Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9751
Gene name	Syntaphilin
Gene symbol	SNPH
Synonyms (NCBI Gene)	-
Chromosome	20
Chromosome location	20p13
Summary	Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin

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Show/Hide all (171)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019920	hsa-miR-375	Microarray	20215506
MIRT050355	hsa-miR-25-3p	CLASH	23622248
MIRT1375697	hsa-miR-1193	CLIP-seq
MIRT1375698	hsa-miR-1207-5p	CLIP-seq
MIRT1375699	hsa-miR-1245b-5p	CLIP-seq
MIRT1375700	hsa-miR-1266	CLIP-seq
MIRT1375701	hsa-miR-1292	CLIP-seq
MIRT1375702	hsa-miR-1321	CLIP-seq
MIRT1375703	hsa-miR-151-3p	CLIP-seq
MIRT1375704	hsa-miR-1909	CLIP-seq
MIRT1375705	hsa-miR-2392	CLIP-seq
MIRT1375706	hsa-miR-2467-3p	CLIP-seq
MIRT1375707	hsa-miR-3132	CLIP-seq
MIRT1375708	hsa-miR-3142	CLIP-seq
MIRT1375709	hsa-miR-3154	CLIP-seq
MIRT1375710	hsa-miR-3189-5p	CLIP-seq
MIRT1375711	hsa-miR-324-5p	CLIP-seq
MIRT1375712	hsa-miR-328	CLIP-seq
MIRT1375713	hsa-miR-331-3p	CLIP-seq
MIRT1375714	hsa-miR-411	CLIP-seq
MIRT1375715	hsa-miR-4292	CLIP-seq
MIRT1375716	hsa-miR-4318	CLIP-seq
MIRT1375717	hsa-miR-4436b-3p	CLIP-seq
MIRT1375718	hsa-miR-4463	CLIP-seq
MIRT1375719	hsa-miR-4499	CLIP-seq
MIRT1375720	hsa-miR-4518	CLIP-seq
MIRT1375721	hsa-miR-4716-3p	CLIP-seq
MIRT1375722	hsa-miR-4723-5p	CLIP-seq
MIRT1375723	hsa-miR-4728-5p	CLIP-seq
MIRT1375724	hsa-miR-4739	CLIP-seq
MIRT1375725	hsa-miR-4756-5p	CLIP-seq
MIRT1375726	hsa-miR-4760-3p	CLIP-seq
MIRT1375727	hsa-miR-4763-3p	CLIP-seq
MIRT1375728	hsa-miR-4797-5p	CLIP-seq
MIRT1375729	hsa-miR-625	CLIP-seq
MIRT1375730	hsa-miR-663b	CLIP-seq
MIRT1375731	hsa-miR-759	CLIP-seq
MIRT1375732	hsa-miR-922	CLIP-seq
MIRT2111704	hsa-miR-1291	CLIP-seq
MIRT2111705	hsa-miR-1470	CLIP-seq
MIRT2111706	hsa-miR-3150a-3p	CLIP-seq
MIRT2111707	hsa-miR-3175	CLIP-seq
MIRT2111708	hsa-miR-3189-3p	CLIP-seq
MIRT2111709	hsa-miR-3622b-5p	CLIP-seq
MIRT2111710	hsa-miR-4300	CLIP-seq
MIRT2111711	hsa-miR-4468	CLIP-seq
MIRT2111712	hsa-miR-4469	CLIP-seq
MIRT2111713	hsa-miR-4481	CLIP-seq
MIRT2111714	hsa-miR-4492	CLIP-seq
MIRT2111715	hsa-miR-4498	CLIP-seq
MIRT2111716	hsa-miR-4650-5p	CLIP-seq
MIRT2111717	hsa-miR-4656	CLIP-seq
MIRT2111718	hsa-miR-4667-3p	CLIP-seq
MIRT2111719	hsa-miR-4745-5p	CLIP-seq
MIRT2111720	hsa-miR-4758-5p	CLIP-seq
MIRT2111721	hsa-miR-491-5p	CLIP-seq
MIRT2111722	hsa-miR-558	CLIP-seq
MIRT2111723	hsa-miR-762	CLIP-seq
MIRT2111724	hsa-miR-920	CLIP-seq
MIRT2111725	hsa-miR-939	CLIP-seq
MIRT2334925	hsa-miR-1200	CLIP-seq
MIRT2334926	hsa-miR-1251	CLIP-seq
MIRT2334927	hsa-miR-1275	CLIP-seq
MIRT2334928	hsa-miR-1324	CLIP-seq
MIRT2334929	hsa-miR-146b-3p	CLIP-seq
MIRT2111705	hsa-miR-1470	CLIP-seq
MIRT2334930	hsa-miR-15a	CLIP-seq
MIRT2334931	hsa-miR-15b	CLIP-seq
MIRT2334932	hsa-miR-16	CLIP-seq
MIRT2334933	hsa-miR-1912	CLIP-seq
MIRT2334934	hsa-miR-195	CLIP-seq
MIRT2334935	hsa-miR-3125	CLIP-seq
MIRT2334936	hsa-miR-3153	CLIP-seq
MIRT2334937	hsa-miR-3200-3p	CLIP-seq
MIRT2334938	hsa-miR-329	CLIP-seq
MIRT2334939	hsa-miR-339-5p	CLIP-seq
MIRT2334940	hsa-miR-362-3p	CLIP-seq
MIRT2334941	hsa-miR-3916	CLIP-seq
MIRT1375714	hsa-miR-411	CLIP-seq
MIRT2334942	hsa-miR-424	CLIP-seq
MIRT2334943	hsa-miR-4269	CLIP-seq
MIRT2334944	hsa-miR-4290	CLIP-seq
MIRT2334945	hsa-miR-4323	CLIP-seq
MIRT2334946	hsa-miR-4324	CLIP-seq
MIRT2334947	hsa-miR-4446-3p	CLIP-seq
MIRT2111711	hsa-miR-4468	CLIP-seq
MIRT2334948	hsa-miR-4480	CLIP-seq
MIRT2111714	hsa-miR-4492	CLIP-seq
MIRT2111715	hsa-miR-4498	CLIP-seq
MIRT2334949	hsa-miR-4514	CLIP-seq
MIRT2334950	hsa-miR-4524	CLIP-seq
MIRT2334951	hsa-miR-4525	CLIP-seq
MIRT2111716	hsa-miR-4650-5p	CLIP-seq
MIRT2334952	hsa-miR-4665-5p	CLIP-seq
MIRT2334953	hsa-miR-4681	CLIP-seq
MIRT2334954	hsa-miR-4684-5p	CLIP-seq
MIRT2334955	hsa-miR-4692	CLIP-seq
MIRT1375722	hsa-miR-4723-5p	CLIP-seq
MIRT2334956	hsa-miR-4731-5p	CLIP-seq
MIRT2334957	hsa-miR-4734	CLIP-seq
MIRT2334958	hsa-miR-4742-5p	CLIP-seq
MIRT2334959	hsa-miR-4755-3p	CLIP-seq
MIRT1375728	hsa-miR-4797-5p	CLIP-seq
MIRT2334960	hsa-miR-497	CLIP-seq
MIRT2334961	hsa-miR-503	CLIP-seq
MIRT2334962	hsa-miR-520g	CLIP-seq
MIRT2334963	hsa-miR-520h	CLIP-seq
MIRT2334964	hsa-miR-544b	CLIP-seq
MIRT1375729	hsa-miR-625	CLIP-seq
MIRT2334965	hsa-miR-642b	CLIP-seq
MIRT2334966	hsa-miR-646	CLIP-seq
MIRT2334967	hsa-miR-661	CLIP-seq
MIRT2111723	hsa-miR-762	CLIP-seq
MIRT1375732	hsa-miR-922	CLIP-seq
MIRT2334968	hsa-miR-942	CLIP-seq
MIRT2334927	hsa-miR-1275	CLIP-seq
MIRT2394921	hsa-miR-3652	CLIP-seq
MIRT2394922	hsa-miR-4430	CLIP-seq
MIRT2394923	hsa-miR-4505	CLIP-seq
MIRT2334951	hsa-miR-4525	CLIP-seq
MIRT2334952	hsa-miR-4665-5p	CLIP-seq
MIRT2394924	hsa-miR-4691-5p	CLIP-seq
MIRT1375722	hsa-miR-4723-5p	CLIP-seq
MIRT2334956	hsa-miR-4731-5p	CLIP-seq
MIRT1375729	hsa-miR-625	CLIP-seq
MIRT2394925	hsa-miR-637	CLIP-seq
MIRT2111706	hsa-miR-3150a-3p	CLIP-seq
MIRT2460123	hsa-miR-1225-3p	CLIP-seq
MIRT2334926	hsa-miR-1251	CLIP-seq
MIRT2334930	hsa-miR-15a	CLIP-seq
MIRT2334931	hsa-miR-15b	CLIP-seq
MIRT2334932	hsa-miR-16	CLIP-seq
MIRT2334934	hsa-miR-195	CLIP-seq
MIRT2334942	hsa-miR-424	CLIP-seq
MIRT2460124	hsa-miR-4493	CLIP-seq
MIRT2334950	hsa-miR-4524	CLIP-seq
MIRT2334954	hsa-miR-4684-5p	CLIP-seq
MIRT2460125	hsa-miR-4768-3p	CLIP-seq
MIRT2334960	hsa-miR-497	CLIP-seq
MIRT2334961	hsa-miR-503	CLIP-seq
MIRT2334966	hsa-miR-646	CLIP-seq
MIRT2460126	hsa-miR-665	CLIP-seq
MIRT1375732	hsa-miR-922	CLIP-seq
MIRT2334968	hsa-miR-942	CLIP-seq
MIRT2111705	hsa-miR-1470	CLIP-seq
MIRT2111706	hsa-miR-3150a-3p	CLIP-seq
MIRT2111707	hsa-miR-3175	CLIP-seq
MIRT2111710	hsa-miR-4300	CLIP-seq
MIRT2111712	hsa-miR-4469	CLIP-seq
MIRT2111713	hsa-miR-4481	CLIP-seq
MIRT2111718	hsa-miR-4667-3p	CLIP-seq
MIRT2111719	hsa-miR-4745-5p	CLIP-seq
MIRT2111720	hsa-miR-4758-5p	CLIP-seq
MIRT2111721	hsa-miR-491-5p	CLIP-seq
MIRT2111722	hsa-miR-558	CLIP-seq
MIRT2111724	hsa-miR-920	CLIP-seq
MIRT2111725	hsa-miR-939	CLIP-seq
MIRT2111705	hsa-miR-1470	CLIP-seq
MIRT2111706	hsa-miR-3150a-3p	CLIP-seq
MIRT2111707	hsa-miR-3175	CLIP-seq
MIRT2111710	hsa-miR-4300	CLIP-seq
MIRT2111712	hsa-miR-4469	CLIP-seq
MIRT2111713	hsa-miR-4481	CLIP-seq
MIRT2111718	hsa-miR-4667-3p	CLIP-seq
MIRT2111719	hsa-miR-4745-5p	CLIP-seq
MIRT2111720	hsa-miR-4758-5p	CLIP-seq
MIRT2111721	hsa-miR-491-5p	CLIP-seq
MIRT2111722	hsa-miR-558	CLIP-seq
MIRT2691655	hsa-miR-617	CLIP-seq
MIRT2111724	hsa-miR-920	CLIP-seq
MIRT2111725	hsa-miR-939	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IDA	15459722
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005881	Component	Cytoplasmic microtubule	IBA
GO:0005881	Component	Cytoplasmic microtubule	IDA	23264731
GO:0007269	Process	Neurotransmitter secretion	NAS	10707983
GO:0016020	Component	Membrane	IEA
GO:0016081	Process	Synaptic vesicle docking	NAS	10707983
GO:0017075	Function	Syntaxin-1 binding	NAS	10707983
GO:0030182	Process	Neuron differentiation	IBA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0098793	Component	Presynapse	IEA

MIM	HGNC	e!Ensembl
604942	15931	ENSG00000101298

O15079

Protein name

Syntaphilin

Protein function

Inhibits SNARE complex formation by absorbing free STX1A.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15290	Syntaphilin	18 → 333	Golgi-localised syntaxin-1-binding clamp	Family

Tissue specificity

TISSUE SPECIFICITY: Brain specific. Found in synapses. {ECO:0000269|PubMed:10707983}.

Sequence

MAMSLPGSRRTSAGSRRRTSPPVSVRDAYGTSSLSSSSNSGSYKGSDSSPTPRRSMKYTL
CSDNHGIKPPTPEQYLTPLQQKEVCIRHLKARLKDTQDRLQDRDTEIDDLKTQLSRMQED
WIEEECHRVEAQLALKEARKEIKQLKQVIDTVKNNLIDKDKGLQKYFVDINIQNKKLETL
LHSMEVAQNGMAKEDGTGESAGGSPARSLTRSSTYTKLSDPAVCGDRQPGDPSSGSAEDG
ADSGFAAADDTLSRTDALEASSLLSSGVDCGTEETSLHSSFGLGPRFPASNTYEKLLCGM
EAGVQASCMQERAIQTDFVQYQPDLDTILEKVTQAQVCGTDPESGDRCPELDAHPSGPRD
PNSAVVVTVGDELEAPEPITRGPTPQRPGANPNPGQSVSVVCPMEEEEEAAVAEKEPKSY
WSRHYIVDLLAVVVPAVPTVAWLCRSQRRQGQPIYNISSLLRGCCTVALHSIRRISCRSL
SQPSPSPAGGGSQL

Sequence length

494

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE THROMBOCYTOPENIC PURPURA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28472658, 28812939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	37192718	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31079810		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27991488, 28891816		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28891816, 29898993		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	31079810		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31079810	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

SNPH (syntaphilin)