Gene Gene information from NCBI Gene database.
Entrez ID 9777
Gene name Transmembrane 9 superfamily member 4
Gene symbol TM9SF4
Synonyms (NCBI Gene)
dJ836N17.2
Chromosome 20
Chromosome location 20q11.21
miRNA miRNA information provided by mirtarbase database.
488
miRTarBase ID miRNA Experiments Reference
MIRT036460 hsa-miR-1226-3p CLASH 23622248
MIRT652530 hsa-miR-4311 HITS-CLIP 23824327
MIRT652529 hsa-miR-216b-5p HITS-CLIP 23824327
MIRT652528 hsa-miR-3123 HITS-CLIP 23824327
MIRT652527 hsa-miR-5584-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IDA 25961573
GO:0005515 Function Protein binding IPI 25659576, 28514442, 29125601, 33961781
GO:0005768 Component Endosome IEA
GO:0005769 Component Early endosome IDA 19893578
GO:0005769 Component Early endosome IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
617727 30797 ENSG00000101337
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92544
Protein name Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)
Protein function Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02990 EMP70 55 599 Endomembrane protein 70 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and gran
Sequence
Sequence length 642
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Autism spectrum disorder Likely benign ClinVar
GenCC
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
AUTISM SPECTRUM DISORDERS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Carcinoma Breast Carcinoma BEFREE 31249383
★☆☆☆☆
Found in Text Mining only
Chronic Obstructive Airway Disease Chronic Obstructive Pulmonary Disease GWASCAT_DG 28166215
★☆☆☆☆
Found in Text Mining only
Hypoxia Hypoxia Pubtator 25961573 Inhibit
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory Bowel Disease GWASCAT_DG 23128233
★☆☆☆☆
Found in Text Mining only
Inflammatory Bowel Diseases Inflammatory Bowel Disease GWASDB_DG 23128233
★☆☆☆☆
Found in Text Mining only
Leukemia Leukemia Pubtator 25961573 Associate
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Myeloid leukemia Pubtator 25961573 Stimulate
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 31249383
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 19893578
★☆☆☆☆
Found in Text Mining only
Mammary Neoplasms Mammary Neoplasms BEFREE 31249383
★☆☆☆☆
Found in Text Mining only