Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9732
Gene name	Dedicator of cytokinesis 4
Gene symbol	DOCK4
Synonyms (NCBI Gene)	-
Chromosome	7
Chromosome location	7q31.1
Summary	This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange facto

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Show/Hide all (203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005411	hsa-miR-155-5p	Microarray	19193853
MIRT006313	hsa-miR-21-5p	ImmunoblotLuciferase reporter assayqRT-PCR	22158624
MIRT006313	hsa-miR-21-5p	ImmunoblotLuciferase reporter assayqRT-PCR	22158624
MIRT006313	hsa-miR-21-5p	ImmunoblotLuciferase reporter assayqRT-PCR	22158624
MIRT027576	hsa-miR-98-5p	Microarray	19088304
MIRT524030	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524026	hsa-miR-3924	HITS-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	HITS-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	HITS-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	HITS-CLIP	21572407
MIRT524022	hsa-miR-23c	HITS-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT617974	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT617973	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT617972	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT617971	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT617970	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT617969	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT617974	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT617973	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT617972	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT617971	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT617970	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT617969	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524026	hsa-miR-3924	PAR-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	21572407
MIRT524022	hsa-miR-23c	PAR-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524026	hsa-miR-3924	PAR-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	21572407
MIRT524022	hsa-miR-23c	PAR-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524029	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT524028	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524026	hsa-miR-3924	PAR-CLIP	23446348
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	23446348
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	23446348
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	23446348
MIRT524022	hsa-miR-23c	PAR-CLIP	23446348
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT524030	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT524026	hsa-miR-3924	HITS-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	HITS-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	HITS-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	HITS-CLIP	21572407
MIRT524022	hsa-miR-23c	HITS-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT617974	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT617973	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT617972	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT617971	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT617970	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT617969	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT617974	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT617973	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT617972	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT617971	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT617970	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT617969	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524026	hsa-miR-3924	PAR-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	21572407
MIRT524022	hsa-miR-23c	PAR-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT524026	hsa-miR-3924	PAR-CLIP	21572407
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	21572407
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	21572407
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	21572407
MIRT524022	hsa-miR-23c	PAR-CLIP	21572407
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT524030	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT524029	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT524028	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT524027	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT524026	hsa-miR-3924	PAR-CLIP	23446348
MIRT524025	hsa-miR-130a-5p	PAR-CLIP	23446348
MIRT524024	hsa-miR-23a-3p	PAR-CLIP	23446348
MIRT524023	hsa-miR-23b-3p	PAR-CLIP	23446348
MIRT524022	hsa-miR-23c	PAR-CLIP	23446348
MIRT524021	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT942860	hsa-miR-1256	CLIP-seq
MIRT942861	hsa-miR-1283	CLIP-seq
MIRT942862	hsa-miR-132	CLIP-seq
MIRT942863	hsa-miR-141	CLIP-seq
MIRT942864	hsa-miR-144	CLIP-seq
MIRT942865	hsa-miR-200a	CLIP-seq
MIRT942866	hsa-miR-200b	CLIP-seq
MIRT942867	hsa-miR-200c	CLIP-seq
MIRT942868	hsa-miR-212	CLIP-seq
MIRT942869	hsa-miR-299-3p	CLIP-seq
MIRT942870	hsa-miR-324-5p	CLIP-seq
MIRT942871	hsa-miR-335	CLIP-seq
MIRT942872	hsa-miR-374a	CLIP-seq
MIRT942873	hsa-miR-374b	CLIP-seq
MIRT942874	hsa-miR-374c	CLIP-seq
MIRT942875	hsa-miR-377	CLIP-seq
MIRT942876	hsa-miR-4265	CLIP-seq
MIRT942877	hsa-miR-429	CLIP-seq
MIRT942878	hsa-miR-4296	CLIP-seq
MIRT942879	hsa-miR-4310	CLIP-seq
MIRT942880	hsa-miR-4322	CLIP-seq
MIRT942881	hsa-miR-4417	CLIP-seq
MIRT942882	hsa-miR-4668-5p	CLIP-seq
MIRT942883	hsa-miR-4720-5p	CLIP-seq
MIRT942884	hsa-miR-4775	CLIP-seq
MIRT942885	hsa-miR-4799-3p	CLIP-seq
MIRT942886	hsa-miR-5096	CLIP-seq
MIRT942887	hsa-miR-583	CLIP-seq
MIRT942888	hsa-miR-655	CLIP-seq
MIRT1921209	hsa-miR-412	CLIP-seq
MIRT1979193	hsa-miR-101	CLIP-seq
MIRT942864	hsa-miR-144	CLIP-seq
MIRT1979194	hsa-miR-3065-5p	CLIP-seq
MIRT1979195	hsa-miR-3123	CLIP-seq
MIRT1979196	hsa-miR-3935	CLIP-seq
MIRT942879	hsa-miR-4310	CLIP-seq
MIRT1979197	hsa-miR-4762-5p	CLIP-seq
MIRT1979198	hsa-miR-505	CLIP-seq
MIRT1979199	hsa-miR-936	CLIP-seq
MIRT2214279	hsa-miR-1286	CLIP-seq
MIRT2214280	hsa-miR-1297	CLIP-seq
MIRT2214281	hsa-miR-15a	CLIP-seq
MIRT2214282	hsa-miR-15b	CLIP-seq
MIRT2214283	hsa-miR-16	CLIP-seq
MIRT2214284	hsa-miR-195	CLIP-seq
MIRT2214285	hsa-miR-2113	CLIP-seq
MIRT2214286	hsa-miR-214	CLIP-seq
MIRT2214287	hsa-miR-26a	CLIP-seq
MIRT2214288	hsa-miR-26b	CLIP-seq
MIRT1979194	hsa-miR-3065-5p	CLIP-seq
MIRT2214289	hsa-miR-30a	CLIP-seq
MIRT2214290	hsa-miR-30b	CLIP-seq
MIRT2214291	hsa-miR-30c	CLIP-seq
MIRT2214292	hsa-miR-30d	CLIP-seq
MIRT2214293	hsa-miR-30e	CLIP-seq
MIRT1979195	hsa-miR-3123	CLIP-seq
MIRT2214294	hsa-miR-3169	CLIP-seq
MIRT2214295	hsa-miR-3619-5p	CLIP-seq
MIRT942875	hsa-miR-377	CLIP-seq
MIRT2214296	hsa-miR-3944-5p	CLIP-seq
MIRT2214297	hsa-miR-424	CLIP-seq
MIRT2214298	hsa-miR-4291	CLIP-seq
MIRT2214299	hsa-miR-4465	CLIP-seq
MIRT2214300	hsa-miR-4680-5p	CLIP-seq
MIRT2214301	hsa-miR-4714-5p	CLIP-seq
MIRT2214302	hsa-miR-4722-5p	CLIP-seq
MIRT2214303	hsa-miR-4729	CLIP-seq
MIRT2214304	hsa-miR-4740-5p	CLIP-seq
MIRT2214305	hsa-miR-487a	CLIP-seq
MIRT2214306	hsa-miR-497	CLIP-seq
MIRT2214307	hsa-miR-509-3p	CLIP-seq
MIRT2214308	hsa-miR-548ac	CLIP-seq
MIRT2214309	hsa-miR-548ae	CLIP-seq
MIRT2214310	hsa-miR-548aj	CLIP-seq
MIRT2214311	hsa-miR-548am	CLIP-seq
MIRT2214312	hsa-miR-548d-3p	CLIP-seq
MIRT2214313	hsa-miR-548x	CLIP-seq
MIRT2214314	hsa-miR-548z	CLIP-seq
MIRT2214315	hsa-miR-587	CLIP-seq
MIRT2214316	hsa-miR-761	CLIP-seq
MIRT2214317	hsa-miR-922	CLIP-seq
MIRT942860	hsa-miR-1256	CLIP-seq
MIRT942861	hsa-miR-1283	CLIP-seq
MIRT942869	hsa-miR-299-3p	CLIP-seq
MIRT942870	hsa-miR-324-5p	CLIP-seq
MIRT2518631	hsa-miR-3684	CLIP-seq
MIRT942876	hsa-miR-4265	CLIP-seq
MIRT2518632	hsa-miR-4272	CLIP-seq
MIRT942878	hsa-miR-4296	CLIP-seq
MIRT2518633	hsa-miR-4305	CLIP-seq
MIRT942880	hsa-miR-4322	CLIP-seq
MIRT942881	hsa-miR-4417	CLIP-seq
MIRT2518634	hsa-miR-4426	CLIP-seq
MIRT2518635	hsa-miR-4647	CLIP-seq
MIRT2518636	hsa-miR-4662b	CLIP-seq
MIRT2518637	hsa-miR-4684-3p	CLIP-seq
MIRT942883	hsa-miR-4720-5p	CLIP-seq
MIRT2518638	hsa-miR-4781-3p	CLIP-seq
MIRT942885	hsa-miR-4799-3p	CLIP-seq
MIRT2518639	hsa-miR-4803	CLIP-seq
MIRT2518640	hsa-miR-498	CLIP-seq
MIRT942860	hsa-miR-1256	CLIP-seq
MIRT942870	hsa-miR-324-5p	CLIP-seq
MIRT2518633	hsa-miR-4305	CLIP-seq
MIRT942883	hsa-miR-4720-5p	CLIP-seq
MIRT942885	hsa-miR-4799-3p	CLIP-seq

Show/Hide all (36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	16464467
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	16464467, 20679435, 21706016, 21988832, 31980649, 33961781, 34819669
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IDA	20679435
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0016020	Component	Membrane	IDA	20679435
GO:0016020	Component	Membrane	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0030165	Function	PDZ domain binding	IPI	16464467
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	20679435
GO:0031267	Function	Small GTPase binding	IBA
GO:0031267	Function	Small GTPase binding	IDA	16464467
GO:0032420	Component	Stereocilium	IEA
GO:0032420	Component	Stereocilium	ISS	16464467
GO:0032421	Component	Stereocilium bundle	IEA
GO:0032421	Component	Stereocilium bundle	ISS	16464467
GO:0042995	Component	Cell projection	IEA
GO:0043226	Component	Organelle	IEA
GO:0060326	Process	Cell chemotaxis	IBA
GO:0060326	Process	Cell chemotaxis	IMP	20679435
GO:0098794	Component	Postsynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0150052	Process	Regulation of postsynapse assembly	IEA
GO:1904694	Process	Negative regulation of vascular associated smooth muscle contraction	IMP	22158624
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IMP	22158624

MIM	HGNC	e!Ensembl
607679	19192	ENSG00000128512

Q8N1I0

Protein name

Dedicator of cytokinesis protein 4

Protein function

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (PubMed:12628187, PubMed:16464467). Involved in regulation of adherens

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07653	SH3_2	10 → 64	Variant SH3 domain	Domain
PF16172	DOCK_N	69 → 392	DOCK N-terminus	Family
PF14429	DOCK-C2	397 → 583	C2 domain in Dock180 and Zizimin proteins	Domain
PF06920	DHR-2	1092 → 1588	Dock homology region 2	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. {ECO:0000269|PubMed:12628187}.; TISSUE SPECIFICITY: [Isoform 2]: May be specifically expressed in the brain and eye. {ECO:0000269|PubMed:16464467}.

Sequence

MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSS
YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMN
EILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITEL
YRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLR
LNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRP
FGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVS
LQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSV
ARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKF
RGAHIRFEFRHCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTT
RYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGC
LSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPV
MDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFS
LATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDV
REVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHI
HLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPS
SSAMRFQFQDVTGEFVACLLSLLRQMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIR
PEMFPKDWTVMRLVANNVIITTVLYLSDALRKNFLNENFDYKIWDSYFYLAVIFINQLCL
QLEMFTPSKKKKVLEKYGDMRVTMGCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPD
LRNVMIPIFHDMMDWEQRRSGNFKQVEAKLIDKLDSLMSEGKGDETYRELFNSILLKKIE
RETWRESGVSLIATVTRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYI
RYIHKLYDLHLKAQNFTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTII
QNFDRGKCWENGIILCRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVG
FYGKKFPFFLRNKEFVCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYL
QIYAVTPIPESQEVLQREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVER
TSLYLVQSLPGISRWFEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINP
LTMCLNGVIDAAVNGGVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAV
HEKFVPQDMRPLHKKLVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVS
PDGTRVIPRRSPLSYPAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLS
STHSASPNVTSSAPSSARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFN
HIGDGALPRSDPNLSAPEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASP
ARHTTSVSPSPAGRSPLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTS
ETSGFENQVNEQSAPLPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPVPLPHSL
SIPVTSEPPALPPKPLAARSSHLENGARRTDPGPRPRPLPRKVSQL

Sequence length

1966

Interactions

View interactions

	KEGG		Reactome
	Rap1 signaling pathway		Factors involved in megakaryocyte development and platelet production

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodevelopmental disorder	Likely pathogenic	rs2536798545, rs2536768544, rs1799458667	RCV003388865 RCV003388866 RCV003388867	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHROMOSOMAL DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DOCK4-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POST-TRAUMATIC STRESS DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (40)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	25644601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	31019307		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asperger Syndrome	Asperger syndrome	Pubtator	26176695	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	31019307		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorder	Autism	Pubtator	33660564	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	31388105		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	BEFREE	15128462, 19401682, 20346443, 23720743, 24599690		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	CTD_human_DG	19401682		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autistic Disorder	Autism	Pubtator	19401682, 20346443, 24518835, 24599690, 36150388	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	25944848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bone Marrow Failure Disorders	Bone marrow failure syndromes	Pubtator	21532034	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	30426503		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	30426503	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	19383911		★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	33660564	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental reading disorder	Developmental dyslexia	BEFREE	26184631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	BEFREE	20346443, 23720743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyslexia	Dyslexia	Pubtator	20346443	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28925399		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28925399		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	23979775		★★★★★ ★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASCAT_DG	25944848		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	30426503		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	12628187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	12628187		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	21532034, 26578796, 31308061		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	21532034	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	31308061	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	19147528	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	34432380	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23979775, 25644601		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	23720743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	12628187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancytopenia	Pancytopenia	BEFREE	21532034		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdoid Tumor	Rhabdoid tumor	Pubtator	20212451	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	21682944, 23720743		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	21682944, 23720743		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	GWASCAT_DG	25944848		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Unipolar Depression	Mental Depression	GWASCAT_DG	25944848		★★★★★ ★☆☆☆☆ Found in Text Mining only

DOCK4 (dedicator of cytokinesis 4)