Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9942
Gene name	Xylulokinase
Gene symbol	XYLB
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3p22.2
Summary	The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include f

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miRTarBase ID	miRNA	Experiments	Reference
MIRT484736	hsa-miR-889-3p	PAR-CLIP	23592263
MIRT484735	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT484734	hsa-miR-4452	PAR-CLIP	23592263
MIRT484732	hsa-miR-8081	PAR-CLIP	23592263
MIRT484736	hsa-miR-889-3p	PAR-CLIP	23592263
MIRT484735	hsa-miR-183-3p	PAR-CLIP	23592263
MIRT484734	hsa-miR-4452	PAR-CLIP	23592263
MIRT484732	hsa-miR-8081	PAR-CLIP	23592263
MIRT1497679	hsa-miR-1184	CLIP-seq
MIRT1497680	hsa-miR-1205	CLIP-seq
MIRT1497681	hsa-miR-1245b-5p	CLIP-seq
MIRT1497682	hsa-miR-1255a	CLIP-seq
MIRT1497683	hsa-miR-1255b	CLIP-seq
MIRT1497684	hsa-miR-1265	CLIP-seq
MIRT1497685	hsa-miR-1270	CLIP-seq
MIRT1497686	hsa-miR-1286	CLIP-seq
MIRT1497687	hsa-miR-1299	CLIP-seq
MIRT1497688	hsa-miR-1305	CLIP-seq
MIRT1497689	hsa-miR-2116	CLIP-seq
MIRT1497690	hsa-miR-2392	CLIP-seq
MIRT1497691	hsa-miR-296-3p	CLIP-seq
MIRT1497692	hsa-miR-3115	CLIP-seq
MIRT1497693	hsa-miR-3142	CLIP-seq
MIRT1497694	hsa-miR-3145-5p	CLIP-seq
MIRT1497695	hsa-miR-3158-5p	CLIP-seq
MIRT1497696	hsa-miR-3189-3p	CLIP-seq
MIRT1497697	hsa-miR-3616-5p	CLIP-seq
MIRT1497698	hsa-miR-3647-5p	CLIP-seq
MIRT1497699	hsa-miR-3671	CLIP-seq
MIRT1497700	hsa-miR-3690	CLIP-seq
MIRT1497701	hsa-miR-4254	CLIP-seq
MIRT1497702	hsa-miR-4299	CLIP-seq
MIRT1497703	hsa-miR-4311	CLIP-seq
MIRT1497704	hsa-miR-4426	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497706	hsa-miR-4434	CLIP-seq
MIRT1497707	hsa-miR-4456	CLIP-seq
MIRT1497708	hsa-miR-4481	CLIP-seq
MIRT1497709	hsa-miR-4484	CLIP-seq
MIRT1497710	hsa-miR-4516	CLIP-seq
MIRT1497711	hsa-miR-4531	CLIP-seq
MIRT1497712	hsa-miR-4638-3p	CLIP-seq
MIRT1497713	hsa-miR-4647	CLIP-seq
MIRT1497714	hsa-miR-4662b	CLIP-seq
MIRT1497715	hsa-miR-4677-5p	CLIP-seq
MIRT1497716	hsa-miR-4686	CLIP-seq
MIRT1497717	hsa-miR-4694-5p	CLIP-seq
MIRT1497718	hsa-miR-4722-5p	CLIP-seq
MIRT1497719	hsa-miR-4745-5p	CLIP-seq
MIRT1497720	hsa-miR-4752	CLIP-seq
MIRT1497721	hsa-miR-4760-3p	CLIP-seq
MIRT1497722	hsa-miR-4795-5p	CLIP-seq
MIRT1497723	hsa-miR-4797-3p	CLIP-seq
MIRT1497724	hsa-miR-515-3p	CLIP-seq
MIRT1497725	hsa-miR-519e	CLIP-seq
MIRT1497726	hsa-miR-548an	CLIP-seq
MIRT1497727	hsa-miR-548c-3p	CLIP-seq
MIRT1497728	hsa-miR-548q	CLIP-seq
MIRT1497729	hsa-miR-573	CLIP-seq
MIRT1497730	hsa-miR-607	CLIP-seq
MIRT1497731	hsa-miR-620	CLIP-seq
MIRT1497732	hsa-miR-635	CLIP-seq
MIRT1497733	hsa-miR-653	CLIP-seq
MIRT1497734	hsa-miR-7	CLIP-seq
MIRT1497735	hsa-miR-765	CLIP-seq
MIRT1497736	hsa-miR-875-3p	CLIP-seq
MIRT1497737	hsa-miR-944	CLIP-seq
MIRT1555630	hsa-miR-4716-3p	CLIP-seq
MIRT1555631	hsa-miR-4723-5p	CLIP-seq
MIRT1497686	hsa-miR-1286	CLIP-seq
MIRT2149918	hsa-miR-1324	CLIP-seq
MIRT2149919	hsa-miR-3130-3p	CLIP-seq
MIRT2149920	hsa-miR-3180-5p	CLIP-seq
MIRT2149921	hsa-miR-3614-5p	CLIP-seq
MIRT2149922	hsa-miR-3689a-3p	CLIP-seq
MIRT2149923	hsa-miR-3689c	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2149925	hsa-miR-425	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497718	hsa-miR-4722-5p	CLIP-seq
MIRT2149926	hsa-miR-4737	CLIP-seq
MIRT2149927	hsa-miR-494	CLIP-seq
MIRT2149928	hsa-miR-520a-5p	CLIP-seq
MIRT2149929	hsa-miR-525-5p	CLIP-seq
MIRT2149930	hsa-miR-642b	CLIP-seq
MIRT2149931	hsa-miR-767-5p	CLIP-seq
MIRT2370050	hsa-miR-1236	CLIP-seq
MIRT2370051	hsa-miR-1269	CLIP-seq
MIRT2370052	hsa-miR-1269b	CLIP-seq
MIRT1497685	hsa-miR-1270	CLIP-seq
MIRT2370053	hsa-miR-1288	CLIP-seq
MIRT2370054	hsa-miR-2110	CLIP-seq
MIRT1497691	hsa-miR-296-3p	CLIP-seq
MIRT1497692	hsa-miR-3115	CLIP-seq
MIRT2370055	hsa-miR-3150a-3p	CLIP-seq
MIRT2370056	hsa-miR-3151	CLIP-seq
MIRT2370057	hsa-miR-3170	CLIP-seq
MIRT2149920	hsa-miR-3180-5p	CLIP-seq
MIRT2370058	hsa-miR-3616-3p	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2149925	hsa-miR-425	CLIP-seq
MIRT2370059	hsa-miR-4291	CLIP-seq
MIRT1497705	hsa-miR-4433	CLIP-seq
MIRT1497706	hsa-miR-4434	CLIP-seq
MIRT2370060	hsa-miR-4447	CLIP-seq
MIRT2370061	hsa-miR-4472	CLIP-seq
MIRT1497708	hsa-miR-4481	CLIP-seq
MIRT2370062	hsa-miR-4515	CLIP-seq
MIRT1497710	hsa-miR-4516	CLIP-seq
MIRT1497711	hsa-miR-4531	CLIP-seq
MIRT2370063	hsa-miR-4740-5p	CLIP-seq
MIRT1497719	hsa-miR-4745-5p	CLIP-seq
MIRT1497720	hsa-miR-4752	CLIP-seq
MIRT2370064	hsa-miR-4778-3p	CLIP-seq
MIRT2370065	hsa-miR-491-5p	CLIP-seq
MIRT2149928	hsa-miR-520a-5p	CLIP-seq
MIRT2149929	hsa-miR-525-5p	CLIP-seq
MIRT2370066	hsa-miR-539	CLIP-seq
MIRT2370067	hsa-miR-545	CLIP-seq
MIRT1497731	hsa-miR-620	CLIP-seq
MIRT2149930	hsa-miR-642b	CLIP-seq
MIRT2370068	hsa-miR-760	CLIP-seq
MIRT1497735	hsa-miR-765	CLIP-seq
MIRT2397111	hsa-miR-486-3p	CLIP-seq
MIRT2466344	hsa-miR-3681	CLIP-seq
MIRT2149924	hsa-miR-3919	CLIP-seq
MIRT2466345	hsa-miR-4773	CLIP-seq
MIRT1497722	hsa-miR-4795-5p	CLIP-seq
MIRT2695391	hsa-miR-3180	CLIP-seq
MIRT2695392	hsa-miR-3180-3p	CLIP-seq
MIRT2695393	hsa-miR-3196	CLIP-seq
MIRT2695394	hsa-miR-342-5p	CLIP-seq
MIRT2695395	hsa-miR-3675-5p	CLIP-seq
MIRT2370060	hsa-miR-4447	CLIP-seq
MIRT2370061	hsa-miR-4472	CLIP-seq
MIRT2695396	hsa-miR-4488	CLIP-seq
MIRT2695397	hsa-miR-4651	CLIP-seq
MIRT2695398	hsa-miR-4664-5p	CLIP-seq
MIRT2695399	hsa-miR-4697-5p	CLIP-seq
MIRT2695400	hsa-miR-608	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004856	Function	D-xylulokinase activity	EXP	23179721
GO:0004856	Function	D-xylulokinase activity	IBA
GO:0004856	Function	D-xylulokinase activity	IDA	23179721
GO:0004856	Function	D-xylulokinase activity	IEA
GO:0004856	Function	D-xylulokinase activity	TAS	9763671
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005975	Process	Carbohydrate metabolic process	TAS	9763671
GO:0005997	Process	Xylulose metabolic process	IBA
GO:0005997	Process	Xylulose metabolic process	IDA	23179721
GO:0005998	Process	Xylulose catabolic process	TAS	9763671
GO:0006091	Process	Generation of precursor metabolites and energy	TAS	9763671
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019640	Process	D-glucuronate catabolic process to D-xylulose 5-phosphate	TAS
GO:0042732	Process	D-xylose metabolic process	IEA
GO:0046835	Process	Carbohydrate phosphorylation	IEA

MIM	HGNC	e!Ensembl
604049	12839	ENSG00000093217

O75191

Protein name

Xylulose kinase (Xylulokinase) (EC 2.7.1.17)

Protein function

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

PDB

4BC2 , 4BC3 , 4BC4 , 4BC5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00370	FGGY_N	125 → 287	FGGY family of carbohydrate kinases, N-terminal domain	Domain
PF02782	FGGY_C	295 → 481	FGGY family of carbohydrate kinases, C-terminal domain	Domain

Sequence

MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLT
VTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLR
LHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIY
QQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPH
LEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLG
TSDTLFLWLQEPMPALEGHIFCNPVDSQHYMALLCFKNGSLMREKIRNESVSRSWSDFSK
ALQSTEMGNGGNLGFYFDVMEITPEIIGRHRFNTENHKVAAFPGDVEVRALIEGQFMAKR
IHAEGLGYRVMSKTKILATGGASHNREILQVLADVFDAPVYVIDTANSACVGSAYRAFHG
LAGGTDVPFSEVVKLAPNPRLAATPSPGASQVYEALLPQYAKLEQRILSQTRGPPE

Sequence length

536

Interactions

View interactions

	KEGG		Reactome
	Pentose and glucuronate interconversions Metabolic pathways		Formation of xylulose-5-phosphate

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	33372590	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	25855559, 26352407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension Pulmonary	Pulmonary hypertension	Pubtator	26352407	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	24122314		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	40148931	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

XYLB (xylulokinase)