Gene Gene information from NCBI Gene database.
Entrez ID 993
Gene name Cell division cycle 25A
Gene symbol CDC25A
Synonyms (NCBI Gene)
CDC25A2
Chromosome 3
Chromosome location 3p21.31
Summary CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in respons
miRNA miRNA information provided by mirtarbase database.
446
miRTarBase ID miRNA Experiments Reference
MIRT001011 hsa-miR-34a-5p Western blot 18406353
MIRT000655 hsa-miR-424-5p Luciferase reporter assay 19956200
MIRT000648 hsa-miR-503-5p Luciferase reporter assay 19956200
MIRT000284 hsa-miR-15a-5p Luciferase reporter assay 18949056
MIRT003186 hsa-miR-449a Luciferase reporter assayMicroarrayqRT-PCRWestern blot 19833767
Transcription factors Transcription factors information provided by TRRUST V2 database.
6
Transcription factor Regulation Reference
FOXM1 Unknown 23240008
HMGA1 Activation 22249617
LIN28A Unknown 22467868
MSC Repression 15213307
NANOG Repression 17761754
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity TAS 7667636
GO:0000082 Process G1/S transition of mitotic cell cycle TAS
GO:0000086 Process G2/M transition of mitotic cell cycle IBA
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 2188730
GO:0000086 Process G2/M transition of mitotic cell cycle IDA 20360007
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
116947 1725 ENSG00000164045
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30304
Protein name M-phase inducer phosphatase 1 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25A)
Protein function Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression (PubMed:12676925, PubMed:14559997, PubMed:1836978, PubMed:20360007). Directly dephosphorylates CDK1 and stimulates its kinase activity (PubMed:2036
PDB 1C25 , 8ROZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06617 M-inducer_phosp 86 328 M-phase inducer phosphatase Family
PF00581 Rhodanese 369 476 Rhodanese-like domain Domain
Sequence
Sequence length 524
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell cycle
Cellular senescence
Progesterone-mediated oocyte maturation
MicroRNAs in cancer
Chemical carcinogenesis - receptor activation
  Transcription of E2F targets under negative control by DREAM complex
Polo-like kinase mediated events
Activation of ATR in response to replication stress
Ub-specific processing proteases
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Cyclin A:Cdk2-associated events at S phase entry
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Autosomal dominant polycystic liver disease Likely pathogenic rs3731499 RCV001844878
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARDIOVASCULAR DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute myelomonocytic leukemia Myelomonocytic Leukemia BEFREE 10573135
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 16715141, 29138515
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 27384875
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 16715141
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 22249617
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 11106571 Associate
★☆☆☆☆
Found in Text Mining only
Anemia Anemia BEFREE 12411323
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 17483325
★☆☆☆☆
Found in Text Mining only
Autosomal Recessive Polycystic Kidney Disease Polycystic kidney disease BEFREE 22155366
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 12960694, 25816175, 30106448, 31115494
★☆☆☆☆
Found in Text Mining only