIRT2661604	hsa-miR-760	CLIP-seq
MIRT2661605	hsa-miR-873	CLIP-seq
MIRT2661606	hsa-miR-921	CLIP-seq
MIRT2661607	hsa-miR-940	CLIP-seq
MIRT2368091	hsa-miR-942	CLIP-seq
MIRT2368024	hsa-miR-1180	CLIP-seq
MIRT2661548	hsa-miR-1184	CLIP-seq
MIRT2661549	hsa-miR-1205	CLIP-seq
MIRT2368026	hsa-miR-1229	CLIP-seq
MIRT2368027	hsa-miR-125a-5p	CLIP-seq
MIRT2368028	hsa-miR-125b	CLIP-seq
MIRT2661552	hsa-miR-1321	CLIP-seq
MIRT2368029	hsa-miR-147	CLIP-seq
MIRT2368033	hsa-miR-1908	CLIP-seq
MIRT2661553	hsa-miR-1976	CLIP-seq
MIRT2368036	hsa-miR-2114	CLIP-seq
MIRT2368037	hsa-miR-2467-3p	CLIP-seq
MIRT2661555	hsa-miR-296-5p	CLIP-seq
MIRT2368040	hsa-miR-3158-5p	CLIP-seq
MIRT2661556	hsa-miR-3162-5p	CLIP-seq
MIRT2661557	hsa-miR-3174	CLIP-seq
MIRT2661558	hsa-miR-323-3p	CLIP-seq
MIRT2661559	hsa-miR-342-5p	CLIP-seq
MIRT1922478	hsa-miR-3545-3p	CLIP-seq
MIRT2368023	hsa-miR-3620	CLIP-seq
MIRT2661561	hsa-miR-3622b-5p	CLIP-seq
MIRT2661562	hsa-miR-3648	CLIP-seq
MIRT2368045	hsa-miR-3657	CLIP-seq
MIRT2368046	hsa-miR-3678-3p	CLIP-seq
MIRT2661563	hsa-miR-3689d	CLIP-seq
MIRT2661564	hsa-miR-3714	CLIP-seq
MIRT2661565	hsa-miR-377	CLIP-seq
MIRT2368047	hsa-miR-3923	CLIP-seq
MIRT1922479	hsa-miR-3938	CLIP-seq
MIRT2661567	hsa-miR-3960	CLIP-seq
MIRT2368049	hsa-miR-421	CLIP-seq
MIRT2661568	hsa-miR-4253	CLIP-seq
MIRT2661569	hsa-miR-4283	CLIP-seq
MIRT2661570	hsa-miR-4290	CLIP-seq
MIRT2368050	hsa-miR-4319	CLIP-seq
MIRT2661572	hsa-miR-4447	CLIP-seq
MIRT2661574	hsa-miR-4472	CLIP-seq
MIRT1922480	hsa-miR-448	CLIP-seq
MIRT2661575	hsa-miR-4488	CLIP-seq
MIRT2661576	hsa-miR-4493	CLIP-seq
MIRT2661577	hsa-miR-4514	CLIP-seq
MIRT1922481	hsa-miR-4539	CLIP-seq
MIRT2661578	hsa-miR-4640-5p	CLIP-seq
MIRT2661579	hsa-miR-4651	CLIP-seq
MIRT2661580	hsa-miR-4662a-3p	CLIP-seq
MIRT2661581	hsa-miR-4664-5p	CLIP-seq
MIRT2661582	hsa-miR-4667-3p	CLIP-seq
MIRT2368060	hsa-miR-4669	CLIP-seq
MIRT2368063	hsa-miR-4685-5p	CLIP-seq
MIRT2661583	hsa-miR-4692	CLIP-seq
MIRT2661584	hsa-miR-4697-5p	CLIP-seq
MIRT2661585	hsa-miR-4704-5p	CLIP-seq
MIRT1489758	hsa-miR-4709-5p	CLIP-seq
MIRT2661587	hsa-miR-4722-3p	CLIP-seq
MIRT2661588	hsa-miR-4726-5p	CLIP-seq
MIRT2368066	hsa-miR-4732-3p	CLIP-seq
MIRT2661589	hsa-miR-4739	CLIP-seq
MIRT1489759	hsa-miR-4742-5p	CLIP-seq
MIRT2368069	hsa-miR-4746-5p	CLIP-seq
MIRT2661590	hsa-miR-4756-5p	CLIP-seq
MIRT2434708	hsa-miR-494	CLIP-seq
MIRT2661592	hsa-miR-516b	CLIP-seq
MIRT2661593	hsa-miR-539	CLIP-seq
MIRT2661594	hsa-miR-541	CLIP-seq
MIRT2147693	hsa-miR-544	CLIP-seq
MIRT2368083	hsa-miR-554	CLIP-seq
MIRT2661595	hsa-miR-572	CLIP-seq
MIRT2661596	hsa-miR-581	CLIP-seq
MIRT2661597	hsa-miR-603	CLIP-seq
MIRT2661598	hsa-miR-608	CLIP-seq
MIRT2368084	hsa-miR-618	CLIP-seq
MIRT1922482	hsa-miR-628-5p	CLIP-seq
MIRT1922483	hsa-miR-642a	CLIP-seq
MIRT2661602	hsa-miR-654-5p	CLIP-seq
MIRT2368087	hsa-miR-663	CLIP-seq
MIRT2368088	hsa-miR-670	CLIP-seq
MIRT2661603	hsa-miR-744	CLIP-seq
MIRT2661605	hsa-miR-873	CLIP-seq
MIRT2661606	hsa-miR-921	CLIP-seq
MIRT2661607	hsa-miR-940	CLIP-seq
MIRT2368091	hsa-miR-942	CLIP-seq

Show/Hide all (40)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002102	Component	Podosome	IEA
GO:0002446	Process	Neutrophil mediated immunity	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	30021884, 35271311
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005911	Component	Cell-cell junction	IDA	25792565
GO:0007605	Process	Sensory perception of sound	TAS	10036186
GO:0008360	Process	Regulation of cell shape	IEA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030042	Process	Actin filament depolymerization	IBA
GO:0030043	Process	Actin filament fragmentation	IEA
GO:0030054	Component	Cell junction	IDA
GO:0030220	Process	Platelet formation	IEA
GO:0030834	Process	Regulation of actin filament depolymerization	IDA	15629458
GO:0030836	Process	Positive regulation of actin filament depolymerization	IEA
GO:0030864	Component	Cortical actin cytoskeleton	IBA
GO:0030865	Process	Cortical cytoskeleton organization	IEA
GO:0040011	Process	Locomotion	IBA
GO:0042247	Process	Establishment of planar polarity of follicular epithelium	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043297	Process	Apical junction assembly	IDA	25792565
GO:0045199	Process	Maintenance of epithelial cell apical/basal polarity	IDA	25792565
GO:0045202	Component	Synapse	IEA
GO:0045214	Process	Sarcomere organization	IBA
GO:0045214	Process	Sarcomere organization	IEA
GO:0048713	Process	Regulation of oligodendrocyte differentiation	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IEA
GO:0051015	Function	Actin filament binding	ISS
GO:0060307	Process	Regulation of ventricular cardiac muscle cell membrane repolarization	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070161	Component	Anchoring junction	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:1990266	Process	Neutrophil migration	IEA

MIM	HGNC	e!Ensembl
604734	12754	ENSG00000071127

O75083

Protein name

WD repeat-containing protein 1 (Actin-interacting protein 1) (AIP1) (NORI-1)

Protein function

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotacti

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	179 → 217	WD domain, G-beta repeat	Repeat
PF00400	WD40	223 → 262	WD domain, G-beta repeat	Repeat
PF00400	WD40	310 → 350	WD domain, G-beta repeat	Repeat
PF00400	WD40	523 → 560	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in peripheral blood mononuclear cells (at protein level). {ECO:0000269|PubMed:29751004}.

Sequence

MPYEIKKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQ
VVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYEYQPFAGKIKDIAWTEDSKRIAVV
GEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFK
FKFTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAI
SWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGY
INYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFA
GKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGY
AVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLK
DEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAW
SPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVK
EWTITY

Sequence length

606

Interactions

View interactions

	Reactome
			Platelet degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual developmental disorder 61	Pathogenic	rs1712445918	RCV000999499	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Lazy leukocyte syndrome	Pathogenic	rs1713714520, rs769254295, rs1712525349, rs771058795, rs1712442528, rs1764766492, rs1711679334	RCV001250779 RCV001250780 RCV001250781 RCV001250782 RCV001250783 RCV001250784 RCV001250785 View all (2 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (35)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma susceptibility 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOARDING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERURICEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 61	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THROMBOCYTOPENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WDR1 deficiency	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WDR1-related disorder	Conflicting classifications of pathogenicity; Likely benign; Benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (48)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyloidosis	Amyloidosis	BEFREE	27714968		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	23215816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	21700930, 25732743, 29731721, 30471213, 31619063		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis, Gouty	Gouty arthritis	GWASDB_DG	20884846, 21768215, 23263486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	25732743, 29731721		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Atrial Fibrillation	CTD_human_DG	29892015		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Behcet Syndrome	Behcet Syndrome	BEFREE	31414226		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26139244, 27521604, 28476377, 28822708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bulbo-Spinal Atrophy, X-Linked	Bulbospinal Atrophy, X-Linked	BEFREE	27609643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	22046421, 29989053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	BEFREE	25732743, 27609643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	27609643	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	28348580		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cleft Palate	Cleft palate	Pubtator	24516586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29114386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cyst	Cyst	BEFREE	25792565		★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	32792518	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28339748		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	28339748	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gout	Gout	GWASDB_DG	20884846, 21768215, 23263486		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hemolytic Uremic Syndrome	Hemolytic uremic syndrome	Pubtator	22836280	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	29114386		★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	27521604		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphopenia	Lymphopenia	BEFREE	29751004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Macrothrombocytopenia	Macrothrombocytopenia	BEFREE	17515402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26139244, 27521604, 28476377, 28822708		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	22046421, 29989053		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	26139244		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	BEFREE	27609643		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26139244, 29989053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29989053		★★★★★ ★☆☆☆☆ Found in Text Mining only
Orofacial Cleft 1	Orofacial cleft	Pubtator	24516586	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Osteoporosis, Age-Related	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis, Senile	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	23215816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	CTD_human_DG	29892015		★★★★★ ★☆☆☆☆ Found in Text Mining only
Post-Traumatic Osteoporosis	Osteoporosis	CTD_human_DG	18924182		★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Tract Infections	Respiratory system infectious disease	Pubtator	29751004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19165527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Ulcer	Skin ulcer	Pubtator	29751004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30464518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomatitis	Stomatitis	BEFREE	29751004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomatitis	Stomatitis	Pubtator	29751004	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocytopenia	Thrombocytopenia	Pubtator	27994071	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	23215816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uranostaphyloschisis	Uranostaphyloschisis	BEFREE	24516586		★★★★★ ★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular Diseases	BEFREE	29731721		★★★★★ ★☆☆☆☆ Found in Text Mining only

WDR1 (WD repeat domain 1)