Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9909
Gene name	DENN domain containing 4B
Gene symbol	DENND4B
Synonyms (NCBI Gene)	KIAA0476
Chromosome	1
Chromosome location	1q21.3

Show/Hide all (1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1557853919	G>A	Likely-pathogenic	Coding sequence variant, missense variant, non coding transcript variant

213

Show/Hide all (213)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051981	hsa-let-7b-5p	CLASH	23622248
MIRT050007	hsa-miR-28-5p	CLASH	23622248
MIRT049787	hsa-miR-92a-3p	CLASH	23622248
MIRT044839	hsa-miR-320a	CLASH	23622248
MIRT043613	hsa-miR-151a-3p	CLASH	23622248
MIRT041379	hsa-miR-193b-3p	CLASH	23622248
MIRT041150	hsa-miR-500a-3p	CLASH	23622248
MIRT037992	hsa-miR-501-3p	CLASH	23622248
MIRT571106	hsa-miR-1197	PAR-CLIP	20371350
MIRT571105	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT571104	hsa-miR-4254	PAR-CLIP	20371350
MIRT571103	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT571102	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT571100	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT049787	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727884	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727885	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT571106	hsa-miR-1197	PAR-CLIP	20371350
MIRT571105	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT571104	hsa-miR-4254	PAR-CLIP	20371350
MIRT571103	hsa-miR-1249-5p	PAR-CLIP	20371350
MIRT571102	hsa-miR-6797-5p	PAR-CLIP	20371350
MIRT571100	hsa-miR-6515-5p	PAR-CLIP	20371350
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932439	hsa-miR-132	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932443	hsa-miR-1587	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932445	hsa-miR-185	CLIP-seq
MIRT932446	hsa-miR-1908	CLIP-seq
MIRT932447	hsa-miR-194	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932449	hsa-miR-205	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT932451	hsa-miR-212	CLIP-seq
MIRT932452	hsa-miR-2355-5p	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT932455	hsa-miR-31	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT932457	hsa-miR-3126-5p	CLIP-seq
MIRT932458	hsa-miR-3135b	CLIP-seq
MIRT932459	hsa-miR-3165	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT932461	hsa-miR-3189-3p	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932464	hsa-miR-3622b-5p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932466	hsa-miR-3652	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT932469	hsa-miR-3681	CLIP-seq
MIRT932470	hsa-miR-3910	CLIP-seq
MIRT932471	hsa-miR-3913-3p	CLIP-seq
MIRT932472	hsa-miR-3929	CLIP-seq
MIRT932473	hsa-miR-4270	CLIP-seq
MIRT932474	hsa-miR-4286	CLIP-seq
MIRT932475	hsa-miR-4291	CLIP-seq
MIRT932476	hsa-miR-4306	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932478	hsa-miR-4419b	CLIP-seq
MIRT932479	hsa-miR-4430	CLIP-seq
MIRT932480	hsa-miR-4434	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932482	hsa-miR-4437	CLIP-seq
MIRT932483	hsa-miR-4441	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932485	hsa-miR-4448	CLIP-seq
MIRT932486	hsa-miR-4474-3p	CLIP-seq
MIRT932487	hsa-miR-4478	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932489	hsa-miR-4493	CLIP-seq
MIRT932490	hsa-miR-4511	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932492	hsa-miR-4516	CLIP-seq
MIRT932493	hsa-miR-4531	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932495	hsa-miR-4644	CLIP-seq
MIRT932496	hsa-miR-4674	CLIP-seq
MIRT932497	hsa-miR-4675	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932501	hsa-miR-4741	CLIP-seq
MIRT932502	hsa-miR-4742-5p	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932505	hsa-miR-486-3p	CLIP-seq
MIRT932506	hsa-miR-489	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932509	hsa-miR-545	CLIP-seq
MIRT932510	hsa-miR-548an	CLIP-seq
MIRT932511	hsa-miR-548b-3p	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932515	hsa-miR-635	CLIP-seq
MIRT932516	hsa-miR-645	CLIP-seq
MIRT932517	hsa-miR-646	CLIP-seq
MIRT932518	hsa-miR-663	CLIP-seq
MIRT932519	hsa-miR-744	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT1547928	hsa-miR-4277	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932445	hsa-miR-185	CLIP-seq
MIRT932476	hsa-miR-4306	CLIP-seq
MIRT932495	hsa-miR-4644	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT1976085	hsa-miR-3065-3p	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT1976086	hsa-miR-3132	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT1976087	hsa-miR-361-3p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT1976088	hsa-miR-495	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932437	hsa-miR-1262	CLIP-seq
MIRT932438	hsa-miR-1293	CLIP-seq
MIRT932440	hsa-miR-1323	CLIP-seq
MIRT932442	hsa-miR-137	CLIP-seq
MIRT932444	hsa-miR-1827	CLIP-seq
MIRT932446	hsa-miR-1908	CLIP-seq
MIRT932452	hsa-miR-2355-5p	CLIP-seq
MIRT932453	hsa-miR-25	CLIP-seq
MIRT932454	hsa-miR-3065-5p	CLIP-seq
MIRT932455	hsa-miR-31	CLIP-seq
MIRT932456	hsa-miR-3117-3p	CLIP-seq
MIRT1976086	hsa-miR-3132	CLIP-seq
MIRT932460	hsa-miR-3169	CLIP-seq
MIRT932462	hsa-miR-32	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932465	hsa-miR-363	CLIP-seq
MIRT932467	hsa-miR-3661	CLIP-seq
MIRT932468	hsa-miR-367	CLIP-seq
MIRT1547928	hsa-miR-4277	CLIP-seq
MIRT932477	hsa-miR-4316	CLIP-seq
MIRT932481	hsa-miR-4436a	CLIP-seq
MIRT932488	hsa-miR-4483	CLIP-seq
MIRT932491	hsa-miR-4515	CLIP-seq
MIRT932498	hsa-miR-4699-3p	CLIP-seq
MIRT932499	hsa-miR-4701-3p	CLIP-seq
MIRT932500	hsa-miR-4710	CLIP-seq
MIRT932502	hsa-miR-4742-5p	CLIP-seq
MIRT932504	hsa-miR-4759	CLIP-seq
MIRT932505	hsa-miR-486-3p	CLIP-seq
MIRT932507	hsa-miR-492	CLIP-seq
MIRT1976088	hsa-miR-495	CLIP-seq
MIRT932508	hsa-miR-500a	CLIP-seq
MIRT932512	hsa-miR-548o	CLIP-seq
MIRT932514	hsa-miR-631	CLIP-seq
MIRT932518	hsa-miR-663	CLIP-seq
MIRT932519	hsa-miR-744	CLIP-seq
MIRT932520	hsa-miR-92a	CLIP-seq
MIRT932521	hsa-miR-92b	CLIP-seq
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT2515202	hsa-miR-1252	CLIP-seq
MIRT2515203	hsa-miR-1283	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT2515204	hsa-miR-3157-3p	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932486	hsa-miR-4474-3p	CLIP-seq
MIRT932490	hsa-miR-4511	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932497	hsa-miR-4675	CLIP-seq
MIRT932501	hsa-miR-4741	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT932511	hsa-miR-548b-3p	CLIP-seq
MIRT2515205	hsa-miR-591	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq
MIRT932436	hsa-miR-1229	CLIP-seq
MIRT2515202	hsa-miR-1252	CLIP-seq
MIRT2515203	hsa-miR-1283	CLIP-seq
MIRT932441	hsa-miR-136	CLIP-seq
MIRT932448	hsa-miR-204	CLIP-seq
MIRT932450	hsa-miR-211	CLIP-seq
MIRT2515204	hsa-miR-3157-3p	CLIP-seq
MIRT932463	hsa-miR-3619-3p	CLIP-seq
MIRT932484	hsa-miR-4446-5p	CLIP-seq
MIRT932494	hsa-miR-4639-3p	CLIP-seq
MIRT932503	hsa-miR-4755-5p	CLIP-seq
MIRT2515205	hsa-miR-591	CLIP-seq
MIRT932513	hsa-miR-623	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005794	Component	Golgi apparatus	IDA	20937701
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0032483	Process	Regulation of Rab protein signal transduction	IBA
GO:0032483	Process	Regulation of Rab protein signal transduction	IDA	20937701

MIM	HGNC	e!Ensembl
619843	29044	ENSG00000198837

O75064

Protein name

DENN domain-containing protein 4B

Protein function

Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03456	uDENN	213 → 278	uDENN domain	Domain
PF02141	DENN	313 → 497	DENN (AEX-3) domain	Family
PF03455	dDENN	603 → 652	dDENN domain	Domain

Sequence

MAEERPPRLVDYFVVAGLAGNGAPIPEETWVPEPSGPLRPPRPAEPITDVAVIARALGEE
VPQGYTCIQASAGGHPLELSAGLLGGTQPVICYRRGRDKPPLVELGVLYEGKERPKPGFQ
VLDTTPYSHSANLAPPGPGHPRTYLTYRRAAEGAGLHALGITDLCLVLPSKGEGTPHTYC
RLPRNLNPGMWGPAVYLCYKVGLAKANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPM
GATIECWPAQTKYPVPVFSTFVLTGAAGDKVYGAALQFYEAFPRARLSERQARALGLLSA
VERGRALGGRAVRSRRAIAVLSRWPAFPAFRAFLTFLYRYSVSGPHRLPLEAHISHFIHN
VPFPSPQRPRILVQMSPYDNLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTE
HKLLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLADVLSAPVPFIVGIHSSYF
DLHDPPADVICVDLDTNTLFQTEEKKLLSPRTLPRRPYKVLLATLTNLYQQLDQTYTGPE
EEASLEFLLTDYEAVCGRRARLEREVQGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVD
NLFFLQGFLKSRERSSHKLYSQLLHTQMFSQFIEECSFGSARHAALEFFDSCVEKVHPEQ
EKPEPTPLVELEELSGSELTVFITPPEEPALPEGSESTPQYCYDGFPELRAELFESLQEQ
PGALPVPGPSRSAPSSPAPRRTKQEMKVAQRMAQKSAAVPELWARCLLGHCYGLWFLCLP
AYVRSAPSRVQALHTAYHVLRQMESGKVVLPDEVCYRVLMQLCSHYGQPVLSVRVMLEMR
QAGIVPNTITYGYYNKAVLESKWPSGTPGGRLRWAKLRNVVLGAAQFRQPLRERQQQQQQ
QQQQQQQQQQEQVSAHQEAGSSQAEPYLERPSPTRPLQRQTTWAGRSLRDPASPPGRLVK
SGSLGSARGAQPTVEAGVAHMIEALGVLEPRGSPVPWHDGSLSDLSLTGEEPLPGGSPGG
SGSALSAQSTEALEGLSGRGPKAGGRQDEAGTPRRGLGARLQQLLTPSRHSPASRIPPPE
LPPDLPPPARRSPMDSLLHPRERPGSTASESSASLGSEWDLSESSLSNLSLRRSSERLSD
TPGSFQSPSLEILLSSCSLCRACDSLVYDEEIMAGWAPDDSNLNTTCPFCACPFVPLLSV
QTLDSRPSVPSPKSAGASGSKDAPVPGGPGPVLSDRRLCLALDEPQLCNGHMGGASRRVE
SGAWAYLSPLVLRKELESLVENEGSEVLALPELPSAHPIIFWNLLWYFQRLRLPSILPGL
VLASCDGPSHSQAPSPWLTPDPASVQVRLLWDVLTPDPNSCPPLYVLWRVHSQIPQRVVW
PGPVPASLSLALLESVLRHVGLNEVHKAVGLLLETLGPPPTGLHLQRGIYREILFLTMAA
LGKDHVDIVAFDKKYKSAFNKLASSMGKEELRHRRAQMPTPKAIDCRKCFGAPPEC

Sequence length

1496

Interactions

View interactions

	Reactome
			RAB GEFs exchange GTP for GDP on RABs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Short stature	Likely pathogenic	rs1557853919	RCV000736142	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CLEFT PALATE, ISOLATED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENND4B-related disorder	Uncertain significance; Likely benign; Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, FAMILIAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Prostate cancer, familial	Prostate cancer	CTD_human_DG	29892016	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER, HEREDITARY, 1	Prostate Cancer, Hereditary	CTD_human_DG	29892016	★★★★★ ★☆☆☆☆ Found in Text Mining only

DENND4B (DENN domain containing 4B)