Gene Gene information from NCBI Gene database.
Entrez ID 9529
Gene name BAG cochaperone 5
Gene symbol BAG5
Synonyms (NCBI Gene)
BAG-5CMD2F
Chromosome 14
Chromosome location 14q32.33
Summary The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroi
miRNA miRNA information provided by mirtarbase database.
1068
miRTarBase ID miRNA Experiments Reference
MIRT020553 hsa-miR-155-5p Proteomics 18668040
MIRT022122 hsa-miR-124-3p Microarray 18668037
MIRT023533 hsa-miR-1-3p Proteomics 18668040
MIRT032220 hsa-let-7b-5p Proteomics 18668040
MIRT041624 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
41
GO ID Ontology Definition Evidence Reference
GO:0000774 Function Adenyl-nucleotide exchange factor activity IBA
GO:0005515 Function Protein binding IPI 24510904, 24947832, 25036637, 25416956, 31515488, 32296183, 33961781, 35044787
GO:0005634 Component Nucleus HDA 21630459
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 24510904
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603885 941 ENSG00000166170
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UL15
Protein name BAG family molecular chaperone regulator 5 (BAG-5) (Bcl-2-associated athanogene 5)
Protein function Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis a
PDB 2D9D , 3A8Y
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02179 BAG 13 85 BAG domain Family
PF02179 BAG 185 258 BAG domain Family
PF02179 BAG 279 349 BAG domain Family
PF02179 BAG 369 441 BAG domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in the heart. {ECO:0000269|PubMed:35044787}.
Sequence
Sequence length 447
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Regulation of HSF1-mediated heat shock response
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
17
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Cardiomyopathy Likely pathogenic rs2507436898 RCV003224082
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cardiomyopathy, dilated, 2F Pathogenic; Likely pathogenic rs906014476, rs182208325, rs2076070300 RCV001836657
RCV001836658
RCV001836659
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANOREXIA NERVOSA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis Pubtator 40033250 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 27571744
★☆☆☆☆
Found in Text Mining only
Epithelial ovarian cancer Ovarian cancer BEFREE 27571744
★☆☆☆☆
Found in Text Mining only
Huntington Disease Huntington disease Pubtator 33049985 Associate
★☆☆☆☆
Found in Text Mining only
Lymphoma, Non-Hodgkin Non-Hodgkin lymphoma BEFREE 20855536
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of pancreas Pancreatic cancer BEFREE 27571739
★☆☆☆☆
Found in Text Mining only
Malignant neoplasm of prostate Prostate cancer BEFREE 23448667
★☆☆☆☆
Found in Text Mining only
Neoplasms Neoplasms BEFREE 27571739, 27571744
★☆☆☆☆
Found in Text Mining only
Ovarian Neoplasms Ovarian neoplasm Pubtator 34126157 Inhibit
★☆☆☆☆
Found in Text Mining only
Pancreatic carcinoma Pancreatic carcinoma BEFREE 27571739
★☆☆☆☆
Found in Text Mining only