Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9832
Gene name	Janus kinase and microtubule interacting protein 2
Gene symbol	JAKMIP2
Synonyms (NCBI Gene)	JAMIP2NECC1
Chromosome	5
Chromosome location	5q32
Summary	The protein encoded by this gene is reported to be a component of the Golgi matrix. It may act as a golgin protein by negatively regulating transit of secretory cargo and by acting as a structural scaffold of the Golgi. Alternative splicing results in mul

Show/Hide all (78)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018139	hsa-miR-335-5p	Microarray	18185580
MIRT027136	hsa-miR-103a-3p	Sequencing	20371350
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608786	hsa-miR-8068	HITS-CLIP	21572407
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608784	hsa-miR-147a	HITS-CLIP	21572407
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608782	hsa-miR-4455	HITS-CLIP	21572407
MIRT608781	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608786	hsa-miR-8068	HITS-CLIP	24906430
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608784	hsa-miR-147a	HITS-CLIP	24906430
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608782	hsa-miR-4455	HITS-CLIP	24906430
MIRT608781	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT526307	hsa-miR-4307	PAR-CLIP	22012620
MIRT526306	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT526305	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608784	hsa-miR-147a	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608782	hsa-miR-4455	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608781	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608786	hsa-miR-8068	HITS-CLIP	27418678
MIRT608787	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT608786	hsa-miR-8068	HITS-CLIP	21572407
MIRT608785	hsa-miR-6818-5p	HITS-CLIP	21572407
MIRT608784	hsa-miR-147a	HITS-CLIP	21572407
MIRT608783	hsa-miR-5010-3p	HITS-CLIP	21572407
MIRT608782	hsa-miR-4455	HITS-CLIP	21572407
MIRT608781	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT526307	hsa-miR-4307	PAR-CLIP	22012620
MIRT526306	hsa-miR-302b-5p	PAR-CLIP	22012620
MIRT526305	hsa-miR-302d-5p	PAR-CLIP	22012620
MIRT1076255	hsa-miR-1297	CLIP-seq
MIRT1076256	hsa-miR-26a	CLIP-seq
MIRT1076257	hsa-miR-26b	CLIP-seq
MIRT1076258	hsa-miR-3941	CLIP-seq
MIRT1076259	hsa-miR-4465	CLIP-seq
MIRT1076260	hsa-miR-4539	CLIP-seq
MIRT1076261	hsa-miR-466	CLIP-seq
MIRT1076262	hsa-miR-4672	CLIP-seq
MIRT1076263	hsa-miR-4731-3p	CLIP-seq
MIRT1076264	hsa-miR-4801	CLIP-seq
MIRT1076265	hsa-miR-628-5p	CLIP-seq
MIRT2250802	hsa-miR-1305	CLIP-seq
MIRT2250803	hsa-miR-421	CLIP-seq
MIRT2250804	hsa-miR-4709-5p	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 27107012, 31515488, 32296183
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0019900	Function	Kinase binding	IEA

MIM	HGNC	e!Ensembl
611197	29067	ENSG00000176049

Q96AA8

Protein name

Janus kinase and microtubule-interacting protein 2 (CTCL tumor antigen HD-CL-04) (Neuroendocrine long coiled-coil protein 1)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16034	JAKMIP_CC3	409 → 602	JAKMIP CC3 domain	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in brain, moderately expressed in thymus, spleen and lung, and weakly expressed in kidney, liver and peripheral blood lymphocytes. Also expressed in adrenal and pituitary glands, as well as testis. {ECO:0000269|PubMed:

Sequence

MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE
LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA
LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK
AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ
KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED
RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE
MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR
RSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ
LTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDS
HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP
FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL
SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE
ATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQA
HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG

Sequence length

810

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Choriocarcinoma	Choriocarcinoma	BEFREE	12573257, 14614883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Complete hydatidiform mole	Complete Hydatidiform Mole	BEFREE	14614883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	30796769		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves disease	Pubtator	30796769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	22842228		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	18234960		★★★★★ ★☆☆☆☆ Found in Text Mining only

JAKMIP2 (janus kinase and microtubule interacting protein 2)