Gene Gene information from NCBI Gene database.
Entrez ID 957
Gene name Ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
Gene symbol ENTPD5
Synonyms (NCBI Gene)
CD39L4NTPDase-5PCPH
Chromosome 14
Chromosome location 14q24.3
Summary The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [pr
miRNA miRNA information provided by mirtarbase database.
486
miRTarBase ID miRNA Experiments Reference
MIRT614197 hsa-miR-329-5p HITS-CLIP 23824327
MIRT614196 hsa-miR-6817-3p HITS-CLIP 23824327
MIRT614195 hsa-miR-130b-5p HITS-CLIP 23824327
MIRT614194 hsa-miR-6873-3p HITS-CLIP 23824327
MIRT614193 hsa-miR-4753-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0004382 Function GDP phosphatase activity IDA 10400613, 15698960
GO:0004382 Function GDP phosphatase activity IEA
GO:0004382 Function GDP phosphatase activity ISS
GO:0005515 Function Protein binding IPI 25416956, 32814053
GO:0005576 Component Extracellular region IDA 15698960
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603162 3367 ENSG00000187097
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75356
Protein name Nucleoside diphosphate phosphatase ENTPD5 (EC 3.6.1.6) (CD39 antigen-like 4) (ER-UDPase) (Ectonucleoside triphosphate diphosphohydrolase 5) (NTPDase 5) (Guanosine-diphosphatase ENTPD5) (GDPase ENTPD5) (Inosine diphosphate phosphatase ENTPD5) (Nucleoside d
Protein function Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01150 GDA1_CD39 41 427 GDA1/CD39 (nucleoside phosphatase) family Family
Tissue specificity TISSUE SPECIFICITY: Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues. {ECO:0000269|PubMed:9676430}.
Sequence
Sequence length 428
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Purine metabolism
Pyrimidine metabolism
Metabolic pathways
Nucleotide metabolism
  Phosphate bond hydrolysis by NTPDase proteins
Purinergic signaling in leishmaniasis infection
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COENZYME Q10 DEFICIENCY, PRIMARY, 6 Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anaplasia Anaplasia BEFREE 25115394
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 25115394 Inhibit
★☆☆☆☆
Found in Text Mining only
Carcinoma of larynx Laryngeal carcinoma BEFREE 12489110
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 25794010
★☆☆☆☆
Found in Text Mining only
COENZYME Q10 DEFICIENCY, PRIMARY, 6 Coenzyme Q10 Deficiency CLINVAR_DG 21540551, 24140869
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Colon Carcinoma Colon Carcinoma BEFREE 21061036
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 23921441
★☆☆☆☆
Found in Text Mining only
Germ cell tumor Tumor BEFREE 16465363
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma BEFREE 22992974, 31242188
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 31242188 Associate
★☆☆☆☆
Found in Text Mining only