MFAP3L (microfibril associated protein 3 like)

Gene

• Entrez ID: 9848
• Gene name: Microfibril associated protein 3 like
• Gene symbol: MFAP3L
• Synonyms (NCBI Gene): NYD-sp9
• Chromosome: 4
• Chromosome location: 4q33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT535968	hsa-miR-3133	PAR-CLIP	22012620
MIRT535967	hsa-miR-4528	PAR-CLIP	22012620
MIRT535966	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT535965	hsa-miR-6846-3p	PAR-CLIP	22012620
MIRT535968	hsa-miR-3133	PAR-CLIP	22012620
MIRT535967	hsa-miR-4528	PAR-CLIP	22012620
MIRT535966	hsa-miR-6859-3p	PAR-CLIP	22012620
MIRT535965	hsa-miR-6846-3p	PAR-CLIP	22012620
MIRT1145873	hsa-let-7a	CLIP-seq
MIRT1145874	hsa-let-7b	CLIP-seq
MIRT1145875	hsa-let-7c	CLIP-seq
MIRT1145876	hsa-let-7d	CLIP-seq
MIRT1145877	hsa-let-7e	CLIP-seq
MIRT1145878	hsa-let-7f	CLIP-seq
MIRT1145879	hsa-let-7g	CLIP-seq
MIRT1145880	hsa-let-7i	CLIP-seq
MIRT1145881	hsa-miR-106a	CLIP-seq
MIRT1145882	hsa-miR-106b	CLIP-seq
MIRT1145883	hsa-miR-128	CLIP-seq
MIRT1145884	hsa-miR-1306	CLIP-seq
MIRT1145885	hsa-miR-1324	CLIP-seq
MIRT1145886	hsa-miR-134	CLIP-seq
MIRT1145887	hsa-miR-140-3p	CLIP-seq
MIRT1145888	hsa-miR-17	CLIP-seq
MIRT1145889	hsa-miR-202	CLIP-seq
MIRT1145890	hsa-miR-20a	CLIP-seq
MIRT1145891	hsa-miR-20b	CLIP-seq
MIRT1145892	hsa-miR-302a	CLIP-seq
MIRT1145893	hsa-miR-302b	CLIP-seq
MIRT1145894	hsa-miR-302c	CLIP-seq
MIRT1145895	hsa-miR-302d	CLIP-seq
MIRT1145896	hsa-miR-302e	CLIP-seq
MIRT1145897	hsa-miR-30a	CLIP-seq
MIRT1145898	hsa-miR-30b	CLIP-seq
MIRT1145899	hsa-miR-30c	CLIP-seq
MIRT1145900	hsa-miR-30d	CLIP-seq
MIRT1145901	hsa-miR-30e	CLIP-seq
MIRT1145902	hsa-miR-3118	CLIP-seq
MIRT1145903	hsa-miR-3607-5p	CLIP-seq
MIRT1145904	hsa-miR-3609	CLIP-seq
MIRT1145905	hsa-miR-3665	CLIP-seq
MIRT1145906	hsa-miR-372	CLIP-seq
MIRT1145907	hsa-miR-373	CLIP-seq
MIRT1145908	hsa-miR-3921	CLIP-seq
MIRT1145909	hsa-miR-3934	CLIP-seq
MIRT1145910	hsa-miR-3978	CLIP-seq
MIRT1145911	hsa-miR-4252	CLIP-seq
MIRT1145912	hsa-miR-4261	CLIP-seq
MIRT1145913	hsa-miR-4264	CLIP-seq
MIRT1145914	hsa-miR-4279	CLIP-seq
MIRT1145915	hsa-miR-4328	CLIP-seq
MIRT1145916	hsa-miR-4458	CLIP-seq
MIRT1145917	hsa-miR-4497	CLIP-seq
MIRT1145918	hsa-miR-4500	CLIP-seq
MIRT1145919	hsa-miR-4649-3p	CLIP-seq
MIRT1145920	hsa-miR-4653-5p	CLIP-seq
MIRT1145921	hsa-miR-4659a-3p	CLIP-seq
MIRT1145922	hsa-miR-4659b-3p	CLIP-seq
MIRT1145923	hsa-miR-4705	CLIP-seq
MIRT1145924	hsa-miR-4796-3p	CLIP-seq
MIRT1145925	hsa-miR-4797-3p	CLIP-seq
MIRT1145926	hsa-miR-4803	CLIP-seq
MIRT1145927	hsa-miR-494	CLIP-seq
MIRT1145928	hsa-miR-495	CLIP-seq
MIRT1145929	hsa-miR-519d	CLIP-seq
MIRT1145930	hsa-miR-520a-3p	CLIP-seq
MIRT1145931	hsa-miR-520b	CLIP-seq
MIRT1145932	hsa-miR-520c-3p	CLIP-seq
MIRT1145933	hsa-miR-520d-3p	CLIP-seq
MIRT1145934	hsa-miR-520e	CLIP-seq
MIRT1145935	hsa-miR-548ah	CLIP-seq
MIRT1145936	hsa-miR-548b-3p	CLIP-seq
MIRT1145937	hsa-miR-561	CLIP-seq
MIRT1145938	hsa-miR-593	CLIP-seq
MIRT1145939	hsa-miR-646	CLIP-seq
MIRT1145940	hsa-miR-93	CLIP-seq
MIRT1145941	hsa-miR-98	CLIP-seq
MIRT1145873	hsa-let-7a	CLIP-seq
MIRT1145874	hsa-let-7b	CLIP-seq
MIRT1145875	hsa-let-7c	CLIP-seq
MIRT1145876	hsa-let-7d	CLIP-seq
MIRT1145877	hsa-let-7e	CLIP-seq
MIRT1145878	hsa-let-7f	CLIP-seq
MIRT1145879	hsa-let-7g	CLIP-seq
MIRT1145880	hsa-let-7i	CLIP-seq
MIRT1145942	hsa-miR-1224-5p	CLIP-seq
MIRT1145943	hsa-miR-1253	CLIP-seq
MIRT1145944	hsa-miR-1257	CLIP-seq
MIRT1145945	hsa-miR-1265	CLIP-seq
MIRT1145946	hsa-miR-186	CLIP-seq
MIRT1145947	hsa-miR-1913	CLIP-seq
MIRT1145948	hsa-miR-198	CLIP-seq
MIRT1145889	hsa-miR-202	CLIP-seq
MIRT1145949	hsa-miR-21	CLIP-seq
MIRT1145950	hsa-miR-23a	CLIP-seq
MIRT1145951	hsa-miR-23b	CLIP-seq
MIRT1145952	hsa-miR-23c	CLIP-seq
MIRT1145953	hsa-miR-302f	CLIP-seq
MIRT1145954	hsa-miR-3074-3p	CLIP-seq
MIRT1145955	hsa-miR-3124-3p	CLIP-seq
MIRT1145956	hsa-miR-3146	CLIP-seq
MIRT1145957	hsa-miR-3157-3p	CLIP-seq
MIRT1145958	hsa-miR-3160-5p	CLIP-seq
MIRT1145959	hsa-miR-3180-5p	CLIP-seq
MIRT1145960	hsa-miR-324-3p	CLIP-seq
MIRT1145961	hsa-miR-342-3p	CLIP-seq
MIRT1145962	hsa-miR-34c-3p	CLIP-seq
MIRT1145963	hsa-miR-3611	CLIP-seq
MIRT1145964	hsa-miR-3613-3p	CLIP-seq
MIRT1145965	hsa-miR-3647-3p	CLIP-seq
MIRT1145966	hsa-miR-3678-3p	CLIP-seq
MIRT1145967	hsa-miR-3688-5p	CLIP-seq
MIRT1145968	hsa-miR-380	CLIP-seq
MIRT1145908	hsa-miR-3921	CLIP-seq
MIRT1145969	hsa-miR-3942-3p	CLIP-seq
MIRT1145970	hsa-miR-3942-5p	CLIP-seq
MIRT1145971	hsa-miR-4251	CLIP-seq
MIRT1145912	hsa-miR-4261	CLIP-seq
MIRT1145972	hsa-miR-4272	CLIP-seq
MIRT1145973	hsa-miR-4289	CLIP-seq
MIRT1145974	hsa-miR-4433	CLIP-seq
MIRT1145916	hsa-miR-4458	CLIP-seq
MIRT1145918	hsa-miR-4500	CLIP-seq
MIRT1145919	hsa-miR-4649-3p	CLIP-seq
MIRT1145920	hsa-miR-4653-5p	CLIP-seq
MIRT1145975	hsa-miR-4703-5p	CLIP-seq
MIRT1145976	hsa-miR-4717-3p	CLIP-seq
MIRT1145977	hsa-miR-4738-3p	CLIP-seq
MIRT1145978	hsa-miR-4751	CLIP-seq
MIRT1145979	hsa-miR-4759	CLIP-seq
MIRT1145980	hsa-miR-4760-3p	CLIP-seq
MIRT1145981	hsa-miR-4777-5p	CLIP-seq
MIRT1145982	hsa-miR-4795-3p	CLIP-seq
MIRT1145924	hsa-miR-4796-3p	CLIP-seq
MIRT1145926	hsa-miR-4803	CLIP-seq
MIRT1145927	hsa-miR-494	CLIP-seq
MIRT1145983	hsa-miR-498	CLIP-seq
MIRT1145984	hsa-miR-518d-5p	CLIP-seq
MIRT1145985	hsa-miR-519b-5p	CLIP-seq
MIRT1145986	hsa-miR-519c-5p	CLIP-seq
MIRT1145987	hsa-miR-520c-5p	CLIP-seq
MIRT1145988	hsa-miR-526a	CLIP-seq
MIRT1145989	hsa-miR-548a-3p	CLIP-seq
MIRT1145990	hsa-miR-548ac	CLIP-seq
MIRT1145991	hsa-miR-548d-3p	CLIP-seq
MIRT1145992	hsa-miR-548e	CLIP-seq
MIRT1145993	hsa-miR-548f	CLIP-seq
MIRT1145994	hsa-miR-548p	CLIP-seq
MIRT1145995	hsa-miR-548t	CLIP-seq
MIRT1145996	hsa-miR-548z	CLIP-seq
MIRT1145997	hsa-miR-554	CLIP-seq
MIRT1145998	hsa-miR-576-3p	CLIP-seq
MIRT1145999	hsa-miR-578	CLIP-seq
MIRT1146000	hsa-miR-587	CLIP-seq
MIRT1146001	hsa-miR-590-5p	CLIP-seq
MIRT1145938	hsa-miR-593	CLIP-seq
MIRT1146002	hsa-miR-606	CLIP-seq
MIRT1146003	hsa-miR-616	CLIP-seq
MIRT1146004	hsa-miR-659	CLIP-seq
MIRT1146005	hsa-miR-662	CLIP-seq
MIRT1146006	hsa-miR-671-5p	CLIP-seq
MIRT1146007	hsa-miR-874	CLIP-seq
MIRT1146008	hsa-miR-9	CLIP-seq
MIRT1145941	hsa-miR-98	CLIP-seq
MIRT1145937	hsa-miR-561	CLIP-seq
MIRT1145881	hsa-miR-106a	CLIP-seq
MIRT1145882	hsa-miR-106b	CLIP-seq
MIRT2041487	hsa-miR-1207-3p	CLIP-seq
MIRT2041488	hsa-miR-1251	CLIP-seq
MIRT1145943	hsa-miR-1253	CLIP-seq
MIRT2041489	hsa-miR-1255a	CLIP-seq
MIRT2041490	hsa-miR-1255b	CLIP-seq
MIRT2041491	hsa-miR-1297	CLIP-seq
MIRT1145888	hsa-miR-17	CLIP-seq
MIRT2041492	hsa-miR-181a	CLIP-seq
MIRT2041493	hsa-miR-181b	CLIP-seq
MIRT2041494	hsa-miR-181c	CLIP-seq
MIRT2041495	hsa-miR-181d	CLIP-seq
MIRT2041496	hsa-miR-1976	CLIP-seq
MIRT1145890	hsa-miR-20a	CLIP-seq
MIRT1145891	hsa-miR-20b	CLIP-seq
MIRT1145949	hsa-miR-21	CLIP-seq
MIRT1145950	hsa-miR-23a	CLIP-seq
MIRT1145951	hsa-miR-23b	CLIP-seq
MIRT1145952	hsa-miR-23c	CLIP-seq
MIRT2041497	hsa-miR-26a	CLIP-seq
MIRT2041498	hsa-miR-26b	CLIP-seq
MIRT2041499	hsa-miR-3125	CLIP-seq
MIRT2041500	hsa-miR-3134	CLIP-seq
MIRT1145958	hsa-miR-3160-5p	CLIP-seq
MIRT2041501	hsa-miR-3202	CLIP-seq
MIRT2041502	hsa-miR-338-3p	CLIP-seq
MIRT1145962	hsa-miR-34c-3p	CLIP-seq
MIRT1145964	hsa-miR-3613-3p	CLIP-seq
MIRT2041503	hsa-miR-3916	CLIP-seq
MIRT1145971	hsa-miR-4251	CLIP-seq
MIRT2041504	hsa-miR-4262	CLIP-seq
MIRT1145972	hsa-miR-4272	CLIP-seq
MIRT2041505	hsa-miR-4465	CLIP-seq
MIRT2041506	hsa-miR-4476	CLIP-seq
MIRT2041507	hsa-miR-4530	CLIP-seq
MIRT2041508	hsa-miR-4642	CLIP-seq
MIRT1145921	hsa-miR-4659a-3p	CLIP-seq
MIRT1145922	hsa-miR-4659b-3p	CLIP-seq
MIRT2041509	hsa-miR-4663	CLIP-seq
MIRT2041510	hsa-miR-4684-5p	CLIP-seq
MIRT2041511	hsa-miR-4694-5p	CLIP-seq
MIRT1145977	hsa-miR-4738-3p	CLIP-seq
MIRT1145982	hsa-miR-4795-3p	CLIP-seq
MIRT1145924	hsa-miR-4796-3p	CLIP-seq
MIRT1145929	hsa-miR-519d	CLIP-seq
MIRT2041512	hsa-miR-526b	CLIP-seq
MIRT1145989	hsa-miR-548a-3p	CLIP-seq
MIRT1145992	hsa-miR-548e	CLIP-seq
MIRT1145993	hsa-miR-548f	CLIP-seq
MIRT2041513	hsa-miR-548n	CLIP-seq
MIRT1145999	hsa-miR-578	CLIP-seq
MIRT2041514	hsa-miR-582-5p	CLIP-seq
MIRT1146001	hsa-miR-590-5p	CLIP-seq
MIRT1145939	hsa-miR-646	CLIP-seq
MIRT1145940	hsa-miR-93	CLIP-seq
MIRT1145881	hsa-miR-106a	CLIP-seq
MIRT1145882	hsa-miR-106b	CLIP-seq
MIRT2041489	hsa-miR-1255a	CLIP-seq
MIRT2041490	hsa-miR-1255b	CLIP-seq
MIRT1145888	hsa-miR-17	CLIP-seq
MIRT1145890	hsa-miR-20a	CLIP-seq
MIRT1145891	hsa-miR-20b	CLIP-seq
MIRT1145924	hsa-miR-4796-3p	CLIP-seq
MIRT1145929	hsa-miR-519d	CLIP-seq
MIRT1145940	hsa-miR-93	CLIP-seq
MIRT1145911	hsa-miR-4252	CLIP-seq
MIRT2271144	hsa-miR-4321	CLIP-seq
MIRT2271145	hsa-miR-548aa	CLIP-seq
MIRT1146004	hsa-miR-659	CLIP-seq
MIRT1145911	hsa-miR-4252	CLIP-seq
MIRT2454045	hsa-miR-1299	CLIP-seq
MIRT1145965	hsa-miR-3647-3p	CLIP-seq
MIRT2454046	hsa-miR-378	CLIP-seq
MIRT2454047	hsa-miR-378b	CLIP-seq
MIRT2454048	hsa-miR-378c	CLIP-seq
MIRT2454049	hsa-miR-378d	CLIP-seq
MIRT2454050	hsa-miR-378e	CLIP-seq
MIRT2454051	hsa-miR-378f	CLIP-seq
MIRT2454052	hsa-miR-378h	CLIP-seq
MIRT2454053	hsa-miR-378i	CLIP-seq
MIRT2454054	hsa-miR-422a	CLIP-seq
MIRT2454055	hsa-miR-4501	CLIP-seq
MIRT2454056	hsa-miR-4638-3p	CLIP-seq
MIRT2454057	hsa-miR-4666-3p	CLIP-seq
MIRT2454058	hsa-miR-4782-5p	CLIP-seq
MIRT2454059	hsa-miR-516b	CLIP-seq
MIRT2570180	hsa-miR-105	CLIP-seq
MIRT1145963	hsa-miR-3611	CLIP-seq
MIRT1145912	hsa-miR-4261	CLIP-seq
MIRT1145924	hsa-miR-4796-3p	CLIP-seq
MIRT1145926	hsa-miR-4803	CLIP-seq
MIRT1145927	hsa-miR-494	CLIP-seq
MIRT1145995	hsa-miR-548t	CLIP-seq
MIRT2684895	hsa-miR-1252	CLIP-seq
MIRT2684896	hsa-miR-1290	CLIP-seq
MIRT2684897	hsa-miR-3662	CLIP-seq
MIRT2684898	hsa-miR-4699-3p	CLIP-seq
MIRT2684899	hsa-miR-4724-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24735981
GO:0005634	Component	Nucleus	IDA	24735981
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	24735981
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA	24735981
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030054	Component	Cell junction	IDA
GO:0043005	Component	Neuron projection	IBA

Other IDs

• MIM: 616523
• HGNC: 29083
• e!Ensembl: ENSG00000198948

Protein

• UniProt ID: O75121
• Protein name: Microfibrillar-associated protein 3-like (Testis development protein NYD-SP9)
• Protein function: May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	47 → 142	Immunoglobulin I-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in testis. {ECO:0000269|Ref.1}.
• Sequence:

  MDRLKSHLTVCFLPSVPFLILVSTLATAKSVTNSTLNGTNVVLGSVPVIIARTDHIIVKE
  GNSALINCSVYGIPDPQFKWYNSIGKLLKEEEDEKERGGGKWQMHDSGLLNITKVSFSDR
  GKYTCVASNIYGTVNNTVTLRVIFTSGDMGVYYMVVCLVAFTIVMVLNITRLCMMSSHLK
  KTEKAINEFFRTEGAEKLQKAFEIAKRIPIITSAKTLELAKVTQFKTMEFARYIEELARS
  VPLPPLIMNCRTIMEEIMEVVGLEEQGQNFVRHTPEGQEAADRDEVYTIPNSLKRSDSPA
  ADSDASSLHEQPQQIAIKVSVHPQSKKEHADDQEGGQFEVKDVEETELSAEHSPETAEPS
  TDVTSTELTSEEPTPVEVPDKVLPPAYLEATEPAVTHDKNTCIIYESHV

• Sequence length: 409

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anxiety Disorders	Anxiety Disorder	GWASCAT_DG	25390645		★☆☆☆☆ Found in Text Mining only
Anxiety Disorders	Anxiety disorder	Pubtator	25390645	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	24735981		★☆☆☆☆ Found in Text Mining only