Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9666
Gene name	DAZ interacting zinc finger protein 3
Gene symbol	DZIP3
Synonyms (NCBI Gene)	PPP1R66UURF2hRUL138
Chromosome	3
Chromosome location	3q13.13

190

Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT048750	hsa-miR-93-5p	CLASH	23622248
MIRT038320	hsa-miR-130b-5p	CLASH	23622248
MIRT950024	hsa-miR-103a	CLIP-seq
MIRT950025	hsa-miR-107	CLIP-seq
MIRT950026	hsa-miR-1266	CLIP-seq
MIRT950027	hsa-miR-15a	CLIP-seq
MIRT950028	hsa-miR-15b	CLIP-seq
MIRT950029	hsa-miR-16	CLIP-seq
MIRT950030	hsa-miR-18a	CLIP-seq
MIRT950031	hsa-miR-18b	CLIP-seq
MIRT950032	hsa-miR-190	CLIP-seq
MIRT950033	hsa-miR-190b	CLIP-seq
MIRT950034	hsa-miR-195	CLIP-seq
MIRT950035	hsa-miR-214	CLIP-seq
MIRT950036	hsa-miR-3124-3p	CLIP-seq
MIRT950037	hsa-miR-34b	CLIP-seq
MIRT950038	hsa-miR-3606	CLIP-seq
MIRT950039	hsa-miR-361-5p	CLIP-seq
MIRT950040	hsa-miR-3619-5p	CLIP-seq
MIRT950041	hsa-miR-3646	CLIP-seq
MIRT950042	hsa-miR-3647-3p	CLIP-seq
MIRT950043	hsa-miR-3653	CLIP-seq
MIRT950044	hsa-miR-3658	CLIP-seq
MIRT950045	hsa-miR-3662	CLIP-seq
MIRT950046	hsa-miR-3664-3p	CLIP-seq
MIRT950047	hsa-miR-3689a-5p	CLIP-seq
MIRT950048	hsa-miR-3689b	CLIP-seq
MIRT950049	hsa-miR-3689e	CLIP-seq
MIRT950050	hsa-miR-3689f	CLIP-seq
MIRT950051	hsa-miR-3974	CLIP-seq
MIRT950052	hsa-miR-424	CLIP-seq
MIRT950053	hsa-miR-4275	CLIP-seq
MIRT950054	hsa-miR-4291	CLIP-seq
MIRT950055	hsa-miR-4422	CLIP-seq
MIRT950056	hsa-miR-4502	CLIP-seq
MIRT950057	hsa-miR-4504	CLIP-seq
MIRT950058	hsa-miR-4518	CLIP-seq
MIRT950059	hsa-miR-4694-3p	CLIP-seq
MIRT950060	hsa-miR-4698	CLIP-seq
MIRT950061	hsa-miR-4711-3p	CLIP-seq
MIRT950062	hsa-miR-4729	CLIP-seq
MIRT950063	hsa-miR-4735-3p	CLIP-seq
MIRT950064	hsa-miR-4736	CLIP-seq
MIRT950065	hsa-miR-486-3p	CLIP-seq
MIRT950066	hsa-miR-494	CLIP-seq
MIRT950067	hsa-miR-497	CLIP-seq
MIRT950068	hsa-miR-499a-5p	CLIP-seq
MIRT950069	hsa-miR-511	CLIP-seq
MIRT950070	hsa-miR-548c-3p	CLIP-seq
MIRT950071	hsa-miR-584	CLIP-seq
MIRT950072	hsa-miR-643	CLIP-seq
MIRT950073	hsa-miR-654-3p	CLIP-seq
MIRT950074	hsa-miR-760	CLIP-seq
MIRT950075	hsa-miR-761	CLIP-seq
MIRT950076	hsa-miR-921	CLIP-seq
MIRT950077	hsa-miR-922	CLIP-seq
MIRT1981410	hsa-miR-1179	CLIP-seq
MIRT950026	hsa-miR-1266	CLIP-seq
MIRT1981411	hsa-miR-1294	CLIP-seq
MIRT1981412	hsa-miR-134	CLIP-seq
MIRT950027	hsa-miR-15a	CLIP-seq
MIRT950028	hsa-miR-15b	CLIP-seq
MIRT950029	hsa-miR-16	CLIP-seq
MIRT950032	hsa-miR-190	CLIP-seq
MIRT950033	hsa-miR-190b	CLIP-seq
MIRT950034	hsa-miR-195	CLIP-seq
MIRT950035	hsa-miR-214	CLIP-seq
MIRT1981413	hsa-miR-219-5p	CLIP-seq
MIRT1981414	hsa-miR-3118	CLIP-seq
MIRT1981415	hsa-miR-3120-3p	CLIP-seq
MIRT1981416	hsa-miR-3164	CLIP-seq
MIRT950039	hsa-miR-361-5p	CLIP-seq
MIRT950040	hsa-miR-3619-5p	CLIP-seq
MIRT950042	hsa-miR-3647-3p	CLIP-seq
MIRT950046	hsa-miR-3664-3p	CLIP-seq
MIRT1981417	hsa-miR-377	CLIP-seq
MIRT950052	hsa-miR-424	CLIP-seq
MIRT1981418	hsa-miR-4268	CLIP-seq
MIRT950054	hsa-miR-4291	CLIP-seq
MIRT1981419	hsa-miR-4310	CLIP-seq
MIRT1981420	hsa-miR-4316	CLIP-seq
MIRT1981421	hsa-miR-4426	CLIP-seq
MIRT1981422	hsa-miR-4445	CLIP-seq
MIRT1981423	hsa-miR-4446-5p	CLIP-seq
MIRT1981424	hsa-miR-4448	CLIP-seq
MIRT1981425	hsa-miR-4501	CLIP-seq
MIRT950056	hsa-miR-4502	CLIP-seq
MIRT950058	hsa-miR-4518	CLIP-seq
MIRT1981426	hsa-miR-4647	CLIP-seq
MIRT1981427	hsa-miR-4662b	CLIP-seq
MIRT950059	hsa-miR-4694-3p	CLIP-seq
MIRT950061	hsa-miR-4711-3p	CLIP-seq
MIRT1981428	hsa-miR-4716-5p	CLIP-seq
MIRT1981429	hsa-miR-4755-5p	CLIP-seq
MIRT1981430	hsa-miR-4782-3p	CLIP-seq
MIRT950067	hsa-miR-497	CLIP-seq
MIRT1981431	hsa-miR-508-3p	CLIP-seq
MIRT950069	hsa-miR-511	CLIP-seq
MIRT950070	hsa-miR-548c-3p	CLIP-seq
MIRT1981432	hsa-miR-576-3p	CLIP-seq
MIRT950071	hsa-miR-584	CLIP-seq
MIRT950073	hsa-miR-654-3p	CLIP-seq
MIRT950074	hsa-miR-760	CLIP-seq
MIRT950075	hsa-miR-761	CLIP-seq
MIRT950077	hsa-miR-922	CLIP-seq
MIRT950024	hsa-miR-103a	CLIP-seq
MIRT950025	hsa-miR-107	CLIP-seq
MIRT2216439	hsa-miR-1256	CLIP-seq
MIRT950026	hsa-miR-1266	CLIP-seq
MIRT2216440	hsa-miR-1297	CLIP-seq
MIRT1981412	hsa-miR-134	CLIP-seq
MIRT950027	hsa-miR-15a	CLIP-seq
MIRT950028	hsa-miR-15b	CLIP-seq
MIRT950029	hsa-miR-16	CLIP-seq
MIRT950032	hsa-miR-190	CLIP-seq
MIRT950033	hsa-miR-190b	CLIP-seq
MIRT950034	hsa-miR-195	CLIP-seq
MIRT950035	hsa-miR-214	CLIP-seq
MIRT1981413	hsa-miR-219-5p	CLIP-seq
MIRT2216441	hsa-miR-26a	CLIP-seq
MIRT2216442	hsa-miR-26b	CLIP-seq
MIRT2216443	hsa-miR-300	CLIP-seq
MIRT1981414	hsa-miR-3118	CLIP-seq
MIRT2216444	hsa-miR-3152-5p	CLIP-seq
MIRT1981416	hsa-miR-3164	CLIP-seq
MIRT950039	hsa-miR-361-5p	CLIP-seq
MIRT950040	hsa-miR-3619-5p	CLIP-seq
MIRT950042	hsa-miR-3647-3p	CLIP-seq
MIRT950046	hsa-miR-3664-3p	CLIP-seq
MIRT2216445	hsa-miR-3678-5p	CLIP-seq
MIRT950047	hsa-miR-3689a-5p	CLIP-seq
MIRT950048	hsa-miR-3689b	CLIP-seq
MIRT950049	hsa-miR-3689e	CLIP-seq
MIRT950050	hsa-miR-3689f	CLIP-seq
MIRT2216446	hsa-miR-374c	CLIP-seq
MIRT2216447	hsa-miR-381	CLIP-seq
MIRT950052	hsa-miR-424	CLIP-seq
MIRT1981418	hsa-miR-4268	CLIP-seq
MIRT950054	hsa-miR-4291	CLIP-seq
MIRT2216448	hsa-miR-4297	CLIP-seq
MIRT1981421	hsa-miR-4426	CLIP-seq
MIRT1981422	hsa-miR-4445	CLIP-seq
MIRT1981423	hsa-miR-4446-5p	CLIP-seq
MIRT1981424	hsa-miR-4448	CLIP-seq
MIRT2216449	hsa-miR-4465	CLIP-seq
MIRT1981425	hsa-miR-4501	CLIP-seq
MIRT950058	hsa-miR-4518	CLIP-seq
MIRT2216450	hsa-miR-4642	CLIP-seq
MIRT1981426	hsa-miR-4647	CLIP-seq
MIRT1981427	hsa-miR-4662b	CLIP-seq
MIRT2216451	hsa-miR-4666-5p	CLIP-seq
MIRT950059	hsa-miR-4694-3p	CLIP-seq
MIRT950060	hsa-miR-4698	CLIP-seq
MIRT950061	hsa-miR-4711-3p	CLIP-seq
MIRT1981428	hsa-miR-4716-5p	CLIP-seq
MIRT2216452	hsa-miR-4719	CLIP-seq
MIRT1981429	hsa-miR-4755-5p	CLIP-seq
MIRT2216453	hsa-miR-4774-3p	CLIP-seq
MIRT1981430	hsa-miR-4782-3p	CLIP-seq
MIRT950067	hsa-miR-497	CLIP-seq
MIRT1981431	hsa-miR-508-3p	CLIP-seq
MIRT950069	hsa-miR-511	CLIP-seq
MIRT1981432	hsa-miR-576-3p	CLIP-seq
MIRT950071	hsa-miR-584	CLIP-seq
MIRT2216454	hsa-miR-624	CLIP-seq
MIRT950073	hsa-miR-654-3p	CLIP-seq
MIRT2216455	hsa-miR-655	CLIP-seq
MIRT2216456	hsa-miR-670	CLIP-seq
MIRT950074	hsa-miR-760	CLIP-seq
MIRT950075	hsa-miR-761	CLIP-seq
MIRT950077	hsa-miR-922	CLIP-seq
MIRT1981418	hsa-miR-4268	CLIP-seq
MIRT1981424	hsa-miR-4448	CLIP-seq
MIRT1981412	hsa-miR-134	CLIP-seq
MIRT950032	hsa-miR-190	CLIP-seq
MIRT950033	hsa-miR-190b	CLIP-seq
MIRT1981414	hsa-miR-3118	CLIP-seq
MIRT1981416	hsa-miR-3164	CLIP-seq
MIRT1981421	hsa-miR-4426	CLIP-seq
MIRT1981425	hsa-miR-4501	CLIP-seq
MIRT1981426	hsa-miR-4647	CLIP-seq
MIRT1981427	hsa-miR-4662b	CLIP-seq
MIRT950061	hsa-miR-4711-3p	CLIP-seq
MIRT1981428	hsa-miR-4716-5p	CLIP-seq
MIRT1981432	hsa-miR-576-3p	CLIP-seq
MIRT950071	hsa-miR-584	CLIP-seq
MIRT950074	hsa-miR-760	CLIP-seq
MIRT950056	hsa-miR-4502	CLIP-seq
MIRT950070	hsa-miR-548c-3p	CLIP-seq
MIRT950056	hsa-miR-4502	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0000209	Process	Protein polyubiquitination	IDA	12538761
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IDA	12538761
GO:0003723	Function	RNA binding	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	12538761
GO:0005515	Function	Protein binding	IPI	16713569, 19549727, 21516116, 21903422, 25416956, 28514442, 29892012, 31515488, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12538761
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019902	Function	Phosphatase binding	IDA	19389623
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IBA
GO:0031593	Function	Polyubiquitin modification-dependent protein binding	IDA	12538761
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
608672	30938	ENSG00000198919

Q86Y13

Protein name

E3 ubiquitin-protein ligase DZIP3 (EC 2.3.2.27) (DAZ-interacting protein 3) (RING-type E3 ubiquitin transferase DZIP3) (RNA-binding ubiquitin ligase of 138 kDa) (hRUL138)

Protein function

E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF19179	DUF5861	223 → 337	Family of unknown function (DUF5861)	Family
PF18738	HEPN_DZIP3	418 → 563	DZIP3/ hRUL138-like HEPN	Domain
PF13639	zf-RING_2	1146 → 1188	Ring finger domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas. {ECO:0000269|PubMed:12538761}.

Sequence

MDSLPDEFFVRHPAVEDQRKEETENKLEKSSGQLNKQENDIPTDLVPVNLLLEVKKLLNA
INTLPKGVVPHIKKFLQEDFSFQTMQREVAANSQNGEEIVPALTLRFLITQLEAALRNIQ
AGNYTAHQINIGYYLTLLFLYGVALTERGKKEDYTEAENKFLVMKMMIQENEICENFMSL
VYFGRGLLRCAQKRYNGGLLEFHKSLQEIGDKNDHWFDIDPTEDEDLPTTFKDLLNNFIK
TTESNIMKQTICSYLDCERSCEADILKNTSYKGFFQLMCSKSCCVYFHKICWKKFKNLKY
PGENDQSFSGKKCLKEGCTGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYRKLI
SLKITDTDIRPKISLKFNTKDEMPIFKLDYNYFYHLLHIIIISGTDIVRQIFDEAMPPPL
LKKELLIHKNVLESYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVF
PAPKKGWNMEPPSSDISKSADILRLCKYRDILLSEILMNGLTESQFNSIWKKVSDILLRL
GMMQEDIDKVKENPIENISLDYHQLSVYLGIPVPEIIQRMLSCYQQGIALQSITGSQRIE
IEELQNEEEELSPPLMEYNINVKSHPEIQFAEINKDGTSIPSESSTESLKDLQEVKSKQR
KKKKTKNKKNKDSKEDQVPYVVEKEEQLRKEQANPHSVSRLIKDDASDVQEDSAMEDKFY
SLDELHILDMIEQGSAGKVTTDYGETEKERLARQRQLYKLHYQCEDFKRQLRTVTFRWQE
NQMQIKKKDKIIASLNQQVAFGINKVSKLQRQIHAKDNEIKNLKEQLSMKRSQWEMEKHN
LESTMKTYVSKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNL
ESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEI
LMQQFLGRPLVKESFFRPILTVPQMPAVCPGVVSATGQPRAPLMTGIAWALPAPVGDAVP
PSAGLRSDPSIMNWERITDRLKTAFPQQTRKELTDFLRKLKDAYGKSLSELTFDEIVCKI
SQFIDPKKSQSQGKSVSNVNCVSPSHSPSQPDAAQPPKPAWRPLTSQGPATWEGASNPDE
EEEEEEPCVICHENLSPENLSVLPCAHKFHAQCIRPWLMQQGTCPTCRLHVLLPEEFPGH
PSRQLPKI

Sequence length

1208

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioma	Glioma	Pubtator	33229627	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

DZIP3 (DAZ interacting zinc finger protein 3)