Gene Gene information from NCBI Gene database.
Entrez ID 9943
Gene name Oxidative stress responsive kinase 1
Gene symbol OXSR1
Synonyms (NCBI Gene)
OSR1
Chromosome 3
Chromosome location 3p22.2
Summary The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
550
miRTarBase ID miRNA Experiments Reference
MIRT029769 hsa-miR-26b-5p Microarray 19088304
MIRT030472 hsa-miR-24-3p Microarray 19748357
MIRT043941 hsa-miR-378a-3p CLASH 23622248
MIRT655571 hsa-miR-7113-5p HITS-CLIP 23824327
MIRT655572 hsa-miR-4685-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
61
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000287 Function Magnesium ion binding IDA 14707132
GO:0004672 Function Protein kinase activity IEA
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 14707132, 18270262, 19665974, 21321328, 24393035
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604046 8508 ENSG00000172939
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95747
Protein name Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
Protein function Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:16669787, PubMed:18270262, PubMed:213
PDB 2V3S , 2VWI , 3DAK , 7OKW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 17 291 Protein kinase domain Domain
PF12202 OSR1_C 434 491 Oxidative-stress-responsive kinase 1 C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed in all tissue examined. {ECO:0000269|PubMed:10083736}.
Sequence
Sequence length 527
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Parathyroid hormone synthesis, secretion and action  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ASTROCYTOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colorectal cancer Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSIVE DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma Pubtator 34983467 Associate
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 31362998
★☆☆☆☆
Found in Text Mining only
Essential Hypertension Hypertension BEFREE 18277153
★☆☆☆☆
Found in Text Mining only
Hypertensive disease Hypertension BEFREE 20889219, 28566208, 31020807, 31608673
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hypertensive disease Hypertension CTD_human_DG 22949526
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Metastatic melanoma Metastatic Melanoma UNIPROT_DG
★☆☆☆☆
Found in Text Mining only
Polycystic Kidney Diseases Polycystic kidney disease BEFREE 31020807
★☆☆☆☆
Found in Text Mining only
Polycystic Kidney, Autosomal Dominant Polycystic kidney disease BEFREE 31020807
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia BEFREE 20819979
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Schizophrenia Schizophrenia PSYGENET_DG 20819979
★★☆☆☆
Found in Text Mining + Unknown/Other Associations