KBTBD11 (kelch repeat and BTB domain containing 11)

Gene

• Entrez ID: 9920
• Gene name: Kelch repeat and BTB domain containing 11
• Gene symbol: KBTBD11
• Synonyms (NCBI Gene): KLHDC7C
• Chromosome: 8
• Chromosome location: 8p23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016377	hsa-miR-193b-3p	Microarray	20304954
MIRT024631	hsa-miR-215-5p	Microarray	19074876
MIRT026418	hsa-miR-192-5p	Microarray	19074876
MIRT714300	hsa-miR-128-3p	HITS-CLIP	19536157
MIRT714299	hsa-miR-216a-3p	HITS-CLIP	19536157
MIRT714298	hsa-miR-3681-3p	HITS-CLIP	19536157
MIRT714297	hsa-miR-6733-3p	HITS-CLIP	19536157
MIRT714296	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT714295	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT714294	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT714293	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT714292	hsa-miR-5008-3p	HITS-CLIP	19536157
MIRT714291	hsa-miR-6737-3p	HITS-CLIP	19536157
MIRT714290	hsa-miR-7157-3p	HITS-CLIP	19536157
MIRT714289	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT714288	hsa-miR-1202	HITS-CLIP	19536157
MIRT714287	hsa-miR-3972	HITS-CLIP	19536157
MIRT663887	hsa-miR-4700-3p	HITS-CLIP	23824327
MIRT663888	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT663885	hsa-miR-5095	HITS-CLIP	23824327
MIRT663886	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT714300	hsa-miR-128-3p	HITS-CLIP	19536157
MIRT714299	hsa-miR-216a-3p	HITS-CLIP	19536157
MIRT714298	hsa-miR-3681-3p	HITS-CLIP	19536157
MIRT714297	hsa-miR-6733-3p	HITS-CLIP	19536157
MIRT714296	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT714295	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT714294	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT714293	hsa-miR-6889-3p	HITS-CLIP	19536157
MIRT714292	hsa-miR-5008-3p	HITS-CLIP	19536157
MIRT714291	hsa-miR-6737-3p	HITS-CLIP	19536157
MIRT714290	hsa-miR-7157-3p	HITS-CLIP	19536157
MIRT714289	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT714288	hsa-miR-1202	HITS-CLIP	19536157
MIRT714287	hsa-miR-3972	HITS-CLIP	19536157
MIRT663887	hsa-miR-4700-3p	HITS-CLIP	23824327
MIRT663888	hsa-miR-138-2-3p	HITS-CLIP	23824327
MIRT663885	hsa-miR-5095	HITS-CLIP	23824327
MIRT663886	hsa-miR-7151-3p	HITS-CLIP	23824327
MIRT1079369	hsa-miR-103a	CLIP-seq
MIRT1079370	hsa-miR-107	CLIP-seq
MIRT1079371	hsa-miR-1184	CLIP-seq
MIRT1079372	hsa-miR-1245b-3p	CLIP-seq
MIRT1079373	hsa-miR-129-5p	CLIP-seq
MIRT1079374	hsa-miR-1305	CLIP-seq
MIRT1079375	hsa-miR-1324	CLIP-seq
MIRT1079376	hsa-miR-146a	CLIP-seq
MIRT1079377	hsa-miR-146b-3p	CLIP-seq
MIRT1079378	hsa-miR-146b-5p	CLIP-seq
MIRT1079379	hsa-miR-219-1-3p	CLIP-seq
MIRT1079380	hsa-miR-22	CLIP-seq
MIRT1079381	hsa-miR-2278	CLIP-seq
MIRT1079382	hsa-miR-298	CLIP-seq
MIRT1079383	hsa-miR-3074-3p	CLIP-seq
MIRT1079384	hsa-miR-3150b-3p	CLIP-seq
MIRT1079385	hsa-miR-3154	CLIP-seq
MIRT1079386	hsa-miR-3155	CLIP-seq
MIRT1079387	hsa-miR-3155b	CLIP-seq
MIRT1079388	hsa-miR-3173-5p	CLIP-seq
MIRT1079389	hsa-miR-3179	CLIP-seq
MIRT1079390	hsa-miR-3198	CLIP-seq
MIRT1079391	hsa-miR-323-3p	CLIP-seq
MIRT1079392	hsa-miR-342-3p	CLIP-seq
MIRT1079393	hsa-miR-361-5p	CLIP-seq
MIRT1079394	hsa-miR-3646	CLIP-seq
MIRT1079395	hsa-miR-365	CLIP-seq
MIRT1079396	hsa-miR-3660	CLIP-seq
MIRT1079397	hsa-miR-3662	CLIP-seq
MIRT1079398	hsa-miR-3674	CLIP-seq
MIRT1079399	hsa-miR-3678-3p	CLIP-seq
MIRT1079400	hsa-miR-3974	CLIP-seq
MIRT1079401	hsa-miR-3978	CLIP-seq
MIRT1079402	hsa-miR-4272	CLIP-seq
MIRT1079403	hsa-miR-4274	CLIP-seq
MIRT1079404	hsa-miR-4283	CLIP-seq
MIRT1079405	hsa-miR-4309	CLIP-seq
MIRT1079406	hsa-miR-4324	CLIP-seq
MIRT1079407	hsa-miR-433	CLIP-seq
MIRT1079408	hsa-miR-4448	CLIP-seq
MIRT1079409	hsa-miR-4468	CLIP-seq
MIRT1079410	hsa-miR-4499	CLIP-seq
MIRT1079411	hsa-miR-4508	CLIP-seq
MIRT1079412	hsa-miR-450b-5p	CLIP-seq
MIRT1079413	hsa-miR-4513	CLIP-seq
MIRT1079414	hsa-miR-4524	CLIP-seq
MIRT1079415	hsa-miR-4526	CLIP-seq
MIRT1079416	hsa-miR-4539	CLIP-seq
MIRT1079417	hsa-miR-4653-3p	CLIP-seq
MIRT1079418	hsa-miR-4662a-5p	CLIP-seq
MIRT1079419	hsa-miR-4672	CLIP-seq
MIRT1079420	hsa-miR-4689	CLIP-seq
MIRT1079421	hsa-miR-4695-3p	CLIP-seq
MIRT1079422	hsa-miR-4698	CLIP-seq
MIRT1079423	hsa-miR-4707-5p	CLIP-seq
MIRT1079424	hsa-miR-4717-3p	CLIP-seq
MIRT1079425	hsa-miR-4775	CLIP-seq
MIRT1079426	hsa-miR-4784	CLIP-seq
MIRT1079427	hsa-miR-4789-5p	CLIP-seq
MIRT1079428	hsa-miR-484	CLIP-seq
MIRT1079429	hsa-miR-505	CLIP-seq
MIRT1079430	hsa-miR-507	CLIP-seq
MIRT1079431	hsa-miR-548p	CLIP-seq
MIRT1079432	hsa-miR-550b	CLIP-seq
MIRT1079433	hsa-miR-557	CLIP-seq
MIRT1079434	hsa-miR-589	CLIP-seq
MIRT1079435	hsa-miR-606	CLIP-seq
MIRT1079436	hsa-miR-626	CLIP-seq
MIRT1079437	hsa-miR-767-5p	CLIP-seq
MIRT1079438	hsa-miR-874	CLIP-seq
MIRT1079439	hsa-miR-95	CLIP-seq
MIRT2019744	hsa-miR-101	CLIP-seq
MIRT2019745	hsa-miR-10a	CLIP-seq
MIRT2019746	hsa-miR-10b	CLIP-seq
MIRT2019747	hsa-miR-1238	CLIP-seq
MIRT2019748	hsa-miR-128	CLIP-seq
MIRT2019749	hsa-miR-1281	CLIP-seq
MIRT2019750	hsa-miR-1307	CLIP-seq
MIRT2019751	hsa-miR-144	CLIP-seq
MIRT2019752	hsa-miR-1976	CLIP-seq
MIRT2019753	hsa-miR-2467-5p	CLIP-seq
MIRT2019754	hsa-miR-3130-3p	CLIP-seq
MIRT2019755	hsa-miR-3145-3p	CLIP-seq
MIRT2019756	hsa-miR-3194-3p	CLIP-seq
MIRT2019757	hsa-miR-340	CLIP-seq
MIRT2019758	hsa-miR-3545-3p	CLIP-seq
MIRT2019759	hsa-miR-3647-3p	CLIP-seq
MIRT2019760	hsa-miR-3664-5p	CLIP-seq
MIRT2019761	hsa-miR-3909	CLIP-seq
MIRT2019762	hsa-miR-3940-5p	CLIP-seq
MIRT2019763	hsa-miR-4252	CLIP-seq
MIRT1079402	hsa-miR-4272	CLIP-seq
MIRT1079404	hsa-miR-4283	CLIP-seq
MIRT2019764	hsa-miR-4286	CLIP-seq
MIRT2019765	hsa-miR-4291	CLIP-seq
MIRT2019766	hsa-miR-4304	CLIP-seq
MIRT2019767	hsa-miR-4320	CLIP-seq
MIRT1079408	hsa-miR-4448	CLIP-seq
MIRT2019768	hsa-miR-4475	CLIP-seq
MIRT2019769	hsa-miR-4506	CLIP-seq
MIRT2019770	hsa-miR-4507	CLIP-seq
MIRT1079411	hsa-miR-4508	CLIP-seq
MIRT2019771	hsa-miR-4520a-5p	CLIP-seq
MIRT2019772	hsa-miR-4520b-5p	CLIP-seq
MIRT2019773	hsa-miR-4638-5p	CLIP-seq
MIRT2019774	hsa-miR-4701-5p	CLIP-seq
MIRT2019775	hsa-miR-4714-5p	CLIP-seq
MIRT2019776	hsa-miR-4742-3p	CLIP-seq
MIRT2019777	hsa-miR-4766-5p	CLIP-seq
MIRT1079425	hsa-miR-4775	CLIP-seq
MIRT1079427	hsa-miR-4789-5p	CLIP-seq
MIRT2019778	hsa-miR-4793-3p	CLIP-seq
MIRT2019779	hsa-miR-502-5p	CLIP-seq
MIRT2019780	hsa-miR-544	CLIP-seq
MIRT2019781	hsa-miR-545	CLIP-seq
MIRT1079431	hsa-miR-548p	CLIP-seq
MIRT2019782	hsa-miR-582-5p	CLIP-seq
MIRT2019783	hsa-miR-588	CLIP-seq
MIRT2019784	hsa-miR-600	CLIP-seq
MIRT2019785	hsa-miR-617	CLIP-seq
MIRT2019786	hsa-miR-633	CLIP-seq
MIRT2019787	hsa-miR-760	CLIP-seq
MIRT2019753	hsa-miR-2467-5p	CLIP-seq
MIRT2251647	hsa-miR-3934	CLIP-seq
MIRT2251648	hsa-miR-421	CLIP-seq
MIRT2251649	hsa-miR-4703-3p	CLIP-seq
MIRT2251650	hsa-miR-4709-5p	CLIP-seq
MIRT1079431	hsa-miR-548p	CLIP-seq
MIRT2251651	hsa-miR-552	CLIP-seq
MIRT2452128	hsa-miR-4282	CLIP-seq
MIRT2019764	hsa-miR-4286	CLIP-seq
MIRT2465501	hsa-miR-181a	CLIP-seq
MIRT2465502	hsa-miR-181b	CLIP-seq
MIRT2465503	hsa-miR-181c	CLIP-seq
MIRT2465504	hsa-miR-181d	CLIP-seq
MIRT1079382	hsa-miR-298	CLIP-seq
MIRT2465505	hsa-miR-3120-3p	CLIP-seq
MIRT2465506	hsa-miR-4262	CLIP-seq
MIRT2465507	hsa-miR-543	CLIP-seq
MIRT2465508	hsa-miR-579	CLIP-seq
MIRT2019784	hsa-miR-600	CLIP-seq
MIRT2465509	hsa-miR-664	CLIP-seq
MIRT2465510	hsa-miR-922	CLIP-seq
MIRT2554951	hsa-miR-1205	CLIP-seq
MIRT1079372	hsa-miR-1245b-3p	CLIP-seq
MIRT2554952	hsa-miR-1283	CLIP-seq
MIRT2554953	hsa-miR-1286	CLIP-seq
MIRT1079381	hsa-miR-2278	CLIP-seq
MIRT2554954	hsa-miR-320a	CLIP-seq
MIRT2554955	hsa-miR-320b	CLIP-seq
MIRT2554956	hsa-miR-320c	CLIP-seq
MIRT2554957	hsa-miR-320d	CLIP-seq
MIRT2554958	hsa-miR-337-5p	CLIP-seq
MIRT2554959	hsa-miR-3616-5p	CLIP-seq
MIRT2554960	hsa-miR-3647-5p	CLIP-seq
MIRT2554961	hsa-miR-4267	CLIP-seq
MIRT1079402	hsa-miR-4272	CLIP-seq
MIRT2554962	hsa-miR-4429	CLIP-seq
MIRT1079409	hsa-miR-4468	CLIP-seq
MIRT2554963	hsa-miR-4519	CLIP-seq
MIRT1079414	hsa-miR-4524	CLIP-seq
MIRT2554964	hsa-miR-4722-5p	CLIP-seq
MIRT2554965	hsa-miR-4724-5p	CLIP-seq
MIRT2554966	hsa-miR-4795-5p	CLIP-seq
MIRT2554967	hsa-miR-520d-5p	CLIP-seq
MIRT2554968	hsa-miR-524-5p	CLIP-seq
MIRT2554969	hsa-miR-573	CLIP-seq
MIRT2554970	hsa-miR-605	CLIP-seq
MIRT1079439	hsa-miR-95	CLIP-seq

Other IDs

• MIM: 618794
• HGNC: 29104
• e!Ensembl: ENSG00000176595

Protein

• UniProt ID: O94819
• Protein name: Kelch repeat and BTB domain-containing protein 11 (Chronic myelogenous leukemia-associated protein) (Kelch domain-containing protein 7B)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00651	BTB	138 → 231	BTB/POZ domain	Domain
  PF01344	Kelch_1	348 → 399	Kelch motif	Repeat
  PF01344	Kelch_1	401 → 442	Kelch motif	Repeat

• Sequence:

  MEHAVAPCVLYPGTEPGAAGESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEG
  AATSPPSSGGPRVVERQWEAGSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASP
  EEPGEPAPVPPGFGAVYGEPDLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVS
  LTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLPGAAQRATDAVGPQLSLANCYEVL
  SAAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAA
  LGPAGERAGSRPQSPSGDADARGDAAVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNY
  LFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGE
  CLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEW
  QECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAP
  LRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFEALGAPLDV
  RGVLIPFALSLPEKPPRGEQGAP

• Sequence length: 623

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	31452764		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	29267898	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	29267898		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29267898	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	31452764		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	31452764		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	27153397		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	30582777		★★☆☆☆ Found in Text Mining + Unknown/Other Associations