ARHGEF11 (Rho guanine nucleotide exchange factor 11)

Gene

• Entrez ID: 9826
• Gene name: Rho guanine nucleotide exchange factor 11
• Gene symbol: ARHGEF11
• Synonyms (NCBI Gene): GTRAP48, PDZ-RHOGEF
• Chromosome: 1
• Chromosome location: 1q23.1
• Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A sim

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT707303	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707302	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707301	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707300	hsa-miR-3924	HITS-CLIP	21572407
MIRT707299	hsa-miR-6083	HITS-CLIP	21572407
MIRT707298	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT707303	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707302	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707301	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707300	hsa-miR-3924	HITS-CLIP	21572407
MIRT707299	hsa-miR-6083	HITS-CLIP	21572407
MIRT707298	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT795308	hsa-miR-139-5p	CLIP-seq
MIRT795309	hsa-miR-2110	CLIP-seq
MIRT795310	hsa-miR-3977	CLIP-seq
MIRT795311	hsa-miR-4271	CLIP-seq
MIRT795312	hsa-miR-4420	CLIP-seq
MIRT795313	hsa-miR-4725-3p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT795315	hsa-miR-548c-3p	CLIP-seq
MIRT795316	hsa-miR-299-3p	CLIP-seq
MIRT795317	hsa-miR-3151	CLIP-seq
MIRT795318	hsa-miR-3177-5p	CLIP-seq
MIRT795319	hsa-miR-329	CLIP-seq
MIRT795320	hsa-miR-338-3p	CLIP-seq
MIRT795321	hsa-miR-338-5p	CLIP-seq
MIRT795322	hsa-miR-342-5p	CLIP-seq
MIRT795323	hsa-miR-3613-3p	CLIP-seq
MIRT795324	hsa-miR-3616-3p	CLIP-seq
MIRT795325	hsa-miR-362-3p	CLIP-seq
MIRT795326	hsa-miR-3941	CLIP-seq
MIRT795327	hsa-miR-3973	CLIP-seq
MIRT795328	hsa-miR-3974	CLIP-seq
MIRT795329	hsa-miR-4310	CLIP-seq
MIRT795330	hsa-miR-4436b-3p	CLIP-seq
MIRT795331	hsa-miR-4447	CLIP-seq
MIRT795332	hsa-miR-4472	CLIP-seq
MIRT795333	hsa-miR-4481	CLIP-seq
MIRT795334	hsa-miR-4488	CLIP-seq
MIRT795335	hsa-miR-4491	CLIP-seq
MIRT795336	hsa-miR-4530	CLIP-seq
MIRT795337	hsa-miR-4651	CLIP-seq
MIRT795338	hsa-miR-4657	CLIP-seq
MIRT795339	hsa-miR-4664-5p	CLIP-seq
MIRT795340	hsa-miR-4697-5p	CLIP-seq
MIRT795341	hsa-miR-4699-3p	CLIP-seq
MIRT795342	hsa-miR-4710	CLIP-seq
MIRT795343	hsa-miR-4721	CLIP-seq
MIRT795344	hsa-miR-4745-5p	CLIP-seq
MIRT795345	hsa-miR-4758-5p	CLIP-seq
MIRT795346	hsa-miR-4789-3p	CLIP-seq
MIRT795347	hsa-miR-4792	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT795348	hsa-miR-520g	CLIP-seq
MIRT795349	hsa-miR-520h	CLIP-seq
MIRT795350	hsa-miR-548p	CLIP-seq
MIRT795351	hsa-miR-591	CLIP-seq
MIRT795352	hsa-miR-603	CLIP-seq
MIRT795353	hsa-miR-608	CLIP-seq
MIRT795354	hsa-miR-766	CLIP-seq
MIRT795355	hsa-miR-873	CLIP-seq
MIRT1934815	hsa-miR-516b	CLIP-seq
MIRT795308	hsa-miR-139-5p	CLIP-seq
MIRT1934816	hsa-miR-1972	CLIP-seq
MIRT795309	hsa-miR-2110	CLIP-seq
MIRT1934817	hsa-miR-3678-5p	CLIP-seq
MIRT795310	hsa-miR-3977	CLIP-seq
MIRT795311	hsa-miR-4271	CLIP-seq
MIRT795329	hsa-miR-4310	CLIP-seq
MIRT795312	hsa-miR-4420	CLIP-seq
MIRT795333	hsa-miR-4481	CLIP-seq
MIRT795342	hsa-miR-4710	CLIP-seq
MIRT1934818	hsa-miR-4716-3p	CLIP-seq
MIRT795313	hsa-miR-4725-3p	CLIP-seq
MIRT795344	hsa-miR-4745-5p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT1934816	hsa-miR-1972	CLIP-seq
MIRT2174599	hsa-miR-3150a-3p	CLIP-seq
MIRT2174600	hsa-miR-3175	CLIP-seq
MIRT795324	hsa-miR-3616-3p	CLIP-seq
MIRT795326	hsa-miR-3941	CLIP-seq
MIRT2174601	hsa-miR-4270	CLIP-seq
MIRT795330	hsa-miR-4436b-3p	CLIP-seq
MIRT2174602	hsa-miR-4441	CLIP-seq
MIRT2174603	hsa-miR-4468	CLIP-seq
MIRT2174604	hsa-miR-4654	CLIP-seq
MIRT795343	hsa-miR-4721	CLIP-seq
MIRT2174605	hsa-miR-4769-5p	CLIP-seq
MIRT795314	hsa-miR-491-5p	CLIP-seq
MIRT2174606	hsa-miR-664	CLIP-seq
MIRT795355	hsa-miR-873	CLIP-seq
MIRT2174607	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	NAS	10026210
GO:0001664	Function	G protein-coupled receptor binding	IBA
GO:0001664	Function	G protein-coupled receptor binding	IDA	15755723
GO:0001664	Function	G protein-coupled receptor binding	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	10026210
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	10026210, 15530360, 17474147, 20300064, 20844236, 21988832, 22632972, 28514442, 32203420, 33961781, 34591642
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15755723
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006941	Process	Striated muscle contraction	NAS	10026210
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IDA	15755723
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	10026210
GO:0007266	Process	Rho protein signal transduction	IDA	10026210
GO:0007266	Process	Rho protein signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0030010	Process	Establishment of cell polarity	NAS	10026210
GO:0030036	Process	Actin cytoskeleton organization	NAS	10026210
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	10026210
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS

Other IDs

• MIM: 605708
• HGNC: 14580
• e!Ensembl: ENSG00000132694

Protein

• UniProt ID: O15085
• Protein name: Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
• Protein function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and G
• PDB: 1HTJ, 1XCG, 2DLS, 3KZ1, 3T06, 5E6P, 5JHG, 5JHH, 5TYT
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00595	PDZ	47 → 120	PDZ domain	Domain
  PF09128	RGS-like	307 → 486	Regulator of G protein signalling-like domain	Domain
  PF00621	RhoGEF	738 → 921	RhoGEF domain	Domain
  PF17838	PH_16	950 → 1079	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10026210}.
• Sequence:

  MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQKDQHGFGFT
  VSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSGAYVALTLL
  GSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPPQRITGPKPLQDPEVQKHATQ
  ILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQEGDSGLDSGTERFPSLSESLMNR
  NSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVPSTGDQGVDQSPKPLIIGPEEDYDP
  GYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQADPSPLLFYLCAEVYQQASPKDSRSL
  GKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLRNSEDARGVLCEAQEAAMPEIQEQIHDYR
  TKRTLGLGSLYGENDLLDLDGDPLRERQVAEKQLAALGDILSKYEEDRSAPMDFALNTYM
  SHAGIRLREARPSNTAEKAQSAPDKDKWLPFFPKTKKSSNSKKEKDALEDKKRNPILKYI
  GKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLES
  DSSRSEIRLGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLS
  TRSLENPTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTV
  GKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFP
  NLPELIEIHNSWCEAMKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL
  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT
  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD
  LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ
  TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN
  ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ
  GKHQVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADS
  ALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGG
  EGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGY
  KVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAP
  MSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLK
  DMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPC
  PEDGSDAPLEDSTADAAASPGP

• Sequence length: 1522

Pathways

KEGG:

Vascular smooth muscle contraction
Parathyroid hormone synthesis, secretion and action
Pathogenic Escherichia coli infection
Human cytomegalovirus infection
Pathways in cancer

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	29190905		★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	16691626	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33122451	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	16691626		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	25319871	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	17287471, 17369523, 18231709, 21210224, 25319871		★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	18497548	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30219706		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	33122451	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30219706		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	30219706		★☆☆☆☆ Found in Text Mining only
Hyperinsulinism	Hyperinsulinism	BEFREE	17287471		★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial Aneurysm	BEFREE	20613766		★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	22987919		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	16691626		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	16691626	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	29190905		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	16691626		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16691626		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30219706		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33122451	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	14684465		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	18678470, 25319871		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	18678470, 25319871		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	Pubtator	25319871	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations