Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9633
Gene name	Testis expressed metallothionein like protein
Gene symbol	TESMIN
Synonyms (NCBI Gene)	CXCDC2MTL5MTLT
Chromosome	11
Chromosome location	11q13.3
Summary	Metallothionein proteins are highly conserved low-molecular-weight cysteine-rich proteins that are induced by and bind to heavy metal ions and have no enzymatic activity. They may play a central role in the regulation of cell growth and differentiation an

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Show/Hide all (137)

miRTarBase ID	miRNA	Experiments	Reference
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT650084	hsa-miR-622	HITS-CLIP	23824327
MIRT650083	hsa-miR-7114-5p	HITS-CLIP	23824327
MIRT650082	hsa-miR-134-3p	HITS-CLIP	23824327
MIRT650081	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT650080	hsa-miR-4271	HITS-CLIP	23824327
MIRT650079	hsa-miR-4725-3p	HITS-CLIP	23824327
MIRT650078	hsa-miR-6780b-5p	HITS-CLIP	23824327
MIRT650077	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630035	hsa-miR-4284	HITS-CLIP	23824327
MIRT630034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630033	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT630032	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT630031	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT630030	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT630029	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT630028	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT630026	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT630025	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT630024	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT630023	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT630022	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT630021	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT630020	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT630019	hsa-miR-3689c	HITS-CLIP	23824327
MIRT630018	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT630017	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT630016	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT630015	hsa-miR-3122	HITS-CLIP	23824327
MIRT630014	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT630013	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT630012	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630035	hsa-miR-4284	HITS-CLIP	23824327
MIRT630034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630033	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT630032	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT630031	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT630030	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT630029	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT630028	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT630026	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT630025	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT630024	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT630023	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT630022	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT630021	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT630020	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT630019	hsa-miR-3689c	HITS-CLIP	23824327
MIRT630018	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT630017	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT630016	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT630015	hsa-miR-3122	HITS-CLIP	23824327
MIRT630014	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT630013	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT630012	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630033	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT630032	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT630031	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT630030	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT630029	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT630028	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT630026	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT630025	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT630024	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT630023	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT630022	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT630021	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT630020	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT630019	hsa-miR-3689c	HITS-CLIP	23824327
MIRT630018	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT630017	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT630016	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT630015	hsa-miR-3122	HITS-CLIP	23824327
MIRT630014	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT630013	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT630012	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630033	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT630032	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT630031	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT630030	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT630029	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT630028	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT630026	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT630025	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT630024	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT630023	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT630022	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT630021	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT630020	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT630019	hsa-miR-3689c	HITS-CLIP	23824327
MIRT630018	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT630017	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT630016	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT630015	hsa-miR-3122	HITS-CLIP	23824327
MIRT630014	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT630013	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT630012	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT630037	hsa-miR-4267	HITS-CLIP	23824327
MIRT630036	hsa-miR-9-5p	HITS-CLIP	23824327
MIRT630035	hsa-miR-4284	HITS-CLIP	23824327
MIRT630034	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT630033	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT630032	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT630031	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT630030	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT630029	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT630028	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT630027	hsa-miR-7977	HITS-CLIP	23824327
MIRT630026	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT630025	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT630024	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT630023	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT630022	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT630021	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT630020	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT630019	hsa-miR-3689c	HITS-CLIP	23824327
MIRT630018	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT630017	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT630016	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT630015	hsa-miR-3122	HITS-CLIP	23824327
MIRT630014	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT630013	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT630012	hsa-miR-6513-5p	HITS-CLIP	23824327

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001673	Component	Male germ cell nucleus	IEA
GO:0005515	Function	Protein binding	IPI	24907116, 32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007140	Process	Male meiotic nuclear division	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0007283	Process	Spermatogenesis	NAS	10191092
GO:0010038	Process	Response to metal ion	NAS	10191092
GO:0030003	Process	Intracellular monoatomic cation homeostasis	NAS	10191092
GO:0030154	Process	Cell differentiation	IEA
GO:0046872	Function	Metal ion binding	NAS	10191092
GO:0051321	Process	Meiotic cell cycle	IEA

MIM	HGNC	e!Ensembl
604374	7446	ENSG00000132749

Q9Y4I5

Protein name

Tesmin (Metallothionein-like 5, testis-specific) (Testis-specific metallothionein-like protein)

Protein function

Essential for normal spermatogenesis and male fertility (By similarity). Required for the completion of meiosis in male germ cells (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03638	TCR	367 → 404	Tesmin/TSO1-like CXC domain, cysteine-rich domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed specifically in testis.

Sequence

MEEGPLPGGLPSPEDAMVTELLSPEGPFASENIGLKAPVKYEEDEFHVFKEAYLGPADPK
EPVLHAFNPALGADCKGQVKAKLAGGDSDGGELLGEYPGIPELSALEDVALLQAPQPPAC
NVHFLSSLLPAHRSPAVLPLGAWVLEGASHPGVRMIPVEIKEAGGTTTSNNPEEATLQNL
LAQESCCKFPSSQELEDASCCSLKKDSNPMVICQLKGGTQMLCIDNSRTRELKALHLVPQ
YQDQNNYLQSDVPKPMTALVGRFLPASTKLNLITQQLEGALPSVVNGSAFPSGSTLPGPP
KITLAGYCDCFASGDFCNNCNCNNCCNNLHHDIERFKAIKACLGRNPEAFQPKIGKGQLG
NVKPQHNKGCNCRRSGCLKNYCECYEAQIMCSSICKCIGCKNYEESPERKTLMSMPNYMQ
TGGLEGSHYLPPTKFSGLPRFSHDRRPSSCISWEVVEATCACLLAQGEEAEKEHCSKCLA
EQMILEEFGRCLSQILHTEFKSKGLKME

Sequence length

508

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
SQUAMOUS CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	38283987	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31059101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	34545296	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31059101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31059101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31059101		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	28369098		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	28369098	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25371445	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TESMIN (testis expressed metallothionein like protein)