Gene Gene information from NCBI Gene database.
Entrez ID 9545
Gene name RAB3D, member RAS oncogene family
Gene symbol RAB3D
Synonyms (NCBI Gene)
D2-2GOVRAB16RAD3D
Chromosome 19
Chromosome location 19p13.2
miRNA miRNA information provided by mirtarbase database.
1219
miRTarBase ID miRNA Experiments Reference
MIRT018959 hsa-miR-335-5p Microarray 18185580
MIRT020003 hsa-miR-375 Microarray 20215506
MIRT376162 hsa-miR-508-5p PAR-CLIP 21572407
MIRT552280 hsa-miR-25-3p PAR-CLIP 21572407
MIRT552279 hsa-miR-32-5p PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
30
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IBA
GO:0003924 Function GTPase activity IEA
GO:0003924 Function GTPase activity TAS 10023084
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604350 9779 ENSG00000105514
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95716
Protein name Ras-related protein Rab-3D (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to r
PDB 2GF9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 24 185 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in granulocytes of peripheral blood (PubMed:10023084). Constitutively expressed at low levels in all hematopoietic cell lines investigated (PubMed:10023084). {ECO:0000269|PubMed:10023084}.
Sequence
Sequence length 219
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Pancreatic secretion   Neutrophil degranulation
RAB geranylgeranylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer`s Disease Alzheimer disease GWASCAT_DG 26830138
★☆☆☆☆
Found in Text Mining only
B-Cell Lymphomas B-Cell Lymphoma BEFREE 31541431
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 20484105
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 28510306
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 27046094, 29423086
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 24643204 Associate
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Systemic Lupus Erythematosus BEFREE 31541431
★☆☆☆☆
Found in Text Mining only
Major Depressive Disorder Mental Depression BEFREE 29195125
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of breast Breast Cancer BEFREE 20484105
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of lung Lung Cancer BEFREE 28510306
★☆☆☆☆
Found in Text Mining only