Gene Gene information from NCBI Gene database.
Entrez ID 9671
Gene name WSC domain containing 2
Gene symbol WSCD2
Synonyms (NCBI Gene)
-
Chromosome 12
Chromosome location 12q23.3
miRNA miRNA information provided by mirtarbase database.
421
miRTarBase ID miRNA Experiments Reference
MIRT607317 hsa-miR-8485 HITS-CLIP 23824327
MIRT614283 hsa-miR-329-3p HITS-CLIP 23824327
MIRT614282 hsa-miR-362-3p HITS-CLIP 23824327
MIRT607316 hsa-miR-603 HITS-CLIP 23824327
MIRT607315 hsa-miR-4704-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane ISS
GO:0005794 Component Golgi apparatus IEA
GO:0008146 Function Sulfotransferase activity IEA
GO:0008146 Function Sulfotransferase activity ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619253 29117 ENSG00000075035
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q2TBF2
Protein name Sialate:O-sulfotransferase 2 (WSC domain-containing protein 2)
Protein function Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycoproteins such as TF/transf
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01822 WSC 130 209 WSC domain Domain
PF01822 WSC 233 314 WSC domain Domain
Sequence
MAKLWFKFQRYFRRKPVRFFTFLALYLTAGSLVFLHSGFVGQPAVSGNQANPAAAGGPAE
GAELSFLGDMHLGRGFRDTGEASSIARRYGPWFKGKDGNERAKLGDYGGAWSRALKGRVV
REKEEERAKYIGCYLDDTQSRALRGVSFFDYKKMTIFRCQDNCAERGYLYGGLEFGAECY
CGHKIQATNVSEAECDMECKGERGSVCGG
ANRLSVYRLQLAQESARRYGSAVFRGCFRRP
DNLSLALPVTAAMLNMSVDKCVDFCTEKEYPLAALAGTACHCGFPTTRFPLHDREDEQLC
AQKCSAEEFESCGT
PSYFIVYQTQVQDNRCMDRRFLPGKSKQLIALASFPGAGNTWARHL
IELATGFYTGSYYFDGSLYNKGFKGERDHWRSGRTICIKTHESGQKEIEAFDAAILLIRN
PYKALMAEFNRKYGGHIGFAAHAHWKGKEWPEFVRNYAPWWATHTLDWLKFGKKVLVVHF
EDLKQDLFVQLGRMVSLLGVAVREDRLLCVESQKDGNFKRSGLRKLEYDPYTADMQKTIS
AYIKMVDAALKGRNLTGVPDDYYPR
Sequence length 565
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
21
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anxiety Anxiety Disorder GWASCAT_DG 29942085
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 35082309 Associate
★☆☆☆☆
Found in Text Mining only
Depressive disorder Mental Depression BEFREE 29805500
★☆☆☆☆
Found in Text Mining only
Depressive Disorder Major depressive disorder Pubtator 36982982 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Gestational Gestational diabetes Pubtator 35721735 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent Diabetes Mellitus GWASCAT_DG 29632382, 30718926
★☆☆☆☆
Found in Text Mining only
Mental Depression Mental Depression BEFREE 29805500
★☆☆☆☆
Found in Text Mining only
Multiple Myeloma Multiple myeloma Pubtator 33950175 Associate
★☆☆☆☆
Found in Text Mining only
NEUROTICISM Neuroticism BEFREE 27918536
★☆☆☆☆
Found in Text Mining only
Papillary thyroid carcinoma Papillary thyroid carcinoma BEFREE 29805500
★☆☆☆☆
Found in Text Mining only