Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9588
Gene name	Peroxiredoxin 6
Gene symbol	PRDX6
Synonyms (NCBI Gene)	1-CysAOP2HEL-S-128mLPCAT-5NSGPxPRXaiPLA2p29
Chromosome	1
Chromosome location	1q25.1
Summary	The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain org

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miRTarBase ID	miRNA	Experiments	Reference
MIRT004940	hsa-miR-632	qRT-PCRWestern blot	17980029
MIRT044389	hsa-miR-320a	CLASH	23622248
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assayWestern blot	27484502
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assayWestern blot	27484502
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260576	hsa-miR-1178	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260578	hsa-miR-122	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT1260587	hsa-miR-137	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260589	hsa-miR-183	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260604	hsa-miR-3134	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260607	hsa-miR-3171	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT1260611	hsa-miR-342-3p	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260613	hsa-miR-361-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260615	hsa-miR-3679-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260619	hsa-miR-3714	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT1260623	hsa-miR-3921	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260625	hsa-miR-4252	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT1260631	hsa-miR-4493	CLIP-seq
MIRT1260632	hsa-miR-4502	CLIP-seq
MIRT1260633	hsa-miR-4530	CLIP-seq
MIRT1260634	hsa-miR-4534	CLIP-seq
MIRT1260635	hsa-miR-4653-5p	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260642	hsa-miR-4727-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260646	hsa-miR-4769-3p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260648	hsa-miR-4790-3p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260655	hsa-miR-512-3p	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT1260658	hsa-miR-518a-3p	CLIP-seq
MIRT1260659	hsa-miR-518b	CLIP-seq
MIRT1260660	hsa-miR-518c	CLIP-seq
MIRT1260661	hsa-miR-518d-3p	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260663	hsa-miR-518f	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT1260671	hsa-miR-607	CLIP-seq
MIRT1260672	hsa-miR-628-5p	CLIP-seq
MIRT1260673	hsa-miR-634	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT1260675	hsa-miR-759	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260678	hsa-miR-922	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT2303390	hsa-miR-142-5p	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT2303394	hsa-miR-3065-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT2303395	hsa-miR-340	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT2303396	hsa-miR-4494	CLIP-seq
MIRT2303397	hsa-miR-4499	CLIP-seq
MIRT2303398	hsa-miR-4506	CLIP-seq
MIRT2303399	hsa-miR-4517	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT2303401	hsa-miR-505	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303402	hsa-miR-617	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT2688556	hsa-miR-1305	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004601	Function	Peroxidase activity	IBA
GO:0004601	Function	Peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IEA
GO:0004602	Function	Glutathione peroxidase activity	IMP	10893423
GO:0004623	Function	Phospholipase A2 activity	IDA	26830860
GO:0004623	Function	Phospholipase A2 activity	IEA
GO:0005515	Function	Protein binding	IPI	16186110, 19188445, 20849852, 21044950, 21911577, 26030842, 29128334, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	16186110
GO:0005737	Component	Cytoplasm	IDA	16186110, 19188445, 25468996
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	NAS	9497358
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006979	Process	Response to oxidative stress	IMP	10893423
GO:0016020	Component	Membrane	HDA	19946888
GO:0016042	Process	Lipid catabolic process	IEA
GO:0016209	Function	Antioxidant activity	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19725078
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IMP	9587003
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045454	Process	Cell redox homeostasis	IBA
GO:0046475	Process	Glycerophospholipid catabolic process	IMP	10893423
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IDA	26830860
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IEA
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IMP	10893423
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IGI	16186110
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16186110
GO:0051920	Function	Peroxiredoxin activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IEA
GO:0098869	Process	Cellular oxidant detoxification	IMP	10893423

MIM	HGNC	e!Ensembl
602316	16753	ENSG00000117592

P30041

Protein name

Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylch

Protein function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholip

PDB

1PRX , 5B6M , 5B6N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00578	AhpC-TSA	7 → 146	AhpC/TSA family	Domain
PF10417	1-cysPrx_C	166 → 205	C-terminal domain of 1-Cys peroxiredoxin	Domain

Sequence

MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

Sequence length

224

Interactions

View interactions

	KEGG		Reactome
	Glutathione metabolism Metabolic pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONTACT DERMATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATITIS, CONTACT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DOWN SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

PRDX6 (peroxiredoxin 6)