Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9902
Gene name	Mannose receptor C-type 2
Gene symbol	MRC2
Synonyms (NCBI Gene)	CD280CLEC13EENDO180UPARAP
Chromosome	17
Chromosome location	17q23.2
Summary	This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001355	hsa-miR-1-3p	pSILAC	18668040
MIRT001355	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT051126	hsa-miR-16-5p	CLASH	23622248
MIRT047526	hsa-miR-10a-5p	CLASH	23622248
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1157633	hsa-miR-3170	CLIP-seq
MIRT1157634	hsa-miR-342-5p	CLIP-seq
MIRT1157635	hsa-miR-3690	CLIP-seq
MIRT1157636	hsa-miR-4254	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT1157638	hsa-miR-4448	CLIP-seq
MIRT1157639	hsa-miR-4651	CLIP-seq
MIRT1157640	hsa-miR-4664-5p	CLIP-seq
MIRT1157641	hsa-miR-593	CLIP-seq
MIRT1157642	hsa-miR-608	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT1551383	hsa-miR-4755-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2045098	hsa-miR-548ac	CLIP-seq
MIRT2045099	hsa-miR-548ae	CLIP-seq
MIRT2045100	hsa-miR-548aj	CLIP-seq
MIRT2045101	hsa-miR-548am	CLIP-seq
MIRT2045102	hsa-miR-548d-3p	CLIP-seq
MIRT2045103	hsa-miR-548x	CLIP-seq
MIRT2045104	hsa-miR-548z	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2465650	hsa-miR-2467-5p	CLIP-seq
MIRT2465651	hsa-miR-3194-3p	CLIP-seq
MIRT2465652	hsa-miR-3944-3p	CLIP-seq
MIRT1157637	hsa-miR-4268	CLIP-seq
MIRT2465653	hsa-miR-760	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2573116	hsa-miR-24	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq
MIRT2573109	hsa-miR-1207-3p	CLIP-seq
MIRT2573110	hsa-miR-1224-3p	CLIP-seq
MIRT2573111	hsa-miR-1260	CLIP-seq
MIRT2573112	hsa-miR-1260b	CLIP-seq
MIRT2573113	hsa-miR-1280	CLIP-seq
MIRT2573114	hsa-miR-1538	CLIP-seq
MIRT2454445	hsa-miR-1915	CLIP-seq
MIRT2573115	hsa-miR-193a-5p	CLIP-seq
MIRT2685295	hsa-miR-214	CLIP-seq
MIRT1157632	hsa-miR-2355-5p	CLIP-seq
MIRT2438781	hsa-miR-2392	CLIP-seq
MIRT1551377	hsa-miR-23a	CLIP-seq
MIRT1551378	hsa-miR-23b	CLIP-seq
MIRT1551379	hsa-miR-23c	CLIP-seq
MIRT2685296	hsa-miR-3619-5p	CLIP-seq
MIRT2573117	hsa-miR-3620	CLIP-seq
MIRT2454446	hsa-miR-3918	CLIP-seq
MIRT1551380	hsa-miR-3919	CLIP-seq
MIRT2573118	hsa-miR-3940-3p	CLIP-seq
MIRT2573119	hsa-miR-4267	CLIP-seq
MIRT2685297	hsa-miR-4269	CLIP-seq
MIRT2573120	hsa-miR-4292	CLIP-seq
MIRT1551381	hsa-miR-4444	CLIP-seq
MIRT2685298	hsa-miR-4530	CLIP-seq
MIRT2438782	hsa-miR-4646-3p	CLIP-seq
MIRT2454447	hsa-miR-4685-5p	CLIP-seq
MIRT2573121	hsa-miR-4690-3p	CLIP-seq
MIRT2685299	hsa-miR-4690-5p	CLIP-seq
MIRT2685300	hsa-miR-4691-3p	CLIP-seq
MIRT1551382	hsa-miR-4716-5p	CLIP-seq
MIRT2454448	hsa-miR-4721	CLIP-seq
MIRT2573122	hsa-miR-4725-5p	CLIP-seq
MIRT2438783	hsa-miR-4733-3p	CLIP-seq
MIRT2573123	hsa-miR-4745-3p	CLIP-seq
MIRT2685301	hsa-miR-4758-3p	CLIP-seq
MIRT2573124	hsa-miR-4793-3p	CLIP-seq
MIRT1551384	hsa-miR-4797-5p	CLIP-seq
MIRT2573125	hsa-miR-504	CLIP-seq
MIRT2573126	hsa-miR-512-5p	CLIP-seq
MIRT2573127	hsa-miR-532-3p	CLIP-seq
MIRT2573128	hsa-miR-548c-3p	CLIP-seq
MIRT2573129	hsa-miR-662	CLIP-seq
MIRT2685302	hsa-miR-761	CLIP-seq
MIRT2573130	hsa-miR-873	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0005515	Function	Protein binding	IPI	7904248, 26481812
GO:0005518	Function	Collagen binding	IDA	10636902, 12972549
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006897	Process	Endocytosis	IEA
GO:0016020	Component	Membrane	HDA	16210410
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0030574	Process	Collagen catabolic process	IDA	12972549
GO:0038023	Function	Signaling receptor activity	IBA

MIM	HGNC	e!Ensembl
612264	16875	ENSG00000011028

Q9UBG0

Protein name

C-type mannose receptor 2 (C-type lectin domain family 13 member E) (Endocytic receptor 180) (Macrophage mannose receptor 2) (Urokinase-type plasminogen activator receptor-associated protein) (UPAR-associated protein) (Urokinase receptor-associated protei

Protein function

May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involve

PDB

5AO5 , 5AO6 , 5E4K , 5E4L , 5EW6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00040	fn2	187 → 228	Fibronectin type II domain	Domain
PF00059	Lectin_C	255 → 361	Lectin C-type domain	Domain
PF00059	Lectin_C	399 → 506	Lectin C-type domain	Domain
PF00059	Lectin_C	538 → 646	Lectin C-type domain	Domain
PF00059	Lectin_C	693 → 810	Lectin C-type domain	Domain
PF00059	Lectin_C	842 → 952	Lectin C-type domain	Domain
PF00059	Lectin_C	993 → 1109	Lectin C-type domain	Domain
PF00059	Lectin_C	1142 → 1245	Lectin C-type domain	Domain
PF00059	Lectin_C	1285 → 1395	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon. Expressed in endothelial cells, fibroblasts and macrophages. Highly expressed in fetal lung and kidney. {ECO:0000269|PubMed:10683150,

Sequence

MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGG
QVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLR
WHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQG
NSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWD
KDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGL
NDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCK
KKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSI
HSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLED
CVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQV
TYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDE
VMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPD
PTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEE
HFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDD
DIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFF
EHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRF
RWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQ
PPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQ
AFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAV
VLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLL
QKPLRWHDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVS
EEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGS
CPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQS
YEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWR
PGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQ
SIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE

Sequence length

1479

Interactions

View interactions

	KEGG		Reactome
	Phagosome Tuberculosis		Cross-presentation of soluble exogenous antigens (endosomes)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AORTIC ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC RHYTHM DISEASE	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HOARDING DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (25)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenal Gland Pheochromocytoma	Adrenal Gland Pheochromocytoma	BEFREE	29061505		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anaplastic carcinoma	Anaplastic Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	CTD_human_DG	16316942		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	34768883	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	20339555, 28365151	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	20339555	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	20845060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	11920633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	25162823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Glioma	Glioma	BEFREE	20845060		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	17974964		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	25408555		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25162823, 28574834		★★★★★ ★☆☆☆☆ Found in Text Mining only
Marfan Syndrome	Marfan syndrome	Pubtator	33230159	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma Malignant	Mesothelioma	Pubtator	34768883	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	11920633, 17974964, 22072289		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	11920633		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	35312779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	34336102, 39972314	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22792318	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	25408555		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25381222, 26567111, 36613987	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	LHGDN	17189524		★★★★★ ★☆☆☆☆ Found in Text Mining only
Undifferentiated carcinoma	Carcinoma	CTD_human_DG	16316942		★★★★★ ★☆☆☆☆ Found in Text Mining only

MRC2 (mannose receptor C-type 2)