Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9816
Gene name	URB2 ribosome biogenesis homolog
Gene symbol	URB2
Synonyms (NCBI Gene)	KIAA0133NET10NPA2
Chromosome	1
Chromosome location	1q42.13

Show/Hide all (92)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027740	hsa-miR-98-5p	Microarray	19088304
MIRT029987	hsa-miR-26b-5p	Microarray	19088304
MIRT049621	hsa-miR-92a-3p	CLASH	23622248
MIRT046400	hsa-miR-15b-5p	CLASH	23622248
MIRT042651	hsa-miR-423-3p	CLASH	23622248
MIRT1476896	hsa-miR-1264	CLIP-seq
MIRT1476897	hsa-miR-1290	CLIP-seq
MIRT1476898	hsa-miR-1298	CLIP-seq
MIRT1476899	hsa-miR-154	CLIP-seq
MIRT1476900	hsa-miR-217	CLIP-seq
MIRT1476901	hsa-miR-25	CLIP-seq
MIRT1476902	hsa-miR-3126-3p	CLIP-seq
MIRT1476903	hsa-miR-3145-5p	CLIP-seq
MIRT1476904	hsa-miR-32	CLIP-seq
MIRT1476905	hsa-miR-323b-3p	CLIP-seq
MIRT1476906	hsa-miR-363	CLIP-seq
MIRT1476907	hsa-miR-367	CLIP-seq
MIRT1476908	hsa-miR-3672	CLIP-seq
MIRT1476909	hsa-miR-378	CLIP-seq
MIRT1476910	hsa-miR-378b	CLIP-seq
MIRT1476911	hsa-miR-378c	CLIP-seq
MIRT1476912	hsa-miR-378d	CLIP-seq
MIRT1476913	hsa-miR-378e	CLIP-seq
MIRT1476914	hsa-miR-378f	CLIP-seq
MIRT1476915	hsa-miR-378h	CLIP-seq
MIRT1476916	hsa-miR-378i	CLIP-seq
MIRT1476917	hsa-miR-3924	CLIP-seq
MIRT1476918	hsa-miR-3925-3p	CLIP-seq
MIRT1476919	hsa-miR-3942-3p	CLIP-seq
MIRT1476920	hsa-miR-422a	CLIP-seq
MIRT1476921	hsa-miR-4267	CLIP-seq
MIRT1476922	hsa-miR-4320	CLIP-seq
MIRT1476923	hsa-miR-4329	CLIP-seq
MIRT1476924	hsa-miR-4418	CLIP-seq
MIRT1476925	hsa-miR-4446-3p	CLIP-seq
MIRT1476926	hsa-miR-4504	CLIP-seq
MIRT1476927	hsa-miR-4520a-3p	CLIP-seq
MIRT1476928	hsa-miR-4638-3p	CLIP-seq
MIRT1476929	hsa-miR-4656	CLIP-seq
MIRT1476930	hsa-miR-4680-3p	CLIP-seq
MIRT1476931	hsa-miR-4761-5p	CLIP-seq
MIRT1476932	hsa-miR-4773	CLIP-seq
MIRT1476933	hsa-miR-498	CLIP-seq
MIRT1476934	hsa-miR-508-5p	CLIP-seq
MIRT1476935	hsa-miR-509-3-5p	CLIP-seq
MIRT1476936	hsa-miR-509-5p	CLIP-seq
MIRT1476937	hsa-miR-515-5p	CLIP-seq
MIRT1476938	hsa-miR-542-3p	CLIP-seq
MIRT1476939	hsa-miR-549	CLIP-seq
MIRT1476940	hsa-miR-555	CLIP-seq
MIRT1476941	hsa-miR-591	CLIP-seq
MIRT1476942	hsa-miR-597	CLIP-seq
MIRT1476943	hsa-miR-668	CLIP-seq
MIRT1476944	hsa-miR-766	CLIP-seq
MIRT1476945	hsa-miR-92a	CLIP-seq
MIRT1476946	hsa-miR-92b	CLIP-seq
MIRT1476896	hsa-miR-1264	CLIP-seq
MIRT1476897	hsa-miR-1290	CLIP-seq
MIRT1476898	hsa-miR-1298	CLIP-seq
MIRT1476917	hsa-miR-3924	CLIP-seq
MIRT1476918	hsa-miR-3925-3p	CLIP-seq
MIRT1476921	hsa-miR-4267	CLIP-seq
MIRT2363901	hsa-miR-4501	CLIP-seq
MIRT1476926	hsa-miR-4504	CLIP-seq
MIRT2363902	hsa-miR-4643	CLIP-seq
MIRT2363903	hsa-miR-466	CLIP-seq
MIRT2363904	hsa-miR-4789-3p	CLIP-seq
MIRT2363905	hsa-miR-488	CLIP-seq
MIRT2363906	hsa-miR-501-3p	CLIP-seq
MIRT2363907	hsa-miR-502-3p	CLIP-seq
MIRT1476937	hsa-miR-515-5p	CLIP-seq
MIRT2363908	hsa-miR-548an	CLIP-seq
MIRT1476944	hsa-miR-766	CLIP-seq
MIRT2396724	hsa-miR-1915	CLIP-seq
MIRT2396725	hsa-miR-216a	CLIP-seq
MIRT2396726	hsa-miR-216b	CLIP-seq
MIRT2396727	hsa-miR-4452	CLIP-seq
MIRT2396728	hsa-miR-4726-3p	CLIP-seq
MIRT2462974	hsa-miR-3973	CLIP-seq
MIRT2462975	hsa-miR-4480	CLIP-seq
MIRT2462976	hsa-miR-548a-5p	CLIP-seq
MIRT2462977	hsa-miR-548ab	CLIP-seq
MIRT2462978	hsa-miR-548ak	CLIP-seq
MIRT2462979	hsa-miR-548b-5p	CLIP-seq
MIRT2462980	hsa-miR-548c-5p	CLIP-seq
MIRT2462981	hsa-miR-548d-5p	CLIP-seq
MIRT2462982	hsa-miR-548h	CLIP-seq
MIRT2462983	hsa-miR-548i	CLIP-seq
MIRT2462984	hsa-miR-548j	CLIP-seq
MIRT2462985	hsa-miR-548w	CLIP-seq
MIRT2462986	hsa-miR-548y	CLIP-seq
MIRT2462987	hsa-miR-559	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0016235	Component	Aggresome	IDA
GO:0030496	Component	Midbody	IDA	19799413
GO:0042254	Process	Ribosome biogenesis	IBA
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	ISS

MIM	HGNC	e!Ensembl
619372	28967	ENSG00000135763

Q14146

Protein name

Unhealthy ribosome biogenesis protein 2 homolog

Protein function

Essential for hematopietic stem cell development through the regulation of p53/TP53 pathway.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10441	Urb2	1321 → 1517	Urb2/Npa2 family	Family

Sequence

MAAVYSGISLKLKSKTTSWEDKLKLAHFAWISHQCFLPNKEQVLLDWARQSLVAFYKKKL
ELKEDIVERLWIYIDNILHSRKLQNLLKNGKTINLQISLVKIINERVAEFSLSGSQRNIC
AVLRCCQGILSTPALAVIYTAKQELMVALLSQLCWSACRQPEGAVVAQLFEVIHLALGHY
LLILQQQVNPRRAFGDVTAHLLQPCLVLRHLLSGGTWTQAGQGQLRQVLSRDIRSQIEAM
FRGGIFQPELLSSYKEGLLDQQQGDVKTGAMKNLLAPMDTVLNRLVDAGYCAASLHTSVV
ANSVALLYKLFLDSYFKEGNQLLCFQVLPRLFGCLKISHLQEEQSKALSTSDWTTELLVV
EQLLNSVANNNIYNIAADRIRHEEAQFRFYRHVAELLINHAQAPIPAWFRCLKTLISLNH
LILEPDLDDLLASAWIDAEVTEFRTKKAQEALIRTVFQTYAKLRQVPRLFEEVLGVICRP
AAEALRQPVLASGPSTVLSACLLELPPSQILDTWSLVLEKFQSLVLPYLQSDADMALKSL
SLSLLLHCIMFNMRSLDSSTPLPIVRRTQCMMERMMRELVQPLLALLPDTPGPEPELWLQ
KVSDSVLLLSYTWAQVDAMFSLNCSQYHSMSGPLIGVALEISNLPSLLPGVKTQHWKKIE
KFTAQFSSLGTYCLEQLYLQKMKRTLMQTSFRSEGAIQSLRCDAAFIIGSGRKSLNQRTT
ASWDGQVGMVSGLTYPVAHWHLIVSNLTILISYLCPDDVGYLASVLLRTLPMGKAQEVSI
DEEAYITLEKISKAFLHSPLFPEMQSLHSAFLTCVTTSCSSILCSGAQRDSGLVSQQLPW
LFEKDHMVVGHWENRFAKAGPEGIEPRGEIAQNLLSLVKSDFPIQLEGEQLESILGLLEV
ISALQLDSLLPPYHVHYFLVLLSMAVTKLGCSCSSSLALKFLTTCYQLLGYLQKGKSARS
VFKIMYGSDIFEVVLTSLFRASSRFLIEMDDPAWLEFLQVIGTFLEELMQMLIQMKLSLV
LNFRKITAFLSSSKPYTEAASSKQLENQNPQGRQLLLVSLTRLCHVLGPFLKEQKLGQEA
PAALSELLQQVVLQTGAVLQLCSVPGARGWRLPSVLISSVSTLLEADLGQHCRDGGADIS
QGSDRTLLSHVALYQGVYSQILLELPALAGHDQSFQAALQFLTLFFLAPELHPKKDSVFT
SMFHSVRRVLADPEIPVQVTQDIEPHLGALFTQMLEVGTTEDLRLVMQCILQGLDVSNMW
KADVQAVVSAVTLLRLLLNCPLSGEKASLLWRACPQIVTALTLLNREASQEQPVSLTVVG
PVLDVLAALLRQGEEAIGNPHHVSLAFSILLTVPLDHLKPLEYGSVFPRLHNVLFSILQC
HPKVMLKAIPSFLNSFNRLVFSVMREGRQKDKGSIDDLPTVLKCARLVERMYSHIAARAE
EFAVFSPFMVAQYVLEVQKVTLYPAVKSLLQEGIYLILDLCIEPDVQFLRASLQPGMRDI
FKELYNDYLKYHKAKHEGEKRYTA

Sequence length

1524

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Epilepsy	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28732507	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

URB2 (URB2 ribosome biogenesis homolog)