Gene Gene information from NCBI Gene database.
Entrez ID 9867
Gene name Praja ring finger ubiquitin ligase 2
Gene symbol PJA2
Synonyms (NCBI Gene)
Neurodap1RNF131
Chromosome 5
Chromosome location 5q21.3
miRNA miRNA information provided by mirtarbase database.
692
miRTarBase ID miRNA Experiments Reference
MIRT017318 hsa-miR-335-5p Microarray 18185580
MIRT028703 hsa-miR-27a-3p Sequencing 20371350
MIRT041028 hsa-miR-505-3p CLASH 23622248
MIRT439964 hsa-miR-485-3p HITS-CLIP 24374217
MIRT439964 hsa-miR-485-3p HITS-CLIP 24374217
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0004842 Function Ubiquitin-protein transferase activity IDA 21423175
GO:0005515 Function Protein binding IPI 28471450, 33934390
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IDA 21423175, 28471450
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619341 17481 ENSG00000198961
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O43164
Protein name E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)
Protein function Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal de
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13639 zf-RING_2 632 675 Ring finger domain Domain
Sequence
MSQYTEKEPAAMDQESGKAVWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAG
DDYEVLELDDVPKENSSGSSPLDQVDSSLPSEPIFEKSETEIPTCGSALNQTTESSQSFV
AVHHSEEGRDTLGSSTNLHNHSEGEYIPGACSASSVQNGIALVHTDSYDPDGKHGEDNDH
LQLSAEVVEGSRYQESLGNTVFELENREAEAYTGLSPPVPSFNCEVRDEFEELDSVPLVK
SSAGDTEFVHQNSQEIQRSSQDEMVSTKQQNNTSQERQTEHSPEDAACGPGHICSEQNTN
DREKNHGSSPEQVVRPKVRKLISSSQVDQETGFNRHEAKQRSVQRWREALEVEESGSDDL
LIKCEEYDGEHDCMFLDPPYSRVITQRETENNQMTSESGATAGRQEVDNTFWNGCGDYYQ
LYDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEE
ENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPAFMLDGNNNLEDDS
SVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVD
VEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPC
VSIWLQKSGTCPVCR
RHFPPAVIEASAAPSSEPDPDAPPSNDSIAEAP
Sequence length 708
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DUPUYTREN CONTRACTURE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FRONTOTEMPORAL DEMENTIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NASAL DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PSORIASIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 22948757
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 31254375 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 30651076
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30651076 Associate
★☆☆☆☆
Found in Text Mining only
Differentiated Thyroid Gland Carcinoma Thyroid Carcinoma BEFREE 22948757
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 33885249 Associate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of thyroid Thyroid cancer BEFREE 22948757
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 22948757
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 22948757, 30651076
★☆☆☆☆
Found in Text Mining only
Non-Small Cell Lung Carcinoma Lung carcinoma BEFREE 23931849
★☆☆☆☆
Found in Text Mining only