TRIM14 (tripartite motif containing 14)

Gene

• Entrez ID: 9830
• Gene name: Tripartite motif containing 14
• Gene symbol: TRIM14
• Synonyms (NCBI Gene): -
• Chromosome: 9
• Chromosome location: 9q22.33
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and it

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025840	hsa-miR-7-5p	Microarray	19073608
MIRT044852	hsa-miR-320a	CLASH	23622248
MIRT646923	hsa-miR-21-3p	HITS-CLIP	23824327
MIRT646922	hsa-miR-3591-3p	HITS-CLIP	23824327
MIRT646921	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT646920	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT646919	hsa-miR-4261	HITS-CLIP	23824327
MIRT646918	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646917	hsa-miR-3153	HITS-CLIP	23824327
MIRT646916	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT646915	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT646914	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT646913	hsa-miR-4425	HITS-CLIP	23824327
MIRT646912	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT646911	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT736994	hsa-miR-325	Luciferase reporter assay, Western blotting, qRT-PCR	34054957
MIRT646923	hsa-miR-21-3p	HITS-CLIP	23824327
MIRT646922	hsa-miR-3591-3p	HITS-CLIP	23824327
MIRT646921	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT646920	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT646919	hsa-miR-4261	HITS-CLIP	23824327
MIRT646918	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT646917	hsa-miR-3153	HITS-CLIP	23824327
MIRT646916	hsa-miR-6733-5p	HITS-CLIP	23824327
MIRT646915	hsa-miR-6739-5p	HITS-CLIP	23824327
MIRT646914	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT646913	hsa-miR-4425	HITS-CLIP	23824327
MIRT646912	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT646911	hsa-miR-659-3p	HITS-CLIP	23824327
MIRT1453007	hsa-miR-1183	CLIP-seq
MIRT1453008	hsa-miR-1207-5p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT1453010	hsa-miR-1224-5p	CLIP-seq
MIRT1453011	hsa-miR-124	CLIP-seq
MIRT1453012	hsa-miR-1243	CLIP-seq
MIRT1453013	hsa-miR-1245b-3p	CLIP-seq
MIRT1453014	hsa-miR-1252	CLIP-seq
MIRT1453015	hsa-miR-1253	CLIP-seq
MIRT1453016	hsa-miR-1254	CLIP-seq
MIRT1453017	hsa-miR-1262	CLIP-seq
MIRT1453018	hsa-miR-1297	CLIP-seq
MIRT1453019	hsa-miR-1299	CLIP-seq
MIRT1453020	hsa-miR-1301	CLIP-seq
MIRT1453021	hsa-miR-142-3p	CLIP-seq
MIRT1453022	hsa-miR-148a	CLIP-seq
MIRT1453023	hsa-miR-148b	CLIP-seq
MIRT1453024	hsa-miR-152	CLIP-seq
MIRT1453025	hsa-miR-15a	CLIP-seq
MIRT1453026	hsa-miR-15b	CLIP-seq
MIRT1453027	hsa-miR-16	CLIP-seq
MIRT1453028	hsa-miR-190	CLIP-seq
MIRT1453029	hsa-miR-190b	CLIP-seq
MIRT1453030	hsa-miR-195	CLIP-seq
MIRT1453031	hsa-miR-216a	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT1453033	hsa-miR-2682	CLIP-seq
MIRT1453034	hsa-miR-26a	CLIP-seq
MIRT1453035	hsa-miR-26b	CLIP-seq
MIRT1453036	hsa-miR-2861	CLIP-seq
MIRT1453037	hsa-miR-2909	CLIP-seq
MIRT1453038	hsa-miR-3116	CLIP-seq
MIRT1453039	hsa-miR-3117-3p	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT1453041	hsa-miR-3138	CLIP-seq
MIRT1453042	hsa-miR-3149	CLIP-seq
MIRT1453043	hsa-miR-3169	CLIP-seq
MIRT1453044	hsa-miR-3182	CLIP-seq
MIRT1453045	hsa-miR-3185	CLIP-seq
MIRT1453046	hsa-miR-3186-5p	CLIP-seq
MIRT1453047	hsa-miR-3190	CLIP-seq
MIRT1453048	hsa-miR-3192	CLIP-seq
MIRT1453049	hsa-miR-320b	CLIP-seq
MIRT1453050	hsa-miR-320c	CLIP-seq
MIRT1453051	hsa-miR-320d	CLIP-seq
MIRT1453052	hsa-miR-320e	CLIP-seq
MIRT1453053	hsa-miR-330-3p	CLIP-seq
MIRT1453054	hsa-miR-335	CLIP-seq
MIRT1453055	hsa-miR-340	CLIP-seq
MIRT1453056	hsa-miR-342-5p	CLIP-seq
MIRT1453057	hsa-miR-3529	CLIP-seq
MIRT1453058	hsa-miR-3616-3p	CLIP-seq
MIRT1453059	hsa-miR-3622a-3p	CLIP-seq
MIRT1453060	hsa-miR-3622b-3p	CLIP-seq
MIRT1453061	hsa-miR-3649	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT1453063	hsa-miR-3653	CLIP-seq
MIRT1453064	hsa-miR-370	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453066	hsa-miR-377	CLIP-seq
MIRT1453067	hsa-miR-379	CLIP-seq
MIRT1453068	hsa-miR-3910	CLIP-seq
MIRT1453069	hsa-miR-3927	CLIP-seq
MIRT1453070	hsa-miR-424	CLIP-seq
MIRT1453071	hsa-miR-4270	CLIP-seq
MIRT1453072	hsa-miR-4300	CLIP-seq
MIRT1453073	hsa-miR-4311	CLIP-seq
MIRT1453074	hsa-miR-4327	CLIP-seq
MIRT1453075	hsa-miR-4419a	CLIP-seq
MIRT1453076	hsa-miR-4422	CLIP-seq
MIRT1453077	hsa-miR-4429	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT1453079	hsa-miR-4436b-3p	CLIP-seq
MIRT1453080	hsa-miR-4438	CLIP-seq
MIRT1453081	hsa-miR-4441	CLIP-seq
MIRT1453082	hsa-miR-4446-3p	CLIP-seq
MIRT1453083	hsa-miR-4465	CLIP-seq
MIRT1453084	hsa-miR-4466	CLIP-seq
MIRT1453085	hsa-miR-4475	CLIP-seq
MIRT1453086	hsa-miR-4476	CLIP-seq
MIRT1453087	hsa-miR-4477b	CLIP-seq
MIRT1453088	hsa-miR-4491	CLIP-seq
MIRT1453089	hsa-miR-4492	CLIP-seq
MIRT1453090	hsa-miR-4498	CLIP-seq
MIRT1453091	hsa-miR-449c	CLIP-seq
MIRT1453092	hsa-miR-4502	CLIP-seq
MIRT1453093	hsa-miR-4505	CLIP-seq
MIRT1453094	hsa-miR-4510	CLIP-seq
MIRT1453095	hsa-miR-4515	CLIP-seq
MIRT1453096	hsa-miR-4528	CLIP-seq
MIRT1453097	hsa-miR-455-3p	CLIP-seq
MIRT1453098	hsa-miR-4639-3p	CLIP-seq
MIRT1453099	hsa-miR-4639-5p	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT1453101	hsa-miR-4651	CLIP-seq
MIRT1453102	hsa-miR-4652-3p	CLIP-seq
MIRT1453103	hsa-miR-4657	CLIP-seq
MIRT1453104	hsa-miR-4660	CLIP-seq
MIRT1453105	hsa-miR-4664-5p	CLIP-seq
MIRT1453106	hsa-miR-4679	CLIP-seq
MIRT1453107	hsa-miR-4699-5p	CLIP-seq
MIRT1453108	hsa-miR-4701-3p	CLIP-seq
MIRT1453109	hsa-miR-4707-3p	CLIP-seq
MIRT1453110	hsa-miR-4710	CLIP-seq
MIRT1453111	hsa-miR-4712-3p	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT1453113	hsa-miR-4731-5p	CLIP-seq
MIRT1453114	hsa-miR-4735-5p	CLIP-seq
MIRT1453115	hsa-miR-4751	CLIP-seq
MIRT1453116	hsa-miR-4759	CLIP-seq
MIRT1453117	hsa-miR-4763-3p	CLIP-seq
MIRT1453118	hsa-miR-4766-3p	CLIP-seq
MIRT1453119	hsa-miR-4766-5p	CLIP-seq
MIRT1453120	hsa-miR-4771	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453122	hsa-miR-4782-5p	CLIP-seq
MIRT1453123	hsa-miR-4800-5p	CLIP-seq
MIRT1453124	hsa-miR-486-3p	CLIP-seq
MIRT1453125	hsa-miR-497	CLIP-seq
MIRT1453126	hsa-miR-499a-5p	CLIP-seq
MIRT1453127	hsa-miR-501-3p	CLIP-seq
MIRT1453128	hsa-miR-502-3p	CLIP-seq
MIRT1453129	hsa-miR-5047	CLIP-seq
MIRT1453130	hsa-miR-506	CLIP-seq
MIRT1453131	hsa-miR-509-3p	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT1453133	hsa-miR-510	CLIP-seq
MIRT1453134	hsa-miR-512-5p	CLIP-seq
MIRT1453135	hsa-miR-516b	CLIP-seq
MIRT1453136	hsa-miR-541	CLIP-seq
MIRT1453137	hsa-miR-542-5p	CLIP-seq
MIRT1453138	hsa-miR-548a-5p	CLIP-seq
MIRT1453139	hsa-miR-548ab	CLIP-seq
MIRT1453140	hsa-miR-548ag	CLIP-seq
MIRT1453141	hsa-miR-548ai	CLIP-seq
MIRT1453142	hsa-miR-548ak	CLIP-seq
MIRT1453143	hsa-miR-548b-5p	CLIP-seq
MIRT1453144	hsa-miR-548c-5p	CLIP-seq
MIRT1453145	hsa-miR-548d-5p	CLIP-seq
MIRT1453146	hsa-miR-548h	CLIP-seq
MIRT1453147	hsa-miR-548i	CLIP-seq
MIRT1453148	hsa-miR-548j	CLIP-seq
MIRT1453149	hsa-miR-548k	CLIP-seq
MIRT1453150	hsa-miR-548l	CLIP-seq
MIRT1453151	hsa-miR-548m	CLIP-seq
MIRT1453152	hsa-miR-548w	CLIP-seq
MIRT1453153	hsa-miR-548y	CLIP-seq
MIRT1453154	hsa-miR-559	CLIP-seq
MIRT1453155	hsa-miR-568	CLIP-seq
MIRT1453156	hsa-miR-582-5p	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq
MIRT1453158	hsa-miR-608	CLIP-seq
MIRT1453159	hsa-miR-637	CLIP-seq
MIRT1453160	hsa-miR-642b	CLIP-seq
MIRT1453161	hsa-miR-651	CLIP-seq
MIRT1453162	hsa-miR-654-5p	CLIP-seq
MIRT1453163	hsa-miR-658	CLIP-seq
MIRT1453164	hsa-miR-661	CLIP-seq
MIRT1453165	hsa-miR-675	CLIP-seq
MIRT1453166	hsa-miR-7	CLIP-seq
MIRT1453167	hsa-miR-758	CLIP-seq
MIRT1453168	hsa-miR-762	CLIP-seq
MIRT1453169	hsa-miR-767-5p	CLIP-seq
MIRT1453170	hsa-miR-920	CLIP-seq
MIRT1453171	hsa-miR-922	CLIP-seq
MIRT1453172	hsa-miR-1234	CLIP-seq
MIRT1453173	hsa-miR-150	CLIP-seq
MIRT1453172	hsa-miR-1234	CLIP-seq
MIRT1453173	hsa-miR-150	CLIP-seq
MIRT1453013	hsa-miR-1245b-3p	CLIP-seq
MIRT1453015	hsa-miR-1253	CLIP-seq
MIRT1453016	hsa-miR-1254	CLIP-seq
MIRT2135699	hsa-miR-125a-3p	CLIP-seq
MIRT2135700	hsa-miR-1285	CLIP-seq
MIRT2135701	hsa-miR-185	CLIP-seq
MIRT2135702	hsa-miR-18a	CLIP-seq
MIRT2135703	hsa-miR-18b	CLIP-seq
MIRT1453028	hsa-miR-190	CLIP-seq
MIRT1453029	hsa-miR-190b	CLIP-seq
MIRT2135704	hsa-miR-1914	CLIP-seq
MIRT2135705	hsa-miR-1915	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT2135706	hsa-miR-2681	CLIP-seq
MIRT2135707	hsa-miR-28-5p	CLIP-seq
MIRT1453037	hsa-miR-2909	CLIP-seq
MIRT1453038	hsa-miR-3116	CLIP-seq
MIRT2135708	hsa-miR-3139	CLIP-seq
MIRT2135709	hsa-miR-3152-5p	CLIP-seq
MIRT2135710	hsa-miR-3158-3p	CLIP-seq
MIRT1453043	hsa-miR-3169	CLIP-seq
MIRT2135711	hsa-miR-3171	CLIP-seq
MIRT2135712	hsa-miR-3184	CLIP-seq
MIRT2135713	hsa-miR-3187-5p	CLIP-seq
MIRT2135714	hsa-miR-326	CLIP-seq
MIRT2135715	hsa-miR-330-5p	CLIP-seq
MIRT2135716	hsa-miR-345	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT1453063	hsa-miR-3653	CLIP-seq
MIRT2135717	hsa-miR-3689d	CLIP-seq
MIRT1453064	hsa-miR-370	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453066	hsa-miR-377	CLIP-seq
MIRT2135718	hsa-miR-378g	CLIP-seq
MIRT2135719	hsa-miR-383	CLIP-seq
MIRT2135720	hsa-miR-3911	CLIP-seq
MIRT2135721	hsa-miR-3978	CLIP-seq
MIRT2135722	hsa-miR-423-5p	CLIP-seq
MIRT2135723	hsa-miR-4251	CLIP-seq
MIRT2135724	hsa-miR-4256	CLIP-seq
MIRT2135725	hsa-miR-4305	CLIP-seq
MIRT2135726	hsa-miR-4306	CLIP-seq
MIRT1453074	hsa-miR-4327	CLIP-seq
MIRT2135727	hsa-miR-4330	CLIP-seq
MIRT1453075	hsa-miR-4419a	CLIP-seq
MIRT1453076	hsa-miR-4422	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2135728	hsa-miR-4434	CLIP-seq
MIRT1453080	hsa-miR-4438	CLIP-seq
MIRT1453082	hsa-miR-4446-3p	CLIP-seq
MIRT1453086	hsa-miR-4476	CLIP-seq
MIRT2135729	hsa-miR-4486	CLIP-seq
MIRT2135730	hsa-miR-4496	CLIP-seq
MIRT1453094	hsa-miR-4510	CLIP-seq
MIRT1453095	hsa-miR-4515	CLIP-seq
MIRT2135731	hsa-miR-4516	CLIP-seq
MIRT2135732	hsa-miR-452	CLIP-seq
MIRT2135733	hsa-miR-4536	CLIP-seq
MIRT2135734	hsa-miR-4633-3p	CLIP-seq
MIRT1453098	hsa-miR-4639-3p	CLIP-seq
MIRT1453099	hsa-miR-4639-5p	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT2135735	hsa-miR-4644	CLIP-seq
MIRT2135736	hsa-miR-4676-3p	CLIP-seq
MIRT1453110	hsa-miR-4710	CLIP-seq
MIRT2135737	hsa-miR-4718	CLIP-seq
MIRT2135738	hsa-miR-4726-3p	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT2135739	hsa-miR-4735-3p	CLIP-seq
MIRT2135740	hsa-miR-4753-5p	CLIP-seq
MIRT2135741	hsa-miR-4762-3p	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453127	hsa-miR-501-3p	CLIP-seq
MIRT1453128	hsa-miR-502-3p	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT2135742	hsa-miR-520f	CLIP-seq
MIRT2135743	hsa-miR-544	CLIP-seq
MIRT2135744	hsa-miR-548u	CLIP-seq
MIRT2135745	hsa-miR-552	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq
MIRT2135746	hsa-miR-604	CLIP-seq
MIRT2135747	hsa-miR-605	CLIP-seq
MIRT2135748	hsa-miR-612	CLIP-seq
MIRT2135749	hsa-miR-630	CLIP-seq
MIRT1453164	hsa-miR-661	CLIP-seq
MIRT2135750	hsa-miR-708	CLIP-seq
MIRT2135751	hsa-miR-873	CLIP-seq
MIRT2135752	hsa-miR-885-3p	CLIP-seq
MIRT1453171	hsa-miR-922	CLIP-seq
MIRT1453008	hsa-miR-1207-5p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT1453011	hsa-miR-124	CLIP-seq
MIRT2356886	hsa-miR-1273c	CLIP-seq
MIRT2356887	hsa-miR-1281	CLIP-seq
MIRT2356888	hsa-miR-1343	CLIP-seq
MIRT2135704	hsa-miR-1914	CLIP-seq
MIRT2356889	hsa-miR-196a	CLIP-seq
MIRT2356890	hsa-miR-196b	CLIP-seq
MIRT1453031	hsa-miR-216a	CLIP-seq
MIRT1453032	hsa-miR-2355-5p	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2135709	hsa-miR-3152-5p	CLIP-seq
MIRT2356891	hsa-miR-3189-3p	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2356892	hsa-miR-3683	CLIP-seq
MIRT1453065	hsa-miR-3714	CLIP-seq
MIRT1453068	hsa-miR-3910	CLIP-seq
MIRT1453069	hsa-miR-3927	CLIP-seq
MIRT1453071	hsa-miR-4270	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT1453081	hsa-miR-4441	CLIP-seq
MIRT1453087	hsa-miR-4477b	CLIP-seq
MIRT1453100	hsa-miR-4640-5p	CLIP-seq
MIRT2356893	hsa-miR-4719	CLIP-seq
MIRT1453112	hsa-miR-4726-5p	CLIP-seq
MIRT1453117	hsa-miR-4763-3p	CLIP-seq
MIRT1453119	hsa-miR-4766-5p	CLIP-seq
MIRT1453124	hsa-miR-486-3p	CLIP-seq
MIRT1453126	hsa-miR-499a-5p	CLIP-seq
MIRT1453130	hsa-miR-506	CLIP-seq
MIRT1453132	hsa-miR-5095	CLIP-seq
MIRT2135747	hsa-miR-605	CLIP-seq
MIRT1453160	hsa-miR-642b	CLIP-seq
MIRT2135752	hsa-miR-885-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT2650332	hsa-miR-4772-3p	CLIP-seq
MIRT1453009	hsa-miR-122	CLIP-seq
MIRT2462335	hsa-miR-1307	CLIP-seq
MIRT1453040	hsa-miR-3135b	CLIP-seq
MIRT1453042	hsa-miR-3149	CLIP-seq
MIRT2462336	hsa-miR-3650	CLIP-seq
MIRT1453062	hsa-miR-3652	CLIP-seq
MIRT2462337	hsa-miR-4284	CLIP-seq
MIRT1453078	hsa-miR-4430	CLIP-seq
MIRT2462338	hsa-miR-4638-5p	CLIP-seq
MIRT2694117	hsa-miR-4659a-5p	CLIP-seq
MIRT2694118	hsa-miR-4659b-5p	CLIP-seq
MIRT2462339	hsa-miR-4695-3p	CLIP-seq
MIRT1453114	hsa-miR-4735-5p	CLIP-seq
MIRT2650332	hsa-miR-4772-3p	CLIP-seq
MIRT1453121	hsa-miR-4775	CLIP-seq
MIRT1453157	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	35145029
GO:0005737	Component	Cytoplasm	IDA	11331580
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0006954	Process	Inflammatory response	IDA	21914792
GO:0006954	Process	Inflammatory response	IDA	35145029
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032897	Process	Negative regulation of viral transcription	IDA	18248090
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IDA	18248090
GO:0045087	Process	Innate immune response	IEA
GO:0045335	Component	Phagocytic vesicle	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	35145029
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0071108	Process	Protein K48-linked deubiquitination	IMP	18162577

Other IDs

• MIM: 606556
• HGNC: 16283
• e!Ensembl: ENSG00000106785

Protein

• UniProt ID: Q14142
• Protein name: Tripartite motif-containing protein 14
• Protein function: Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of v
• PDB: 6JBM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00643	zf-B_box	21 → 61	B-box zinc finger	Domain
  PF13765	PRY	269 → 317	SPRY-associated domain	Family
  PF00622	SPRY	321 → 438	SPRY domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Highest expression in liver; undetectable in skeletal muscle.
• Sequence:

  MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGL
  ALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRL
  LLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQA
  YTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLS
  DPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPV
  PVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQ
  SWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRAT
  FQEPLYPALRLWEGAISIPRLP

• Sequence length: 442

Pathways

Reactome:

Interferon gamma signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPONDYLOEPIMETAPHYSEAL DYSPLASIA, GENEVIEVE TYPE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arteriosclerosis	Arteriosclerosis	BEFREE	31070748		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	31070748		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	31070748, 33892646	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	29562956		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	29562956	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33174608, 34787066	Associate	★☆☆☆☆ Found in Text Mining only
Cervical spondylosis	Cervical spondylosis	BEFREE	31322007		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30555277, 31296997		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30728039		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	30728039	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30728039		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	29867201		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33316781	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	34656078	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29485416		★☆☆☆☆ Found in Text Mining only
Macular Degeneration	Macular degeneration	Pubtator	34534445	Associate	★☆☆☆☆ Found in Text Mining only
Malignant Bone Neoplasm	Malignant Bone Neoplasm	BEFREE	28631557		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29562956		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	30272351		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28350138, 30272351, 31668806		★☆☆☆☆ Found in Text Mining only
Malignant Squamous Cell Neoplasm	Neoplasm	BEFREE	28350138		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33982666	Stimulate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28059079, 29204446, 29485416		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28059079		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	28205534, 28631557, 29467844		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	33174608	Associate	★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	31668806		★☆☆☆☆ Found in Text Mining only
Spondyloepimetaphyseal dysplasia, Genevieve type	Spondyloepimetaphyseal dysplasia	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Spondylosis	Spondylosis	Pubtator	31322007	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	28350138		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	29204446	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	26799420, 28350138		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	30272351		★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	33174608	Associate	★☆☆☆☆ Found in Text Mining only
Vascular Diseases	Vascular disease	Pubtator	31070748	Associate	★☆☆☆☆ Found in Text Mining only