URB1 (URB1 ribosome biogenesis factor)

Gene

• Entrez ID: 9875
• Gene name: URB1 ribosome biogenesis factor
• Gene symbol: URB1
• Synonyms (NCBI Gene): C21orf108, NPA1
• Chromosome: 21
• Chromosome location: 21q22.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018081	hsa-miR-335-5p	Microarray	18185580
MIRT038597	hsa-miR-106b-3p	CLASH	23622248
MIRT037624	hsa-miR-744-5p	CLASH	23622248
MIRT036788	hsa-miR-760	CLASH	23622248
MIRT1476773	hsa-miR-105	CLIP-seq
MIRT1476774	hsa-miR-1183	CLIP-seq
MIRT1476775	hsa-miR-1193	CLIP-seq
MIRT1476776	hsa-miR-1208	CLIP-seq
MIRT1476777	hsa-miR-1225-5p	CLIP-seq
MIRT1476778	hsa-miR-1233	CLIP-seq
MIRT1476779	hsa-miR-1260	CLIP-seq
MIRT1476780	hsa-miR-1260b	CLIP-seq
MIRT1476781	hsa-miR-1266	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476783	hsa-miR-1276	CLIP-seq
MIRT1476784	hsa-miR-1287	CLIP-seq
MIRT1476785	hsa-miR-1294	CLIP-seq
MIRT1476786	hsa-miR-1297	CLIP-seq
MIRT1476787	hsa-miR-183	CLIP-seq
MIRT1476788	hsa-miR-186	CLIP-seq
MIRT1476789	hsa-miR-188-3p	CLIP-seq
MIRT1476790	hsa-miR-1909	CLIP-seq
MIRT1476791	hsa-miR-1915	CLIP-seq
MIRT1476792	hsa-miR-194	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT1476794	hsa-miR-200b	CLIP-seq
MIRT1476795	hsa-miR-200c	CLIP-seq
MIRT1476796	hsa-miR-214	CLIP-seq
MIRT1476797	hsa-miR-26a	CLIP-seq
MIRT1476798	hsa-miR-26b	CLIP-seq
MIRT1476799	hsa-miR-299-3p	CLIP-seq
MIRT1476800	hsa-miR-3121-3p	CLIP-seq
MIRT1476801	hsa-miR-3132	CLIP-seq
MIRT1476802	hsa-miR-3133	CLIP-seq
MIRT1476803	hsa-miR-3135b	CLIP-seq
MIRT1476804	hsa-miR-3136-5p	CLIP-seq
MIRT1476805	hsa-miR-3137	CLIP-seq
MIRT1476806	hsa-miR-3147	CLIP-seq
MIRT1476807	hsa-miR-3152-5p	CLIP-seq
MIRT1476808	hsa-miR-3156-3p	CLIP-seq
MIRT1476809	hsa-miR-3163	CLIP-seq
MIRT1476810	hsa-miR-3167	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT1476812	hsa-miR-3194-3p	CLIP-seq
MIRT1476813	hsa-miR-320e	CLIP-seq
MIRT1476814	hsa-miR-3613-3p	CLIP-seq
MIRT1476815	hsa-miR-3614-5p	CLIP-seq
MIRT1476816	hsa-miR-3619-5p	CLIP-seq
MIRT1476817	hsa-miR-3647-3p	CLIP-seq
MIRT1476818	hsa-miR-3652	CLIP-seq
MIRT1476819	hsa-miR-3657	CLIP-seq
MIRT1476820	hsa-miR-3664-3p	CLIP-seq
MIRT1476821	hsa-miR-3672	CLIP-seq
MIRT1476822	hsa-miR-3689a-3p	CLIP-seq
MIRT1476823	hsa-miR-3689c	CLIP-seq
MIRT1476824	hsa-miR-371-5p	CLIP-seq
MIRT1476825	hsa-miR-371b-5p	CLIP-seq
MIRT1476826	hsa-miR-3909	CLIP-seq
MIRT1476827	hsa-miR-3929	CLIP-seq
MIRT1476828	hsa-miR-3944-5p	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT1476830	hsa-miR-425	CLIP-seq
MIRT1476831	hsa-miR-4253	CLIP-seq
MIRT1476832	hsa-miR-4272	CLIP-seq
MIRT1476833	hsa-miR-429	CLIP-seq
MIRT1476834	hsa-miR-4291	CLIP-seq
MIRT1476835	hsa-miR-4302	CLIP-seq
MIRT1476836	hsa-miR-4308	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT1476838	hsa-miR-4419b	CLIP-seq
MIRT1476839	hsa-miR-4425	CLIP-seq
MIRT1476840	hsa-miR-4430	CLIP-seq
MIRT1476841	hsa-miR-4439	CLIP-seq
MIRT1476842	hsa-miR-4440	CLIP-seq
MIRT1476843	hsa-miR-4450	CLIP-seq
MIRT1476844	hsa-miR-4465	CLIP-seq
MIRT1476845	hsa-miR-4474-5p	CLIP-seq
MIRT1476846	hsa-miR-4478	CLIP-seq
MIRT1476847	hsa-miR-4491	CLIP-seq
MIRT1476848	hsa-miR-4511	CLIP-seq
MIRT1476849	hsa-miR-4513	CLIP-seq
MIRT1476850	hsa-miR-4518	CLIP-seq
MIRT1476851	hsa-miR-4650-5p	CLIP-seq
MIRT1476852	hsa-miR-4654	CLIP-seq
MIRT1476853	hsa-miR-4657	CLIP-seq
MIRT1476854	hsa-miR-4666-5p	CLIP-seq
MIRT1476855	hsa-miR-4669	CLIP-seq
MIRT1476856	hsa-miR-4695-3p	CLIP-seq
MIRT1476857	hsa-miR-4710	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT1476859	hsa-miR-4724-5p	CLIP-seq
MIRT1476860	hsa-miR-4725-5p	CLIP-seq
MIRT1476861	hsa-miR-4726-3p	CLIP-seq
MIRT1476862	hsa-miR-4728-5p	CLIP-seq
MIRT1476863	hsa-miR-4742-5p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT1476865	hsa-miR-4755-3p	CLIP-seq
MIRT1476866	hsa-miR-4761-3p	CLIP-seq
MIRT1476867	hsa-miR-4769-5p	CLIP-seq
MIRT1476868	hsa-miR-4774-3p	CLIP-seq
MIRT1476869	hsa-miR-4781-3p	CLIP-seq
MIRT1476870	hsa-miR-491-5p	CLIP-seq
MIRT1476871	hsa-miR-498	CLIP-seq
MIRT1476872	hsa-miR-501-5p	CLIP-seq
MIRT1476873	hsa-miR-504	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT1476875	hsa-miR-520d-5p	CLIP-seq
MIRT1476876	hsa-miR-524-5p	CLIP-seq
MIRT1476877	hsa-miR-548ac	CLIP-seq
MIRT1476878	hsa-miR-548d-3p	CLIP-seq
MIRT1476879	hsa-miR-548p	CLIP-seq
MIRT1476880	hsa-miR-548z	CLIP-seq
MIRT1476881	hsa-miR-555	CLIP-seq
MIRT1476882	hsa-miR-556-3p	CLIP-seq
MIRT1476883	hsa-miR-564	CLIP-seq
MIRT1476884	hsa-miR-592	CLIP-seq
MIRT1476885	hsa-miR-599	CLIP-seq
MIRT1476886	hsa-miR-600	CLIP-seq
MIRT1476887	hsa-miR-642b	CLIP-seq
MIRT1476888	hsa-miR-645	CLIP-seq
MIRT1476889	hsa-miR-662	CLIP-seq
MIRT1476890	hsa-miR-671-5p	CLIP-seq
MIRT1476891	hsa-miR-761	CLIP-seq
MIRT1476892	hsa-miR-873	CLIP-seq
MIRT1476893	hsa-miR-876-5p	CLIP-seq
MIRT1476894	hsa-miR-922	CLIP-seq
MIRT1476895	hsa-miR-943	CLIP-seq
MIRT2143652	hsa-let-7a	CLIP-seq
MIRT2143653	hsa-let-7b	CLIP-seq
MIRT2143654	hsa-let-7c	CLIP-seq
MIRT2143655	hsa-let-7d	CLIP-seq
MIRT2143656	hsa-let-7e	CLIP-seq
MIRT2143657	hsa-let-7f	CLIP-seq
MIRT2143658	hsa-let-7g	CLIP-seq
MIRT2143659	hsa-let-7i	CLIP-seq
MIRT1476774	hsa-miR-1183	CLIP-seq
MIRT1476776	hsa-miR-1208	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476785	hsa-miR-1294	CLIP-seq
MIRT2143660	hsa-miR-1587	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT2143661	hsa-miR-202	CLIP-seq
MIRT2143662	hsa-miR-216a	CLIP-seq
MIRT2143663	hsa-miR-300	CLIP-seq
MIRT2143664	hsa-miR-3120-3p	CLIP-seq
MIRT1476805	hsa-miR-3137	CLIP-seq
MIRT2143665	hsa-miR-3149	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT2143666	hsa-miR-3179	CLIP-seq
MIRT2143667	hsa-miR-34b	CLIP-seq
MIRT2143668	hsa-miR-3646	CLIP-seq
MIRT2143669	hsa-miR-3662	CLIP-seq
MIRT2143670	hsa-miR-3667-5p	CLIP-seq
MIRT1476821	hsa-miR-3672	CLIP-seq
MIRT2143671	hsa-miR-3674	CLIP-seq
MIRT2143672	hsa-miR-3688-5p	CLIP-seq
MIRT2143673	hsa-miR-381	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT2143674	hsa-miR-4276	CLIP-seq
MIRT1476835	hsa-miR-4302	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT2143675	hsa-miR-4458	CLIP-seq
MIRT2143676	hsa-miR-4477b	CLIP-seq
MIRT2143677	hsa-miR-4500	CLIP-seq
MIRT2143678	hsa-miR-4674	CLIP-seq
MIRT1476856	hsa-miR-4695-3p	CLIP-seq
MIRT2143679	hsa-miR-4715-5p	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT2143680	hsa-miR-4735-5p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT2143681	hsa-miR-4762-5p	CLIP-seq
MIRT2143682	hsa-miR-4773	CLIP-seq
MIRT2143683	hsa-miR-502-5p	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT2143684	hsa-miR-545	CLIP-seq
MIRT2143685	hsa-miR-548aa	CLIP-seq
MIRT2143686	hsa-miR-548al	CLIP-seq
MIRT2143687	hsa-miR-590-3p	CLIP-seq
MIRT2143688	hsa-miR-635	CLIP-seq
MIRT2143689	hsa-miR-98	CLIP-seq
MIRT2363862	hsa-miR-106a	CLIP-seq
MIRT2363863	hsa-miR-106b	CLIP-seq
MIRT2363864	hsa-miR-1258	CLIP-seq
MIRT2363865	hsa-miR-1265	CLIP-seq
MIRT2363866	hsa-miR-17	CLIP-seq
MIRT1476787	hsa-miR-183	CLIP-seq
MIRT2363867	hsa-miR-18a	CLIP-seq
MIRT2363868	hsa-miR-18b	CLIP-seq
MIRT1476791	hsa-miR-1915	CLIP-seq
MIRT1476794	hsa-miR-200b	CLIP-seq
MIRT1476795	hsa-miR-200c	CLIP-seq
MIRT2363869	hsa-miR-20a	CLIP-seq
MIRT2363870	hsa-miR-20b	CLIP-seq
MIRT2363871	hsa-miR-2392	CLIP-seq
MIRT2143663	hsa-miR-300	CLIP-seq
MIRT2363872	hsa-miR-302a	CLIP-seq
MIRT2363873	hsa-miR-302b	CLIP-seq
MIRT2363874	hsa-miR-302c	CLIP-seq
MIRT2363875	hsa-miR-302d	CLIP-seq
MIRT2363876	hsa-miR-302e	CLIP-seq
MIRT1476803	hsa-miR-3135b	CLIP-seq
MIRT1476809	hsa-miR-3163	CLIP-seq
MIRT2363877	hsa-miR-3186-5p	CLIP-seq
MIRT1476813	hsa-miR-320e	CLIP-seq
MIRT2363878	hsa-miR-331-3p	CLIP-seq
MIRT2363879	hsa-miR-3622a-3p	CLIP-seq
MIRT2363880	hsa-miR-3622b-3p	CLIP-seq
MIRT2143668	hsa-miR-3646	CLIP-seq
MIRT2143669	hsa-miR-3662	CLIP-seq
MIRT2363881	hsa-miR-3663-5p	CLIP-seq
MIRT2363882	hsa-miR-372	CLIP-seq
MIRT2363883	hsa-miR-373	CLIP-seq
MIRT2143673	hsa-miR-381	CLIP-seq
MIRT1476833	hsa-miR-429	CLIP-seq
MIRT2363884	hsa-miR-4297	CLIP-seq
MIRT2363885	hsa-miR-4327	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT1476842	hsa-miR-4440	CLIP-seq
MIRT1476843	hsa-miR-4450	CLIP-seq
MIRT1476856	hsa-miR-4695-3p	CLIP-seq
MIRT2363886	hsa-miR-4708-3p	CLIP-seq
MIRT2143679	hsa-miR-4715-5p	CLIP-seq
MIRT1476861	hsa-miR-4726-3p	CLIP-seq
MIRT2363887	hsa-miR-4731-5p	CLIP-seq
MIRT2363888	hsa-miR-4735-3p	CLIP-seq
MIRT2363889	hsa-miR-4740-3p	CLIP-seq
MIRT2363890	hsa-miR-4761-5p	CLIP-seq
MIRT1476870	hsa-miR-491-5p	CLIP-seq
MIRT1476871	hsa-miR-498	CLIP-seq
MIRT1476872	hsa-miR-501-5p	CLIP-seq
MIRT2363891	hsa-miR-512-3p	CLIP-seq
MIRT2363892	hsa-miR-519d	CLIP-seq
MIRT2363893	hsa-miR-520a-3p	CLIP-seq
MIRT2363894	hsa-miR-520b	CLIP-seq
MIRT2363895	hsa-miR-520c-3p	CLIP-seq
MIRT2363896	hsa-miR-520d-3p	CLIP-seq
MIRT2363897	hsa-miR-520e	CLIP-seq
MIRT2363898	hsa-miR-532-5p	CLIP-seq
MIRT1476882	hsa-miR-556-3p	CLIP-seq
MIRT1476883	hsa-miR-564	CLIP-seq
MIRT1476884	hsa-miR-592	CLIP-seq
MIRT1476885	hsa-miR-599	CLIP-seq
MIRT2143688	hsa-miR-635	CLIP-seq
MIRT2363899	hsa-miR-651	CLIP-seq
MIRT1476889	hsa-miR-662	CLIP-seq
MIRT2363900	hsa-miR-93	CLIP-seq
MIRT2396723	hsa-miR-591	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476784	hsa-miR-1287	CLIP-seq
MIRT2143660	hsa-miR-1587	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT2143663	hsa-miR-300	CLIP-seq
MIRT1476806	hsa-miR-3147	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT2143668	hsa-miR-3646	CLIP-seq
MIRT2143669	hsa-miR-3662	CLIP-seq
MIRT2143673	hsa-miR-381	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT1476839	hsa-miR-4425	CLIP-seq
MIRT2143678	hsa-miR-4674	CLIP-seq
MIRT2143679	hsa-miR-4715-5p	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT1476869	hsa-miR-4781-3p	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT2143688	hsa-miR-635	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT2143663	hsa-miR-300	CLIP-seq
MIRT1476806	hsa-miR-3147	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT2143673	hsa-miR-381	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT1476839	hsa-miR-4425	CLIP-seq
MIRT2143679	hsa-miR-4715-5p	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT1476869	hsa-miR-4781-3p	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT1476775	hsa-miR-1193	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476784	hsa-miR-1287	CLIP-seq
MIRT2657683	hsa-miR-129-5p	CLIP-seq
MIRT2657684	hsa-miR-143	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT1476806	hsa-miR-3147	CLIP-seq
MIRT2143665	hsa-miR-3149	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT2143668	hsa-miR-3646	CLIP-seq
MIRT2143669	hsa-miR-3662	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT1476839	hsa-miR-4425	CLIP-seq
MIRT2657685	hsa-miR-4534	CLIP-seq
MIRT2657686	hsa-miR-4708-5p	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT2657687	hsa-miR-4770	CLIP-seq
MIRT1476869	hsa-miR-4781-3p	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT1476782	hsa-miR-1273f	CLIP-seq
MIRT1476784	hsa-miR-1287	CLIP-seq
MIRT1476791	hsa-miR-1915	CLIP-seq
MIRT1476793	hsa-miR-197	CLIP-seq
MIRT1476806	hsa-miR-3147	CLIP-seq
MIRT2143665	hsa-miR-3149	CLIP-seq
MIRT1476811	hsa-miR-3170	CLIP-seq
MIRT2363878	hsa-miR-331-3p	CLIP-seq
MIRT2143668	hsa-miR-3646	CLIP-seq
MIRT2143669	hsa-miR-3662	CLIP-seq
MIRT1476829	hsa-miR-411	CLIP-seq
MIRT1476837	hsa-miR-4330	CLIP-seq
MIRT1476839	hsa-miR-4425	CLIP-seq
MIRT1476842	hsa-miR-4440	CLIP-seq
MIRT1476858	hsa-miR-4716-5p	CLIP-seq
MIRT1476861	hsa-miR-4726-3p	CLIP-seq
MIRT2363889	hsa-miR-4740-3p	CLIP-seq
MIRT1476864	hsa-miR-4747-5p	CLIP-seq
MIRT1476869	hsa-miR-4781-3p	CLIP-seq
MIRT1476871	hsa-miR-498	CLIP-seq
MIRT1476874	hsa-miR-5096	CLIP-seq
MIRT1476884	hsa-miR-592	CLIP-seq
MIRT1476885	hsa-miR-599	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	16963496
GO:0005730	Component	Nucleolus	IEA
GO:0005730	Component	Nucleolus	NAS	12429849

Other IDs

• MIM: 608865
• HGNC: 17344
• e!Ensembl: ENSG00000142207

Protein

• UniProt ID: O60287
• Protein name: Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11707	Npa1	78 → 393	Ribosome 60S biogenesis N-terminal	Family
  PF16201	NopRA1	1668 → 1857	Nucleolar pre-ribosomal-associated protein 1	Family

• Sequence:

  MGVPKRKASGGQDGAASSAGAAKRARKEELTGVRFKAQLKDPQGPGPGLEAFVSAAKKLP
  REDVYDVVEGYIKISVECVEIFQLLSGEKRPESETMLIFQVFEAILLRTASDLSHFHVVG
  TNIVKKLMNNHMKLICESLYASGYRLARACLSLMTAMVTQGPEAARDVCSHFDLNKKTLY
  TLVTKRDSKGVYDVRQAYVQFALSFLIAGDDSTIVQVLEVKEFIPCIFSSGIKEDRISTI
  NILLSTLKTKVVHNKNITKTQKVRFFTGQLLNHIASLYNWNGITDVNPENVKVSAEEAGK
  TMVRELVHNFLMDLCCSLKHGINFYDASLGTFGRGGNLTLLHFLLGLKTAADDDLVADLV
  VNILKVCPDLLNKYFKEVTFSFIPRAKSTWLNNIKLLNKIYEAQPEISRAFQTREFIPLP
  RLLAMVMVTTVPLVCNKSMFTQALNLDSTSVRHTALSLISVILKRALKTVDHCLNKEVWQ
  ESGVYTAVMMEEFVQLFREALSKILPDLNTVVWVWQSLKKQETKQDDKKGQKRSDGPPAA
  CDAHQCDDAETILLKAVLLQVICLYQKVVPHVVMQYNFDFSKLLKGVISEQGLREEVPPI
  LQHHMLKVALELPASKFLWLKAQEGPDAEIIGGERSVFYLLMKMFVTSSHLQLKSLTKLL
  IMKILRDTGVFEHTWKELELWLEHLENTMEEDKETVIQFLERILLTLVANPYSYTDKASD
  FVQEASMLQATMTKQEADDMSIPISHIDDVLDMVDVLVEGSEGLDEEIGFTLSEDMILLT
  FPFSAVVPAALEARNKLLLGTGNEAAENVVTYLTAVLTDLLHTQRDPLALCLLLQAYDKL
  EPPCLVPCCQQLSRFNRYYSLWIPEQAREAWLLQAQGSPSPPALPLASSFTALLQAAYES
  QALRDEHIQVQLQATMPHLSMQQVLLAAKQVLLYLRSTVENFGQLGRSVGPPLLQLFLDL
  LRRLVVHCEQLDAQNQQRCEAARAEADLFLDMESVASLELANDQTLEEVLVAILRHPTLE
  GWFLALEQQALPPHTLSPVLVKLLATHFSAGVLQLLAASAPILQNIGQLGLLARYSEAIT
  QSVLKELQNRRAGPATSPPKTPPQLEALQELHPYMEGAQLREVTLALLSLPETHLVTQQP
  TKSPGKERHLNALGKTLVQLLTCSPQDQLQSGELLWSSEYVRGLGALLPTLAVDELDTVL
  LHTLQRDPVLAPAVGADLLDYCLARRTQAALSIAALLLQESCTHLLWFEQWCLQAGPGLG
  LQGDLDDFLPLIHVYLQCRTRSHFTRPAGVSSAVIPVLRKTLWRQLQSRLLSTDSPPASG
  LYQEILAQLVPFARAKDLSVLMDRLPSLLHTPSSHKRWIVADSISAALEGSAEELCAWRR
  TLLESCVKWLIVSFSGGQQDDDNTQNQEKEMLLRLNALLHALNEVDPGDWQKFVKKGLKF
  RYQDHTFLKMLLTAVQLLYSPESSVRTKLIQLPVVYVMLMQHSLFLPTLLTSDGEESPDS
  QVKEALVDLMLTVVEMCPSVCESSHFAVLLGAYGATLSVLDQKILLLLRAYEQNKLSLIN
  FRVLLWGPAAVEHHKTCRSLGRSLWQQPSVGDILRLLDRDRMMQTILHFPQNRRLLPPED
  TQELIFKDKSRVDLDGLYDPCFLLQLFSELTRPEFVVDCRKFLDSNALGLTVTALSSYDP
  QMRAIAYHVLAAYYSHLEGARFQEQSQLLYLLDVVRNGIRTQDMRLTFTLALFIAKAALQ
  ILKPEEHMYLKVSNFLLSHEYLNMDKVPGFYQFFYSSDFEQKTEQKWVFGVLRQGIRDKQ
  CYELCARRGIFHIILSFFHSPLCDEAAQNWILEILQNAAQVARSAYEIIRDYSLLTWILH
  ILESKFLETPLLSNVISLLHTLWVTNLGDKAVEWESQRLCQPSSQEPAKRLALHLVNEFL
  YVLIVLMKHLRPTLAPVQLTNFFGTLDSVLRYRATVIQAFRDMNRFTVNETVLSTKDVLV
  LLHKWSLIERDLKLQEDLRAAIEKAQARELMKMLKDKNKPVMPARAKGPRGRKRRPGEAE
  EMADPELMASTLETCKGLLRSILTYWRPVIPGPDPTQEPVDSASPESDAPGPVYAAASLA
  VSWVLRSVAEHPLSRAEAAGLIGWLKSHILPHPVVVADLLKDSAVRSSIFRLYSRLCGAE
  GLAGPVQEVACLFNTVMLQLVAAQGRAGSPFHPAMEALSLSSLSEKDEATQASAAFLVSL
  YIKDIWLGAQRPDTLLTHVRMVCEAADDAPSSEEEAIVVLCKDAASAASDA

• Sequence length: 2271

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL GLUCOCORTICOID DEFICIENCY TYPE 2	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinogenesis	Carcinogenesis	Pubtator	32888357	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32888357	Stimulate	★☆☆☆☆ Found in Text Mining only
Pituitary Neoplasms	Pituitary neoplasm	Pubtator	37154079	Stimulate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33621953	Associate	★☆☆☆☆ Found in Text Mining only