ARHGEF17 (Rho guanine nucleotide exchange factor 17)

Gene

• Entrez ID: 9828
• Gene name: Rho guanine nucleotide exchange factor 17
• Gene symbol: ARHGEF17
• Synonyms (NCBI Gene): P164RHOGEF, RHOGEF17, TEM4, p164-RhoGEF
• Chromosome: 11
• Chromosome location: 11q13.4

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT539134	hsa-miR-6834-3p	PAR-CLIP	22012620
MIRT539133	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT539132	hsa-miR-5685	PAR-CLIP	22012620
MIRT539131	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	22012620
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	22012620
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	22012620
MIRT539126	hsa-miR-4320	PAR-CLIP	22012620
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	22012620
MIRT539124	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	27292025
MIRT539126	hsa-miR-4320	PAR-CLIP	27292025
MIRT539126	hsa-miR-4320	PAR-CLIP	27292025
MIRT539126	hsa-miR-4320	PAR-CLIP	27292025
MIRT539126	hsa-miR-4320	PAR-CLIP	27292025
MIRT539124	hsa-miR-452-3p	PAR-CLIP	27292025
MIRT539124	hsa-miR-452-3p	PAR-CLIP	27292025
MIRT539124	hsa-miR-452-3p	PAR-CLIP	27292025
MIRT539124	hsa-miR-452-3p	PAR-CLIP	27292025
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	27292025
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	27292025
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	27292025
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	27292025
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	27292025
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	27292025
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	27292025
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	27292025
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	27292025
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	27292025
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	27292025
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	27292025
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	27292025
MIRT539134	hsa-miR-6834-3p	PAR-CLIP	22012620
MIRT539133	hsa-miR-4690-3p	PAR-CLIP	22012620
MIRT539132	hsa-miR-5685	PAR-CLIP	22012620
MIRT539131	hsa-miR-361-3p	PAR-CLIP	22012620
MIRT539130	hsa-miR-7153-3p	PAR-CLIP	22012620
MIRT539129	hsa-miR-4772-3p	PAR-CLIP	22012620
MIRT539128	hsa-miR-2276-3p	PAR-CLIP	22012620
MIRT539127	hsa-miR-4708-3p	PAR-CLIP	22012620
MIRT539126	hsa-miR-4320	PAR-CLIP	22012620
MIRT539125	hsa-miR-4666a-5p	PAR-CLIP	22012620
MIRT539124	hsa-miR-452-3p	PAR-CLIP	22012620
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT795530	hsa-miR-181a	CLIP-seq
MIRT795531	hsa-miR-181b	CLIP-seq
MIRT795532	hsa-miR-181c	CLIP-seq
MIRT795533	hsa-miR-181d	CLIP-seq
MIRT795534	hsa-miR-221	CLIP-seq
MIRT795535	hsa-miR-222	CLIP-seq
MIRT795536	hsa-miR-3157-5p	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT795538	hsa-miR-374c	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT795540	hsa-miR-4262	CLIP-seq
MIRT795541	hsa-miR-4311	CLIP-seq
MIRT795542	hsa-miR-4424	CLIP-seq
MIRT795543	hsa-miR-452	CLIP-seq
MIRT795544	hsa-miR-4656	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT795546	hsa-miR-4676-3p	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT795549	hsa-miR-655	CLIP-seq
MIRT795550	hsa-miR-759	CLIP-seq
MIRT795551	hsa-miR-943	CLIP-seq
MIRT1934913	hsa-miR-1200	CLIP-seq
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT1934914	hsa-miR-1291	CLIP-seq
MIRT795530	hsa-miR-181a	CLIP-seq
MIRT795531	hsa-miR-181b	CLIP-seq
MIRT795532	hsa-miR-181c	CLIP-seq
MIRT795533	hsa-miR-181d	CLIP-seq
MIRT1934915	hsa-miR-1913	CLIP-seq
MIRT1934916	hsa-miR-3074-5p	CLIP-seq
MIRT1934917	hsa-miR-3125	CLIP-seq
MIRT1934918	hsa-miR-3155	CLIP-seq
MIRT1934919	hsa-miR-3155b	CLIP-seq
MIRT795536	hsa-miR-3157-5p	CLIP-seq
MIRT1934920	hsa-miR-3169	CLIP-seq
MIRT1934921	hsa-miR-3189-5p	CLIP-seq
MIRT1934922	hsa-miR-324-3p	CLIP-seq
MIRT1934923	hsa-miR-346	CLIP-seq
MIRT1934924	hsa-miR-3616-3p	CLIP-seq
MIRT1934925	hsa-miR-3665	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT1934926	hsa-miR-3916	CLIP-seq
MIRT1934927	hsa-miR-3927	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT795540	hsa-miR-4262	CLIP-seq
MIRT1934928	hsa-miR-4290	CLIP-seq
MIRT1934929	hsa-miR-4310	CLIP-seq
MIRT1934930	hsa-miR-4323	CLIP-seq
MIRT1934931	hsa-miR-4436b-3p	CLIP-seq
MIRT1934932	hsa-miR-4455	CLIP-seq
MIRT1934933	hsa-miR-4527	CLIP-seq
MIRT1934934	hsa-miR-455-5p	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT1934935	hsa-miR-4685-5p	CLIP-seq
MIRT1934936	hsa-miR-4721	CLIP-seq
MIRT1934937	hsa-miR-4736	CLIP-seq
MIRT1934938	hsa-miR-4740-5p	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT1934939	hsa-miR-4761-5p	CLIP-seq
MIRT1934940	hsa-miR-484	CLIP-seq
MIRT1934941	hsa-miR-518d-5p	CLIP-seq
MIRT1934942	hsa-miR-519b-5p	CLIP-seq
MIRT1934943	hsa-miR-519c-5p	CLIP-seq
MIRT1934944	hsa-miR-520c-5p	CLIP-seq
MIRT1934945	hsa-miR-526a	CLIP-seq
MIRT1934946	hsa-miR-591	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT1934947	hsa-miR-633	CLIP-seq
MIRT1934948	hsa-miR-877	CLIP-seq
MIRT1934949	hsa-miR-940	CLIP-seq
MIRT1934913	hsa-miR-1200	CLIP-seq
MIRT2174684	hsa-miR-1227	CLIP-seq
MIRT2174685	hsa-miR-125a-3p	CLIP-seq
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT1934914	hsa-miR-1291	CLIP-seq
MIRT2174686	hsa-miR-1296	CLIP-seq
MIRT2174687	hsa-miR-1324	CLIP-seq
MIRT2174688	hsa-miR-1343	CLIP-seq
MIRT2174689	hsa-miR-1470	CLIP-seq
MIRT2174690	hsa-miR-148a	CLIP-seq
MIRT2174691	hsa-miR-148b	CLIP-seq
MIRT2174692	hsa-miR-152	CLIP-seq
MIRT2174693	hsa-miR-1825	CLIP-seq
MIRT1934915	hsa-miR-1913	CLIP-seq
MIRT2174694	hsa-miR-1915	CLIP-seq
MIRT2174695	hsa-miR-198	CLIP-seq
MIRT2174696	hsa-miR-204	CLIP-seq
MIRT2174697	hsa-miR-210	CLIP-seq
MIRT2174698	hsa-miR-211	CLIP-seq
MIRT2174699	hsa-miR-2355-5p	CLIP-seq
MIRT2174700	hsa-miR-2909	CLIP-seq
MIRT2174701	hsa-miR-298	CLIP-seq
MIRT2174702	hsa-miR-3140-5p	CLIP-seq
MIRT2174703	hsa-miR-3154	CLIP-seq
MIRT2174704	hsa-miR-3166	CLIP-seq
MIRT1934920	hsa-miR-3169	CLIP-seq
MIRT2174705	hsa-miR-3179	CLIP-seq
MIRT1934922	hsa-miR-324-3p	CLIP-seq
MIRT2174706	hsa-miR-328	CLIP-seq
MIRT1934923	hsa-miR-346	CLIP-seq
MIRT1934925	hsa-miR-3665	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT2174707	hsa-miR-3714	CLIP-seq
MIRT795538	hsa-miR-374c	CLIP-seq
MIRT2174708	hsa-miR-3911	CLIP-seq
MIRT2174709	hsa-miR-3918	CLIP-seq
MIRT1934927	hsa-miR-3927	CLIP-seq
MIRT2174710	hsa-miR-3929	CLIP-seq
MIRT2174711	hsa-miR-3936	CLIP-seq
MIRT2174712	hsa-miR-3978	CLIP-seq
MIRT2174713	hsa-miR-4257	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT2174714	hsa-miR-4283	CLIP-seq
MIRT1934928	hsa-miR-4290	CLIP-seq
MIRT2174715	hsa-miR-4302	CLIP-seq
MIRT795541	hsa-miR-4311	CLIP-seq
MIRT2174716	hsa-miR-4419b	CLIP-seq
MIRT795542	hsa-miR-4424	CLIP-seq
MIRT1934931	hsa-miR-4436b-3p	CLIP-seq
MIRT1934932	hsa-miR-4455	CLIP-seq
MIRT2174717	hsa-miR-4476	CLIP-seq
MIRT2174718	hsa-miR-4478	CLIP-seq
MIRT2174719	hsa-miR-4488	CLIP-seq
MIRT2174720	hsa-miR-4493	CLIP-seq
MIRT2174721	hsa-miR-4512	CLIP-seq
MIRT2174722	hsa-miR-4515	CLIP-seq
MIRT2174723	hsa-miR-451b	CLIP-seq
MIRT795543	hsa-miR-452	CLIP-seq
MIRT2174724	hsa-miR-4520a-3p	CLIP-seq
MIRT2174725	hsa-miR-4520b-3p	CLIP-seq
MIRT1934933	hsa-miR-4527	CLIP-seq
MIRT1934934	hsa-miR-455-5p	CLIP-seq
MIRT2174726	hsa-miR-4640-5p	CLIP-seq
MIRT2174727	hsa-miR-4643	CLIP-seq
MIRT2174728	hsa-miR-4649-5p	CLIP-seq
MIRT2174729	hsa-miR-466	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT2174730	hsa-miR-4667-3p	CLIP-seq
MIRT795546	hsa-miR-4676-3p	CLIP-seq
MIRT1934935	hsa-miR-4685-5p	CLIP-seq
MIRT2174731	hsa-miR-4697-5p	CLIP-seq
MIRT2174732	hsa-miR-4711-3p	CLIP-seq
MIRT2174733	hsa-miR-4726-3p	CLIP-seq
MIRT2174734	hsa-miR-4726-5p	CLIP-seq
MIRT1934937	hsa-miR-4736	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT2174735	hsa-miR-4755-5p	CLIP-seq
MIRT1934939	hsa-miR-4761-5p	CLIP-seq
MIRT2174736	hsa-miR-4762-5p	CLIP-seq
MIRT2174737	hsa-miR-4767	CLIP-seq
MIRT2174738	hsa-miR-4780	CLIP-seq
MIRT2174739	hsa-miR-4789-3p	CLIP-seq
MIRT2174740	hsa-miR-4803	CLIP-seq
MIRT2174741	hsa-miR-494	CLIP-seq
MIRT2174742	hsa-miR-505	CLIP-seq
MIRT2174743	hsa-miR-511	CLIP-seq
MIRT2174744	hsa-miR-541	CLIP-seq
MIRT2174745	hsa-miR-561	CLIP-seq
MIRT1934946	hsa-miR-591	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT2174746	hsa-miR-623	CLIP-seq
MIRT2174747	hsa-miR-637	CLIP-seq
MIRT2174748	hsa-miR-648	CLIP-seq
MIRT2174749	hsa-miR-654-5p	CLIP-seq
MIRT795549	hsa-miR-655	CLIP-seq
MIRT2174750	hsa-miR-665	CLIP-seq
MIRT795550	hsa-miR-759	CLIP-seq
MIRT2174751	hsa-miR-760	CLIP-seq
MIRT2174752	hsa-miR-9	CLIP-seq
MIRT1934949	hsa-miR-940	CLIP-seq
MIRT795551	hsa-miR-943	CLIP-seq
MIRT2174753	hsa-miR-95	CLIP-seq
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT2384432	hsa-miR-3614-3p	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT2384433	hsa-miR-4300	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT2384434	hsa-miR-920	CLIP-seq
MIRT2384435	hsa-miR-942	CLIP-seq
MIRT2435479	hsa-miR-1238	CLIP-seq
MIRT2435480	hsa-miR-4464	CLIP-seq
MIRT2435481	hsa-miR-4748	CLIP-seq
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT2478124	hsa-miR-1294	CLIP-seq
MIRT2478125	hsa-miR-2681	CLIP-seq
MIRT2478126	hsa-miR-296-5p	CLIP-seq
MIRT2478127	hsa-miR-3150b-3p	CLIP-seq
MIRT2174703	hsa-miR-3154	CLIP-seq
MIRT1934920	hsa-miR-3169	CLIP-seq
MIRT2174705	hsa-miR-3179	CLIP-seq
MIRT2478128	hsa-miR-3185	CLIP-seq
MIRT2478129	hsa-miR-3198	CLIP-seq
MIRT2478130	hsa-miR-3529	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT2478131	hsa-miR-379	CLIP-seq
MIRT2174708	hsa-miR-3911	CLIP-seq
MIRT2174709	hsa-miR-3918	CLIP-seq
MIRT2174711	hsa-miR-3936	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT2478132	hsa-miR-4276	CLIP-seq
MIRT2478133	hsa-miR-4279	CLIP-seq
MIRT2478134	hsa-miR-4309	CLIP-seq
MIRT2478135	hsa-miR-4316	CLIP-seq
MIRT2478136	hsa-miR-4324	CLIP-seq
MIRT2478137	hsa-miR-4451	CLIP-seq
MIRT1934932	hsa-miR-4455	CLIP-seq
MIRT2174719	hsa-miR-4488	CLIP-seq
MIRT2174722	hsa-miR-4515	CLIP-seq
MIRT2478138	hsa-miR-4650-3p	CLIP-seq
MIRT2478139	hsa-miR-4653-3p	CLIP-seq
MIRT795544	hsa-miR-4656	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT2478140	hsa-miR-4677-3p	CLIP-seq
MIRT2478141	hsa-miR-4683	CLIP-seq
MIRT1934935	hsa-miR-4685-5p	CLIP-seq
MIRT2478142	hsa-miR-4689	CLIP-seq
MIRT2174731	hsa-miR-4697-5p	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT2478143	hsa-miR-4784	CLIP-seq
MIRT2174743	hsa-miR-511	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT2174747	hsa-miR-637	CLIP-seq
MIRT795550	hsa-miR-759	CLIP-seq
MIRT2174751	hsa-miR-760	CLIP-seq
MIRT2174752	hsa-miR-9	CLIP-seq
MIRT795529	hsa-miR-1275	CLIP-seq
MIRT2174703	hsa-miR-3154	CLIP-seq
MIRT1934920	hsa-miR-3169	CLIP-seq
MIRT2174705	hsa-miR-3179	CLIP-seq
MIRT2478129	hsa-miR-3198	CLIP-seq
MIRT2478130	hsa-miR-3529	CLIP-seq
MIRT795537	hsa-miR-3667-3p	CLIP-seq
MIRT2478131	hsa-miR-379	CLIP-seq
MIRT2174708	hsa-miR-3911	CLIP-seq
MIRT2174709	hsa-miR-3918	CLIP-seq
MIRT2174711	hsa-miR-3936	CLIP-seq
MIRT795539	hsa-miR-4260	CLIP-seq
MIRT2478132	hsa-miR-4276	CLIP-seq
MIRT2478134	hsa-miR-4309	CLIP-seq
MIRT2478137	hsa-miR-4451	CLIP-seq
MIRT1934932	hsa-miR-4455	CLIP-seq
MIRT2174719	hsa-miR-4488	CLIP-seq
MIRT2174722	hsa-miR-4515	CLIP-seq
MIRT2174723	hsa-miR-451b	CLIP-seq
MIRT795543	hsa-miR-452	CLIP-seq
MIRT2478138	hsa-miR-4650-3p	CLIP-seq
MIRT2478139	hsa-miR-4653-3p	CLIP-seq
MIRT795545	hsa-miR-4665-5p	CLIP-seq
MIRT795546	hsa-miR-4676-3p	CLIP-seq
MIRT1934935	hsa-miR-4685-5p	CLIP-seq
MIRT2174731	hsa-miR-4697-5p	CLIP-seq
MIRT795547	hsa-miR-4749-3p	CLIP-seq
MIRT2174743	hsa-miR-511	CLIP-seq
MIRT795548	hsa-miR-615-5p	CLIP-seq
MIRT2174747	hsa-miR-637	CLIP-seq
MIRT2174752	hsa-miR-9	CLIP-seq
MIRT795551	hsa-miR-943	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	12071859
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030036	Process	Actin cytoskeleton organization	IDA	12071859
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 617043
• HGNC: 21726
• e!Ensembl: ENSG00000110237

Protein

• UniProt ID: Q96PE2
• Protein name: Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)
• Protein function: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	1070 → 1252	RhoGEF domain	Domain
  PF19057	PH_19	1277 → 1376		Domain
  PF19056	WD40_2	1727 → 1981		Repeat

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in the heart. {ECO:0000269|PubMed:12071859}.
• Sequence:

  MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASCRPTTAARGQPSRRVSK
  LASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPAR
  GAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLA
  GLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASY
  PVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSS
  LLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLR
  PMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDDLWSSRGSGGWGVYRSPS
  FGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRS
  DLSELRVRKPGGSSGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTAT
  LRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFE
  KIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFC
  GLGTTGMWRPLSSSSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGS
  ELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLT
  SGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGP
  GFEGPGGEPIREVEPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAH
  RNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHA
  SVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVP
  APVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQS
  YVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHA
  QQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQ
  ALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEE
  AERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL
  KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRL
  DEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCA
  TRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFS
  CAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQ
  PRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMT
  PGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETT
  SSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSS
  VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREA
  GHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSS
  RCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAA
  CLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQ
  LPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSS
  GGGSSSETVGRDDSTNHLLLWRV

• Sequence length: 2063

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma of lung	Lung carcinoma	BEFREE	30297789		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	24172857		★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	29997225	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	30297789		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	24172857		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	18677770		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	LHGDN	18677770		★☆☆☆☆ Found in Text Mining only