Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9924
Gene name	Poly(A) specific ribonuclease subunit PAN2
Gene symbol	PAN2
Synonyms (NCBI Gene)	USP52
Chromosome	12
Chromosome location	12q13.3
Summary	This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3` to 5` exoribonuclease that is involved in the degradation of c

196

Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049988	hsa-miR-29a-3p	CLASH	23622248
MIRT046587	hsa-miR-222-3p	CLASH	23622248
MIRT655425	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT655424	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT655423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655421	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT655420	hsa-miR-1249-3p	HITS-CLIP	23824327
MIRT655419	hsa-miR-4294	HITS-CLIP	23824327
MIRT655418	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT655417	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655416	hsa-miR-6726-3p	HITS-CLIP	23824327
MIRT655415	hsa-miR-3672	HITS-CLIP	23824327
MIRT655414	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT655413	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655412	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT655411	hsa-miR-8055	HITS-CLIP	23824327
MIRT655410	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT627878	hsa-miR-3155a	HITS-CLIP	23824327
MIRT627877	hsa-miR-3155b	HITS-CLIP	23824327
MIRT627876	hsa-miR-484	HITS-CLIP	23824327
MIRT627875	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT627874	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT627873	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT627872	hsa-miR-6131	HITS-CLIP	23824327
MIRT627871	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT627870	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT627869	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT440050	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440048	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT440050	hsa-miR-377-5p	HITS-CLIP	24374217
MIRT440048	hsa-miR-770-5p	HITS-CLIP	24374217
MIRT655425	hsa-miR-6782-3p	HITS-CLIP	23824327
MIRT655424	hsa-miR-875-5p	HITS-CLIP	23824327
MIRT655423	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655422	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655421	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT655420	hsa-miR-1249-3p	HITS-CLIP	23824327
MIRT655419	hsa-miR-4294	HITS-CLIP	23824327
MIRT655418	hsa-miR-3144-3p	HITS-CLIP	23824327
MIRT655417	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655416	hsa-miR-6726-3p	HITS-CLIP	23824327
MIRT655415	hsa-miR-3672	HITS-CLIP	23824327
MIRT655414	hsa-miR-6864-3p	HITS-CLIP	23824327
MIRT655413	hsa-miR-3679-3p	HITS-CLIP	23824327
MIRT655412	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT655411	hsa-miR-8055	HITS-CLIP	23824327
MIRT655410	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT627878	hsa-miR-3155a	HITS-CLIP	23824327
MIRT627877	hsa-miR-3155b	HITS-CLIP	23824327
MIRT627876	hsa-miR-484	HITS-CLIP	23824327
MIRT627875	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT627874	hsa-miR-302b-5p	HITS-CLIP	23824327
MIRT627873	hsa-miR-302d-5p	HITS-CLIP	23824327
MIRT627872	hsa-miR-6131	HITS-CLIP	23824327
MIRT627871	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT627870	hsa-miR-4764-3p	HITS-CLIP	23824327
MIRT627869	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT1211992	hsa-miR-214	CLIP-seq
MIRT1211993	hsa-miR-3157-5p	CLIP-seq
MIRT1211994	hsa-miR-3619-5p	CLIP-seq
MIRT1211995	hsa-miR-4291	CLIP-seq
MIRT1211996	hsa-miR-4654	CLIP-seq
MIRT1211997	hsa-miR-4691-3p	CLIP-seq
MIRT1211998	hsa-miR-4769-5p	CLIP-seq
MIRT1211999	hsa-miR-7	CLIP-seq
MIRT1212000	hsa-miR-761	CLIP-seq
MIRT1212001	hsa-miR-922	CLIP-seq
MIRT1212002	hsa-miR-125a-5p	CLIP-seq
MIRT1212003	hsa-miR-125b	CLIP-seq
MIRT1212004	hsa-miR-149	CLIP-seq
MIRT1212005	hsa-miR-150	CLIP-seq
MIRT1212006	hsa-miR-188-5p	CLIP-seq
MIRT1212007	hsa-miR-3064-5p	CLIP-seq
MIRT1212008	hsa-miR-3121-5p	CLIP-seq
MIRT1212009	hsa-miR-3125	CLIP-seq
MIRT1212010	hsa-miR-3126-3p	CLIP-seq
MIRT1212011	hsa-miR-3149	CLIP-seq
MIRT1212012	hsa-miR-3916	CLIP-seq
MIRT1212013	hsa-miR-3919	CLIP-seq
MIRT1212014	hsa-miR-3925-5p	CLIP-seq
MIRT1212015	hsa-miR-4319	CLIP-seq
MIRT1212016	hsa-miR-4496	CLIP-seq
MIRT1212017	hsa-miR-4499	CLIP-seq
MIRT1212018	hsa-miR-450b-5p	CLIP-seq
MIRT1212019	hsa-miR-4672	CLIP-seq
MIRT1212020	hsa-miR-4713-5p	CLIP-seq
MIRT1212021	hsa-miR-4732-3p	CLIP-seq
MIRT1212022	hsa-miR-4735-5p	CLIP-seq
MIRT1212023	hsa-miR-4775	CLIP-seq
MIRT1212024	hsa-miR-4786-3p	CLIP-seq
MIRT1212025	hsa-miR-4794	CLIP-seq
MIRT1212026	hsa-miR-532-3p	CLIP-seq
MIRT1212027	hsa-miR-589	CLIP-seq
MIRT1212028	hsa-miR-590-3p	CLIP-seq
MIRT1212029	hsa-miR-670	CLIP-seq
MIRT1211999	hsa-miR-7	CLIP-seq
MIRT2060850	hsa-miR-1224-3p	CLIP-seq
MIRT2060851	hsa-miR-3676	CLIP-seq
MIRT2289516	hsa-miR-106a	CLIP-seq
MIRT2289517	hsa-miR-106b	CLIP-seq
MIRT2289518	hsa-miR-1208	CLIP-seq
MIRT2289519	hsa-miR-1243	CLIP-seq
MIRT1212002	hsa-miR-125a-5p	CLIP-seq
MIRT1212003	hsa-miR-125b	CLIP-seq
MIRT2289520	hsa-miR-1278	CLIP-seq
MIRT1212005	hsa-miR-150	CLIP-seq
MIRT2289521	hsa-miR-17	CLIP-seq
MIRT2289522	hsa-miR-198	CLIP-seq
MIRT2289523	hsa-miR-20a	CLIP-seq
MIRT2289524	hsa-miR-20b	CLIP-seq
MIRT2289525	hsa-miR-302a	CLIP-seq
MIRT2289526	hsa-miR-302b	CLIP-seq
MIRT2289527	hsa-miR-302c	CLIP-seq
MIRT2289528	hsa-miR-302d	CLIP-seq
MIRT2289529	hsa-miR-302e	CLIP-seq
MIRT2289530	hsa-miR-3159	CLIP-seq
MIRT2289531	hsa-miR-3654	CLIP-seq
MIRT2289532	hsa-miR-3663-3p	CLIP-seq
MIRT2289533	hsa-miR-372	CLIP-seq
MIRT2289534	hsa-miR-373	CLIP-seq
MIRT2289535	hsa-miR-4277	CLIP-seq
MIRT1212015	hsa-miR-4319	CLIP-seq
MIRT2289536	hsa-miR-4712-5p	CLIP-seq
MIRT2289537	hsa-miR-4725-5p	CLIP-seq
MIRT2289538	hsa-miR-504	CLIP-seq
MIRT2289539	hsa-miR-519d	CLIP-seq
MIRT2289540	hsa-miR-520a-3p	CLIP-seq
MIRT2289541	hsa-miR-520b	CLIP-seq
MIRT2289542	hsa-miR-520c-3p	CLIP-seq
MIRT2289543	hsa-miR-520d-3p	CLIP-seq
MIRT2289544	hsa-miR-520e	CLIP-seq
MIRT2289545	hsa-miR-520g	CLIP-seq
MIRT2289546	hsa-miR-520h	CLIP-seq
MIRT2289547	hsa-miR-665	CLIP-seq
MIRT2289548	hsa-miR-668	CLIP-seq
MIRT2289549	hsa-miR-93	CLIP-seq
MIRT2289518	hsa-miR-1208	CLIP-seq
MIRT2289519	hsa-miR-1243	CLIP-seq
MIRT2587346	hsa-miR-1254	CLIP-seq
MIRT1212002	hsa-miR-125a-5p	CLIP-seq
MIRT1212003	hsa-miR-125b	CLIP-seq
MIRT2289520	hsa-miR-1278	CLIP-seq
MIRT1212005	hsa-miR-150	CLIP-seq
MIRT2289522	hsa-miR-198	CLIP-seq
MIRT2587347	hsa-miR-28-5p	CLIP-seq
MIRT2587348	hsa-miR-3116	CLIP-seq
MIRT2587349	hsa-miR-3138	CLIP-seq
MIRT2587350	hsa-miR-3139	CLIP-seq
MIRT1212011	hsa-miR-3149	CLIP-seq
MIRT2587351	hsa-miR-3651	CLIP-seq
MIRT2289531	hsa-miR-3654	CLIP-seq
MIRT2289532	hsa-miR-3663-3p	CLIP-seq
MIRT2587352	hsa-miR-3914	CLIP-seq
MIRT2587353	hsa-miR-411	CLIP-seq
MIRT2289535	hsa-miR-4277	CLIP-seq
MIRT2587354	hsa-miR-4314	CLIP-seq
MIRT1212015	hsa-miR-4319	CLIP-seq
MIRT2587355	hsa-miR-4476	CLIP-seq
MIRT2587356	hsa-miR-4662a-5p	CLIP-seq
MIRT2587357	hsa-miR-4667-5p	CLIP-seq
MIRT2587358	hsa-miR-4676-5p	CLIP-seq
MIRT2587359	hsa-miR-4700-5p	CLIP-seq
MIRT2289536	hsa-miR-4712-5p	CLIP-seq
MIRT1212020	hsa-miR-4713-5p	CLIP-seq
MIRT2289537	hsa-miR-4725-5p	CLIP-seq
MIRT1212022	hsa-miR-4735-5p	CLIP-seq
MIRT1212023	hsa-miR-4775	CLIP-seq
MIRT1212024	hsa-miR-4786-3p	CLIP-seq
MIRT2587360	hsa-miR-4795-5p	CLIP-seq
MIRT2289538	hsa-miR-504	CLIP-seq
MIRT1212026	hsa-miR-532-3p	CLIP-seq
MIRT2587361	hsa-miR-575	CLIP-seq
MIRT2587362	hsa-miR-582-5p	CLIP-seq
MIRT2587363	hsa-miR-584	CLIP-seq
MIRT1212028	hsa-miR-590-3p	CLIP-seq
MIRT2587364	hsa-miR-600	CLIP-seq
MIRT2587365	hsa-miR-624	CLIP-seq
MIRT2587366	hsa-miR-637	CLIP-seq
MIRT2587367	hsa-miR-661	CLIP-seq
MIRT2289547	hsa-miR-665	CLIP-seq
MIRT2289548	hsa-miR-668	CLIP-seq
MIRT2587368	hsa-miR-671-5p	CLIP-seq
MIRT2587369	hsa-miR-708	CLIP-seq
MIRT2587370	hsa-miR-942	CLIP-seq
MIRT2289518	hsa-miR-1208	CLIP-seq
MIRT2289522	hsa-miR-198	CLIP-seq
MIRT1212011	hsa-miR-3149	CLIP-seq
MIRT2587352	hsa-miR-3914	CLIP-seq
MIRT2587358	hsa-miR-4676-5p	CLIP-seq
MIRT1212022	hsa-miR-4735-5p	CLIP-seq
MIRT1212023	hsa-miR-4775	CLIP-seq
MIRT2587361	hsa-miR-575	CLIP-seq
MIRT1212028	hsa-miR-590-3p	CLIP-seq
MIRT2289547	hsa-miR-665	CLIP-seq
MIRT2289548	hsa-miR-668	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000175	Function	3'-5'-RNA exonuclease activity	IDA	14583602
GO:0000288	Process	Nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IEA
GO:0000289	Process	Nuclear-transcribed mRNA poly(A) tail shortening	IBA
GO:0000289	Process	Nuclear-transcribed mRNA poly(A) tail shortening	IEA
GO:0000289	Process	Nuclear-transcribed mRNA poly(A) tail shortening	TAS
GO:0000932	Component	P-body	IBA
GO:0000932	Component	P-body	IEA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0004535	Function	Poly(A)-specific ribonuclease activity	IDA	14583602
GO:0004535	Function	Poly(A)-specific ribonuclease activity	IEA
GO:0004535	Function	Poly(A)-specific ribonuclease activity	TAS
GO:0004843	Function	Cysteine-type deubiquitinase activity	IKR	14715245
GO:0005515	Function	Protein binding	IPI	14583602, 19615732, 21984185, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0010606	Process	Positive regulation of cytoplasmic mRNA processing body assembly	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031251	Component	PAN complex	IBA
GO:0031251	Component	PAN complex	IDA	14583602
GO:0031251	Component	PAN complex	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
617447	20074	ENSG00000135473

Q504Q3

Protein name

PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit

Protein function

Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated b

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13423	UCH_1	517 → 898	Ubiquitin carboxyl-terminal hydrolase	Family
PF00929	RNase_T	975 → 1147	Exonuclease	Family

Sequence

MNFEGLDPGLAEYAPAMHSALDPVLDAHLNPSLLQNVELDPEGVALEALPVQESVHIMEG
VYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFGPALERYSSFQVNGSDDIR
QIQSLENGILFLTKNNLKYMARGGLIIFDYLLDENEDMHSLLLTDSSTLLVGGLQNHIIE
IDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKVSLRDLRTFKVEHEFDAFSGSLS
DFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMRAITPLQVHVDPAFLRFIPTYTSRL
AIISQSGQCQFCEPTGLANPADIFHVNPVGPLLMTFDVSASKQALAFGDSEGCVHLWTDS
PEPSFNPYSRETEFALPCLVDSLPPLDWSQDLLPLSLIPVPLTTDTLLSDWPAANSAPAP
RRAPPVDAEILRTMKKVGFIGYAPNPRTRLRNQIPYRLKESDSEFDSFSQVTESPVGREE
EPHLHMVSKKYRKVTIKYSKLGLEDFDFKHYNKTLFAGLEPHIPNAYCNCMIQVLYFLEP
VRCLIQNHLCQKEFCLACELGFLFHMLDLSRGDPCQGNNFLRAFRTIPEASALGLILADS
DEASGKGNLARLIQRWNRFILTQLHQDMQELEIPQAYRGAGGSSFCSSGDSVIGQLFSCE
MENCSLCRCGSETVRASSTLLFTLSYPDGSKSDKTGKNYDFAQVLKRSICLDQNTQAWCD
TCEKYQPTIQTRNIRHLPDILVINCEVNSSKEADFWRMQAEVAFKMAVKKHGGEISKNKE
FALADWKELGSPEGVLVCPSIEELKNVWLPFSIRMKMTKNKGLDVCNWTDGDEMQWGPAR
AEEEHGVYVYDLMATVVHILDSRTGGSLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEP
IDKHEAVQFDMNWKVPAILYYVKRNLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTF
IPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNE
GIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFV
GHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDA
RTALQLYRKYLELSKNGTEPESFHKVLKGLYEKGRKMDWKVPEPEGQTSPKNAAVFSSVL
AL

Sequence length

1202

Interactions

View interactions

	KEGG		Reactome
	RNA degradation		Deadenylation of mRNA

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
DEVELOPMENTAL DELAY WITH VARIABLE CARDIAC AND RENAL CONGENITAL ANOMALIES AND DYSMORPHIC FACIES	Likely pathogenic; Pathogenic	rs754998068, rs2135946371	RCV006250187 RCV006250188	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
PAN2-related multiple congenital anomalies syndrome	Likely pathogenic; Pathogenic	rs754998068, rs2135946371, rs1875318087	RCV001843346 RCV001843347 RCV001843348	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CHOLESTASIS	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAN2-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PAN2 (poly(A) specific ribonuclease subunit PAN2)