Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9737
Gene name	G protein-coupled receptor associated sorting protein 1
Gene symbol	GPRASP1
Synonyms (NCBI Gene)	GASPGASP-1GASP1
Chromosome	X
Chromosome location	Xq22.1
Summary	This gene encodes a member of the GPRASP (G protein-coupled receptor associated sorting protein) family. The protein may modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. It targets receptors for degrad

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miRTarBase ID	miRNA	Experiments	Reference
MIRT640963	hsa-miR-3140-3p	HITS-CLIP	23313552
MIRT640962	hsa-miR-2681-5p	HITS-CLIP	23313552
MIRT640963	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT640962	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT640963	hsa-miR-3140-3p	HITS-CLIP	23313552
MIRT640962	hsa-miR-2681-5p	HITS-CLIP	23313552
MIRT640963	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT640962	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT1032115	hsa-miR-1207-3p	CLIP-seq
MIRT1032116	hsa-miR-1324	CLIP-seq
MIRT1032117	hsa-miR-3119	CLIP-seq
MIRT1032118	hsa-miR-3127-5p	CLIP-seq
MIRT1032119	hsa-miR-3158-3p	CLIP-seq
MIRT1032120	hsa-miR-3685	CLIP-seq
MIRT1032121	hsa-miR-384	CLIP-seq
MIRT1032122	hsa-miR-3918	CLIP-seq
MIRT1032123	hsa-miR-4267	CLIP-seq
MIRT1032124	hsa-miR-4642	CLIP-seq
MIRT1032125	hsa-miR-4711-5p	CLIP-seq
MIRT1032126	hsa-miR-4720-5p	CLIP-seq
MIRT1032127	hsa-miR-4797-5p	CLIP-seq
MIRT1032128	hsa-miR-4799-3p	CLIP-seq
MIRT1032129	hsa-miR-548aa	CLIP-seq
MIRT1032130	hsa-miR-600	CLIP-seq
MIRT1032131	hsa-miR-766	CLIP-seq
MIRT1032132	hsa-miR-129-5p	CLIP-seq
MIRT1032133	hsa-miR-320a	CLIP-seq
MIRT1032134	hsa-miR-320b	CLIP-seq
MIRT1032135	hsa-miR-320c	CLIP-seq
MIRT1032136	hsa-miR-320d	CLIP-seq
MIRT1032137	hsa-miR-3607-3p	CLIP-seq
MIRT1032138	hsa-miR-3662	CLIP-seq
MIRT1032139	hsa-miR-4251	CLIP-seq
MIRT1032140	hsa-miR-4429	CLIP-seq
MIRT1032141	hsa-miR-450a	CLIP-seq
MIRT1032142	hsa-miR-539	CLIP-seq
MIRT1032143	hsa-miR-3647-3p	CLIP-seq
MIRT1032120	hsa-miR-3685	CLIP-seq
MIRT1032121	hsa-miR-384	CLIP-seq
MIRT1032144	hsa-miR-4282	CLIP-seq
MIRT1032145	hsa-miR-4764-3p	CLIP-seq
MIRT2006095	hsa-miR-3154	CLIP-seq
MIRT2006096	hsa-miR-3185	CLIP-seq
MIRT2006097	hsa-miR-4684-3p	CLIP-seq
MIRT2006098	hsa-miR-4727-5p	CLIP-seq
MIRT2006099	hsa-miR-4769-3p	CLIP-seq
MIRT2006100	hsa-miR-4781-3p	CLIP-seq
MIRT2006101	hsa-miR-498	CLIP-seq
MIRT2006102	hsa-miR-544	CLIP-seq
MIRT2238638	hsa-miR-1272	CLIP-seq
MIRT2238639	hsa-miR-1322	CLIP-seq
MIRT2238640	hsa-miR-4687-3p	CLIP-seq
MIRT2006095	hsa-miR-3154	CLIP-seq
MIRT2006096	hsa-miR-3185	CLIP-seq
MIRT2006098	hsa-miR-4727-5p	CLIP-seq
MIRT2006101	hsa-miR-498	CLIP-seq
MIRT2006102	hsa-miR-544	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15086532, 23954414
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0008333	Process	Endosome to lysosome transport	IMP	23954414
GO:1990172	Process	G protein-coupled receptor catabolic process	IMP	23954414
GO:1990172	Process	G protein-coupled receptor catabolic process	IPI	23954414

MIM	HGNC	e!Ensembl
300417	24834	ENSG00000198932

Q5JY77

Protein name

G-protein coupled receptor-associated sorting protein 1 (GASP-1)

Protein function

Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2. {ECO:0000269|PubMed:12142540, ECO:0000269|PubMed:15452121, ECO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04826	Arm_2	1142 → 1391	Armadillo-like	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brain, with lower expression in medulla, spinal cord and substantia nigra. {ECO:0000269|PubMed:12142540, ECO:0000269|PubMed:15086532}.

Sequence

MTGAEIESGAQVKPEKKPGEEVVGGAEIENDVPLVVRPKVRTQAQIMPGARPKNKSKVMP
GASTKVETSAVGGARPKSKAKAIPVSRFKEEAQMWAQPRFGAERLSKTERNSQTNIIASP
LVSTDSVLVAKTKYLSEDRELVNTDTESFPRRKAHYQAGFQPSFRSKEETNMGSWCCPRP
TSKQEASPNSDFKWVDKSVSSLFWSGDEVTAKFHPGNRVKDSNRSMHMANQEANTMSRSQ
TNQELYIASSSGSEDESVKTPWFWARDKTNTWSGPREDPNSRSRFRSKKEVYVESSSGSE
HEDHLESWFGAGKEAKFRSKMRAGKEANNRARHRAKREACIDFMPGSIDVIKKESCFWPE
ENANTFSRPMIKKEARARAMTKEEAKTKARARAKQEARSEEEALIGTWFWATDESSMADE
ASIESSLQVEDESIIGSWFWTEEEASMGTGASSKSRPRTDGERIGDSLFGAREKTSMKTG
AEATSESILAADDEQVIIGSWFWAGEEVNQEAEEETIFGSWFWVIDAASVESGVGVSCES
RTRSEEEEVIGPWFWSGEQVDIEAGIGEEARPGAEEETIFGSWFWAENQTYMDCRAETSC
DTMQGAEEEEPIIGSWFWTRVEACVEGDVNSKSSLEDKEEAMIPCFGAKEEVSMKHGTGV
RCRFMAGAEETNNKSCFWAEKEPCMYPAGGGSWKSRPEEEEDIVNSWFWSRKYTKPEAII
GSWLWATEESNIDGTGEKAKLLTEEETIINSWFWKEDEAISEATDREESRPEAEEGDIIG
SWFWAGEEDRLEPAAETREEDRLAAEKEGIVGSWFGAREETIRREAGSCSKSSPKAEEEE
VIIGSWFWEEEASPEAVAGVGFESKPGTEEEEITVGSWFWPEEEASIQAGSQAVEEMESE
TEEETIFGSWFWDGKEVSEEAGPCCVSKPEDDEEMIVESWFWSRDKAIKETGTVATCESK
PENEEGAIVGSWFEAEDEVDNRTDNGSNCGSRTLADEDEAIVGSWFWAGDEAHFESNPSP
VFRAICRSTCSVEQEPDPSRRPQSWEEVTVQFKPGPWGRVGFPSISPFRFPKEAASLFCE
MFGGKPRNMVLSPEGEDQESLLQPDQPSPEFPFQYDPSYRSVQEIREHLRAKESTEPESS
SCNCIQCELKIGSEEFEELLLLMEKIRDPFIHEISKIAMGMRSASQFTRDFIRDSGVVSL
IETLLNYPSSRVRTSFLENMIRMAPPYPNLNIIQTYICKVCEETLAYSVDSPEQLSGIRM
IRHLTTTTDYHTLVANYMSGFLSLLATGNAKTRFHVLKMLLNLSENLFMTKELLSAEAVS
EFIGLFNREETNDNIQIVLAIFENIGNNIKKETVFSDDDFNIEPLISAFHKVEKFAKELQ
GKTDNQNDPEGDQEN

Sequence length

1395

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GPRASP1-related disorder	Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual disability	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	BEFREE	30552067		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36801507	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	36801507	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Cancer Papillary	Papillary thyroid cancer	Pubtator	30278442	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GPRASP1 (G protein-coupled receptor associated sorting protein 1)