FAM131B (family with sequence similarity 131 member B)

Gene

• Entrez ID: 9715
• Gene name: Family with sequence similarity 131 member B
• Gene symbol: FAM131B
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q34

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT716308	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT716307	hsa-miR-4530	HITS-CLIP	19536157
MIRT716306	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT716305	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT716304	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT716303	hsa-miR-3137	HITS-CLIP	19536157
MIRT716302	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT716301	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT452837	hsa-miR-3714	PAR-CLIP	23592263
MIRT452836	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT452835	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT452834	hsa-miR-940	PAR-CLIP	23592263
MIRT452833	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT452832	hsa-miR-764	PAR-CLIP	23592263
MIRT452831	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT452830	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT452829	hsa-miR-6132	PAR-CLIP	23592263
MIRT452827	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT452828	hsa-miR-4533	PAR-CLIP	23592263
MIRT452826	hsa-miR-3202	PAR-CLIP	23592263
MIRT452825	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT452824	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT452823	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT452822	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT452821	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT716308	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT716307	hsa-miR-4530	HITS-CLIP	19536157
MIRT716306	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT716305	hsa-miR-766-3p	HITS-CLIP	19536157
MIRT716304	hsa-miR-3925-3p	HITS-CLIP	19536157
MIRT716303	hsa-miR-3137	HITS-CLIP	19536157
MIRT716302	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT716301	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT452837	hsa-miR-3714	PAR-CLIP	23592263
MIRT452836	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT452835	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT452834	hsa-miR-940	PAR-CLIP	23592263
MIRT452833	hsa-miR-125a-3p	PAR-CLIP	23592263
MIRT452832	hsa-miR-764	PAR-CLIP	23592263
MIRT452831	hsa-miR-3934-5p	PAR-CLIP	23592263
MIRT452830	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT452829	hsa-miR-6132	PAR-CLIP	23592263
MIRT452827	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT452828	hsa-miR-4533	PAR-CLIP	23592263
MIRT452826	hsa-miR-3202	PAR-CLIP	23592263
MIRT452825	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT452824	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT452823	hsa-miR-3190-3p	PAR-CLIP	23592263
MIRT452822	hsa-miR-1233-5p	PAR-CLIP	23592263
MIRT452821	hsa-miR-6778-5p	PAR-CLIP	23592263
MIRT980000	hsa-miR-1255a	CLIP-seq
MIRT980001	hsa-miR-1255b	CLIP-seq
MIRT980002	hsa-miR-1268	CLIP-seq
MIRT980003	hsa-miR-1268b	CLIP-seq
MIRT980004	hsa-miR-139-3p	CLIP-seq
MIRT980005	hsa-miR-3605-5p	CLIP-seq
MIRT980006	hsa-miR-3915	CLIP-seq
MIRT980007	hsa-miR-3928	CLIP-seq
MIRT980008	hsa-miR-4428	CLIP-seq
MIRT980009	hsa-miR-1227	CLIP-seq
MIRT980010	hsa-miR-1827	CLIP-seq
MIRT980011	hsa-miR-1914	CLIP-seq
MIRT980012	hsa-miR-2861	CLIP-seq
MIRT980013	hsa-miR-3150a-3p	CLIP-seq
MIRT980014	hsa-miR-3153	CLIP-seq
MIRT980015	hsa-miR-3173-3p	CLIP-seq
MIRT980016	hsa-miR-3175	CLIP-seq
MIRT980017	hsa-miR-3189-3p	CLIP-seq
MIRT980018	hsa-miR-3661	CLIP-seq
MIRT980019	hsa-miR-370	CLIP-seq
MIRT980020	hsa-miR-3914	CLIP-seq
MIRT980006	hsa-miR-3915	CLIP-seq
MIRT980007	hsa-miR-3928	CLIP-seq
MIRT980021	hsa-miR-4434	CLIP-seq
MIRT980022	hsa-miR-4446-3p	CLIP-seq
MIRT980023	hsa-miR-4480	CLIP-seq
MIRT980024	hsa-miR-4492	CLIP-seq
MIRT980025	hsa-miR-4498	CLIP-seq
MIRT980026	hsa-miR-4505	CLIP-seq
MIRT980027	hsa-miR-4516	CLIP-seq
MIRT980028	hsa-miR-4649-3p	CLIP-seq
MIRT980029	hsa-miR-4663	CLIP-seq
MIRT980030	hsa-miR-4667-5p	CLIP-seq
MIRT980031	hsa-miR-4668-5p	CLIP-seq
MIRT980032	hsa-miR-4680-5p	CLIP-seq
MIRT980033	hsa-miR-4700-5p	CLIP-seq
MIRT980034	hsa-miR-4710	CLIP-seq
MIRT980035	hsa-miR-4731-5p	CLIP-seq
MIRT980036	hsa-miR-4747-5p	CLIP-seq
MIRT980037	hsa-miR-4764-3p	CLIP-seq
MIRT980038	hsa-miR-502-5p	CLIP-seq
MIRT980039	hsa-miR-516a-3p	CLIP-seq
MIRT980040	hsa-miR-631	CLIP-seq
MIRT980041	hsa-miR-762	CLIP-seq
MIRT980042	hsa-miR-939	CLIP-seq
MIRT1990350	hsa-miR-1254	CLIP-seq
MIRT1990351	hsa-miR-2277-3p	CLIP-seq
MIRT1990352	hsa-miR-3064-5p	CLIP-seq
MIRT1990353	hsa-miR-3116	CLIP-seq
MIRT1990354	hsa-miR-3126-5p	CLIP-seq
MIRT1990355	hsa-miR-4419a	CLIP-seq
MIRT1990356	hsa-miR-4510	CLIP-seq
MIRT1990357	hsa-miR-542-3p	CLIP-seq
MIRT1990358	hsa-miR-661	CLIP-seq
MIRT2224560	hsa-miR-1203	CLIP-seq
MIRT2224561	hsa-miR-3155	CLIP-seq
MIRT2224562	hsa-miR-3155b	CLIP-seq
MIRT2224563	hsa-miR-484	CLIP-seq
MIRT2387723	hsa-miR-34a	CLIP-seq
MIRT2387724	hsa-miR-34c-5p	CLIP-seq
MIRT2387725	hsa-miR-449a	CLIP-seq
MIRT2387726	hsa-miR-449b	CLIP-seq
MIRT2528204	hsa-miR-1343	CLIP-seq
MIRT2528205	hsa-miR-2355-5p	CLIP-seq
MIRT980015	hsa-miR-3173-3p	CLIP-seq
MIRT2528206	hsa-miR-320a	CLIP-seq
MIRT2528207	hsa-miR-320b	CLIP-seq
MIRT2528208	hsa-miR-320c	CLIP-seq
MIRT2528209	hsa-miR-320d	CLIP-seq
MIRT980007	hsa-miR-3928	CLIP-seq
MIRT2528210	hsa-miR-409-3p	CLIP-seq
MIRT2528211	hsa-miR-4429	CLIP-seq
MIRT2528212	hsa-miR-671-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21044950
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS

Other IDs

• MIM: 619282
• HGNC: 22202
• e!Ensembl: ENSG00000159784

Protein

• UniProt ID: Q86XD5
• Protein name: Protein FAM131B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15010	FAM131	33 → 325	Putative cell signalling	Family

• Sequence:

  MDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSF
  SGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKTPAVQPQHSHESVRRDTDAYSDLSDGE
  KEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNYQELMDSQDALAQ
  APMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHEMGPSQP
  ASGYSALEPPPLLGGDTDWAPGVGAVDLARGPAEEEKRPLAPEEEEDAGCRDLESLSPRE
  DPEMSTALSRKVSDVTSSGVQSFDEEEGEANN

• Sequence length: 332

Pathways

Reactome:

Signaling by BRAF and RAF fusions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BECKER GENERALIZED MYOTONIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Astrocytoma	Astrocytoma	Pubtator	25040262	Associate	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	28597942		★☆☆☆☆ Found in Text Mining only
Dysembryoplastic neuroepithelial tumor	Dysembryoplastic Neuroepithelial Tumor	BEFREE	24767714, 25040262		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25040262	Associate	★☆☆☆☆ Found in Text Mining only
Pilocytic Astrocytoma	Astrocytoma	BEFREE	21424530, 25040262		★☆☆☆☆ Found in Text Mining only