Gene Gene information from NCBI Gene database.
Entrez ID 9903
Gene name Kelch like family member 21
Gene symbol KLHL21
Synonyms (NCBI Gene)
-
Chromosome 1
Chromosome location 1p36.31
miRNA miRNA information provided by mirtarbase database.
929
miRTarBase ID miRNA Experiments Reference
MIRT020304 hsa-miR-130b-3p Sequencing 20371350
MIRT029862 hsa-miR-26b-5p Microarray 19088304
MIRT031234 hsa-miR-19b-3p Sequencing 20371350
MIRT556725 hsa-miR-4475 HITS-CLIP 21572407
MIRT556726 hsa-miR-519a-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IDA 19995937
GO:0005515 Function Protein binding IPI 32296183
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
GO:0005819 Component Spindle IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
616262 29041 ENSG00000162413
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UJP4
Protein name Kelch-like protein 21
Protein function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 25 133 BTB/POZ domain Domain
PF07707 BACK 138 239 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 281 321 Kelch motif Repeat
PF01344 Kelch_1 325 369 Kelch motif Repeat
PF13964 Kelch_6 501 550 Repeat
Sequence
MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPY
FRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPA
VKEACGAFLQQQL
DLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLAR
LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVE
A
EPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDE
LVTVDCYNPQTGQWRYLAEFP
DHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVN
EWAEVAPML
KAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTAC
RGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA
EVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW
SVVGRLPEPT
FWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH
Sequence length 597
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ependymoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
KLHL21-related disorder Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Cholangiocarcinoma Cholangiocarcinoma BEFREE 29574153
★☆☆☆☆
Found in Text Mining only
Congenital contractural arachnodactyly Congenital Contractural Arachnodactyly BEFREE 29574153
★☆☆☆☆
Found in Text Mining only
Liver carcinoma Liver carcinoma BEFREE 27769251
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 29574153
★☆☆☆☆
Found in Text Mining only