TATDN2 (TatD DNase domain containing 2)

Gene

• Entrez ID: 9797
• Gene name: TatD DNase domain containing 2
• Gene symbol: TATDN2
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016680	hsa-miR-423-3p	Sequencing	20371350
MIRT025466	hsa-miR-34a-5p	Sequencing	20371350
MIRT046738	hsa-miR-222-3p	CLASH	23622248
MIRT040413	hsa-miR-615-3p	CLASH	23622248
MIRT533927	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT533926	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT533924	hsa-miR-8485	PAR-CLIP	22012620
MIRT533925	hsa-miR-603	PAR-CLIP	22012620
MIRT533923	hsa-miR-873-5p	PAR-CLIP	22012620
MIRT533921	hsa-miR-4682	PAR-CLIP	22012620
MIRT533922	hsa-miR-4424	PAR-CLIP	22012620
MIRT533920	hsa-miR-3941	PAR-CLIP	22012620
MIRT533919	hsa-miR-4672	PAR-CLIP	22012620
MIRT533918	hsa-miR-466	PAR-CLIP	22012620
MIRT533917	hsa-miR-190a-5p	PAR-CLIP	22012620
MIRT533916	hsa-miR-190b	PAR-CLIP	22012620
MIRT533915	hsa-miR-7855-5p	PAR-CLIP	22012620
MIRT533914	hsa-miR-599	PAR-CLIP	22012620
MIRT533927	hsa-miR-362-3p	PAR-CLIP	22012620
MIRT533926	hsa-miR-329-3p	PAR-CLIP	22012620
MIRT533924	hsa-miR-8485	PAR-CLIP	22012620
MIRT533925	hsa-miR-603	PAR-CLIP	22012620
MIRT533923	hsa-miR-873-5p	PAR-CLIP	22012620
MIRT533921	hsa-miR-4682	PAR-CLIP	22012620
MIRT533922	hsa-miR-4424	PAR-CLIP	22012620
MIRT533920	hsa-miR-3941	PAR-CLIP	22012620
MIRT533919	hsa-miR-4672	PAR-CLIP	22012620
MIRT533918	hsa-miR-466	PAR-CLIP	22012620
MIRT533917	hsa-miR-190a-5p	PAR-CLIP	22012620
MIRT533916	hsa-miR-190b	PAR-CLIP	22012620
MIRT533915	hsa-miR-7855-5p	PAR-CLIP	22012620
MIRT533914	hsa-miR-599	PAR-CLIP	22012620
MIRT1411644	hsa-miR-1321	CLIP-seq
MIRT1411645	hsa-miR-219-1-3p	CLIP-seq
MIRT1411646	hsa-miR-2682	CLIP-seq
MIRT1411647	hsa-miR-3135b	CLIP-seq
MIRT1411648	hsa-miR-3192	CLIP-seq
MIRT1411649	hsa-miR-3202	CLIP-seq
MIRT1411650	hsa-miR-320a	CLIP-seq
MIRT1411651	hsa-miR-320b	CLIP-seq
MIRT1411652	hsa-miR-320c	CLIP-seq
MIRT1411653	hsa-miR-320d	CLIP-seq
MIRT1411654	hsa-miR-329	CLIP-seq
MIRT1411655	hsa-miR-3612	CLIP-seq
MIRT1411656	hsa-miR-3613-3p	CLIP-seq
MIRT1411657	hsa-miR-3652	CLIP-seq
MIRT1411658	hsa-miR-3689a-3p	CLIP-seq
MIRT1411659	hsa-miR-3689c	CLIP-seq
MIRT1411660	hsa-miR-4420	CLIP-seq
MIRT1411661	hsa-miR-4429	CLIP-seq
MIRT1411662	hsa-miR-4430	CLIP-seq
MIRT1411663	hsa-miR-4438	CLIP-seq
MIRT1411664	hsa-miR-449c	CLIP-seq
MIRT1411665	hsa-miR-4505	CLIP-seq
MIRT1411666	hsa-miR-4514	CLIP-seq
MIRT1411667	hsa-miR-4653-3p	CLIP-seq
MIRT1411668	hsa-miR-4668-3p	CLIP-seq
MIRT1411669	hsa-miR-4684-3p	CLIP-seq
MIRT1411670	hsa-miR-4685-5p	CLIP-seq
MIRT1411671	hsa-miR-4692	CLIP-seq
MIRT1411672	hsa-miR-4696	CLIP-seq
MIRT1411673	hsa-miR-4728-5p	CLIP-seq
MIRT1411674	hsa-miR-4731-3p	CLIP-seq
MIRT1411675	hsa-miR-4732-3p	CLIP-seq
MIRT1411676	hsa-miR-4739	CLIP-seq
MIRT1411677	hsa-miR-4747-5p	CLIP-seq
MIRT1411678	hsa-miR-4756-5p	CLIP-seq
MIRT1411679	hsa-miR-4801	CLIP-seq
MIRT1411680	hsa-miR-5095	CLIP-seq
MIRT1411681	hsa-miR-514	CLIP-seq
MIRT1411682	hsa-miR-514b-3p	CLIP-seq
MIRT1411683	hsa-miR-605	CLIP-seq
MIRT1411684	hsa-miR-642b	CLIP-seq
MIRT1411685	hsa-miR-647	CLIP-seq
MIRT1411686	hsa-miR-650	CLIP-seq
MIRT1411687	hsa-miR-765	CLIP-seq
MIRT1411688	hsa-miR-873	CLIP-seq
MIRT1411689	hsa-miR-885-3p	CLIP-seq
MIRT1557173	hsa-miR-140-3p	CLIP-seq
MIRT1557174	hsa-miR-3126-5p	CLIP-seq
MIRT1557175	hsa-miR-508-5p	CLIP-seq
MIRT2123604	hsa-miR-105	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT2123606	hsa-miR-1236	CLIP-seq
MIRT2123607	hsa-miR-125a-3p	CLIP-seq
MIRT2123608	hsa-miR-125a-5p	CLIP-seq
MIRT2123609	hsa-miR-125b	CLIP-seq
MIRT2123610	hsa-miR-1289	CLIP-seq
MIRT1411644	hsa-miR-1321	CLIP-seq
MIRT1557173	hsa-miR-140-3p	CLIP-seq
MIRT2123611	hsa-miR-1908	CLIP-seq
MIRT2123612	hsa-miR-196a	CLIP-seq
MIRT2123613	hsa-miR-196b	CLIP-seq
MIRT2123614	hsa-miR-2355-5p	CLIP-seq
MIRT2123615	hsa-miR-3121-5p	CLIP-seq
MIRT1557174	hsa-miR-3126-5p	CLIP-seq
MIRT2123616	hsa-miR-3150b-3p	CLIP-seq
MIRT2123617	hsa-miR-3164	CLIP-seq
MIRT2123618	hsa-miR-3169	CLIP-seq
MIRT2123619	hsa-miR-3170	CLIP-seq
MIRT2123620	hsa-miR-3171	CLIP-seq
MIRT2123621	hsa-miR-3194-5p	CLIP-seq
MIRT1411649	hsa-miR-3202	CLIP-seq
MIRT1411654	hsa-miR-329	CLIP-seq
MIRT2123622	hsa-miR-361-3p	CLIP-seq
MIRT2123623	hsa-miR-361-5p	CLIP-seq
MIRT2123624	hsa-miR-3616-3p	CLIP-seq
MIRT2123625	hsa-miR-3622a-3p	CLIP-seq
MIRT2123626	hsa-miR-3622b-3p	CLIP-seq
MIRT2123627	hsa-miR-3909	CLIP-seq
MIRT2123628	hsa-miR-4254	CLIP-seq
MIRT2123629	hsa-miR-4260	CLIP-seq
MIRT2123630	hsa-miR-4269	CLIP-seq
MIRT2123631	hsa-miR-4276	CLIP-seq
MIRT2123632	hsa-miR-4319	CLIP-seq
MIRT2123633	hsa-miR-432	CLIP-seq
MIRT2123634	hsa-miR-4324	CLIP-seq
MIRT2123635	hsa-miR-4329	CLIP-seq
MIRT1411660	hsa-miR-4420	CLIP-seq
MIRT2123636	hsa-miR-4421	CLIP-seq
MIRT1411663	hsa-miR-4438	CLIP-seq
MIRT2123637	hsa-miR-4443	CLIP-seq
MIRT2123638	hsa-miR-4446-3p	CLIP-seq
MIRT2123639	hsa-miR-4475	CLIP-seq
MIRT2123640	hsa-miR-4486	CLIP-seq
MIRT2123641	hsa-miR-4492	CLIP-seq
MIRT2123642	hsa-miR-4498	CLIP-seq
MIRT2123643	hsa-miR-4503	CLIP-seq
MIRT2123644	hsa-miR-4530	CLIP-seq
MIRT2123645	hsa-miR-4645-3p	CLIP-seq
MIRT2123646	hsa-miR-4652-3p	CLIP-seq
MIRT2123647	hsa-miR-4659a-3p	CLIP-seq
MIRT2123648	hsa-miR-4659b-3p	CLIP-seq
MIRT1411669	hsa-miR-4684-3p	CLIP-seq
MIRT1411670	hsa-miR-4685-5p	CLIP-seq
MIRT2123649	hsa-miR-4689	CLIP-seq
MIRT2123650	hsa-miR-4690-5p	CLIP-seq
MIRT1411672	hsa-miR-4696	CLIP-seq
MIRT2123651	hsa-miR-4709-3p	CLIP-seq
MIRT2123652	hsa-miR-4711-5p	CLIP-seq
MIRT2123653	hsa-miR-4714-3p	CLIP-seq
MIRT2123654	hsa-miR-4716-5p	CLIP-seq
MIRT2123655	hsa-miR-4721	CLIP-seq
MIRT2123656	hsa-miR-4724-5p	CLIP-seq
MIRT1411674	hsa-miR-4731-3p	CLIP-seq
MIRT1411676	hsa-miR-4739	CLIP-seq
MIRT1411677	hsa-miR-4747-5p	CLIP-seq
MIRT1411678	hsa-miR-4756-5p	CLIP-seq
MIRT2123657	hsa-miR-4761-3p	CLIP-seq
MIRT2123658	hsa-miR-4773	CLIP-seq
MIRT2123659	hsa-miR-4784	CLIP-seq
MIRT2123660	hsa-miR-4793-5p	CLIP-seq
MIRT1411679	hsa-miR-4801	CLIP-seq
MIRT2123661	hsa-miR-4804-3p	CLIP-seq
MIRT2123662	hsa-miR-490-3p	CLIP-seq
MIRT2123663	hsa-miR-498	CLIP-seq
MIRT2123664	hsa-miR-499a-5p	CLIP-seq
MIRT2123665	hsa-miR-5096	CLIP-seq
MIRT2123666	hsa-miR-542-3p	CLIP-seq
MIRT2123667	hsa-miR-544b	CLIP-seq
MIRT2123668	hsa-miR-570	CLIP-seq
MIRT2123669	hsa-miR-615-5p	CLIP-seq
MIRT2123670	hsa-miR-622	CLIP-seq
MIRT2123671	hsa-miR-634	CLIP-seq
MIRT1411684	hsa-miR-642b	CLIP-seq
MIRT2123672	hsa-miR-663	CLIP-seq
MIRT2123673	hsa-miR-718	CLIP-seq
MIRT2123674	hsa-miR-762	CLIP-seq
MIRT1411687	hsa-miR-765	CLIP-seq
MIRT2123675	hsa-miR-922	CLIP-seq
MIRT2123604	hsa-miR-105	CLIP-seq
MIRT2345696	hsa-miR-1185	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT1411644	hsa-miR-1321	CLIP-seq
MIRT2345697	hsa-miR-136	CLIP-seq
MIRT2123611	hsa-miR-1908	CLIP-seq
MIRT2123612	hsa-miR-196a	CLIP-seq
MIRT2123613	hsa-miR-196b	CLIP-seq
MIRT2345698	hsa-miR-203	CLIP-seq
MIRT2345699	hsa-miR-2681	CLIP-seq
MIRT2345700	hsa-miR-3159	CLIP-seq
MIRT2123618	hsa-miR-3169	CLIP-seq
MIRT1411649	hsa-miR-3202	CLIP-seq
MIRT1411654	hsa-miR-329	CLIP-seq
MIRT2345701	hsa-miR-3605-5p	CLIP-seq
MIRT2123623	hsa-miR-361-5p	CLIP-seq
MIRT2123624	hsa-miR-3616-3p	CLIP-seq
MIRT2123625	hsa-miR-3622a-3p	CLIP-seq
MIRT2123626	hsa-miR-3622b-3p	CLIP-seq
MIRT2345702	hsa-miR-3679-5p	CLIP-seq
MIRT2345703	hsa-miR-3690	CLIP-seq
MIRT2123628	hsa-miR-4254	CLIP-seq
MIRT2123633	hsa-miR-432	CLIP-seq
MIRT2123638	hsa-miR-4446-3p	CLIP-seq
MIRT2345704	hsa-miR-4457	CLIP-seq
MIRT2123640	hsa-miR-4486	CLIP-seq
MIRT2123641	hsa-miR-4492	CLIP-seq
MIRT2123642	hsa-miR-4498	CLIP-seq
MIRT2123646	hsa-miR-4652-3p	CLIP-seq
MIRT1411670	hsa-miR-4685-5p	CLIP-seq
MIRT2123650	hsa-miR-4690-5p	CLIP-seq
MIRT2123651	hsa-miR-4709-3p	CLIP-seq
MIRT2123652	hsa-miR-4711-5p	CLIP-seq
MIRT2123653	hsa-miR-4714-3p	CLIP-seq
MIRT2123656	hsa-miR-4724-5p	CLIP-seq
MIRT1411674	hsa-miR-4731-3p	CLIP-seq
MIRT1411676	hsa-miR-4739	CLIP-seq
MIRT1411677	hsa-miR-4747-5p	CLIP-seq
MIRT1411678	hsa-miR-4756-5p	CLIP-seq
MIRT2123657	hsa-miR-4761-3p	CLIP-seq
MIRT2345705	hsa-miR-4768-3p	CLIP-seq
MIRT2123658	hsa-miR-4773	CLIP-seq
MIRT2123660	hsa-miR-4793-5p	CLIP-seq
MIRT1411679	hsa-miR-4801	CLIP-seq
MIRT2345706	hsa-miR-4803	CLIP-seq
MIRT2123661	hsa-miR-4804-3p	CLIP-seq
MIRT2123662	hsa-miR-490-3p	CLIP-seq
MIRT2123665	hsa-miR-5096	CLIP-seq
MIRT2345707	hsa-miR-513b	CLIP-seq
MIRT2345708	hsa-miR-617	CLIP-seq
MIRT1411684	hsa-miR-642b	CLIP-seq
MIRT2123672	hsa-miR-663	CLIP-seq
MIRT2345709	hsa-miR-665	CLIP-seq
MIRT2123673	hsa-miR-718	CLIP-seq
MIRT2123674	hsa-miR-762	CLIP-seq
MIRT1411687	hsa-miR-765	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT2123611	hsa-miR-1908	CLIP-seq
MIRT2123612	hsa-miR-196a	CLIP-seq
MIRT2123613	hsa-miR-196b	CLIP-seq
MIRT1411654	hsa-miR-329	CLIP-seq
MIRT2123625	hsa-miR-3622a-3p	CLIP-seq
MIRT2123626	hsa-miR-3622b-3p	CLIP-seq
MIRT2123638	hsa-miR-4446-3p	CLIP-seq
MIRT2123640	hsa-miR-4486	CLIP-seq
MIRT2123641	hsa-miR-4492	CLIP-seq
MIRT2123642	hsa-miR-4498	CLIP-seq
MIRT2123650	hsa-miR-4690-5p	CLIP-seq
MIRT2123653	hsa-miR-4714-3p	CLIP-seq
MIRT2123656	hsa-miR-4724-5p	CLIP-seq
MIRT1411674	hsa-miR-4731-3p	CLIP-seq
MIRT1411679	hsa-miR-4801	CLIP-seq
MIRT2123662	hsa-miR-490-3p	CLIP-seq
MIRT2123665	hsa-miR-5096	CLIP-seq
MIRT1411684	hsa-miR-642b	CLIP-seq
MIRT2123672	hsa-miR-663	CLIP-seq
MIRT2123673	hsa-miR-718	CLIP-seq
MIRT2123674	hsa-miR-762	CLIP-seq
MIRT1411688	hsa-miR-873	CLIP-seq
MIRT2461160	hsa-miR-103a	CLIP-seq
MIRT2461161	hsa-miR-107	CLIP-seq
MIRT2461162	hsa-miR-1184	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT2461163	hsa-miR-1260	CLIP-seq
MIRT2461164	hsa-miR-1260b	CLIP-seq
MIRT2461165	hsa-miR-188-3p	CLIP-seq
MIRT2461166	hsa-miR-3148	CLIP-seq
MIRT2461167	hsa-miR-3156-3p	CLIP-seq
MIRT2461168	hsa-miR-3158-5p	CLIP-seq
MIRT2461169	hsa-miR-4640-5p	CLIP-seq
MIRT2461170	hsa-miR-4668-5p	CLIP-seq
MIRT2461171	hsa-miR-4717-3p	CLIP-seq
MIRT2461172	hsa-miR-4726-5p	CLIP-seq
MIRT2461173	hsa-miR-4797-5p	CLIP-seq
MIRT2345708	hsa-miR-617	CLIP-seq
MIRT2638620	hsa-miR-1193	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT2638621	hsa-miR-1207-5p	CLIP-seq
MIRT2638622	hsa-miR-1273f	CLIP-seq
MIRT2638623	hsa-miR-1287	CLIP-seq
MIRT2638624	hsa-miR-183	CLIP-seq
MIRT2638625	hsa-miR-185	CLIP-seq
MIRT2638626	hsa-miR-1972	CLIP-seq
MIRT2638627	hsa-miR-218	CLIP-seq
MIRT2638628	hsa-miR-3127-5p	CLIP-seq
MIRT1411647	hsa-miR-3135b	CLIP-seq
MIRT2123616	hsa-miR-3150b-3p	CLIP-seq
MIRT2638629	hsa-miR-3158-3p	CLIP-seq
MIRT2638630	hsa-miR-3165	CLIP-seq
MIRT2638631	hsa-miR-3189-3p	CLIP-seq
MIRT2638632	hsa-miR-323b-5p	CLIP-seq
MIRT2123624	hsa-miR-3616-3p	CLIP-seq
MIRT2123625	hsa-miR-3622a-3p	CLIP-seq
MIRT2123626	hsa-miR-3622b-3p	CLIP-seq
MIRT2638633	hsa-miR-3665	CLIP-seq
MIRT2638634	hsa-miR-3691-5p	CLIP-seq
MIRT2638635	hsa-miR-3918	CLIP-seq
MIRT2638636	hsa-miR-3922-5p	CLIP-seq
MIRT2638637	hsa-miR-3929	CLIP-seq
MIRT2123630	hsa-miR-4269	CLIP-seq
MIRT2638638	hsa-miR-4306	CLIP-seq
MIRT2638639	hsa-miR-4419b	CLIP-seq
MIRT1411663	hsa-miR-4438	CLIP-seq
MIRT2123638	hsa-miR-4446-3p	CLIP-seq
MIRT2638640	hsa-miR-4478	CLIP-seq
MIRT2123641	hsa-miR-4492	CLIP-seq
MIRT2123642	hsa-miR-4498	CLIP-seq
MIRT2638641	hsa-miR-4644	CLIP-seq
MIRT2638642	hsa-miR-4645-5p	CLIP-seq
MIRT2638643	hsa-miR-4673	CLIP-seq
MIRT2123655	hsa-miR-4721	CLIP-seq
MIRT2638644	hsa-miR-4736	CLIP-seq
MIRT2123657	hsa-miR-4761-3p	CLIP-seq
MIRT2638645	hsa-miR-4763-3p	CLIP-seq
MIRT2123659	hsa-miR-4784	CLIP-seq
MIRT2123665	hsa-miR-5096	CLIP-seq
MIRT2345708	hsa-miR-617	CLIP-seq
MIRT2123674	hsa-miR-762	CLIP-seq
MIRT2123605	hsa-miR-1205	CLIP-seq
MIRT2123612	hsa-miR-196a	CLIP-seq
MIRT2123613	hsa-miR-196b	CLIP-seq
MIRT2123623	hsa-miR-361-5p	CLIP-seq
MIRT2123625	hsa-miR-3622a-3p	CLIP-seq
MIRT2123626	hsa-miR-3622b-3p	CLIP-seq
MIRT2123630	hsa-miR-4269	CLIP-seq
MIRT2123638	hsa-miR-4446-3p	CLIP-seq
MIRT2123641	hsa-miR-4492	CLIP-seq
MIRT2123642	hsa-miR-4498	CLIP-seq
MIRT2123650	hsa-miR-4690-5p	CLIP-seq
MIRT2123656	hsa-miR-4724-5p	CLIP-seq
MIRT1411674	hsa-miR-4731-3p	CLIP-seq
MIRT1411679	hsa-miR-4801	CLIP-seq
MIRT2123665	hsa-miR-5096	CLIP-seq
MIRT1411684	hsa-miR-642b	CLIP-seq
MIRT2123674	hsa-miR-762	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004518	Function	Nuclease activity	IEA
GO:0004527	Function	Exonuclease activity	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 619330
• HGNC: 28988
• e!Ensembl: ENSG00000157014

Protein

• UniProt ID: Q93075
• Protein name: 3'-5' RNA nuclease TATDN2 (EC 3.1.13.-) (TatD DNase domain containing 2)
• Protein function: Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA stucture (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01026	TatD_DNase	496 → 760	TatD related DNase	Domain

• Sequence:

  MASERGKVKHNWSSTSEGCPRKRSCLREPCDVAPSSRPAQRSASRSGGPSSPKRLKAQKE
  DDVACSRRLSWGSSRRRNNSSSSFSPHFLGPGVGGAASKGCLIRNTRGFLSSGGSPLRPA
  NASLEEMASLEEEACSLKVDSKDSSHNSTNSEFAAEAEGQNDTIEEPNKVQKRKRDRLRD
  QGSTMIYLKAIQGILGKSMPKRKGEAATRAKPSAAEHPSHGEGPARSEGPAKTAEGAARS
  VTVTAAQKEKDATPEVSMEEDKTVPERSSFYDRRVVIDPQEKPSEEPLGDRRTVIDKCSP
  PLEFLDDSDSHLEIQKHKDREVVMEHPSSGSDWSDVEEISTVRFSQEEPVSLKPSAVPEP
  SSFTTDYVMYPPHLYSSPWCDYASYWTSSPKPSSYPSTGSSSNDAAQVGKSSRSRMSDYS
  PNSTGSVQNTSRDMEASEEGWSQNSRSFRFSRSSEEREVKEKRTFQEEMPPRPCGGHASS
  SLPKSHLEPSLEEGFIDTHCHLDMLYSKLSFQGTFTKFRKIYSSSFPKEFQGCISDFCDP
  RTLTDCLWEELLKEDLVWGAFGCHPHFARYYSESQERNLLQALRHPKAVAFGEMGLDYSY
  KCTTPVPEQHKVFERQLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGS
  YPVIEPLLKYFPNMSVGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSL
  CQYAHPGLALHTVREIARVKDQPLSLTLAALRENTSRLYSL

• Sequence length: 761

Pathways

Reactome:

XBP1(S) activates chaperone genes

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
GASTRIC CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TATDN2-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	37696853	Associate	★☆☆☆☆ Found in Text Mining only