Gene Gene information from NCBI Gene database.
Entrez ID 9783
Gene name Regulating synaptic membrane exocytosis 3
Gene symbol RIMS3
Synonyms (NCBI Gene)
NIM3RIM 3RIM3
Chromosome 1
Chromosome location 1p34.2
miRNA miRNA information provided by mirtarbase database.
506
miRTarBase ID miRNA Experiments Reference
MIRT019723 hsa-miR-375 Microarray 20215506
MIRT021100 hsa-miR-186-5p Sequencing 20371350
MIRT027028 hsa-miR-103a-3p Sequencing 20371350
MIRT031509 hsa-miR-16-5p Sequencing 20371350
MIRT712230 hsa-miR-4286 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 28514442, 32296183, 32814053, 33961781
GO:0006836 Process Neurotransmitter transport IEA
GO:0006887 Process Exocytosis IEA
GO:0016020 Component Membrane IEA
GO:0016081 Process Synaptic vesicle docking IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611600 21292 ENSG00000117016
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UJD0
Protein name Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3)
Protein function Regulates synaptic membrane exocytosis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00168 C2 169 276 C2 domain Domain
Sequence
MFNGEPGPASSGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLT
QWSKSTLQLPQPEGATKKLRSNIRRSTETGIAVEMRSRVTRQGSRESTDGSTNSNSSDGT
FIFPTTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIMDRSGQLEVEVIEARG
LTPKPGSKSLPATYIKVYLLENGACLAKKKTKMTKKTCDPLYQQALLFDEGPQGKVLQVI
VWGDYGRMDHKCFMGMAQIMLDELDLSAAVTGWYKL
FPTSSVADSTLGSLTRRLSQSSLE
SATSPSCS
Sequence length 308
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
RIMS3-related disorder Uncertain significance; Likely benign; Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Autistic Disorder Autism BEFREE 19546099, 26142343
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism Pubtator 19546099 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36160034 Associate
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia BEFREE 18490030
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Schizophrenia Schizophrenia LHGDN 18490030
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Schizophrenia Schizophrenia PSYGENET_DG 18490030
★★☆☆☆
Found in Text Mining + Unknown/Other Associations