CDA (cytidine deaminase)

Gene

• Entrez ID: 978
• Gene name: Cytidine deaminase
• Gene symbol: CDA
• Synonyms (NCBI Gene): CDD
• Chromosome: 1
• Chromosome location: 1p36.12
• Summary: This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several dea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018180	hsa-miR-335-5p	Microarray	18185580
MIRT876664	hsa-miR-2110	CLIP-seq
MIRT876665	hsa-miR-3929	CLIP-seq
MIRT876666	hsa-miR-4271	CLIP-seq
MIRT876667	hsa-miR-4274	CLIP-seq
MIRT876668	hsa-miR-4419b	CLIP-seq
MIRT876669	hsa-miR-4478	CLIP-seq
MIRT876670	hsa-miR-4725-3p	CLIP-seq
MIRT876671	hsa-miR-4747-5p	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2385813	hsa-miR-3151	CLIP-seq
MIRT2500055	hsa-miR-122	CLIP-seq
MIRT2500056	hsa-miR-1285	CLIP-seq
MIRT2500057	hsa-miR-1299	CLIP-seq
MIRT2500058	hsa-miR-1915	CLIP-seq
MIRT2500059	hsa-miR-2114	CLIP-seq
MIRT2500060	hsa-miR-2355-5p	CLIP-seq
MIRT2500061	hsa-miR-3135b	CLIP-seq
MIRT2500062	hsa-miR-3155	CLIP-seq
MIRT2500063	hsa-miR-3155b	CLIP-seq
MIRT2500064	hsa-miR-3158-3p	CLIP-seq
MIRT2500065	hsa-miR-3187-5p	CLIP-seq
MIRT2500066	hsa-miR-339-5p	CLIP-seq
MIRT2500067	hsa-miR-3652	CLIP-seq
MIRT2500068	hsa-miR-3657	CLIP-seq
MIRT2500069	hsa-miR-3665	CLIP-seq
MIRT2500070	hsa-miR-3934	CLIP-seq
MIRT2500071	hsa-miR-4261	CLIP-seq
MIRT2500072	hsa-miR-4430	CLIP-seq
MIRT2500073	hsa-miR-4446-3p	CLIP-seq
MIRT2500074	hsa-miR-4492	CLIP-seq
MIRT2500075	hsa-miR-4498	CLIP-seq
MIRT2500076	hsa-miR-4505	CLIP-seq
MIRT2500077	hsa-miR-4675	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2500078	hsa-miR-4685-5p	CLIP-seq
MIRT2500079	hsa-miR-4731-5p	CLIP-seq
MIRT2500080	hsa-miR-4736	CLIP-seq
MIRT2500081	hsa-miR-4741	CLIP-seq
MIRT2500082	hsa-miR-484	CLIP-seq
MIRT2500083	hsa-miR-494	CLIP-seq
MIRT2500084	hsa-miR-510	CLIP-seq
MIRT2500085	hsa-miR-612	CLIP-seq
MIRT2500086	hsa-miR-762	CLIP-seq
MIRT2500087	hsa-miR-875-3p	CLIP-seq
MIRT2500055	hsa-miR-122	CLIP-seq
MIRT2500056	hsa-miR-1285	CLIP-seq
MIRT2500057	hsa-miR-1299	CLIP-seq
MIRT2500058	hsa-miR-1915	CLIP-seq
MIRT2500059	hsa-miR-2114	CLIP-seq
MIRT2500060	hsa-miR-2355-5p	CLIP-seq
MIRT2500061	hsa-miR-3135b	CLIP-seq
MIRT2500062	hsa-miR-3155	CLIP-seq
MIRT2500063	hsa-miR-3155b	CLIP-seq
MIRT2500064	hsa-miR-3158-3p	CLIP-seq
MIRT2500065	hsa-miR-3187-5p	CLIP-seq
MIRT2500066	hsa-miR-339-5p	CLIP-seq
MIRT2500067	hsa-miR-3652	CLIP-seq
MIRT2500068	hsa-miR-3657	CLIP-seq
MIRT2500069	hsa-miR-3665	CLIP-seq
MIRT2500070	hsa-miR-3934	CLIP-seq
MIRT2500071	hsa-miR-4261	CLIP-seq
MIRT2500072	hsa-miR-4430	CLIP-seq
MIRT2500073	hsa-miR-4446-3p	CLIP-seq
MIRT2500074	hsa-miR-4492	CLIP-seq
MIRT2500075	hsa-miR-4498	CLIP-seq
MIRT2500076	hsa-miR-4505	CLIP-seq
MIRT2500077	hsa-miR-4675	CLIP-seq
MIRT2196831	hsa-miR-4677-3p	CLIP-seq
MIRT2500078	hsa-miR-4685-5p	CLIP-seq
MIRT2500079	hsa-miR-4731-5p	CLIP-seq
MIRT2500080	hsa-miR-4736	CLIP-seq
MIRT2500081	hsa-miR-4741	CLIP-seq
MIRT2500082	hsa-miR-484	CLIP-seq
MIRT2500083	hsa-miR-494	CLIP-seq
MIRT2500084	hsa-miR-510	CLIP-seq
MIRT2500085	hsa-miR-612	CLIP-seq
MIRT2500086	hsa-miR-762	CLIP-seq
MIRT2500087	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA1	Activation	14744791

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001882	Function	Nucleoside binding	IDA	15689149
GO:0003824	Function	Catalytic activity	IEA
GO:0004126	Function	Cytidine deaminase activity	IBA
GO:0004126	Function	Cytidine deaminase activity	IDA	7923172, 9596658
GO:0004126	Function	Cytidine deaminase activity	IEA
GO:0005515	Function	Protein binding	IPI	25416956, 25910212, 31515488, 32296183
GO:0005576	Component	Extracellular region	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	9596658
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	NAS	16303324
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IBA
GO:0008270	Function	Zinc ion binding	IDA	15689149
GO:0008270	Function	Zinc ion binding	IEA
GO:0008655	Process	Pyrimidine-containing compound salvage	NAS	9596658
GO:0016787	Function	Hydrolase activity	IEA
GO:0019858	Process	Cytosine metabolic process	TAS	7923172
GO:0034774	Component	Secretory granule lumen	TAS
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	9596658, 31515488, 32296183
GO:0042803	Function	Protein homodimerization activity	IDA	15689149
GO:0044206	Process	UMP salvage	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046898	Process	Response to cycloheximide	IEA
GO:0055086	Process	Nucleobase-containing small molecule metabolic process	IEA
GO:0071217	Process	Cellular response to external biotic stimulus	IEA
GO:0072527	Process	Pyrimidine-containing compound metabolic process	IEA
GO:1901135	Process	Carbohydrate derivative metabolic process	IEA
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 123920
• HGNC: 1712
• e!Ensembl: ENSG00000158825

Protein

• UniProt ID: P32320
• Protein name: Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase)
• Protein function: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
• PDB: 1MQ0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00383	dCMP_cyt_deam_1	12 → 118	Cytidine and deoxycytidylate deaminase zinc-binding region	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in granulocytes while expression is very low in fibroblasts, chondrocytes, monocytes, and T- as well as B-cell lines.
• Sequence:

  MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
  PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
  DGTYIVMTVQELLPSSFGPEDLQKTQ

• Sequence length: 146

Pathways

KEGG:

Pyrimidine metabolism
Drug metabolism - other enzymes
Metabolic pathways
Nucleotide metabolism

Reactome:

Neutrophil degranulation
Pyrimidine salvage

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute leukemia	Leukemia	BEFREE	23479503		★☆☆☆☆ Found in Text Mining only
Acute Megakaryocytic Leukemias	Megakaryocytic Leukemia	LHGDN	14744791		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	26354033, 29490977		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	31624127		★☆☆☆☆ Found in Text Mining only
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	BEFREE	31624127		★☆☆☆☆ Found in Text Mining only
Anemia, Diamond-Blackfan	Anemia	BEFREE	31401766		★☆☆☆☆ Found in Text Mining only
Anemia, Sickle Cell	Anemia	BEFREE	30891745		★☆☆☆☆ Found in Text Mining only
Aplasia Cutis Congenita	Aplasia Cutis Congenita	BEFREE	31624127		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	29549113		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	1540020	Stimulate	★☆☆☆☆ Found in Text Mining only
Avellino corneal dystrophy	Avellino Corneal Dystrophy	BEFREE	22379997		★☆☆☆☆ Found in Text Mining only
Biliary Tract Cancer	Biliary Tract Cancer	BEFREE	26418006		★☆☆☆☆ Found in Text Mining only
Bloom Syndrome	Bloom syndrome	Pubtator	26181065, 28463527, 28947735	Associate	★☆☆☆☆ Found in Text Mining only
Bloom Syndrome	Bloom Syndrome	BEFREE	27601591		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	35796015	Associate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	10811482, 25330770		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	19459041, 24858917, 25643696		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	35982128	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	30889042		★☆☆☆☆ Found in Text Mining only
Chronic Kidney Diseases	Kidney Disease	BEFREE	29016969		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	18203981, 25691056, 30392417, 8672545		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	25691056, 37754498, 8672545	Associate	★☆☆☆☆ Found in Text Mining only
Congenital dyserythropoietic anemia	Congenital dyserythropoietic anemia	BEFREE	22379997		★☆☆☆☆ Found in Text Mining only
Congenital dyserythropoietic anemia, type II	Congenital dyserythropoietic anemia	BEFREE	22208203		★☆☆☆☆ Found in Text Mining only
Craniodiaphyseal dysplasia	Craniodiaphyseal Dysplasia	BEFREE	28575517		★☆☆☆☆ Found in Text Mining only
CRANIODIAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT (disorder)	Craniodiaphyseal dysplasia	BEFREE	28575517		★☆☆☆☆ Found in Text Mining only
Cryopyrin-Associated Periodic Syndromes	Cryopyrin-Associated Periodic Syndromes	BEFREE	29549113		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	17660224		★☆☆☆☆ Found in Text Mining only
Diarrhea	Diarrhea	Pubtator	23736036	Associate	★☆☆☆☆ Found in Text Mining only
Down Syndrome	Down Syndrome	BEFREE	14744791, 15687366		★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	34404882	Associate	★☆☆☆☆ Found in Text Mining only
Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome	BEFREE	9431914		★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	24025329	Associate	★☆☆☆☆ Found in Text Mining only
Hyalinosis, Systemic	Hyalinosis	BEFREE	18473752, 21325291		★☆☆☆☆ Found in Text Mining only
Intervertebral Disc Degeneration	Intervertebral Disc Degeneration	BEFREE	17660224		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	LHGDN	12844405		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	14744791, 17296311, 30002603		★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	23873772, 26090398, 29490977, 32708452, 36316809	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	12008078, 15687366, 19036079, 22304580, 22884143, 23287564, 26090398, 26354033, 29490977, 9886326		★☆☆☆☆ Found in Text Mining only
Leukopenia	Leukopenia	BEFREE	18347182, 18538445, 20028759, 20665488, 21590444, 22031394, 22546611, 25582275, 30889042		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	17847074		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	35999456	Associate	★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	LHGDN	12113294		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	BEFREE	28672935		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	22645179	Associate	★☆☆☆☆ Found in Text Mining only
Malignant mesothelioma	Malignant Mesothelioma	BEFREE	22134350		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	10811482, 25330770		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	19459041, 24858917, 25643696		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	21625252, 28887583, 29064388		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	11593336, 17194903, 20010457, 21625252, 24557790, 24841663, 25401976, 25495470, 26200337, 26258849, 27601591, 30701582, 8672545		★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	BEFREE	30701582		★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	Pubtator	30701582	Associate	★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	10811482, 25330770		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	10811482, 25330770		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	30093965		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	10811482, 25330770		★☆☆☆☆ Found in Text Mining only
Mastocytosis, Systemic	Mastocytosis	BEFREE	29137311		★☆☆☆☆ Found in Text Mining only
Myelodysplasia	Myelodysplasia	BEFREE	23479503, 26651614		★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	23287564, 26651614, 26944860, 30926081, 31040918		★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	30002603		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	12477049, 16585222, 20665488, 21915635, 23837479, 26418006, 27601591, 30002603, 9066694		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	15867251, 9066694		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	BEFREE	18347182, 18538445, 20028759, 20665488, 21590444, 22546611, 25582275, 30889042		★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	Pubtator	20028759, 20665488, 30889042	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	18347182, 19500405, 20213492, 21652582, 22031394, 22052224, 24557790, 24841663, 29662657, 29695832, 31603383		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	21625252, 28887583, 29064388		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	27745548		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	20028759, 20665488, 30701582, 34660806, 39215188, 39795998	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	28651752		★☆☆☆☆ Found in Text Mining only
Primary amyloidosis	Amyloidosis	BEFREE	30002603		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	29549113		★☆☆☆☆ Found in Text Mining only
Severe combined immunodeficiency due to adenosine deaminase deficiency	Severe combined immunodeficiency	Pubtator	26308942	Inhibit	★☆☆☆☆ Found in Text Mining only
Spondylarthritis	Spondyloarthritis	BEFREE	17660224		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	31624127		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	8672545	Associate	★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor	BEFREE	27582469		★☆☆☆☆ Found in Text Mining only
Thiopurine S methyltranferase deficiency	Thiopurine s-methyltransferase deficiency	Pubtator	29490977	Associate	★☆☆☆☆ Found in Text Mining only
Unilateral Multicystic Dysplastic Kidney	Unilateral Multicystic Dysplastic Kidney	BEFREE	24481986		★☆☆☆☆ Found in Text Mining only
Xerocytosis	Xerocytosis	BEFREE	31401766		★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum, Complementation Group D	Xeroderma Pigmentosum	BEFREE	18347182, 19307510, 22052224, 24841663		★☆☆☆☆ Found in Text Mining only