EXOG (exo/endonuclease G)

Gene

• Entrez ID: 9941
• Gene name: Exo/endonuclease G
• Gene symbol: EXOG
• Synonyms (NCBI Gene): ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-b, ENGLA, ENGLB
• Chromosome: 3
• Chromosome location: 3p22.2
• Summary: This gene encodes an endo/exonuclease with 5`-3` exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5` end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042345	hsa-miR-484	CLASH	23622248
MIRT438740	hsa-miR-654-3p	qRT-PCR	24974767
MIRT438740	hsa-miR-654-3p	qRT-PCR	24974767
MIRT438740	hsa-miR-654-3p	qRT-PCR	24974767
MIRT438740	hsa-miR-654-3p	qRT-PCR	24974767
MIRT664540	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT664539	hsa-miR-3155a	HITS-CLIP	23824327
MIRT664538	hsa-miR-3155b	HITS-CLIP	23824327
MIRT042345	hsa-miR-484	HITS-CLIP	23824327
MIRT664536	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT664537	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT664535	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT664534	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT664533	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT664532	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT664531	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT381380	hsa-miR-425-5p	PAR-CLIP	23592263
MIRT381383	hsa-miR-642a-3p	PAR-CLIP	23592263
MIRT381384	hsa-miR-642b-3p	PAR-CLIP	23592263
MIRT664540	hsa-miR-205-3p	HITS-CLIP	23824327
MIRT664539	hsa-miR-3155a	HITS-CLIP	23824327
MIRT664538	hsa-miR-3155b	HITS-CLIP	23824327
MIRT042345	hsa-miR-484	HITS-CLIP	23824327
MIRT664536	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT664537	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT664535	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT664534	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT664533	hsa-miR-3157-5p	HITS-CLIP	23824327
MIRT664532	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT664531	hsa-miR-5006-5p	HITS-CLIP	23824327
MIRT381380	hsa-miR-425-5p	PAR-CLIP	23592263
MIRT381383	hsa-miR-642a-3p	PAR-CLIP	23592263
MIRT381384	hsa-miR-642b-3p	PAR-CLIP	23592263
MIRT972999	hsa-miR-1266	CLIP-seq
MIRT973000	hsa-miR-1271	CLIP-seq
MIRT973001	hsa-miR-182	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT973003	hsa-miR-2467-3p	CLIP-seq
MIRT973004	hsa-miR-3126-3p	CLIP-seq
MIRT973005	hsa-miR-3149	CLIP-seq
MIRT973006	hsa-miR-3199	CLIP-seq
MIRT973007	hsa-miR-34a	CLIP-seq
MIRT973008	hsa-miR-34c-5p	CLIP-seq
MIRT973009	hsa-miR-3663-5p	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT973011	hsa-miR-425	CLIP-seq
MIRT973012	hsa-miR-4265	CLIP-seq
MIRT973013	hsa-miR-4296	CLIP-seq
MIRT973014	hsa-miR-4322	CLIP-seq
MIRT973015	hsa-miR-4417	CLIP-seq
MIRT973016	hsa-miR-449a	CLIP-seq
MIRT973017	hsa-miR-449b	CLIP-seq
MIRT973018	hsa-miR-4518	CLIP-seq
MIRT973019	hsa-miR-4735-5p	CLIP-seq
MIRT973020	hsa-miR-4740-3p	CLIP-seq
MIRT973021	hsa-miR-4775	CLIP-seq
MIRT973022	hsa-miR-486-3p	CLIP-seq
MIRT973023	hsa-miR-526b	CLIP-seq
MIRT973024	hsa-miR-552	CLIP-seq
MIRT973025	hsa-miR-577	CLIP-seq
MIRT973026	hsa-miR-590-3p	CLIP-seq
MIRT973027	hsa-miR-642b	CLIP-seq
MIRT973028	hsa-miR-767-3p	CLIP-seq
MIRT973029	hsa-miR-767-5p	CLIP-seq
MIRT973030	hsa-miR-96	CLIP-seq
MIRT972999	hsa-miR-1266	CLIP-seq
MIRT973031	hsa-miR-1276	CLIP-seq
MIRT973032	hsa-miR-200b	CLIP-seq
MIRT973033	hsa-miR-200c	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT973034	hsa-miR-3150b-3p	CLIP-seq
MIRT973035	hsa-miR-3616-3p	CLIP-seq
MIRT973036	hsa-miR-3671	CLIP-seq
MIRT973037	hsa-miR-369-3p	CLIP-seq
MIRT973038	hsa-miR-374a	CLIP-seq
MIRT973039	hsa-miR-374b	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT973040	hsa-miR-4253	CLIP-seq
MIRT973041	hsa-miR-429	CLIP-seq
MIRT973042	hsa-miR-4311	CLIP-seq
MIRT973018	hsa-miR-4518	CLIP-seq
MIRT973043	hsa-miR-4520b-3p	CLIP-seq
MIRT973044	hsa-miR-4529-3p	CLIP-seq
MIRT973045	hsa-miR-4535	CLIP-seq
MIRT973019	hsa-miR-4735-5p	CLIP-seq
MIRT973046	hsa-miR-4744	CLIP-seq
MIRT973047	hsa-miR-4761-3p	CLIP-seq
MIRT973048	hsa-miR-4763-5p	CLIP-seq
MIRT973021	hsa-miR-4775	CLIP-seq
MIRT973049	hsa-miR-4776-5p	CLIP-seq
MIRT973050	hsa-miR-4784	CLIP-seq
MIRT973051	hsa-miR-492	CLIP-seq
MIRT973052	hsa-miR-532-5p	CLIP-seq
MIRT973053	hsa-miR-550a	CLIP-seq
MIRT973024	hsa-miR-552	CLIP-seq
MIRT973054	hsa-miR-583	CLIP-seq
MIRT973026	hsa-miR-590-3p	CLIP-seq
MIRT973028	hsa-miR-767-3p	CLIP-seq
MIRT973029	hsa-miR-767-5p	CLIP-seq
MIRT1988304	hsa-miR-105	CLIP-seq
MIRT972999	hsa-miR-1266	CLIP-seq
MIRT1988305	hsa-miR-1275	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT1988306	hsa-miR-3117-5p	CLIP-seq
MIRT1988307	hsa-miR-3158-5p	CLIP-seq
MIRT1988308	hsa-miR-3609	CLIP-seq
MIRT1988309	hsa-miR-3617	CLIP-seq
MIRT973009	hsa-miR-3663-5p	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT1988310	hsa-miR-4260	CLIP-seq
MIRT1988311	hsa-miR-4287	CLIP-seq
MIRT1988312	hsa-miR-4290	CLIP-seq
MIRT1988313	hsa-miR-4422	CLIP-seq
MIRT973018	hsa-miR-4518	CLIP-seq
MIRT1988314	hsa-miR-4525	CLIP-seq
MIRT1988315	hsa-miR-4665-5p	CLIP-seq
MIRT1988316	hsa-miR-4685-3p	CLIP-seq
MIRT1988317	hsa-miR-4687-5p	CLIP-seq
MIRT1988318	hsa-miR-4690-3p	CLIP-seq
MIRT1988319	hsa-miR-4723-5p	CLIP-seq
MIRT1988320	hsa-miR-4731-3p	CLIP-seq
MIRT1988321	hsa-miR-4738-3p	CLIP-seq
MIRT1988322	hsa-miR-4801	CLIP-seq
MIRT1988323	hsa-miR-510	CLIP-seq
MIRT1988324	hsa-miR-548ah	CLIP-seq
MIRT1988325	hsa-miR-548t	CLIP-seq
MIRT1988326	hsa-miR-625	CLIP-seq
MIRT1988327	hsa-miR-641	CLIP-seq
MIRT973027	hsa-miR-642b	CLIP-seq
MIRT973028	hsa-miR-767-3p	CLIP-seq
MIRT1988328	hsa-miR-1827	CLIP-seq
MIRT973003	hsa-miR-2467-3p	CLIP-seq
MIRT973009	hsa-miR-3663-5p	CLIP-seq
MIRT1988304	hsa-miR-105	CLIP-seq
MIRT2222757	hsa-miR-1825	CLIP-seq
MIRT2222758	hsa-miR-199a-5p	CLIP-seq
MIRT2222759	hsa-miR-199b-5p	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT2222760	hsa-miR-3136-3p	CLIP-seq
MIRT973006	hsa-miR-3199	CLIP-seq
MIRT2222761	hsa-miR-323b-3p	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT973020	hsa-miR-4740-3p	CLIP-seq
MIRT973024	hsa-miR-552	CLIP-seq
MIRT973027	hsa-miR-642b	CLIP-seq
MIRT2222762	hsa-miR-663b	CLIP-seq
MIRT973029	hsa-miR-767-5p	CLIP-seq
MIRT1988304	hsa-miR-105	CLIP-seq
MIRT2526453	hsa-miR-1182	CLIP-seq
MIRT2526454	hsa-miR-1184	CLIP-seq
MIRT2526455	hsa-miR-1200	CLIP-seq
MIRT2526456	hsa-miR-1205	CLIP-seq
MIRT2526457	hsa-miR-1208	CLIP-seq
MIRT972999	hsa-miR-1266	CLIP-seq
MIRT1988305	hsa-miR-1275	CLIP-seq
MIRT973031	hsa-miR-1276	CLIP-seq
MIRT2526458	hsa-miR-129-5p	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT2526459	hsa-miR-30a	CLIP-seq
MIRT2526460	hsa-miR-30b	CLIP-seq
MIRT2526461	hsa-miR-30c	CLIP-seq
MIRT2526462	hsa-miR-30d	CLIP-seq
MIRT2526463	hsa-miR-30e	CLIP-seq
MIRT2526464	hsa-miR-3124-3p	CLIP-seq
MIRT2526465	hsa-miR-3133	CLIP-seq
MIRT2222760	hsa-miR-3136-3p	CLIP-seq
MIRT973005	hsa-miR-3149	CLIP-seq
MIRT1988307	hsa-miR-3158-5p	CLIP-seq
MIRT2526466	hsa-miR-3159	CLIP-seq
MIRT2526467	hsa-miR-3173-3p	CLIP-seq
MIRT973006	hsa-miR-3199	CLIP-seq
MIRT2222761	hsa-miR-323b-3p	CLIP-seq
MIRT2526468	hsa-miR-325	CLIP-seq
MIRT2526469	hsa-miR-330-3p	CLIP-seq
MIRT2526470	hsa-miR-3605-3p	CLIP-seq
MIRT973035	hsa-miR-3616-3p	CLIP-seq
MIRT2526471	hsa-miR-3650	CLIP-seq
MIRT2526472	hsa-miR-3664-3p	CLIP-seq
MIRT2526473	hsa-miR-3665	CLIP-seq
MIRT2526474	hsa-miR-3674	CLIP-seq
MIRT2526475	hsa-miR-3692	CLIP-seq
MIRT2526476	hsa-miR-3923	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT2526477	hsa-miR-3935	CLIP-seq
MIRT973040	hsa-miR-4253	CLIP-seq
MIRT1988310	hsa-miR-4260	CLIP-seq
MIRT2526478	hsa-miR-4285	CLIP-seq
MIRT1988311	hsa-miR-4287	CLIP-seq
MIRT1988312	hsa-miR-4290	CLIP-seq
MIRT2526479	hsa-miR-4297	CLIP-seq
MIRT973042	hsa-miR-4311	CLIP-seq
MIRT2526480	hsa-miR-4324	CLIP-seq
MIRT1988313	hsa-miR-4422	CLIP-seq
MIRT2526481	hsa-miR-4428	CLIP-seq
MIRT2526482	hsa-miR-4436b-5p	CLIP-seq
MIRT2526483	hsa-miR-4462	CLIP-seq
MIRT2526484	hsa-miR-4469	CLIP-seq
MIRT973018	hsa-miR-4518	CLIP-seq
MIRT2526485	hsa-miR-452	CLIP-seq
MIRT2526486	hsa-miR-4521	CLIP-seq
MIRT1988314	hsa-miR-4525	CLIP-seq
MIRT1988315	hsa-miR-4665-5p	CLIP-seq
MIRT2526487	hsa-miR-4676-3p	CLIP-seq
MIRT1988316	hsa-miR-4685-3p	CLIP-seq
MIRT1988317	hsa-miR-4687-5p	CLIP-seq
MIRT1988318	hsa-miR-4690-3p	CLIP-seq
MIRT1988319	hsa-miR-4723-5p	CLIP-seq
MIRT1988320	hsa-miR-4731-3p	CLIP-seq
MIRT973019	hsa-miR-4735-5p	CLIP-seq
MIRT1988321	hsa-miR-4738-3p	CLIP-seq
MIRT973046	hsa-miR-4744	CLIP-seq
MIRT2526488	hsa-miR-4753-3p	CLIP-seq
MIRT973047	hsa-miR-4761-3p	CLIP-seq
MIRT973021	hsa-miR-4775	CLIP-seq
MIRT2526489	hsa-miR-4779	CLIP-seq
MIRT2526490	hsa-miR-4786-5p	CLIP-seq
MIRT1988322	hsa-miR-4801	CLIP-seq
MIRT973022	hsa-miR-486-3p	CLIP-seq
MIRT2526491	hsa-miR-488	CLIP-seq
MIRT1988323	hsa-miR-510	CLIP-seq
MIRT2526492	hsa-miR-512-5p	CLIP-seq
MIRT2526493	hsa-miR-513a-3p	CLIP-seq
MIRT973052	hsa-miR-532-5p	CLIP-seq
MIRT2526494	hsa-miR-544b	CLIP-seq
MIRT2526495	hsa-miR-548ae	CLIP-seq
MIRT2526496	hsa-miR-548aj	CLIP-seq
MIRT2526497	hsa-miR-548am	CLIP-seq
MIRT2526498	hsa-miR-548p	CLIP-seq
MIRT2526499	hsa-miR-548x	CLIP-seq
MIRT973053	hsa-miR-550a	CLIP-seq
MIRT973024	hsa-miR-552	CLIP-seq
MIRT973054	hsa-miR-583	CLIP-seq
MIRT973026	hsa-miR-590-3p	CLIP-seq
MIRT2526500	hsa-miR-593	CLIP-seq
MIRT2526501	hsa-miR-610	CLIP-seq
MIRT1988326	hsa-miR-625	CLIP-seq
MIRT2526502	hsa-miR-642a	CLIP-seq
MIRT973027	hsa-miR-642b	CLIP-seq
MIRT2526503	hsa-miR-651	CLIP-seq
MIRT2526504	hsa-miR-657	CLIP-seq
MIRT2222762	hsa-miR-663b	CLIP-seq
MIRT973028	hsa-miR-767-3p	CLIP-seq
MIRT973029	hsa-miR-767-5p	CLIP-seq
MIRT1988304	hsa-miR-105	CLIP-seq
MIRT2526454	hsa-miR-1184	CLIP-seq
MIRT2526455	hsa-miR-1200	CLIP-seq
MIRT2526456	hsa-miR-1205	CLIP-seq
MIRT2526457	hsa-miR-1208	CLIP-seq
MIRT972999	hsa-miR-1266	CLIP-seq
MIRT1988305	hsa-miR-1275	CLIP-seq
MIRT973031	hsa-miR-1276	CLIP-seq
MIRT2526458	hsa-miR-129-5p	CLIP-seq
MIRT2680393	hsa-miR-149	CLIP-seq
MIRT2680394	hsa-miR-204	CLIP-seq
MIRT2680395	hsa-miR-211	CLIP-seq
MIRT973002	hsa-miR-2114	CLIP-seq
MIRT2680396	hsa-miR-24	CLIP-seq
MIRT2680397	hsa-miR-3064-5p	CLIP-seq
MIRT2526464	hsa-miR-3124-3p	CLIP-seq
MIRT973004	hsa-miR-3126-3p	CLIP-seq
MIRT2526465	hsa-miR-3133	CLIP-seq
MIRT973005	hsa-miR-3149	CLIP-seq
MIRT1988307	hsa-miR-3158-5p	CLIP-seq
MIRT2526466	hsa-miR-3159	CLIP-seq
MIRT2526467	hsa-miR-3173-3p	CLIP-seq
MIRT973006	hsa-miR-3199	CLIP-seq
MIRT2222761	hsa-miR-323b-3p	CLIP-seq
MIRT2526469	hsa-miR-330-3p	CLIP-seq
MIRT973035	hsa-miR-3616-3p	CLIP-seq
MIRT2526471	hsa-miR-3650	CLIP-seq
MIRT2526473	hsa-miR-3665	CLIP-seq
MIRT973036	hsa-miR-3671	CLIP-seq
MIRT2526474	hsa-miR-3674	CLIP-seq
MIRT2526475	hsa-miR-3692	CLIP-seq
MIRT973010	hsa-miR-3934	CLIP-seq
MIRT2526477	hsa-miR-3935	CLIP-seq
MIRT2680398	hsa-miR-3977	CLIP-seq
MIRT973040	hsa-miR-4253	CLIP-seq
MIRT1988310	hsa-miR-4260	CLIP-seq
MIRT2680399	hsa-miR-4284	CLIP-seq
MIRT2526478	hsa-miR-4285	CLIP-seq
MIRT1988311	hsa-miR-4287	CLIP-seq
MIRT1988312	hsa-miR-4290	CLIP-seq
MIRT2526479	hsa-miR-4297	CLIP-seq
MIRT973042	hsa-miR-4311	CLIP-seq
MIRT2526480	hsa-miR-4324	CLIP-seq
MIRT2526481	hsa-miR-4428	CLIP-seq
MIRT2526482	hsa-miR-4436b-5p	CLIP-seq
MIRT2526483	hsa-miR-4462	CLIP-seq
MIRT973018	hsa-miR-4518	CLIP-seq
MIRT2526485	hsa-miR-452	CLIP-seq
MIRT2526486	hsa-miR-4521	CLIP-seq
MIRT1988314	hsa-miR-4525	CLIP-seq
MIRT1988315	hsa-miR-4665-5p	CLIP-seq
MIRT2526487	hsa-miR-4676-3p	CLIP-seq
MIRT1988316	hsa-miR-4685-3p	CLIP-seq
MIRT1988317	hsa-miR-4687-5p	CLIP-seq
MIRT1988318	hsa-miR-4690-3p	CLIP-seq
MIRT2680400	hsa-miR-4691-3p	CLIP-seq
MIRT1988319	hsa-miR-4723-5p	CLIP-seq
MIRT1988320	hsa-miR-4731-3p	CLIP-seq
MIRT973019	hsa-miR-4735-5p	CLIP-seq
MIRT1988321	hsa-miR-4738-3p	CLIP-seq
MIRT973046	hsa-miR-4744	CLIP-seq
MIRT2526488	hsa-miR-4753-3p	CLIP-seq
MIRT973047	hsa-miR-4761-3p	CLIP-seq
MIRT973048	hsa-miR-4763-5p	CLIP-seq
MIRT973021	hsa-miR-4775	CLIP-seq
MIRT2526489	hsa-miR-4779	CLIP-seq
MIRT2526490	hsa-miR-4786-5p	CLIP-seq
MIRT2680401	hsa-miR-4794	CLIP-seq
MIRT1988322	hsa-miR-4801	CLIP-seq
MIRT2526493	hsa-miR-513a-3p	CLIP-seq
MIRT973052	hsa-miR-532-5p	CLIP-seq
MIRT2526494	hsa-miR-544b	CLIP-seq
MIRT2526495	hsa-miR-548ae	CLIP-seq
MIRT2526496	hsa-miR-548aj	CLIP-seq
MIRT2526497	hsa-miR-548am	CLIP-seq
MIRT2526498	hsa-miR-548p	CLIP-seq
MIRT2526499	hsa-miR-548x	CLIP-seq
MIRT973053	hsa-miR-550a	CLIP-seq
MIRT973024	hsa-miR-552	CLIP-seq
MIRT973054	hsa-miR-583	CLIP-seq
MIRT973026	hsa-miR-590-3p	CLIP-seq
MIRT2526500	hsa-miR-593	CLIP-seq
MIRT2526501	hsa-miR-610	CLIP-seq
MIRT1988326	hsa-miR-625	CLIP-seq
MIRT973027	hsa-miR-642b	CLIP-seq
MIRT2526503	hsa-miR-651	CLIP-seq
MIRT2526504	hsa-miR-657	CLIP-seq
MIRT973028	hsa-miR-767-3p	CLIP-seq
MIRT973029	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000014	Function	Single-stranded DNA endodeoxyribonuclease activity	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004519	Function	Endonuclease activity	IDA	18187503
GO:0004519	Function	Endonuclease activity	IEA
GO:0004519	Function	Endonuclease activity	NAS	10231028
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005634	Component	Nucleus	IBA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	18187503
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006309	Process	Apoptotic DNA fragmentation	IBA
GO:0008409	Function	5'-3' exonuclease activity	IBA
GO:0008409	Function	5'-3' exonuclease activity	IDA	18187503
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0032991	Component	Protein-containing complex	IDA	25378300
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 604051
• HGNC: 3347
• e!Ensembl: ENSG00000157036

Protein

• UniProt ID: Q9Y2C4
• Protein name: Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)
• Protein function: Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
• PDB: 4A1N, 5T3V, 5T40, 5T4I, 5T5C, 5ZKI, 5ZKJ, 6IID, 7R6T, 7R6V, 9FXN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01223	Endonuclease_NS	58 → 287	DNA/RNA non-specific endonuclease	Domain
  PF18026	Exog_C	302 → 350	Endo/exonuclease (EXOG) C-terminal domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MAIKSIASRLRGSRRFLSGFVAGAVVGAAGAGLAALQFFRSQGAEGALTGKQPDGSAEKA
  VLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADRKHCKFKPDPNI
  PPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFYLSNIVPQDFDNNSGYWNRIEM
  YCRELTERFEDVWVVSGPLTLPQTRGDGKKIVSYQVIGEDNVAVPSHLYKVILARRSSVS
  TEPLALGAFVVPNEAIGFQPQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCK
  LLDFQEFTLYLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKAKEQS
  GTQIRKPS

• Sequence length: 368

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRUGADA SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Depressive Disorder	Major depressive disorder	Pubtator	37834200	Associate	★☆☆☆☆ Found in Text Mining only
Depressive Disorder Major	Major depressive disorder	Pubtator	37834200	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	17415550		★☆☆☆☆ Found in Text Mining only