ACYP1 (acylphosphatase 1)

Gene

• Entrez ID: 97
• Gene name: Acylphosphatase 1
• Gene symbol: ACYP1
• Synonyms (NCBI Gene): ACYPE
• Chromosome: 14
• Chromosome location: 14q24.3
• Summary: This gene is a member of the acylphosphatase family. The encoded protein is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated and described based on their tissue loca

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT441265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT728392	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT728393	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT728391	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT728390	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT441265	hsa-miR-374a-5p	HITS-CLIP	22473208
MIRT765698	hsa-miR-155	CLIP-seq
MIRT2167004	hsa-miR-181a	CLIP-seq
MIRT2167005	hsa-miR-181b	CLIP-seq
MIRT2167006	hsa-miR-181c	CLIP-seq
MIRT2167007	hsa-miR-181d	CLIP-seq
MIRT2167008	hsa-miR-3143	CLIP-seq
MIRT2167009	hsa-miR-3667-3p	CLIP-seq
MIRT2167010	hsa-miR-369-3p	CLIP-seq
MIRT2167011	hsa-miR-374a	CLIP-seq
MIRT2167012	hsa-miR-374b	CLIP-seq
MIRT2167013	hsa-miR-410	CLIP-seq
MIRT2167014	hsa-miR-4262	CLIP-seq
MIRT2167015	hsa-miR-485-3p	CLIP-seq
MIRT2167016	hsa-miR-487a	CLIP-seq
MIRT2167017	hsa-miR-500a	CLIP-seq
MIRT2167018	hsa-miR-543	CLIP-seq
MIRT2167019	hsa-miR-552	CLIP-seq
MIRT765698	hsa-miR-155	CLIP-seq
MIRT2469497	hsa-miR-3168	CLIP-seq
MIRT2469498	hsa-miR-3675-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003998	Function	Acylphosphatase activity	IBA
GO:0003998	Function	Acylphosphatase activity	IEA
GO:0003998	Function	Acylphosphatase activity	TAS	7796909
GO:0006796	Process	Phosphate-containing compound metabolic process	TAS	3026468
GO:0016787	Function	Hydrolase activity	IEA

Other IDs

• MIM: 600875
• HGNC: 179
• e!Ensembl: ENSG00000119640

Protein

• UniProt ID: P07311
• Protein name: Acylphosphatase-1 (EC 3.6.1.7) (Acylphosphatase, erythrocyte isozyme) (Acylphosphatase, organ-common type isozyme) (Acylphosphate phosphohydrolase 1)
• PDB: 2K7J, 2K7K, 2VH7, 2W4C, 2W4P, 3TOQ, 6CBU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00708	Acylphosphatase	10 → 97	Acylphosphatase	Domain

• Tissue specificity: TISSUE SPECIFICITY: Organ-common type isozyme is found in many different tissues.
• Sequence:

  MAEGNTLISVDYEIFGKVQGVFFRKHTQAEGKKLGLVGWVQNTDRGTVQGQLQGPISKVR
  HMQEWLETRGSPKSHIDKANFNNEKVILKLDYSDFQIVK

• Sequence length: 99

Pathways

KEGG:

Pyruvate metabolism
Metabolic pathways

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRAIN ATROPHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLOBAL DEVELOPMENTAL DELAY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIEMANN-PICK DISEASE, TYPE C1	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NIEMANN-PICK DISEASE, TYPE C2	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	33188160	Associate	★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	Pubtator	30103756	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	35886020	Associate	★☆☆☆☆ Found in Text Mining only