ECE2 (endothelin converting enzyme 2)

Gene

• Entrez ID: 9718
• Gene name: Endothelin converting enzyme 2
• Gene symbol: ECE2
• Synonyms (NCBI Gene): EEF1AKMT4
• Chromosome: 3
• Chromosome location: 3q27.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023101	hsa-miR-124-3p	Microarray	18668037
MIRT951612	hsa-miR-1207-5p	CLIP-seq
MIRT951613	hsa-miR-128	CLIP-seq
MIRT951614	hsa-miR-1287	CLIP-seq
MIRT951615	hsa-miR-15a	CLIP-seq
MIRT951616	hsa-miR-15b	CLIP-seq
MIRT951617	hsa-miR-16	CLIP-seq
MIRT951618	hsa-miR-1827	CLIP-seq
MIRT951619	hsa-miR-1909	CLIP-seq
MIRT951620	hsa-miR-195	CLIP-seq
MIRT951621	hsa-miR-214	CLIP-seq
MIRT951622	hsa-miR-27a	CLIP-seq
MIRT951623	hsa-miR-27b	CLIP-seq
MIRT951624	hsa-miR-3135b	CLIP-seq
MIRT951625	hsa-miR-3151	CLIP-seq
MIRT951626	hsa-miR-3192	CLIP-seq
MIRT951627	hsa-miR-3194-3p	CLIP-seq
MIRT951628	hsa-miR-3612	CLIP-seq
MIRT951629	hsa-miR-3619-5p	CLIP-seq
MIRT951630	hsa-miR-3974	CLIP-seq
MIRT951631	hsa-miR-424	CLIP-seq
MIRT951632	hsa-miR-4283	CLIP-seq
MIRT951633	hsa-miR-4291	CLIP-seq
MIRT951634	hsa-miR-4300	CLIP-seq
MIRT951635	hsa-miR-4443	CLIP-seq
MIRT951636	hsa-miR-4519	CLIP-seq
MIRT951637	hsa-miR-4650-5p	CLIP-seq
MIRT951638	hsa-miR-4688	CLIP-seq
MIRT951639	hsa-miR-4763-3p	CLIP-seq
MIRT951640	hsa-miR-493	CLIP-seq
MIRT951641	hsa-miR-497	CLIP-seq
MIRT951642	hsa-miR-650	CLIP-seq
MIRT951643	hsa-miR-760	CLIP-seq
MIRT951644	hsa-miR-761	CLIP-seq
MIRT951645	hsa-miR-920	CLIP-seq
MIRT951646	hsa-miR-922	CLIP-seq
MIRT951647	hsa-miR-940	CLIP-seq
MIRT951648	hsa-miR-1206	CLIP-seq
MIRT951649	hsa-miR-1587	CLIP-seq
MIRT951650	hsa-miR-1915	CLIP-seq
MIRT951651	hsa-miR-299-3p	CLIP-seq
MIRT951652	hsa-miR-3150b-3p	CLIP-seq
MIRT951653	hsa-miR-3607-5p	CLIP-seq
MIRT951654	hsa-miR-4492	CLIP-seq
MIRT951655	hsa-miR-4498	CLIP-seq
MIRT951656	hsa-miR-4656	CLIP-seq
MIRT951657	hsa-miR-4675	CLIP-seq
MIRT951658	hsa-miR-4685-5p	CLIP-seq
MIRT951659	hsa-miR-4689	CLIP-seq
MIRT951660	hsa-miR-4741	CLIP-seq
MIRT951661	hsa-miR-4742-3p	CLIP-seq
MIRT951662	hsa-miR-4784	CLIP-seq
MIRT951663	hsa-miR-544b	CLIP-seq
MIRT951664	hsa-miR-659	CLIP-seq
MIRT951665	hsa-miR-762	CLIP-seq
MIRT951613	hsa-miR-128	CLIP-seq
MIRT1981837	hsa-miR-2467-3p	CLIP-seq
MIRT951622	hsa-miR-27a	CLIP-seq
MIRT951623	hsa-miR-27b	CLIP-seq
MIRT1981838	hsa-miR-330-3p	CLIP-seq
MIRT951637	hsa-miR-4650-5p	CLIP-seq
MIRT1981837	hsa-miR-2467-3p	CLIP-seq
MIRT1981838	hsa-miR-330-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	ISS
GO:0003824	Function	Catalytic activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	11718899
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007267	Process	Cell-cell signaling	TAS	11718899
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0016485	Process	Protein processing	IBA
GO:0016486	Process	Peptide hormone processing	IDA	11718899
GO:0016486	Process	Peptide hormone processing	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030658	Component	Transport vesicle membrane	ISS
GO:0030658	Component	Transport vesicle membrane	TAS
GO:0030659	Component	Cytoplasmic vesicle membrane	IDA	11718899
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032259	Process	Methylation	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 610145
• HGNC: 13275
• e!Ensembl: ENSG00000145194

Interactions View interactions

Pathways

Reactome:

Peptide ligand-binding receptors

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMERS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EDEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations