Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	9595
Gene name	Cytohesin 1 interacting protein
Gene symbol	CYTIP
Synonyms (NCBI Gene)	B3-1CASPCYBRCYTHIPHEPSCDBP
Chromosome	2
Chromosome location	2q24.1
Summary	The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, but does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells. The encoded protein modulates the

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Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018497	hsa-miR-335-5p	Microarray	18185580
MIRT029853	hsa-miR-26b-5p	Microarray	19088304
MIRT668795	hsa-miR-4668-3p	HITS-CLIP	23706177
MIRT668794	hsa-miR-3925-5p	HITS-CLIP	23706177
MIRT668793	hsa-miR-146a-5p	HITS-CLIP	23706177
MIRT668792	hsa-miR-146b-5p	HITS-CLIP	23706177
MIRT668791	hsa-miR-7153-5p	HITS-CLIP	23706177
MIRT670897	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT670896	hsa-miR-764	HITS-CLIP	23824327
MIRT670895	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT670894	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT670893	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT670892	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT670891	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT670890	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT670889	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT670888	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT670887	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT670885	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679485	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT670884	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT670883	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679484	hsa-miR-6131	HITS-CLIP	23824327
MIRT670881	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT670880	hsa-miR-640	HITS-CLIP	23824327
MIRT679483	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679482	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT670897	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT670896	hsa-miR-764	HITS-CLIP	23824327
MIRT670895	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT670894	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT670893	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT670892	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT670891	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT670890	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT670889	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT670888	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT670887	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT670886	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT670885	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT670884	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT670883	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT670882	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT670881	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT670880	hsa-miR-640	HITS-CLIP	23824327
MIRT668795	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT668794	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT668793	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT668792	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT668791	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT531789	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT531788	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT531787	hsa-miR-6731-3p	PAR-CLIP	22012620
MIRT531786	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT531785	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT531784	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT531783	hsa-miR-7641	PAR-CLIP	22012620
MIRT668793	hsa-miR-146a-5p	PAR-CLIP	27292025
MIRT668792	hsa-miR-146b-5p	PAR-CLIP	27292025
MIRT668794	hsa-miR-3925-5p	PAR-CLIP	27292025
MIRT668791	hsa-miR-7153-5p	PAR-CLIP	27292025
MIRT668793	hsa-miR-146a-5p	HITS-CLIP	27418678
MIRT668792	hsa-miR-146b-5p	HITS-CLIP	27418678
MIRT668794	hsa-miR-3925-5p	HITS-CLIP	27418678
MIRT668791	hsa-miR-7153-5p	HITS-CLIP	27418678
MIRT668795	hsa-miR-4668-3p	HITS-CLIP	23706177
MIRT668794	hsa-miR-3925-5p	HITS-CLIP	23706177
MIRT668793	hsa-miR-146a-5p	HITS-CLIP	23706177
MIRT668792	hsa-miR-146b-5p	HITS-CLIP	23706177
MIRT668791	hsa-miR-7153-5p	HITS-CLIP	23706177
MIRT670897	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT670896	hsa-miR-764	HITS-CLIP	23824327
MIRT670895	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT670894	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT670893	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT670892	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT670891	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT670890	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT670889	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT670888	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT670887	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT670885	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679485	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT670884	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT670883	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679484	hsa-miR-6131	HITS-CLIP	23824327
MIRT670881	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT670880	hsa-miR-640	HITS-CLIP	23824327
MIRT679483	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679482	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT670897	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT670896	hsa-miR-764	HITS-CLIP	23824327
MIRT670895	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT670894	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT670893	hsa-miR-1234-3p	HITS-CLIP	23824327
MIRT670892	hsa-miR-7107-5p	HITS-CLIP	23824327
MIRT670891	hsa-miR-371b-5p	HITS-CLIP	23824327
MIRT670890	hsa-miR-373-5p	HITS-CLIP	23824327
MIRT670889	hsa-miR-616-5p	HITS-CLIP	23824327
MIRT670888	hsa-miR-371a-5p	HITS-CLIP	23824327
MIRT670887	hsa-miR-372-5p	HITS-CLIP	23824327
MIRT670886	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT670885	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT670884	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT670883	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT670882	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT670881	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT670880	hsa-miR-640	HITS-CLIP	23824327
MIRT668795	hsa-miR-4668-3p	HITS-CLIP	23824327
MIRT668794	hsa-miR-3925-5p	HITS-CLIP	23824327
MIRT668793	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT668792	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT668791	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT531789	hsa-miR-4789-3p	PAR-CLIP	22012620
MIRT531788	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT531787	hsa-miR-6731-3p	PAR-CLIP	22012620
MIRT531786	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT531785	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT531784	hsa-miR-138-2-3p	PAR-CLIP	22012620
MIRT531783	hsa-miR-7641	PAR-CLIP	22012620
MIRT922323	hsa-miR-106a	CLIP-seq
MIRT922324	hsa-miR-106b	CLIP-seq
MIRT922325	hsa-miR-1253	CLIP-seq
MIRT922326	hsa-miR-142-5p	CLIP-seq
MIRT922327	hsa-miR-17	CLIP-seq
MIRT922328	hsa-miR-20a	CLIP-seq
MIRT922329	hsa-miR-20b	CLIP-seq
MIRT922330	hsa-miR-320a	CLIP-seq
MIRT922331	hsa-miR-320b	CLIP-seq
MIRT922332	hsa-miR-320c	CLIP-seq
MIRT922333	hsa-miR-320d	CLIP-seq
MIRT922334	hsa-miR-340	CLIP-seq
MIRT922335	hsa-miR-3609	CLIP-seq
MIRT922336	hsa-miR-409-3p	CLIP-seq
MIRT922337	hsa-miR-4269	CLIP-seq
MIRT922338	hsa-miR-4429	CLIP-seq
MIRT922339	hsa-miR-4459	CLIP-seq
MIRT922340	hsa-miR-4514	CLIP-seq
MIRT922341	hsa-miR-4517	CLIP-seq
MIRT922342	hsa-miR-4662a-3p	CLIP-seq
MIRT922343	hsa-miR-4692	CLIP-seq
MIRT922344	hsa-miR-4700-3p	CLIP-seq
MIRT922345	hsa-miR-4742-5p	CLIP-seq
MIRT922346	hsa-miR-4779	CLIP-seq
MIRT922347	hsa-miR-4796-3p	CLIP-seq
MIRT922348	hsa-miR-519d	CLIP-seq
MIRT922349	hsa-miR-548ae	CLIP-seq
MIRT922350	hsa-miR-548ah	CLIP-seq
MIRT922351	hsa-miR-548aj	CLIP-seq
MIRT922352	hsa-miR-548am	CLIP-seq
MIRT922353	hsa-miR-548x	CLIP-seq
MIRT922354	hsa-miR-93	CLIP-seq
MIRT1973188	hsa-miR-198	CLIP-seq
MIRT1973189	hsa-miR-219-2-3p	CLIP-seq
MIRT1973190	hsa-miR-219-5p	CLIP-seq
MIRT1973191	hsa-miR-2964a-3p	CLIP-seq
MIRT1973192	hsa-miR-3201	CLIP-seq
MIRT922330	hsa-miR-320a	CLIP-seq
MIRT922331	hsa-miR-320b	CLIP-seq
MIRT922332	hsa-miR-320c	CLIP-seq
MIRT922333	hsa-miR-320d	CLIP-seq
MIRT1973193	hsa-miR-3613-3p	CLIP-seq
MIRT1973194	hsa-miR-3618	CLIP-seq
MIRT1973195	hsa-miR-376c	CLIP-seq
MIRT922338	hsa-miR-4429	CLIP-seq
MIRT1973196	hsa-miR-4680-3p	CLIP-seq
MIRT1973197	hsa-miR-4782-3p	CLIP-seq
MIRT1973198	hsa-miR-4791	CLIP-seq
MIRT1973199	hsa-miR-556-3p	CLIP-seq
MIRT1973200	hsa-miR-934	CLIP-seq
MIRT2447975	hsa-miR-3974	CLIP-seq
MIRT2447976	hsa-miR-548m	CLIP-seq
MIRT1973189	hsa-miR-219-2-3p	CLIP-seq
MIRT1973191	hsa-miR-2964a-3p	CLIP-seq
MIRT922330	hsa-miR-320a	CLIP-seq
MIRT922331	hsa-miR-320b	CLIP-seq
MIRT922332	hsa-miR-320c	CLIP-seq
MIRT922333	hsa-miR-320d	CLIP-seq
MIRT922337	hsa-miR-4269	CLIP-seq
MIRT922338	hsa-miR-4429	CLIP-seq
MIRT922340	hsa-miR-4514	CLIP-seq
MIRT1973196	hsa-miR-4680-3p	CLIP-seq
MIRT922343	hsa-miR-4692	CLIP-seq
MIRT922345	hsa-miR-4742-5p	CLIP-seq
MIRT1973189	hsa-miR-219-2-3p	CLIP-seq
MIRT1973191	hsa-miR-2964a-3p	CLIP-seq
MIRT922330	hsa-miR-320a	CLIP-seq
MIRT922331	hsa-miR-320b	CLIP-seq
MIRT922332	hsa-miR-320c	CLIP-seq
MIRT922333	hsa-miR-320d	CLIP-seq
MIRT922337	hsa-miR-4269	CLIP-seq
MIRT922338	hsa-miR-4429	CLIP-seq
MIRT922340	hsa-miR-4514	CLIP-seq
MIRT1973196	hsa-miR-4680-3p	CLIP-seq
MIRT922343	hsa-miR-4692	CLIP-seq
MIRT922345	hsa-miR-4742-5p	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	11867758, 28514442, 32296183, 32814053, 33961781
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	12606567
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005938	Component	Cell cortex	IBA
GO:0005938	Component	Cell cortex	IDA	12606567
GO:0030155	Process	Regulation of cell adhesion	IBA
GO:0030155	Process	Regulation of cell adhesion	IDA	12606567

MIM	HGNC	e!Ensembl
604448	9506	ENSG00000115165

O60759

Protein name

Cytohesin-interacting protein (Cytohesin binder and regulator) (CYBR) (Cytohesin-associated scaffolding protein) (CASP) (Cytohesin-binding protein HE) (Cbp HE) (Pleckstrin homology Sec7 and coiled-coil domains-binding protein)

Protein function

By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm.

PDB

2Z17

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00595	PDZ	77 → 163	PDZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in lymph nodes, thymus, spleen, lung, peripheral blood leukocytes and bone marrow. {ECO:0000269|PubMed:11867758, ECO:0000269|PubMed:12606567}.

Sequence

MSLQRLLQHSSNGNLADFCAGPAYSSYSTLTGSLTMDDNRRIQMLADTVATLPRGRKQLA
LTRSSSLSDFSWSQRKLVTVEKQDNETFGFEIQSYRPQNQNACSSEMFTLICKIQEDSPA
HCAGLQAGDVLANINGVSTEGFTYKQVVDLIRSSGNLLTIETLNGTMILKRTELEAKLQV
LKQTLKQKWVEYRSLQLQEHRLLHGDAANCPSLENMDLDELSLFGPLPGPGPALVDRNRL
SSESSCKSWLSSMTMDSEDGYQTCVSEDSSRGAFSRQTSTDDECFIPKEGDDFLRRSSSR
RNRSISNTSSGSMSPLWEGNLSSMFGTLPRKSRKGSVRKQLLKFIPGLHRAVEEEESRF

Sequence length

359

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DYSLEXIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (24)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
beta Thalassemia	Beta thalassemia	Pubtator	37816374	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	30042341		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	16948818, 20025484, 20402676		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	20661084, 23315881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	16948818, 23303631		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	29356567		★★★★★ ★☆☆☆☆ Found in Text Mining only
Depressive disorder	Mental Depression	BEFREE	26404725, 29356567, 29529559, 30596467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	37364045	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Stromal Tumors	Gastrointestinal stromal tumor	BEFREE	19269008		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28453560		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	17071630		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20661084, 23315881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	31611962		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16687442, 16938569, 18058802, 19058873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Depression	Mental Depression	BEFREE	26404725, 29356567, 29529559, 30596467		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	18381704		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	19359048		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	19826114		★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal Diseases	BEFREE	26782454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	29356567		★★★★★ ★☆☆☆☆ Found in Text Mining only
SCAPULOPERONEAL MYOPATHY, X-LINKED DOMINANT	Scapuloperoneal Myopathy, X-Linked	BEFREE	23271051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	37988195	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	23271051		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	31611962		★★★★★ ★☆☆☆☆ Found in Text Mining only

CYTIP (cytohesin 1 interacting protein)