Gene Gene information from NCBI Gene database.
Entrez ID 9686
Gene name Vestigial like family member 4
Gene symbol VGLL4
Synonyms (NCBI Gene)
VGL-4
Chromosome 3
Chromosome location 3p25.3-p25.2
miRNA miRNA information provided by mirtarbase database.
824
miRTarBase ID miRNA Experiments Reference
MIRT019746 hsa-miR-375 Microarray 20215506
MIRT052473 hsa-let-7a-5p CLASH 23622248
MIRT051646 hsa-let-7e-5p CLASH 23622248
MIRT438320 hsa-miR-222-3p ChIP-seqImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 26045994
MIRT438320 hsa-miR-222-3p ChIP-seqImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot 26045994
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0001223 Function Transcription coactivator binding IBA
GO:0005515 Function Protein binding IPI 21044950, 24525233, 28051067, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
GO:0006355 Process Regulation of DNA-templated transcription IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618692 28966 ENSG00000144560
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14135
Protein name Transcription cofactor vestigial-like protein 4 (Vgl-4)
Protein function May act as a specific coactivator for the mammalian TEFs.
PDB 8YTF
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF15245 VGLL4 4 224 Transcription cofactor vestigial-like protein 4 Family
Sequence
Sequence length 290
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alopecia Alopecia GWASCAT_DG 28196072
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 33456372 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 28733631
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 30760814, 36606584 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 29950605, 32323824 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 24458094, 30034932
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Squamous cell carcinoma Pubtator 34004031 Inhibit
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular disease Pubtator 33456372 Associate
★☆☆☆☆
Found in Text Mining only
Chronic Obstructive Airway Disease Chronic Obstructive Pulmonary Disease GWASCAT_DG 30804561
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 28051067
★☆☆☆☆
Found in Text Mining only