SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3)

Gene

• Entrez ID: 9901
• Gene name: SLIT-ROBO Rho GTPase activating protein 3
• Gene symbol: SRGAP3
• Synonyms (NCBI Gene): ARHGAP14, MEGAP, SRGAP2, WRP
• Chromosome: 3
• Chromosome location: 3p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1388873	hsa-let-7a	CLIP-seq
MIRT1388874	hsa-let-7b	CLIP-seq
MIRT1388875	hsa-let-7c	CLIP-seq
MIRT1388876	hsa-let-7d	CLIP-seq
MIRT1388877	hsa-let-7e	CLIP-seq
MIRT1388878	hsa-let-7f	CLIP-seq
MIRT1388879	hsa-let-7g	CLIP-seq
MIRT1388880	hsa-let-7i	CLIP-seq
MIRT1388881	hsa-miR-1178	CLIP-seq
MIRT1388882	hsa-miR-1285	CLIP-seq
MIRT1388883	hsa-miR-132	CLIP-seq
MIRT1388884	hsa-miR-144	CLIP-seq
MIRT1388885	hsa-miR-19a	CLIP-seq
MIRT1388886	hsa-miR-19b	CLIP-seq
MIRT1388887	hsa-miR-202	CLIP-seq
MIRT1388888	hsa-miR-203	CLIP-seq
MIRT1388889	hsa-miR-212	CLIP-seq
MIRT1388890	hsa-miR-2861	CLIP-seq
MIRT1388891	hsa-miR-3145-5p	CLIP-seq
MIRT1388892	hsa-miR-3150b-3p	CLIP-seq
MIRT1388893	hsa-miR-3155	CLIP-seq
MIRT1388894	hsa-miR-3155b	CLIP-seq
MIRT1388895	hsa-miR-3187-5p	CLIP-seq
MIRT1388896	hsa-miR-3200-5p	CLIP-seq
MIRT1388897	hsa-miR-326	CLIP-seq
MIRT1388898	hsa-miR-330-5p	CLIP-seq
MIRT1388899	hsa-miR-342-3p	CLIP-seq
MIRT1388900	hsa-miR-3591-5p	CLIP-seq
MIRT1388901	hsa-miR-3616-3p	CLIP-seq
MIRT1388902	hsa-miR-3622b-5p	CLIP-seq
MIRT1388903	hsa-miR-3653	CLIP-seq
MIRT1388904	hsa-miR-3658	CLIP-seq
MIRT1388905	hsa-miR-3660	CLIP-seq
MIRT1388906	hsa-miR-3677-5p	CLIP-seq
MIRT1388907	hsa-miR-3689a-3p	CLIP-seq
MIRT1388908	hsa-miR-3689c	CLIP-seq
MIRT1388909	hsa-miR-377	CLIP-seq
MIRT1388910	hsa-miR-378g	CLIP-seq
MIRT1388911	hsa-miR-411	CLIP-seq
MIRT1388912	hsa-miR-4457	CLIP-seq
MIRT1388913	hsa-miR-4458	CLIP-seq
MIRT1388914	hsa-miR-4460	CLIP-seq
MIRT1388915	hsa-miR-4468	CLIP-seq
MIRT1388916	hsa-miR-4486	CLIP-seq
MIRT1388917	hsa-miR-4500	CLIP-seq
MIRT1388918	hsa-miR-4526	CLIP-seq
MIRT1388919	hsa-miR-4649-3p	CLIP-seq
MIRT1388920	hsa-miR-4663	CLIP-seq
MIRT1388921	hsa-miR-4710	CLIP-seq
MIRT1388922	hsa-miR-4727-3p	CLIP-seq
MIRT1388923	hsa-miR-4728-5p	CLIP-seq
MIRT1388924	hsa-miR-4743	CLIP-seq
MIRT1388925	hsa-miR-4766-5p	CLIP-seq
MIRT1388926	hsa-miR-4773	CLIP-seq
MIRT1388927	hsa-miR-4784	CLIP-seq
MIRT1388928	hsa-miR-4792	CLIP-seq
MIRT1388929	hsa-miR-4802-5p	CLIP-seq
MIRT1388930	hsa-miR-484	CLIP-seq
MIRT1388931	hsa-miR-490-5p	CLIP-seq
MIRT1388932	hsa-miR-518a-5p	CLIP-seq
MIRT1388933	hsa-miR-527	CLIP-seq
MIRT1388934	hsa-miR-549	CLIP-seq
MIRT1388935	hsa-miR-607	CLIP-seq
MIRT1388936	hsa-miR-612	CLIP-seq
MIRT1388937	hsa-miR-642b	CLIP-seq
MIRT1388938	hsa-miR-767-3p	CLIP-seq
MIRT1388939	hsa-miR-885-3p	CLIP-seq
MIRT1388940	hsa-miR-98	CLIP-seq
MIRT1388941	hsa-miR-1262	CLIP-seq
MIRT1388942	hsa-miR-1470	CLIP-seq
MIRT1388943	hsa-miR-199a-5p	CLIP-seq
MIRT1388944	hsa-miR-199b-5p	CLIP-seq
MIRT1388945	hsa-miR-204	CLIP-seq
MIRT1388946	hsa-miR-211	CLIP-seq
MIRT1388947	hsa-miR-24	CLIP-seq
MIRT1388948	hsa-miR-3153	CLIP-seq
MIRT1388949	hsa-miR-3179	CLIP-seq
MIRT1388950	hsa-miR-3180	CLIP-seq
MIRT1388951	hsa-miR-3180-3p	CLIP-seq
MIRT1388952	hsa-miR-3193	CLIP-seq
MIRT1388953	hsa-miR-3196	CLIP-seq
MIRT1388954	hsa-miR-3202	CLIP-seq
MIRT1388900	hsa-miR-3591-5p	CLIP-seq
MIRT1388955	hsa-miR-3614-5p	CLIP-seq
MIRT1388906	hsa-miR-3677-5p	CLIP-seq
MIRT1388956	hsa-miR-3692	CLIP-seq
MIRT1388957	hsa-miR-3922-5p	CLIP-seq
MIRT1388958	hsa-miR-4268	CLIP-seq
MIRT1388959	hsa-miR-4287	CLIP-seq
MIRT1388960	hsa-miR-4330	CLIP-seq
MIRT1388961	hsa-miR-4436b-5p	CLIP-seq
MIRT1388962	hsa-miR-4448	CLIP-seq
MIRT1388963	hsa-miR-4455	CLIP-seq
MIRT1388912	hsa-miR-4457	CLIP-seq
MIRT1388914	hsa-miR-4460	CLIP-seq
MIRT1388964	hsa-miR-4481	CLIP-seq
MIRT1388965	hsa-miR-4488	CLIP-seq
MIRT1388920	hsa-miR-4663	CLIP-seq
MIRT1388966	hsa-miR-4667-3p	CLIP-seq
MIRT1388967	hsa-miR-4676-5p	CLIP-seq
MIRT1388968	hsa-miR-4685-3p	CLIP-seq
MIRT1388969	hsa-miR-4697-5p	CLIP-seq
MIRT1388970	hsa-miR-4699-3p	CLIP-seq
MIRT1388971	hsa-miR-4701-3p	CLIP-seq
MIRT1388972	hsa-miR-4716-3p	CLIP-seq
MIRT1388973	hsa-miR-4723-5p	CLIP-seq
MIRT1388974	hsa-miR-4724-3p	CLIP-seq
MIRT1388922	hsa-miR-4727-3p	CLIP-seq
MIRT1388923	hsa-miR-4728-5p	CLIP-seq
MIRT1388975	hsa-miR-4745-5p	CLIP-seq
MIRT1388976	hsa-miR-4747-5p	CLIP-seq
MIRT1388977	hsa-miR-4762-5p	CLIP-seq
MIRT1388978	hsa-miR-548l	CLIP-seq
MIRT1388979	hsa-miR-575	CLIP-seq
MIRT1388980	hsa-miR-609	CLIP-seq
MIRT1388981	hsa-miR-668	CLIP-seq
MIRT1388938	hsa-miR-767-3p	CLIP-seq
MIRT1388939	hsa-miR-885-3p	CLIP-seq
MIRT1557124	hsa-miR-4446-5p	CLIP-seq
MIRT1557125	hsa-miR-4742-3p	CLIP-seq
MIRT2116579	hsa-miR-1245	CLIP-seq
MIRT2116580	hsa-miR-1266	CLIP-seq
MIRT2116581	hsa-miR-1299	CLIP-seq
MIRT2116582	hsa-miR-150	CLIP-seq
MIRT2116583	hsa-miR-192	CLIP-seq
MIRT2116584	hsa-miR-215	CLIP-seq
MIRT2116585	hsa-miR-329	CLIP-seq
MIRT2116586	hsa-miR-362-3p	CLIP-seq
MIRT2116587	hsa-miR-3662	CLIP-seq
MIRT2116588	hsa-miR-3664-3p	CLIP-seq
MIRT2116589	hsa-miR-4310	CLIP-seq
MIRT2116590	hsa-miR-4432	CLIP-seq
MIRT2116591	hsa-miR-4433	CLIP-seq
MIRT2116592	hsa-miR-4459	CLIP-seq
MIRT2116593	hsa-miR-4492	CLIP-seq
MIRT2116594	hsa-miR-4498	CLIP-seq
MIRT2116595	hsa-miR-4505	CLIP-seq
MIRT2116596	hsa-miR-4518	CLIP-seq
MIRT2116597	hsa-miR-4713-5p	CLIP-seq
MIRT1388974	hsa-miR-4724-3p	CLIP-seq
MIRT1388923	hsa-miR-4728-5p	CLIP-seq
MIRT2116598	hsa-miR-4768-3p	CLIP-seq
MIRT2116599	hsa-miR-4782-5p	CLIP-seq
MIRT2116600	hsa-miR-499-5p	CLIP-seq
MIRT2116601	hsa-miR-516b	CLIP-seq
MIRT2116602	hsa-miR-519a	CLIP-seq
MIRT2116603	hsa-miR-519b-3p	CLIP-seq
MIRT2116604	hsa-miR-519c-3p	CLIP-seq
MIRT2116605	hsa-miR-532-3p	CLIP-seq
MIRT2116606	hsa-miR-570	CLIP-seq
MIRT2116607	hsa-miR-760	CLIP-seq
MIRT2116608	hsa-miR-762	CLIP-seq
MIRT2116609	hsa-miR-940	CLIP-seq
MIRT2116579	hsa-miR-1245	CLIP-seq
MIRT2116580	hsa-miR-1266	CLIP-seq
MIRT2338924	hsa-miR-1287	CLIP-seq
MIRT2338925	hsa-miR-1298	CLIP-seq
MIRT2116581	hsa-miR-1299	CLIP-seq
MIRT1388883	hsa-miR-132	CLIP-seq
MIRT2338926	hsa-miR-138	CLIP-seq
MIRT2338927	hsa-miR-151-3p	CLIP-seq
MIRT2338928	hsa-miR-1827	CLIP-seq
MIRT2338929	hsa-miR-1913	CLIP-seq
MIRT2116583	hsa-miR-192	CLIP-seq
MIRT1388943	hsa-miR-199a-5p	CLIP-seq
MIRT1388944	hsa-miR-199b-5p	CLIP-seq
MIRT1388889	hsa-miR-212	CLIP-seq
MIRT2116584	hsa-miR-215	CLIP-seq
MIRT2338930	hsa-miR-23a	CLIP-seq
MIRT2338931	hsa-miR-23b	CLIP-seq
MIRT2338932	hsa-miR-23c	CLIP-seq
MIRT2338933	hsa-miR-30a	CLIP-seq
MIRT2338934	hsa-miR-30b	CLIP-seq
MIRT2338935	hsa-miR-30c	CLIP-seq
MIRT2338936	hsa-miR-30d	CLIP-seq
MIRT2338937	hsa-miR-30e	CLIP-seq
MIRT2338938	hsa-miR-3120-3p	CLIP-seq
MIRT1388891	hsa-miR-3145-5p	CLIP-seq
MIRT2338939	hsa-miR-3175	CLIP-seq
MIRT2338940	hsa-miR-3180-5p	CLIP-seq
MIRT1388954	hsa-miR-3202	CLIP-seq
MIRT2338941	hsa-miR-324-3p	CLIP-seq
MIRT1388897	hsa-miR-326	CLIP-seq
MIRT1388898	hsa-miR-330-5p	CLIP-seq
MIRT2338942	hsa-miR-338-3p	CLIP-seq
MIRT2116588	hsa-miR-3664-3p	CLIP-seq
MIRT2338943	hsa-miR-3668	CLIP-seq
MIRT1388906	hsa-miR-3677-5p	CLIP-seq
MIRT2338944	hsa-miR-383	CLIP-seq
MIRT2338945	hsa-miR-384	CLIP-seq
MIRT1388957	hsa-miR-3922-5p	CLIP-seq
MIRT2338946	hsa-miR-3942-5p	CLIP-seq
MIRT1388958	hsa-miR-4268	CLIP-seq
MIRT2338947	hsa-miR-4290	CLIP-seq
MIRT2116589	hsa-miR-4310	CLIP-seq
MIRT2338948	hsa-miR-4316	CLIP-seq
MIRT2338949	hsa-miR-4325	CLIP-seq
MIRT2116590	hsa-miR-4432	CLIP-seq
MIRT2116591	hsa-miR-4433	CLIP-seq
MIRT1388962	hsa-miR-4448	CLIP-seq
MIRT2116592	hsa-miR-4459	CLIP-seq
MIRT2338950	hsa-miR-4463	CLIP-seq
MIRT1388964	hsa-miR-4481	CLIP-seq
MIRT2338951	hsa-miR-4493	CLIP-seq
MIRT2338952	hsa-miR-4494	CLIP-seq
MIRT2338953	hsa-miR-4495	CLIP-seq
MIRT2338954	hsa-miR-4499	CLIP-seq
MIRT2338955	hsa-miR-4503	CLIP-seq
MIRT2116596	hsa-miR-4518	CLIP-seq
MIRT2338956	hsa-miR-4522	CLIP-seq
MIRT2338957	hsa-miR-4530	CLIP-seq
MIRT2338958	hsa-miR-4533	CLIP-seq
MIRT2338959	hsa-miR-4666-5p	CLIP-seq
MIRT1388967	hsa-miR-4676-5p	CLIP-seq
MIRT2338960	hsa-miR-4690-3p	CLIP-seq
MIRT2338961	hsa-miR-4693-3p	CLIP-seq
MIRT2338962	hsa-miR-4703-5p	CLIP-seq
MIRT2338963	hsa-miR-4704-3p	CLIP-seq
MIRT2338964	hsa-miR-4717-5p	CLIP-seq
MIRT2338965	hsa-miR-4732-5p	CLIP-seq
MIRT2338966	hsa-miR-4736	CLIP-seq
MIRT1388975	hsa-miR-4745-5p	CLIP-seq
MIRT2338967	hsa-miR-4753-5p	CLIP-seq
MIRT2116598	hsa-miR-4768-3p	CLIP-seq
MIRT2338968	hsa-miR-4771	CLIP-seq
MIRT2338969	hsa-miR-4772-5p	CLIP-seq
MIRT2116599	hsa-miR-4782-5p	CLIP-seq
MIRT2116600	hsa-miR-499-5p	CLIP-seq
MIRT2338970	hsa-miR-501-3p	CLIP-seq
MIRT2338971	hsa-miR-502-3p	CLIP-seq
MIRT2338972	hsa-miR-507	CLIP-seq
MIRT2116601	hsa-miR-516b	CLIP-seq
MIRT1388934	hsa-miR-549	CLIP-seq
MIRT2338973	hsa-miR-557	CLIP-seq
MIRT2116606	hsa-miR-570	CLIP-seq
MIRT1388979	hsa-miR-575	CLIP-seq
MIRT2338974	hsa-miR-635	CLIP-seq
MIRT2338975	hsa-miR-648	CLIP-seq
MIRT1388938	hsa-miR-767-3p	CLIP-seq
MIRT2338976	hsa-miR-875-3p	CLIP-seq
MIRT2338977	hsa-miR-935	CLIP-seq
MIRT2460543	hsa-miR-3190	CLIP-seq
MIRT2460544	hsa-miR-3911	CLIP-seq
MIRT2338949	hsa-miR-4325	CLIP-seq
MIRT2338972	hsa-miR-507	CLIP-seq
MIRT2338973	hsa-miR-557	CLIP-seq
MIRT2338975	hsa-miR-648	CLIP-seq
MIRT2632524	hsa-miR-1245b-3p	CLIP-seq
MIRT2632525	hsa-miR-1292	CLIP-seq
MIRT2632526	hsa-miR-153	CLIP-seq
MIRT2632527	hsa-miR-3065-5p	CLIP-seq
MIRT2632528	hsa-miR-3173-3p	CLIP-seq
MIRT1388950	hsa-miR-3180	CLIP-seq
MIRT1388951	hsa-miR-3180-3p	CLIP-seq
MIRT2632529	hsa-miR-3187-3p	CLIP-seq
MIRT1388953	hsa-miR-3196	CLIP-seq
MIRT2632530	hsa-miR-3689d	CLIP-seq
MIRT2632531	hsa-miR-371-3p	CLIP-seq
MIRT2632532	hsa-miR-371b-3p	CLIP-seq
MIRT1388909	hsa-miR-377	CLIP-seq
MIRT2632533	hsa-miR-3915	CLIP-seq
MIRT2632534	hsa-miR-3928	CLIP-seq
MIRT2632535	hsa-miR-4276	CLIP-seq
MIRT2632536	hsa-miR-4311	CLIP-seq
MIRT2116591	hsa-miR-4433	CLIP-seq
MIRT2632537	hsa-miR-4471	CLIP-seq
MIRT1388965	hsa-miR-4488	CLIP-seq
MIRT2632538	hsa-miR-4514	CLIP-seq
MIRT2632539	hsa-miR-4529-5p	CLIP-seq
MIRT2632540	hsa-miR-4688	CLIP-seq
MIRT2632541	hsa-miR-4692	CLIP-seq
MIRT1388969	hsa-miR-4697-5p	CLIP-seq
MIRT2632542	hsa-miR-4722-5p	CLIP-seq
MIRT1388923	hsa-miR-4728-5p	CLIP-seq
MIRT2632543	hsa-miR-4795-5p	CLIP-seq
MIRT2632544	hsa-miR-486-3p	CLIP-seq
MIRT2632545	hsa-miR-505	CLIP-seq
MIRT2632546	hsa-miR-515-3p	CLIP-seq
MIRT2632547	hsa-miR-519e	CLIP-seq
MIRT1388939	hsa-miR-885-3p	CLIP-seq
MIRT2116609	hsa-miR-940	CLIP-seq
MIRT2632524	hsa-miR-1245b-3p	CLIP-seq
MIRT2691959	hsa-miR-1252	CLIP-seq
MIRT2632525	hsa-miR-1292	CLIP-seq
MIRT2632526	hsa-miR-153	CLIP-seq
MIRT2691960	hsa-miR-2110	CLIP-seq
MIRT2632527	hsa-miR-3065-5p	CLIP-seq
MIRT2691961	hsa-miR-3121-3p	CLIP-seq
MIRT2691962	hsa-miR-3150a-3p	CLIP-seq
MIRT2632528	hsa-miR-3173-3p	CLIP-seq
MIRT2338939	hsa-miR-3175	CLIP-seq
MIRT2632530	hsa-miR-3689d	CLIP-seq
MIRT2632531	hsa-miR-371-3p	CLIP-seq
MIRT2632532	hsa-miR-371b-3p	CLIP-seq
MIRT1388909	hsa-miR-377	CLIP-seq
MIRT2632533	hsa-miR-3915	CLIP-seq
MIRT2632534	hsa-miR-3928	CLIP-seq
MIRT2691963	hsa-miR-4260	CLIP-seq
MIRT2691964	hsa-miR-4261	CLIP-seq
MIRT2632537	hsa-miR-4471	CLIP-seq
MIRT2691965	hsa-miR-4476	CLIP-seq
MIRT2691966	hsa-miR-4496	CLIP-seq
MIRT2338958	hsa-miR-4533	CLIP-seq
MIRT2632540	hsa-miR-4688	CLIP-seq
MIRT2691967	hsa-miR-4691-3p	CLIP-seq
MIRT2632543	hsa-miR-4795-5p	CLIP-seq
MIRT2632544	hsa-miR-486-3p	CLIP-seq
MIRT2632545	hsa-miR-505	CLIP-seq
MIRT2632546	hsa-miR-515-3p	CLIP-seq
MIRT2632547	hsa-miR-519e	CLIP-seq
MIRT2691968	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	TAS
GO:0005515	Function	Protein binding	IPI	17500595, 25819436
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007399	Process	Nervous system development	IBA
GO:0030336	Process	Negative regulation of cell migration	IBA
GO:0045202	Component	Synapse	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0051963	Process	Regulation of synapse assembly	IBA
GO:0098794	Component	Postsynapse	IDA	30123108
GO:0098794	Component	Postsynapse	IMP	30123108

Other IDs

• MIM: 606525
• HGNC: 19744
• e!Ensembl: ENSG00000196220

Protein

• UniProt ID: O43295
• Protein name: SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)
• Protein function: GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00611	FCH	31 → 115	Fes/CIP4, and EFC/F-BAR homology domain	Family
  PF00620	RhoGAP	520 → 672	RhoGAP domain	Domain
  PF00018	SH3_1	750 → 795	SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}.
• Sequence:

  MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
  LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
  MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
  LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
  NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
  VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
  QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
  SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP
  PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI
  FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL
  ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
  PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH
  SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED
  WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE
  HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP
  LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL
  AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD
  PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA
  VTPTEKMFPNSSADKSGTM

• Sequence length: 1099

Pathways

KEGG:

Axon guidance

Reactome:

Rho GTPase cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Moyamoya angiopathy	Likely pathogenic	rs1033693138	RCV004704510	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHROMOSOME 3, MONOSOMY 3P25	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DISABILITY	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SRGAP3-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations