Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9910
Gene name	RAB GTPase activating protein 1 like
Gene symbol	RABGAP1L
Synonyms (NCBI Gene)	HHLTBC1D18
Chromosome	1
Chromosome location	1q25.1

145

Show/Hide all (145)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002797	hsa-miR-1-3p	Microarray	15685193
MIRT002797	hsa-miR-1-3p	Microarray;Other	15685193
MIRT687098	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT687097	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT687096	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT687095	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT687094	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT687093	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT687092	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT687091	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT687090	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT687089	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT687088	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT687087	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT687086	hsa-miR-302e	HITS-CLIP	23313552
MIRT687085	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT687084	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT687083	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT687082	hsa-miR-520b	HITS-CLIP	23313552
MIRT687081	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT687080	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT687079	hsa-miR-520e	HITS-CLIP	23313552
MIRT687078	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT687077	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT687076	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT687075	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT687074	hsa-miR-520h	HITS-CLIP	23313552
MIRT687073	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT687072	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT687071	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT687070	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT687069	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT687068	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT687067	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT687066	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT687065	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT687064	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT671313	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671312	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671311	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671310	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT671309	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT671308	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT671307	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671306	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671305	hsa-miR-6759-3p	HITS-CLIP	23824327
MIRT671304	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671303	hsa-miR-6131	HITS-CLIP	23824327
MIRT671302	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT671301	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT671300	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671299	hsa-miR-548s	HITS-CLIP	23824327
MIRT671298	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671297	hsa-miR-588	HITS-CLIP	23824327
MIRT671296	hsa-miR-4435	HITS-CLIP	23824327
MIRT671295	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671294	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671293	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636906	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT636905	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT636904	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT636903	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT636902	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636901	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT636900	hsa-miR-4504	HITS-CLIP	23824327
MIRT671307	hsa-miR-3653-5p	PAR-CLIP	27292025
MIRT636903	hsa-miR-4714-3p	PAR-CLIP	27292025
MIRT687068	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT687098	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT687097	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT687096	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT687095	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT687094	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT687093	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT687092	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT687091	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT687090	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT687089	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT687088	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT687087	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT687086	hsa-miR-302e	HITS-CLIP	23313552
MIRT687085	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT687084	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT687083	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT687082	hsa-miR-520b	HITS-CLIP	23313552
MIRT687081	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT687080	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT687079	hsa-miR-520e	HITS-CLIP	23313552
MIRT687078	hsa-miR-576-3p	HITS-CLIP	23313552
MIRT687077	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT687076	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT687075	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT687074	hsa-miR-520h	HITS-CLIP	23313552
MIRT687073	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT687072	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT687071	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT687070	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT687069	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT687068	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT687067	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT687066	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT687065	hsa-miR-6807-5p	HITS-CLIP	23313552
MIRT687064	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT671313	hsa-miR-4781-3p	HITS-CLIP	23824327
MIRT671312	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT671311	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT671310	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT671309	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT671308	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT671307	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT671306	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT671305	hsa-miR-6759-3p	HITS-CLIP	23824327
MIRT671304	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT671303	hsa-miR-6131	HITS-CLIP	23824327
MIRT671302	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT671301	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT671300	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT671299	hsa-miR-548s	HITS-CLIP	23824327
MIRT671298	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT671297	hsa-miR-588	HITS-CLIP	23824327
MIRT671296	hsa-miR-4435	HITS-CLIP	23824327
MIRT671295	hsa-miR-3187-3p	HITS-CLIP	23824327
MIRT671294	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT671293	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT636906	hsa-miR-3156-5p	HITS-CLIP	23824327
MIRT636905	hsa-miR-7161-3p	HITS-CLIP	23824327
MIRT636904	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT636903	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT636902	hsa-miR-676-5p	HITS-CLIP	23824327
MIRT636901	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT636900	hsa-miR-4504	HITS-CLIP	23824327
MIRT1286427	hsa-miR-1264	CLIP-seq
MIRT1286428	hsa-miR-3201	CLIP-seq
MIRT1286429	hsa-miR-3691-5p	CLIP-seq
MIRT1286430	hsa-miR-425	CLIP-seq
MIRT1286431	hsa-miR-4752	CLIP-seq
MIRT1286432	hsa-miR-4791	CLIP-seq
MIRT1286433	hsa-miR-548n	CLIP-seq
MIRT1286434	hsa-miR-548t	CLIP-seq
MIRT2310394	hsa-miR-1324	CLIP-seq
MIRT2310395	hsa-miR-139-5p	CLIP-seq
MIRT2310396	hsa-miR-3622a-3p	CLIP-seq
MIRT2310397	hsa-miR-3622b-3p	CLIP-seq
MIRT1286433	hsa-miR-548n	CLIP-seq
MIRT1286434	hsa-miR-548t	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	16923123
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	20562859, 25814554, 32814053, 35271311
GO:0005634	Component	Nucleus	IDA	16923123
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	16923123
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	IDA	16923123
GO:0005794	Component	Golgi apparatus	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IBA
GO:0031267	Function	Small GTPase binding	IDA	16923123
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032880	Process	Regulation of protein localization	IBA
GO:0032880	Process	Regulation of protein localization	IDA	16923123

MIM	HGNC	e!Ensembl
609238	24663	ENSG00000152061

Q5R372

Protein name

Rab GTPase-activating protein 1-like

Protein function

GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (PubMed:16923123). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylin

PDB

3HZJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12473	DUF3694	290 → 421	Kinesin protein	Family
PF00566	RabGAP-TBC	541 → 744	Rab-GTPase-TBC domain	Family

Sequence

MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAME
EILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSP
GGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSV
RIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAV
SRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDK
FYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDG
RAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPAN
ERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMS
PQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVP
EALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQ
ESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNF
EDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL
LCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIK
VPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL

Sequence length

815

B7ZAP0

Protein name

Rab GTPase-activating protein 1-like, isoform 10

Family and domains

Sequence

MIENSSWSMTFEERENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNK
ELLLTKQRLVETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLST
RLEKQQAASKEELEVVKGKMMACKHCSDIFSKEGALKLAATGREDQGIETDDEKDSLKKQ
LREMELELAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPL
QPAPVTQPPKEST

Sequence length

253

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cholesteatoma	Likely pathogenic	rs1035337401	RCV002292664	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MOOD DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Benign Prostatic Hyperplasia	Benign Prostatic Hyperplasia	BEFREE	31695843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	24563076	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36345155	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Common Migraine	Common Migraine	GWASDB_DG	23793025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	19851296		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	23335107	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	23335107		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	29942085		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31695843		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	12706106		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Migraine Disorders	Migraine	GWASCAT_DG	23793025		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mood Disorders	Mood Disorder	GWASCAT_DG	29942085		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31695843		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	12706106		★★★★★ ★☆☆☆☆ Found in Text Mining only

RABGAP1L (RAB GTPase activating protein 1 like)