Gene Gene information from NCBI Gene database.
Entrez ID 9804
Gene name Translocase of outer mitochondrial membrane 20
Gene symbol TOMM20
Synonyms (NCBI Gene)
MAS20MOM19TOM20
Chromosome 1
Chromosome location 1q42.3
miRNA miRNA information provided by mirtarbase database.
1303
miRTarBase ID miRNA Experiments Reference
MIRT020995 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT024153 hsa-miR-221-3p Sequencing 20371350
MIRT032124 hsa-let-7d-5p Sequencing 20371350
MIRT050518 hsa-miR-20a-5p CLASH 23622248
MIRT043268 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 14557246, 20231292, 30021884, 35271311, 38848361
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005739 Component Mitochondrion IDA 32848200
GO:0005739 Component Mitochondrion IDA 20628368, 25327288
GO:0005739 Component Mitochondrion IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601848 20947 ENSG00000173726
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15388
Protein name Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)
Protein function Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion
PDB 4APO , 7VBY , 7VC9 , 8XVA , 9EIH , 9EII , 9EIJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02064 MAS20 10 124 MAS20 protein import receptor Family
Sequence
Sequence length 145
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal   Pink/Parkin Mediated Mitophagy
Ub-specific processing proteases
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
OBESITY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyloidosis Amyloidosis BEFREE 29097221
★☆☆☆☆
Found in Text Mining only
Anophthalmia with pulmonary hypoplasia Anophthalmia Pubtator 32633891 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 33818294 Associate
★☆☆☆☆
Found in Text Mining only
Autism Spectrum Disorder Autism Pubtator 23333625 Associate
★☆☆☆☆
Found in Text Mining only
Bronchopulmonary Dysplasia Bronchopulmonary dysplasia Pubtator 36261501 Stimulate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 31818360
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 40594722 Associate
★☆☆☆☆
Found in Text Mining only
Hepatitis Autoimmune Autoimmune hepatitis Pubtator 32124227 Associate
★☆☆☆☆
Found in Text Mining only
Hepatitis C Chronic Hepatitis c Pubtator 32124227 Associate
★☆☆☆☆
Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome Hereditary breast and ovarian cancer syndrome Pubtator 37181035 Stimulate
★☆☆☆☆
Found in Text Mining only