Gene Gene information from NCBI Gene database.
Entrez ID 994
Gene name Cell division cycle 25B
Gene symbol CDC25B
Synonyms (NCBI Gene)
MPIP2
Chromosome 20
Chromosome location 20p13
Summary CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear loca
miRNA miRNA information provided by mirtarbase database.
590
miRTarBase ID miRNA Experiments Reference
MIRT025904 hsa-miR-7-5p Microarray 19073608
MIRT026017 hsa-miR-148a-3p Reporter assay;Western blot;Other 21709669
MIRT030153 hsa-miR-26b-5p Microarray 19088304
MIRT052555 hsa-let-7a-5p CLASH 23622248
MIRT038444 hsa-miR-296-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
FOXM1 Activation 19276163
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle IBA
GO:0000086 Process G2/M transition of mitotic cell cycle TAS 12400006
GO:0000278 Process Mitotic cell cycle TAS 1836978, 9188863
GO:0000922 Component Spindle pole IDA 15908796
GO:0000922 Component Spindle pole IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
116949 1726 ENSG00000101224
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30305
Protein name M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)
Protein function Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:20360007). Required for G2/M phases of
PDB 1CWR , 1CWS , 1CWT , 1QB0 , 1YM9 , 1YMD , 1YMK , 1YML , 1YS0 , 2A2K , 2IFD , 2IFV , 2UZQ , 3FQT , 3FQU , 4WH7 , 4WH9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06617 M-inducer_phosp 113 383 M-phase inducer phosphatase Family
PF00581 Rhodanese 418 531 Rhodanese-like domain Domain
Sequence
Sequence length 580
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  MAPK signaling pathway
Cell cycle
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
  Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEART FAILURE, DIASTOLIC CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 12680208
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 21709669
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 28253537
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis Pubtator 28253537 Inhibit
★☆☆☆☆
Found in Text Mining only
Asthenozoospermia Asthenozoospermia BEFREE 17336969
★☆☆☆☆
Found in Text Mining only
Astrocytoma Astrocytoma Pubtator 24344030 Associate
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder GWASCAT_DG 21254220
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar Disorder GWASDB_DG 21254220
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Bipolar Disorder Bipolar disorder Pubtator 29745862 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma BEFREE 25384584
★☆☆☆☆
Found in Text Mining only