OSBPL2 (oxysterol binding protein like 2)

Gene

• Entrez ID: 9885
• Gene name: Oxysterol binding protein like 2
• Gene symbol: OSBPL2
• Synonyms (NCBI Gene): DFNA67, DNFA67, ORP-2, ORP2
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs786205880	TC>-	Pathogenic	Intron variant, coding sequence variant, 5 prime UTR variant, frameshift variant
rs786205881	TG>-	Pathogenic	Intron variant, coding sequence variant, 5 prime UTR variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT049254	hsa-miR-92a-3p	Luciferase reporter assay	23622248
MIRT049254	hsa-miR-92a-3p	CLASH	23622248
MIRT687342	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT687341	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT687340	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT687339	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT687338	hsa-miR-940	HITS-CLIP	23313552
MIRT680045	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT687337	hsa-miR-4514	HITS-CLIP	23313552
MIRT687336	hsa-miR-4692	HITS-CLIP	23313552
MIRT680044	hsa-miR-1827	HITS-CLIP	23313552
MIRT680043	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT680042	hsa-miR-6086	HITS-CLIP	23313552
MIRT687335	hsa-miR-4771	HITS-CLIP	23313552
MIRT680040	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT680039	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT680038	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT680037	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT680036	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT680035	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT680034	hsa-miR-7977	HITS-CLIP	23313552
MIRT680033	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT680032	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT680031	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT680030	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT680029	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT680028	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT680027	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT680026	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT680025	hsa-miR-3689c	HITS-CLIP	23313552
MIRT680024	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT680023	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT680022	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT680021	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT680020	hsa-miR-3122	HITS-CLIP	23313552
MIRT680019	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT680018	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT680017	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT680045	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT118790	hsa-miR-5693	HITS-CLIP	23824327
MIRT680044	hsa-miR-1827	HITS-CLIP	23824327
MIRT680043	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT680042	hsa-miR-6086	HITS-CLIP	23824327
MIRT118784	hsa-miR-4284	HITS-CLIP	23824327
MIRT680041	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT680040	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT680039	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT680038	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT680037	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT680036	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT680035	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT680034	hsa-miR-7977	HITS-CLIP	23824327
MIRT680033	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT680032	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT680031	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT680030	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT680029	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT680028	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT680027	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT680026	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT680025	hsa-miR-3689c	HITS-CLIP	23824327
MIRT680024	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT680023	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT680022	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT680021	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT680020	hsa-miR-3122	HITS-CLIP	23824327
MIRT680019	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT680018	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT680017	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT471743	hsa-miR-4293	PAR-CLIP	23592263
MIRT471744	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT471742	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT471741	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT471740	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT471739	hsa-miR-6771-5p	PAR-CLIP	23592263
MIRT471738	hsa-miR-3672	PAR-CLIP	23592263
MIRT471737	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT687342	hsa-miR-1910-3p	HITS-CLIP	23313552
MIRT687341	hsa-miR-6511a-5p	HITS-CLIP	23313552
MIRT687340	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT687339	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT687338	hsa-miR-940	HITS-CLIP	23313552
MIRT680045	hsa-miR-383-3p	HITS-CLIP	23313552
MIRT687337	hsa-miR-4514	HITS-CLIP	23313552
MIRT687336	hsa-miR-4692	HITS-CLIP	23313552
MIRT680044	hsa-miR-1827	HITS-CLIP	23313552
MIRT680043	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT680042	hsa-miR-6086	HITS-CLIP	23313552
MIRT687335	hsa-miR-4771	HITS-CLIP	23313552
MIRT680040	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT680039	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT680038	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT680037	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT680036	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT680035	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT680034	hsa-miR-7977	HITS-CLIP	23313552
MIRT680033	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT680032	hsa-miR-30c-1-3p	HITS-CLIP	23313552
MIRT680031	hsa-miR-30c-2-3p	HITS-CLIP	23313552
MIRT680030	hsa-miR-6788-5p	HITS-CLIP	23313552
MIRT680029	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT680028	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT680027	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT680026	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT680025	hsa-miR-3689c	HITS-CLIP	23313552
MIRT680024	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT680023	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT680022	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT680021	hsa-miR-450a-1-3p	HITS-CLIP	23313552
MIRT680020	hsa-miR-3122	HITS-CLIP	23313552
MIRT680019	hsa-miR-3913-5p	HITS-CLIP	23313552
MIRT680018	hsa-miR-887-5p	HITS-CLIP	23313552
MIRT680017	hsa-miR-6513-5p	HITS-CLIP	23313552
MIRT680045	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT118790	hsa-miR-5693	HITS-CLIP	23824327
MIRT680044	hsa-miR-1827	HITS-CLIP	23824327
MIRT680043	hsa-miR-377-5p	HITS-CLIP	23824327
MIRT680042	hsa-miR-6086	HITS-CLIP	23824327
MIRT118784	hsa-miR-4284	HITS-CLIP	23824327
MIRT680041	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT680040	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT680039	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT680038	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT680037	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT680036	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT680035	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT680034	hsa-miR-7977	HITS-CLIP	23824327
MIRT680033	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT680032	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT680031	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT680030	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT680029	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT680028	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT680027	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT680026	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT680025	hsa-miR-3689c	HITS-CLIP	23824327
MIRT680024	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT680023	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT680022	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT680021	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT680020	hsa-miR-3122	HITS-CLIP	23824327
MIRT680019	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT680018	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT680017	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT471743	hsa-miR-4293	PAR-CLIP	23592263
MIRT471744	hsa-miR-6849-3p	PAR-CLIP	23592263
MIRT471742	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT471741	hsa-miR-4786-5p	PAR-CLIP	23592263
MIRT471740	hsa-miR-769-5p	PAR-CLIP	23592263
MIRT471739	hsa-miR-6771-5p	PAR-CLIP	23592263
MIRT471738	hsa-miR-3672	PAR-CLIP	23592263
MIRT471737	hsa-miR-6864-3p	PAR-CLIP	23592263
MIRT1206133	hsa-miR-1197	CLIP-seq
MIRT1206134	hsa-miR-1276	CLIP-seq
MIRT1206135	hsa-miR-1285	CLIP-seq
MIRT1206136	hsa-miR-142-5p	CLIP-seq
MIRT1206137	hsa-miR-188-3p	CLIP-seq
MIRT1206138	hsa-miR-217	CLIP-seq
MIRT1206139	hsa-miR-25	CLIP-seq
MIRT1206140	hsa-miR-299-5p	CLIP-seq
MIRT1206141	hsa-miR-3064-3p	CLIP-seq
MIRT1206142	hsa-miR-3152-3p	CLIP-seq
MIRT1206143	hsa-miR-3185	CLIP-seq
MIRT1206144	hsa-miR-3187-5p	CLIP-seq
MIRT1206145	hsa-miR-32	CLIP-seq
MIRT1206146	hsa-miR-340	CLIP-seq
MIRT1206147	hsa-miR-3613-3p	CLIP-seq
MIRT1206148	hsa-miR-363	CLIP-seq
MIRT1206149	hsa-miR-367	CLIP-seq
MIRT1206150	hsa-miR-371-5p	CLIP-seq
MIRT1206151	hsa-miR-371b-5p	CLIP-seq
MIRT1206152	hsa-miR-3925-5p	CLIP-seq
MIRT1206153	hsa-miR-3929	CLIP-seq
MIRT1206154	hsa-miR-4252	CLIP-seq
MIRT1206155	hsa-miR-4256	CLIP-seq
MIRT1206156	hsa-miR-4311	CLIP-seq
MIRT1206157	hsa-miR-4325	CLIP-seq
MIRT1206158	hsa-miR-4419b	CLIP-seq
MIRT1206159	hsa-miR-4436a	CLIP-seq
MIRT1206160	hsa-miR-4478	CLIP-seq
MIRT1206161	hsa-miR-4528	CLIP-seq
MIRT1206162	hsa-miR-4537	CLIP-seq
MIRT1206163	hsa-miR-4649-3p	CLIP-seq
MIRT1206164	hsa-miR-4700-3p	CLIP-seq
MIRT1206165	hsa-miR-4704-3p	CLIP-seq
MIRT1206166	hsa-miR-4715-3p	CLIP-seq
MIRT1206167	hsa-miR-4722-5p	CLIP-seq
MIRT1206168	hsa-miR-4725-5p	CLIP-seq
MIRT1206169	hsa-miR-4727-5p	CLIP-seq
MIRT1206170	hsa-miR-4733-5p	CLIP-seq
MIRT1206171	hsa-miR-4738-3p	CLIP-seq
MIRT1206172	hsa-miR-4746-3p	CLIP-seq
MIRT1206173	hsa-miR-4764-5p	CLIP-seq
MIRT1206174	hsa-miR-4768-3p	CLIP-seq
MIRT1206175	hsa-miR-4776-3p	CLIP-seq
MIRT1206176	hsa-miR-4792	CLIP-seq
MIRT1206177	hsa-miR-485-5p	CLIP-seq
MIRT1206178	hsa-miR-504	CLIP-seq
MIRT1206179	hsa-miR-508-5p	CLIP-seq
MIRT1206180	hsa-miR-532-3p	CLIP-seq
MIRT1206181	hsa-miR-562	CLIP-seq
MIRT1206182	hsa-miR-583	CLIP-seq
MIRT1206183	hsa-miR-612	CLIP-seq
MIRT1206184	hsa-miR-658	CLIP-seq
MIRT1206185	hsa-miR-661	CLIP-seq
MIRT1206186	hsa-miR-766	CLIP-seq
MIRT1206187	hsa-miR-890	CLIP-seq
MIRT1206188	hsa-miR-92a	CLIP-seq
MIRT1206189	hsa-miR-92b	CLIP-seq
MIRT2059373	hsa-miR-1322	CLIP-seq
MIRT2059374	hsa-miR-2115	CLIP-seq
MIRT1206139	hsa-miR-25	CLIP-seq
MIRT2059375	hsa-miR-3163	CLIP-seq
MIRT1206145	hsa-miR-32	CLIP-seq
MIRT2059376	hsa-miR-362-5p	CLIP-seq
MIRT1206148	hsa-miR-363	CLIP-seq
MIRT1206149	hsa-miR-367	CLIP-seq
MIRT2059377	hsa-miR-383	CLIP-seq
MIRT1206153	hsa-miR-3929	CLIP-seq
MIRT2059378	hsa-miR-4264	CLIP-seq
MIRT2059379	hsa-miR-4270	CLIP-seq
MIRT2059380	hsa-miR-4308	CLIP-seq
MIRT1206157	hsa-miR-4325	CLIP-seq
MIRT1206158	hsa-miR-4419b	CLIP-seq
MIRT2059381	hsa-miR-4441	CLIP-seq
MIRT1206160	hsa-miR-4478	CLIP-seq
MIRT1206162	hsa-miR-4537	CLIP-seq
MIRT2059382	hsa-miR-4643	CLIP-seq
MIRT1206163	hsa-miR-4649-3p	CLIP-seq
MIRT2059383	hsa-miR-466	CLIP-seq
MIRT1206167	hsa-miR-4722-5p	CLIP-seq
MIRT1206172	hsa-miR-4746-3p	CLIP-seq
MIRT1206174	hsa-miR-4768-3p	CLIP-seq
MIRT2059384	hsa-miR-4772-5p	CLIP-seq
MIRT2059385	hsa-miR-4789-3p	CLIP-seq
MIRT1206176	hsa-miR-4792	CLIP-seq
MIRT1206177	hsa-miR-485-5p	CLIP-seq
MIRT2059386	hsa-miR-500b	CLIP-seq
MIRT2059387	hsa-miR-548a-3p	CLIP-seq
MIRT2059388	hsa-miR-548e	CLIP-seq
MIRT2059389	hsa-miR-548f	CLIP-seq
MIRT2059390	hsa-miR-549	CLIP-seq
MIRT1206184	hsa-miR-658	CLIP-seq
MIRT1206187	hsa-miR-890	CLIP-seq
MIRT1206188	hsa-miR-92a	CLIP-seq
MIRT1206189	hsa-miR-92b	CLIP-seq
MIRT1206135	hsa-miR-1285	CLIP-seq
MIRT2287731	hsa-miR-1304	CLIP-seq
MIRT1206139	hsa-miR-25	CLIP-seq
MIRT2287732	hsa-miR-3187-3p	CLIP-seq
MIRT1206144	hsa-miR-3187-5p	CLIP-seq
MIRT1206145	hsa-miR-32	CLIP-seq
MIRT1206148	hsa-miR-363	CLIP-seq
MIRT1206149	hsa-miR-367	CLIP-seq
MIRT1206153	hsa-miR-3929	CLIP-seq
MIRT1206157	hsa-miR-4325	CLIP-seq
MIRT1206158	hsa-miR-4419b	CLIP-seq
MIRT1206160	hsa-miR-4478	CLIP-seq
MIRT2287733	hsa-miR-4529-5p	CLIP-seq
MIRT1206162	hsa-miR-4537	CLIP-seq
MIRT1206163	hsa-miR-4649-3p	CLIP-seq
MIRT1206167	hsa-miR-4722-5p	CLIP-seq
MIRT1206172	hsa-miR-4746-3p	CLIP-seq
MIRT1206174	hsa-miR-4768-3p	CLIP-seq
MIRT1206176	hsa-miR-4792	CLIP-seq
MIRT1206177	hsa-miR-485-5p	CLIP-seq
MIRT1206179	hsa-miR-508-5p	CLIP-seq
MIRT2287734	hsa-miR-548n	CLIP-seq
MIRT1206183	hsa-miR-612	CLIP-seq
MIRT1206184	hsa-miR-658	CLIP-seq
MIRT1206185	hsa-miR-661	CLIP-seq
MIRT1206186	hsa-miR-766	CLIP-seq
MIRT1206187	hsa-miR-890	CLIP-seq
MIRT1206188	hsa-miR-92a	CLIP-seq
MIRT1206189	hsa-miR-92b	CLIP-seq
MIRT2391950	hsa-miR-3120-5p	CLIP-seq
MIRT2391951	hsa-miR-3157-5p	CLIP-seq
MIRT2391952	hsa-miR-3934	CLIP-seq
MIRT2391953	hsa-miR-3944-5p	CLIP-seq
MIRT2391954	hsa-miR-4634	CLIP-seq
MIRT2391955	hsa-miR-4675	CLIP-seq
MIRT2391956	hsa-miR-4691-3p	CLIP-seq
MIRT2391957	hsa-miR-4741	CLIP-seq
MIRT2391958	hsa-miR-626	CLIP-seq
MIRT2585719	hsa-miR-1234	CLIP-seq
MIRT2585720	hsa-miR-1267	CLIP-seq
MIRT2585721	hsa-miR-127-5p	CLIP-seq
MIRT2585722	hsa-miR-1283	CLIP-seq
MIRT1206135	hsa-miR-1285	CLIP-seq
MIRT2585723	hsa-miR-1287	CLIP-seq
MIRT2287731	hsa-miR-1304	CLIP-seq
MIRT2585724	hsa-miR-1323	CLIP-seq
MIRT2585725	hsa-miR-187	CLIP-seq
MIRT2059374	hsa-miR-2115	CLIP-seq
MIRT1206139	hsa-miR-25	CLIP-seq
MIRT1206140	hsa-miR-299-5p	CLIP-seq
MIRT2585726	hsa-miR-302a	CLIP-seq
MIRT2585727	hsa-miR-302b	CLIP-seq
MIRT2585728	hsa-miR-302c	CLIP-seq
MIRT2585729	hsa-miR-302d	CLIP-seq
MIRT2585730	hsa-miR-302e	CLIP-seq
MIRT1206141	hsa-miR-3064-3p	CLIP-seq
MIRT2585731	hsa-miR-3135b	CLIP-seq
MIRT2585732	hsa-miR-3138	CLIP-seq
MIRT2585733	hsa-miR-3154	CLIP-seq
MIRT2059375	hsa-miR-3163	CLIP-seq
MIRT2585734	hsa-miR-3176	CLIP-seq
MIRT2585735	hsa-miR-3180-5p	CLIP-seq
MIRT2585736	hsa-miR-3182	CLIP-seq
MIRT1206143	hsa-miR-3185	CLIP-seq
MIRT1206144	hsa-miR-3187-5p	CLIP-seq
MIRT2585737	hsa-miR-3197	CLIP-seq
MIRT1206145	hsa-miR-32	CLIP-seq
MIRT2585738	hsa-miR-339-5p	CLIP-seq
MIRT2585739	hsa-miR-3591-3p	CLIP-seq
MIRT1206147	hsa-miR-3613-3p	CLIP-seq
MIRT2585740	hsa-miR-3618	CLIP-seq
MIRT1206148	hsa-miR-363	CLIP-seq
MIRT2585741	hsa-miR-3659	CLIP-seq
MIRT2585742	hsa-miR-3665	CLIP-seq
MIRT1206149	hsa-miR-367	CLIP-seq
MIRT2585743	hsa-miR-3690	CLIP-seq
MIRT2585744	hsa-miR-371-3p	CLIP-seq
MIRT1206150	hsa-miR-371-5p	CLIP-seq
MIRT1206151	hsa-miR-371b-5p	CLIP-seq
MIRT2585745	hsa-miR-372	CLIP-seq
MIRT2585746	hsa-miR-373	CLIP-seq
MIRT2585747	hsa-miR-378	CLIP-seq
MIRT2585748	hsa-miR-378b	CLIP-seq
MIRT2585749	hsa-miR-378c	CLIP-seq
MIRT2585750	hsa-miR-378d	CLIP-seq
MIRT2585751	hsa-miR-378e	CLIP-seq
MIRT2585752	hsa-miR-378f	CLIP-seq
MIRT2585753	hsa-miR-378g	CLIP-seq
MIRT2585754	hsa-miR-378h	CLIP-seq
MIRT2585755	hsa-miR-378i	CLIP-seq
MIRT2585756	hsa-miR-3921	CLIP-seq
MIRT2585757	hsa-miR-3922-3p	CLIP-seq
MIRT1206153	hsa-miR-3929	CLIP-seq
MIRT2391952	hsa-miR-3934	CLIP-seq
MIRT2585758	hsa-miR-412	CLIP-seq
MIRT2585759	hsa-miR-422a	CLIP-seq
MIRT2585760	hsa-miR-4255	CLIP-seq
MIRT2585761	hsa-miR-4267	CLIP-seq
MIRT2585762	hsa-miR-4274	CLIP-seq
MIRT2585763	hsa-miR-4292	CLIP-seq
MIRT2059380	hsa-miR-4308	CLIP-seq
MIRT2585764	hsa-miR-4323	CLIP-seq
MIRT1206157	hsa-miR-4325	CLIP-seq
MIRT1206158	hsa-miR-4419b	CLIP-seq
MIRT2585765	hsa-miR-4436b-3p	CLIP-seq
MIRT2585766	hsa-miR-4437	CLIP-seq
MIRT2585767	hsa-miR-4446-5p	CLIP-seq
MIRT1206160	hsa-miR-4478	CLIP-seq
MIRT2585768	hsa-miR-4491	CLIP-seq
MIRT1206162	hsa-miR-4537	CLIP-seq
MIRT2391954	hsa-miR-4634	CLIP-seq
MIRT1206163	hsa-miR-4649-3p	CLIP-seq
MIRT2585769	hsa-miR-4652-3p	CLIP-seq
MIRT2585770	hsa-miR-4653-5p	CLIP-seq
MIRT2585771	hsa-miR-4657	CLIP-seq
MIRT2585772	hsa-miR-4674	CLIP-seq
MIRT2585773	hsa-miR-4693-3p	CLIP-seq
MIRT1206164	hsa-miR-4700-3p	CLIP-seq
MIRT2585774	hsa-miR-4709-3p	CLIP-seq
MIRT1206167	hsa-miR-4722-5p	CLIP-seq
MIRT1206168	hsa-miR-4725-5p	CLIP-seq
MIRT1206169	hsa-miR-4727-5p	CLIP-seq
MIRT1206170	hsa-miR-4733-5p	CLIP-seq
MIRT1206171	hsa-miR-4738-3p	CLIP-seq
MIRT1206172	hsa-miR-4746-3p	CLIP-seq
MIRT2585775	hsa-miR-4755-5p	CLIP-seq
MIRT2585776	hsa-miR-4757-5p	CLIP-seq
MIRT1206174	hsa-miR-4768-3p	CLIP-seq
MIRT2585777	hsa-miR-4769-3p	CLIP-seq
MIRT1206176	hsa-miR-4792	CLIP-seq
MIRT2585778	hsa-miR-4800-5p	CLIP-seq
MIRT1206177	hsa-miR-485-5p	CLIP-seq
MIRT2585779	hsa-miR-487a	CLIP-seq
MIRT2585780	hsa-miR-490-3p	CLIP-seq
MIRT1206178	hsa-miR-504	CLIP-seq
MIRT1206179	hsa-miR-508-5p	CLIP-seq
MIRT2585781	hsa-miR-513a-5p	CLIP-seq
MIRT2585782	hsa-miR-516a-3p	CLIP-seq
MIRT2585783	hsa-miR-520a-3p	CLIP-seq
MIRT2585784	hsa-miR-520a-5p	CLIP-seq
MIRT2585785	hsa-miR-520b	CLIP-seq
MIRT2585786	hsa-miR-520c-3p	CLIP-seq
MIRT2585787	hsa-miR-520d-3p	CLIP-seq
MIRT2585788	hsa-miR-520e	CLIP-seq
MIRT2585789	hsa-miR-520f	CLIP-seq
MIRT2585790	hsa-miR-525-5p	CLIP-seq
MIRT2585791	hsa-miR-542-5p	CLIP-seq
MIRT2585792	hsa-miR-544	CLIP-seq
MIRT2059387	hsa-miR-548a-3p	CLIP-seq
MIRT2585793	hsa-miR-548ad	CLIP-seq
MIRT2585794	hsa-miR-548c-3p	CLIP-seq
MIRT2059388	hsa-miR-548e	CLIP-seq
MIRT2059389	hsa-miR-548f	CLIP-seq
MIRT2585795	hsa-miR-548o	CLIP-seq
MIRT2059390	hsa-miR-549	CLIP-seq
MIRT2585796	hsa-miR-550a	CLIP-seq
MIRT2585797	hsa-miR-552	CLIP-seq
MIRT2585798	hsa-miR-570	CLIP-seq
MIRT2585799	hsa-miR-574-5p	CLIP-seq
MIRT2585800	hsa-miR-607	CLIP-seq
MIRT1206183	hsa-miR-612	CLIP-seq
MIRT2585801	hsa-miR-619	CLIP-seq
MIRT2585802	hsa-miR-642b	CLIP-seq
MIRT2585803	hsa-miR-648	CLIP-seq
MIRT2585804	hsa-miR-649	CLIP-seq
MIRT2585805	hsa-miR-653	CLIP-seq
MIRT1206184	hsa-miR-658	CLIP-seq
MIRT1206185	hsa-miR-661	CLIP-seq
MIRT2585806	hsa-miR-668	CLIP-seq
MIRT2585807	hsa-miR-670	CLIP-seq
MIRT2585808	hsa-miR-671-5p	CLIP-seq
MIRT1206186	hsa-miR-766	CLIP-seq
MIRT2585809	hsa-miR-885-3p	CLIP-seq
MIRT1206187	hsa-miR-890	CLIP-seq
MIRT1206188	hsa-miR-92a	CLIP-seq
MIRT1206189	hsa-miR-92b	CLIP-seq
MIRT2585810	hsa-miR-934	CLIP-seq
MIRT2585722	hsa-miR-1283	CLIP-seq
MIRT1206135	hsa-miR-1285	CLIP-seq
MIRT2585723	hsa-miR-1287	CLIP-seq
MIRT2287731	hsa-miR-1304	CLIP-seq
MIRT2585724	hsa-miR-1323	CLIP-seq
MIRT2585725	hsa-miR-187	CLIP-seq
MIRT2059374	hsa-miR-2115	CLIP-seq
MIRT1206139	hsa-miR-25	CLIP-seq
MIRT2585726	hsa-miR-302a	CLIP-seq
MIRT2585727	hsa-miR-302b	CLIP-seq
MIRT2585728	hsa-miR-302c	CLIP-seq
MIRT2585729	hsa-miR-302d	CLIP-seq
MIRT2585730	hsa-miR-302e	CLIP-seq
MIRT2585731	hsa-miR-3135b	CLIP-seq
MIRT2585735	hsa-miR-3180-5p	CLIP-seq
MIRT1206144	hsa-miR-3187-5p	CLIP-seq
MIRT1206145	hsa-miR-32	CLIP-seq
MIRT2585739	hsa-miR-3591-3p	CLIP-seq
MIRT2585740	hsa-miR-3618	CLIP-seq
MIRT1206148	hsa-miR-363	CLIP-seq
MIRT2585741	hsa-miR-3659	CLIP-seq
MIRT1206149	hsa-miR-367	CLIP-seq
MIRT2585745	hsa-miR-372	CLIP-seq
MIRT2585746	hsa-miR-373	CLIP-seq
MIRT1206153	hsa-miR-3929	CLIP-seq
MIRT2391952	hsa-miR-3934	CLIP-seq
MIRT2585760	hsa-miR-4255	CLIP-seq
MIRT2585761	hsa-miR-4267	CLIP-seq
MIRT2585764	hsa-miR-4323	CLIP-seq
MIRT1206157	hsa-miR-4325	CLIP-seq
MIRT1206158	hsa-miR-4419b	CLIP-seq
MIRT2585765	hsa-miR-4436b-3p	CLIP-seq
MIRT1206160	hsa-miR-4478	CLIP-seq
MIRT1206162	hsa-miR-4537	CLIP-seq
MIRT2391954	hsa-miR-4634	CLIP-seq
MIRT1206163	hsa-miR-4649-3p	CLIP-seq
MIRT2585773	hsa-miR-4693-3p	CLIP-seq
MIRT1206164	hsa-miR-4700-3p	CLIP-seq
MIRT1206167	hsa-miR-4722-5p	CLIP-seq
MIRT1206172	hsa-miR-4746-3p	CLIP-seq
MIRT1206174	hsa-miR-4768-3p	CLIP-seq
MIRT1206176	hsa-miR-4792	CLIP-seq
MIRT1206177	hsa-miR-485-5p	CLIP-seq
MIRT1206179	hsa-miR-508-5p	CLIP-seq
MIRT2585781	hsa-miR-513a-5p	CLIP-seq
MIRT2585782	hsa-miR-516a-3p	CLIP-seq
MIRT2585783	hsa-miR-520a-3p	CLIP-seq
MIRT2585784	hsa-miR-520a-5p	CLIP-seq
MIRT2585785	hsa-miR-520b	CLIP-seq
MIRT2585786	hsa-miR-520c-3p	CLIP-seq
MIRT2585787	hsa-miR-520d-3p	CLIP-seq
MIRT2585788	hsa-miR-520e	CLIP-seq
MIRT2585789	hsa-miR-520f	CLIP-seq
MIRT2585790	hsa-miR-525-5p	CLIP-seq
MIRT2585793	hsa-miR-548ad	CLIP-seq
MIRT2585794	hsa-miR-548c-3p	CLIP-seq
MIRT2585795	hsa-miR-548o	CLIP-seq
MIRT2059390	hsa-miR-549	CLIP-seq
MIRT2585796	hsa-miR-550a	CLIP-seq
MIRT2585797	hsa-miR-552	CLIP-seq
MIRT2585798	hsa-miR-570	CLIP-seq
MIRT2585799	hsa-miR-574-5p	CLIP-seq
MIRT2585800	hsa-miR-607	CLIP-seq
MIRT1206183	hsa-miR-612	CLIP-seq
MIRT2585802	hsa-miR-642b	CLIP-seq
MIRT2585803	hsa-miR-648	CLIP-seq
MIRT1206184	hsa-miR-658	CLIP-seq
MIRT1206185	hsa-miR-661	CLIP-seq
MIRT2585808	hsa-miR-671-5p	CLIP-seq
MIRT1206186	hsa-miR-766	CLIP-seq
MIRT2585809	hsa-miR-885-3p	CLIP-seq
MIRT1206187	hsa-miR-890	CLIP-seq
MIRT1206188	hsa-miR-92a	CLIP-seq
MIRT1206189	hsa-miR-92b	CLIP-seq
MIRT2585810	hsa-miR-934	CLIP-seq
MIRT2585802	hsa-miR-642b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25681634, 31515488, 32296183, 33961781
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IDA	30581148
GO:0005737	Component	Cytoplasm	IEA
GO:0005811	Component	Lipid droplet	IEA
GO:0005811	Component	Lipid droplet	IMP	19224871
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	30581148
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006699	Process	Bile acid biosynthetic process	IEA
GO:0006699	Process	Bile acid biosynthetic process	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0007009	Process	Plasma membrane organization	IMP	30581148
GO:0008289	Function	Lipid binding	IEA
GO:0008526	Function	Phosphatidylinositol transfer activity	IMP	30581148
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	30581148
GO:0010807	Process	Regulation of synaptic vesicle priming	IDA	36577376
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IDA	17428193
GO:0015485	Function	Cholesterol binding	IEA
GO:0015914	Process	Phospholipid transport	IMP	30581148
GO:0016020	Component	Membrane	IEA
GO:0030301	Process	Cholesterol transport	IMP	30581148
GO:0032367	Process	Intracellular cholesterol transport	IMP	30581148
GO:0051289	Process	Protein homotetramerization	IDA	30581148
GO:0097038	Component	Perinuclear endoplasmic reticulum	IBA
GO:0098831	Component	Presynaptic active zone cytoplasmic component	IEA
GO:0098978	Component	Glutamatergic synapse	IDA	36577376
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099509	Process	Regulation of presynaptic cytosolic calcium ion concentration	IEA
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:0120015	Function	Sterol transfer activity	IEA
GO:0120015	Function	Sterol transfer activity	TAS
GO:0120020	Function	Cholesterol transfer activity	IMP	30581148

Other IDs

• MIM: 606731
• HGNC: 15761
• e!Ensembl: ENSG00000130703

Protein

• UniProt ID: Q9H1P3
• Protein name: Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)
• Protein function: Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the
• PDB: 5ZM8
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01237	Oxysterol_BP	75 → 470	Oxysterol-binding protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed.
• Sequence:

  MNGEEEFFDAVTGFDSDNSSGEFSEANQKVTGMIDLDTSKNNRIGKTGERPSQENGIQKH
  RTSLPAPMFSRSDFSVWTILKKCVGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHRA
  SCQPQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHP
  PISAFHSEGLNHDFLFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVH
  NVIIGKLWIEQYGTVEILNHRTGHKCVLHFKPCGLFGKELHKVEGHIQDKNKKKLFMIYG
  KWTECLWGIDPVSYESFKKQERRGDHLRKAKLDEDSGKADSDVADDVPVAQETVQVIPGS
  KLLWRINTRPPNSAQMYNFTSFTVSLNELETGMEKTLPPTDCRLRPDIRGMENGNMDLAS
  QEKERLEEKQREARRERAKEEAEWQTRWFYPGNNPYTGTPDWLYAGDYFERNFSDCPDIY
  

• Sequence length: 480

Pathways

Reactome:

Synthesis of bile acids and bile salts

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Autosomal dominant nonsyndromic hearing loss 67	Pathogenic	rs786205880, rs786205881, rs1981202197, rs1981200603	RCV000170349 RCV000170350 RCV001255991 RCV003135912	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT ISOLATED SENSORINEURAL DEAFNESS TYPE DFNA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOSOMAL DOMINANT NONSYNDROMIC HEARING LOSS	—	Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL DOMINANT 67	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSBPL2-related disorder	Likely benign; Conflicting classifications of pathogenicity; Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RESTLESS LEGS SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS OF BILATERAL EARS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autosomal dominant non-syndromic sensorineural deafness type DFNA	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29947926, 36918840	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33258187	Associate	★☆☆☆☆ Found in Text Mining only
Deafness	Deafness	Pubtator	30391516, 30894143, 35682719	Associate	★☆☆☆☆ Found in Text Mining only
DEAFNESS, AUTOSOMAL DOMINANT 67	Deafness	GENOMICS_ENGLAND_DG	9872452		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL DOMINANT 67	Deafness	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL DOMINANT 67	Deafness	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive Disorder	Major depressive disorder	Pubtator	30391516	Associate	★☆☆☆☆ Found in Text Mining only
Distal Myopathies	Distal myopathy	Pubtator	30894143	Associate	★☆☆☆☆ Found in Text Mining only
Dyslipidemias	Dyslipidemias	BEFREE	31451425		★☆☆☆☆ Found in Text Mining only
Hearing Loss	Hearing loss	Pubtator	35682719	Associate	★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	BEFREE	31451425		★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	BEFREE	25077649, 31427568		★☆☆☆☆ Found in Text Mining only
Nonsyndromic Deafness	Nonsyndromic Deafness	CLINGEN_DG	25077649, 25759012		★☆☆☆☆ Found in Text Mining only
Pulmonary Disease Chronic Obstructive	Chronic obstructive pulmonary disease	Pubtator	33854310	Associate	★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only