Gene Gene information from NCBI Gene database.
Entrez ID 9926
Gene name Lysophosphatidylglycerol acyltransferase 1
Gene symbol LPGAT1
Synonyms (NCBI Gene)
FAM34AFAM34A1LPLAT7NET8
Chromosome 1
Chromosome location 1q32.3
Summary This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardi
miRNA miRNA information provided by mirtarbase database.
1174
miRTarBase ID miRNA Experiments Reference
MIRT020116 hsa-miR-130b-3p Sequencing 20371350
MIRT020554 hsa-miR-155-5p Proteomics 18668040
MIRT025088 hsa-miR-181a-5p Microarray 17612493
MIRT030680 hsa-miR-21-5p Microarray 18591254
MIRT031111 hsa-miR-19b-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0003841 Function 1-acylglycerol-3-phosphate O-acyltransferase activity TAS
GO:0003846 Function 2-acylglycerol O-acyltransferase activity IEA
GO:0003846 Function 2-acylglycerol O-acyltransferase activity ISS
GO:0005737 Component Cytoplasm IDA 10942595
GO:0005783 Component Endoplasmic reticulum IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610473 28985 ENSG00000123684
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92604
Protein name Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (2-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.62) (Acyl-CoA:monoacylglycerol acyltransferase LPGAT1) (EC 2.3.1.22) (Lysophospholipid acyltransferase 7) (LPLAT7) (EC 2.3.1.-) (Stearoyl-CoA:1-l
Protein function Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (By similarity). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids fro
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 80 228 Acyltransferase Family
PF16076 Acyltransf_C 271 345 Acyltransferase C-terminus Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. High expression is detected in brain and testis. {ECO:0000269|PubMed:15485873}.
Sequence
Sequence length 370
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Glycerophospholipid metabolism   Acyl chain remodelling of PG
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
7
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Neoplasms Colorectal neoplasm Pubtator 31796117 Associate
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression BEFREE 10512149
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder Mental Depression GWASCAT_DG 29495898
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Obesity Obesity BEFREE 23505186
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 23505186 Associate
★☆☆☆☆
Found in Text Mining only
Unipolar Depression Mental Depression BEFREE 10512149
★☆☆☆☆
Found in Text Mining only