Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9685
Gene name	Clathrin interactor 1
Gene symbol	CLINT1
Synonyms (NCBI Gene)	CLINTENTHEPN4EPNR
Chromosome	5
Chromosome location	5q33.3
Summary	This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated ve

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Show/Hide all (226)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000678	hsa-miR-145-5p	qRT-PCRLuciferase reporter assayMicroarray	19915607
MIRT020844	hsa-miR-155-5p	Proteomics	18668040
MIRT000678	hsa-miR-145-5p	Reporter assay;Other	19915607
MIRT027639	hsa-miR-98-5p	Microarray	19088304
MIRT029629	hsa-miR-26b-5p	Microarray	19088304
MIRT052154	hsa-let-7b-5p	CLASH	23622248
MIRT052154	hsa-let-7b-5p	CLASH	23622248
MIRT440935	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT440935	ebv-miR-BART10-3p	HITS-CLIP	22473208
MIRT896411	hsa-miR-1298	CLIP-seq
MIRT896412	hsa-miR-3150a-3p	CLIP-seq
MIRT896413	hsa-miR-3175	CLIP-seq
MIRT896414	hsa-miR-4686	CLIP-seq
MIRT896415	hsa-miR-548c-3p	CLIP-seq
MIRT896416	hsa-miR-939	CLIP-seq
MIRT896417	hsa-miR-1252	CLIP-seq
MIRT896418	hsa-miR-1276	CLIP-seq
MIRT896419	hsa-miR-1305	CLIP-seq
MIRT896420	hsa-miR-3121-5p	CLIP-seq
MIRT896421	hsa-miR-3140-3p	CLIP-seq
MIRT896412	hsa-miR-3150a-3p	CLIP-seq
MIRT896422	hsa-miR-3163	CLIP-seq
MIRT896413	hsa-miR-3175	CLIP-seq
MIRT896423	hsa-miR-338-5p	CLIP-seq
MIRT896424	hsa-miR-340	CLIP-seq
MIRT896425	hsa-miR-34b	CLIP-seq
MIRT896426	hsa-miR-3646	CLIP-seq
MIRT896427	hsa-miR-3668	CLIP-seq
MIRT896428	hsa-miR-3924	CLIP-seq
MIRT896429	hsa-miR-3935	CLIP-seq
MIRT896430	hsa-miR-3938	CLIP-seq
MIRT896431	hsa-miR-421	CLIP-seq
MIRT896432	hsa-miR-4311	CLIP-seq
MIRT896433	hsa-miR-432	CLIP-seq
MIRT896434	hsa-miR-4520a-3p	CLIP-seq
MIRT896435	hsa-miR-4520b-3p	CLIP-seq
MIRT896436	hsa-miR-4533	CLIP-seq
MIRT896437	hsa-miR-4662a-5p	CLIP-seq
MIRT896438	hsa-miR-4720-3p	CLIP-seq
MIRT896439	hsa-miR-4775	CLIP-seq
MIRT896440	hsa-miR-4803	CLIP-seq
MIRT896441	hsa-miR-4804-3p	CLIP-seq
MIRT896442	hsa-miR-495	CLIP-seq
MIRT896443	hsa-miR-548ac	CLIP-seq
MIRT896444	hsa-miR-548ae	CLIP-seq
MIRT896445	hsa-miR-548aj	CLIP-seq
MIRT896446	hsa-miR-548am	CLIP-seq
MIRT896447	hsa-miR-548d-3p	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT896449	hsa-miR-548x	CLIP-seq
MIRT896450	hsa-miR-548z	CLIP-seq
MIRT896451	hsa-miR-578	CLIP-seq
MIRT896452	hsa-miR-583	CLIP-seq
MIRT896453	hsa-miR-616	CLIP-seq
MIRT896454	hsa-miR-659	CLIP-seq
MIRT896455	hsa-miR-671-5p	CLIP-seq
MIRT896416	hsa-miR-939	CLIP-seq
MIRT1965786	hsa-miR-1260	CLIP-seq
MIRT1965787	hsa-miR-1260b	CLIP-seq
MIRT1965788	hsa-miR-145	CLIP-seq
MIRT1965789	hsa-miR-155	CLIP-seq
MIRT1965790	hsa-miR-188-3p	CLIP-seq
MIRT1965791	hsa-miR-298	CLIP-seq
MIRT1965792	hsa-miR-302a	CLIP-seq
MIRT1965793	hsa-miR-302b	CLIP-seq
MIRT1965794	hsa-miR-302c	CLIP-seq
MIRT1965795	hsa-miR-302d	CLIP-seq
MIRT1965796	hsa-miR-302e	CLIP-seq
MIRT1965797	hsa-miR-3120-3p	CLIP-seq
MIRT1965798	hsa-miR-3136-5p	CLIP-seq
MIRT1965799	hsa-miR-3156-3p	CLIP-seq
MIRT1965800	hsa-miR-3157-5p	CLIP-seq
MIRT1965801	hsa-miR-3161	CLIP-seq
MIRT1965802	hsa-miR-3616-5p	CLIP-seq
MIRT1965803	hsa-miR-3647-5p	CLIP-seq
MIRT1965804	hsa-miR-372	CLIP-seq
MIRT1965805	hsa-miR-373	CLIP-seq
MIRT1965806	hsa-miR-4439	CLIP-seq
MIRT1965807	hsa-miR-4484	CLIP-seq
MIRT1965808	hsa-miR-4690-3p	CLIP-seq
MIRT1965809	hsa-miR-4694-3p	CLIP-seq
MIRT1965810	hsa-miR-4719	CLIP-seq
MIRT1965811	hsa-miR-4728-3p	CLIP-seq
MIRT1965812	hsa-miR-4795-5p	CLIP-seq
MIRT1965813	hsa-miR-520a-3p	CLIP-seq
MIRT1965814	hsa-miR-520b	CLIP-seq
MIRT1965815	hsa-miR-520c-3p	CLIP-seq
MIRT1965816	hsa-miR-520d-3p	CLIP-seq
MIRT1965817	hsa-miR-520e	CLIP-seq
MIRT1965818	hsa-miR-522	CLIP-seq
MIRT1965819	hsa-miR-548an	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT1965820	hsa-miR-573	CLIP-seq
MIRT1965821	hsa-miR-922	CLIP-seq
MIRT1965822	hsa-miR-943	CLIP-seq
MIRT1965788	hsa-miR-145	CLIP-seq
MIRT896425	hsa-miR-34b	CLIP-seq
MIRT1965788	hsa-miR-145	CLIP-seq
MIRT2201728	hsa-miR-3130-3p	CLIP-seq
MIRT2201729	hsa-miR-4793-3p	CLIP-seq
MIRT896415	hsa-miR-548c-3p	CLIP-seq
MIRT2427366	hsa-miR-221	CLIP-seq
MIRT2427367	hsa-miR-222	CLIP-seq
MIRT896423	hsa-miR-338-5p	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT2427368	hsa-miR-552	CLIP-seq
MIRT2427366	hsa-miR-221	CLIP-seq
MIRT2427367	hsa-miR-222	CLIP-seq
MIRT896423	hsa-miR-338-5p	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT2427368	hsa-miR-552	CLIP-seq
MIRT2504652	hsa-miR-1183	CLIP-seq
MIRT2504653	hsa-miR-1243	CLIP-seq
MIRT2504654	hsa-miR-1254	CLIP-seq
MIRT2504655	hsa-miR-1279	CLIP-seq
MIRT2504656	hsa-miR-1291	CLIP-seq
MIRT2504657	hsa-miR-1323	CLIP-seq
MIRT2504658	hsa-miR-137	CLIP-seq
MIRT1965789	hsa-miR-155	CLIP-seq
MIRT2504659	hsa-miR-200b	CLIP-seq
MIRT2504660	hsa-miR-200c	CLIP-seq
MIRT2427366	hsa-miR-221	CLIP-seq
MIRT2427367	hsa-miR-222	CLIP-seq
MIRT1965792	hsa-miR-302a	CLIP-seq
MIRT1965793	hsa-miR-302b	CLIP-seq
MIRT1965794	hsa-miR-302c	CLIP-seq
MIRT1965795	hsa-miR-302d	CLIP-seq
MIRT1965796	hsa-miR-302e	CLIP-seq
MIRT2504661	hsa-miR-3116	CLIP-seq
MIRT2504662	hsa-miR-3145-3p	CLIP-seq
MIRT1965801	hsa-miR-3161	CLIP-seq
MIRT896422	hsa-miR-3163	CLIP-seq
MIRT2504663	hsa-miR-3201	CLIP-seq
MIRT2504664	hsa-miR-328	CLIP-seq
MIRT896423	hsa-miR-338-5p	CLIP-seq
MIRT896424	hsa-miR-340	CLIP-seq
MIRT1965802	hsa-miR-3616-5p	CLIP-seq
MIRT1965803	hsa-miR-3647-5p	CLIP-seq
MIRT2504665	hsa-miR-3654	CLIP-seq
MIRT896427	hsa-miR-3668	CLIP-seq
MIRT2504666	hsa-miR-371b-5p	CLIP-seq
MIRT1965804	hsa-miR-372	CLIP-seq
MIRT1965805	hsa-miR-373	CLIP-seq
MIRT896428	hsa-miR-3924	CLIP-seq
MIRT896429	hsa-miR-3935	CLIP-seq
MIRT2504667	hsa-miR-429	CLIP-seq
MIRT2504668	hsa-miR-4528	CLIP-seq
MIRT2504669	hsa-miR-4639-5p	CLIP-seq
MIRT2504670	hsa-miR-4668-3p	CLIP-seq
MIRT2504671	hsa-miR-4703-3p	CLIP-seq
MIRT2504672	hsa-miR-4764-3p	CLIP-seq
MIRT2504673	hsa-miR-4766-5p	CLIP-seq
MIRT2504674	hsa-miR-4789-5p	CLIP-seq
MIRT2504675	hsa-miR-4791	CLIP-seq
MIRT1965812	hsa-miR-4795-5p	CLIP-seq
MIRT1965813	hsa-miR-520a-3p	CLIP-seq
MIRT1965814	hsa-miR-520b	CLIP-seq
MIRT1965815	hsa-miR-520c-3p	CLIP-seq
MIRT1965816	hsa-miR-520d-3p	CLIP-seq
MIRT1965817	hsa-miR-520e	CLIP-seq
MIRT2504676	hsa-miR-548aa	CLIP-seq
MIRT2504677	hsa-miR-548o	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT2427368	hsa-miR-552	CLIP-seq
MIRT2504678	hsa-miR-568	CLIP-seq
MIRT1965820	hsa-miR-573	CLIP-seq
MIRT896454	hsa-miR-659	CLIP-seq
MIRT2504679	hsa-miR-661	CLIP-seq
MIRT2504680	hsa-miR-888	CLIP-seq
MIRT2504652	hsa-miR-1183	CLIP-seq
MIRT2504653	hsa-miR-1243	CLIP-seq
MIRT2504654	hsa-miR-1254	CLIP-seq
MIRT2504655	hsa-miR-1279	CLIP-seq
MIRT2504656	hsa-miR-1291	CLIP-seq
MIRT2504657	hsa-miR-1323	CLIP-seq
MIRT2504658	hsa-miR-137	CLIP-seq
MIRT1965789	hsa-miR-155	CLIP-seq
MIRT2504659	hsa-miR-200b	CLIP-seq
MIRT2504660	hsa-miR-200c	CLIP-seq
MIRT2427366	hsa-miR-221	CLIP-seq
MIRT2427367	hsa-miR-222	CLIP-seq
MIRT1965792	hsa-miR-302a	CLIP-seq
MIRT1965793	hsa-miR-302b	CLIP-seq
MIRT1965794	hsa-miR-302c	CLIP-seq
MIRT1965795	hsa-miR-302d	CLIP-seq
MIRT1965796	hsa-miR-302e	CLIP-seq
MIRT2504661	hsa-miR-3116	CLIP-seq
MIRT2504662	hsa-miR-3145-3p	CLIP-seq
MIRT1965801	hsa-miR-3161	CLIP-seq
MIRT896422	hsa-miR-3163	CLIP-seq
MIRT2504663	hsa-miR-3201	CLIP-seq
MIRT2504664	hsa-miR-328	CLIP-seq
MIRT896423	hsa-miR-338-5p	CLIP-seq
MIRT896424	hsa-miR-340	CLIP-seq
MIRT1965802	hsa-miR-3616-5p	CLIP-seq
MIRT1965803	hsa-miR-3647-5p	CLIP-seq
MIRT2504665	hsa-miR-3654	CLIP-seq
MIRT896427	hsa-miR-3668	CLIP-seq
MIRT2504666	hsa-miR-371b-5p	CLIP-seq
MIRT1965804	hsa-miR-372	CLIP-seq
MIRT1965805	hsa-miR-373	CLIP-seq
MIRT896428	hsa-miR-3924	CLIP-seq
MIRT896429	hsa-miR-3935	CLIP-seq
MIRT2504667	hsa-miR-429	CLIP-seq
MIRT2504668	hsa-miR-4528	CLIP-seq
MIRT2504669	hsa-miR-4639-5p	CLIP-seq
MIRT2504670	hsa-miR-4668-3p	CLIP-seq
MIRT2504672	hsa-miR-4764-3p	CLIP-seq
MIRT2504673	hsa-miR-4766-5p	CLIP-seq
MIRT2504674	hsa-miR-4789-5p	CLIP-seq
MIRT2504675	hsa-miR-4791	CLIP-seq
MIRT1965812	hsa-miR-4795-5p	CLIP-seq
MIRT1965813	hsa-miR-520a-3p	CLIP-seq
MIRT1965814	hsa-miR-520b	CLIP-seq
MIRT1965815	hsa-miR-520c-3p	CLIP-seq
MIRT1965816	hsa-miR-520d-3p	CLIP-seq
MIRT1965817	hsa-miR-520e	CLIP-seq
MIRT2504676	hsa-miR-548aa	CLIP-seq
MIRT2504677	hsa-miR-548o	CLIP-seq
MIRT896448	hsa-miR-548v	CLIP-seq
MIRT2427368	hsa-miR-552	CLIP-seq
MIRT2504678	hsa-miR-568	CLIP-seq
MIRT1965820	hsa-miR-573	CLIP-seq
MIRT896454	hsa-miR-659	CLIP-seq
MIRT2504679	hsa-miR-661	CLIP-seq
MIRT2504680	hsa-miR-888	CLIP-seq

Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12429846, 14675752, 18033301, 20562859, 26871637, 32814053, 33961781, 35452674
GO:0005543	Function	Phospholipid binding	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005794	Component	Golgi apparatus	IDA	10942595
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030276	Function	Clathrin binding	IBA
GO:0030276	Function	Clathrin binding	IEA
GO:0030276	Function	Clathrin binding	IPI	12429846
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0048268	Process	Clathrin coat assembly	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA

MIM	HGNC	e!Ensembl
607265	23186	ENSG00000113282

Q14677

Protein name

Clathrin interactor 1 (Clathrin-interacting protein localized in the trans-Golgi region) (Clint) (Enthoprotin) (Epsin-4) (Epsin-related protein) (EpsinR)

Protein function

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. {ECO:0000269|PubMed:12429846

PDB

1XGW , 2QY7 , 2V8S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01417	ENTH	21 → 145	ENTH domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed at low to intermediate levels. {ECO:0000269|PubMed:12429846, ECO:0000269|PubMed:12538641}.

Sequence

MLNMWKVRELVDKATNVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPEL
MNMLWSRMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEH
GKDQGINIRQKVKELVEFAQDDDRLREERKKAKKNKDKYVGVSSDSVGGFRYSERYDPEP
KSKWDEEWDKNKSAFPFSDKLGELSDKIGSTIDDTISKFRRKDREDSPERCSDSDEEKKA
RRGRSPKGEFKDEEETVTTKHIHITQATETTTTRHKRTANPSKTIDLGAAAHYTGDKASP
DQNASTHTPQSSVKTSVPSSKSSGDLVDLFDGTSQSTGGSADLFGGFADFGSAAASGSFP
SQVTATSGNGDFGDWSAFNQAPSGPVASSGEFFGSASQPAVELVSGSQSALGPPPAASNS
SDLFDLMGSSQATMTSSQSMNFSMMSTNTVGLGLPMSRSQNTDMVQKSVSKTLPSTWSDP
SVNISLDNLLPGMQPSKPQQPSLNTMIQQQNMQQPMNVMTQSFGAVNLSSPSNMLPVRPQ
TNALIGGPMPMSMPNVMTGTMGMAPLGNTPMMNQSMMGMNMNIGMSAAGMGLTGTMGMGM
PNIAMTSGTVQPKQDAFANFANFSK

Sequence length

625

Interactions

View interactions

	Reactome
			Golgi Associated Vesicle Biogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30881993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis Atopic	Atopic dermatitis	Pubtator	33069716	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	16984960, 18929466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	33069716	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	16984960, 18929466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	15793701, 16402136, 16616458, 16984960, 18696005, 18929466		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	15793701, 16402136		★★★★★ ★☆☆☆☆ Found in Text Mining only

CLINT1 (clathrin interactor 1)