Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9486
Gene name	Carbohydrate sulfotransferase 10
Gene symbol	CHST10
Synonyms (NCBI Gene)	HNK-1STHNK1ST
Chromosome	2
Chromosome location	2q11.2
Summary	This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glyc

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Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT053640	hsa-miR-143-3p	Microarray	22942087
MIRT892127	hsa-miR-1271	CLIP-seq
MIRT892128	hsa-miR-127-5p	CLIP-seq
MIRT892129	hsa-miR-1299	CLIP-seq
MIRT892130	hsa-miR-146b-3p	CLIP-seq
MIRT892131	hsa-miR-182	CLIP-seq
MIRT892132	hsa-miR-184	CLIP-seq
MIRT892133	hsa-miR-203	CLIP-seq
MIRT892134	hsa-miR-23a	CLIP-seq
MIRT892135	hsa-miR-23b	CLIP-seq
MIRT892136	hsa-miR-23c	CLIP-seq
MIRT892137	hsa-miR-3130-3p	CLIP-seq
MIRT892138	hsa-miR-3157-3p	CLIP-seq
MIRT892139	hsa-miR-3173-5p	CLIP-seq
MIRT892140	hsa-miR-3200-3p	CLIP-seq
MIRT892141	hsa-miR-3200-5p	CLIP-seq
MIRT892142	hsa-miR-331-3p	CLIP-seq
MIRT892143	hsa-miR-3690	CLIP-seq
MIRT892144	hsa-miR-3918	CLIP-seq
MIRT892145	hsa-miR-3927	CLIP-seq
MIRT892146	hsa-miR-3978	CLIP-seq
MIRT892147	hsa-miR-4251	CLIP-seq
MIRT892148	hsa-miR-4303	CLIP-seq
MIRT892149	hsa-miR-4308	CLIP-seq
MIRT892150	hsa-miR-4320	CLIP-seq
MIRT892151	hsa-miR-4329	CLIP-seq
MIRT892152	hsa-miR-4426	CLIP-seq
MIRT892153	hsa-miR-4451	CLIP-seq
MIRT892154	hsa-miR-4464	CLIP-seq
MIRT892155	hsa-miR-4496	CLIP-seq
MIRT892156	hsa-miR-4512	CLIP-seq
MIRT892157	hsa-miR-4635	CLIP-seq
MIRT892158	hsa-miR-4638-3p	CLIP-seq
MIRT892159	hsa-miR-4647	CLIP-seq
MIRT892160	hsa-miR-4662b	CLIP-seq
MIRT892161	hsa-miR-4685-5p	CLIP-seq
MIRT892162	hsa-miR-4733-3p	CLIP-seq
MIRT892163	hsa-miR-4748	CLIP-seq
MIRT892164	hsa-miR-4766-5p	CLIP-seq
MIRT892165	hsa-miR-4782-5p	CLIP-seq
MIRT892166	hsa-miR-4804-5p	CLIP-seq
MIRT892167	hsa-miR-513a-3p	CLIP-seq
MIRT892168	hsa-miR-514	CLIP-seq
MIRT892169	hsa-miR-514b-3p	CLIP-seq
MIRT892170	hsa-miR-516b	CLIP-seq
MIRT892171	hsa-miR-522	CLIP-seq
MIRT892172	hsa-miR-539	CLIP-seq
MIRT892173	hsa-miR-548m	CLIP-seq
MIRT892174	hsa-miR-590-3p	CLIP-seq
MIRT892175	hsa-miR-639	CLIP-seq
MIRT892176	hsa-miR-642b	CLIP-seq
MIRT892177	hsa-miR-711	CLIP-seq
MIRT892178	hsa-miR-767-5p	CLIP-seq
MIRT892179	hsa-miR-873	CLIP-seq
MIRT892180	hsa-miR-874	CLIP-seq
MIRT892181	hsa-miR-875-3p	CLIP-seq
MIRT892182	hsa-miR-96	CLIP-seq
MIRT1964396	hsa-miR-3670	CLIP-seq
MIRT892147	hsa-miR-4251	CLIP-seq
MIRT1964397	hsa-miR-4293	CLIP-seq
MIRT892148	hsa-miR-4303	CLIP-seq
MIRT892151	hsa-miR-4329	CLIP-seq
MIRT892155	hsa-miR-4496	CLIP-seq
MIRT892172	hsa-miR-539	CLIP-seq
MIRT892176	hsa-miR-642b	CLIP-seq
MIRT892179	hsa-miR-873	CLIP-seq
MIRT892132	hsa-miR-184	CLIP-seq
MIRT892133	hsa-miR-203	CLIP-seq
MIRT2200530	hsa-miR-3064-5p	CLIP-seq
MIRT2200531	hsa-miR-3138	CLIP-seq
MIRT892141	hsa-miR-3200-5p	CLIP-seq
MIRT2200532	hsa-miR-3620	CLIP-seq
MIRT2200533	hsa-miR-4277	CLIP-seq
MIRT2200534	hsa-miR-4326	CLIP-seq
MIRT2200535	hsa-miR-4676-5p	CLIP-seq
MIRT2200536	hsa-miR-4687-3p	CLIP-seq
MIRT2200537	hsa-miR-4732-3p	CLIP-seq
MIRT892164	hsa-miR-4766-5p	CLIP-seq
MIRT2200538	hsa-miR-4800-5p	CLIP-seq
MIRT892166	hsa-miR-4804-5p	CLIP-seq
MIRT892171	hsa-miR-522	CLIP-seq
MIRT2200539	hsa-miR-575	CLIP-seq
MIRT2200540	hsa-miR-665	CLIP-seq
MIRT892179	hsa-miR-873	CLIP-seq
MIRT2503272	hsa-miR-1202	CLIP-seq
MIRT2503273	hsa-miR-1246	CLIP-seq
MIRT2503274	hsa-miR-1287	CLIP-seq
MIRT892129	hsa-miR-1299	CLIP-seq
MIRT892130	hsa-miR-146b-3p	CLIP-seq
MIRT892132	hsa-miR-184	CLIP-seq
MIRT2503275	hsa-miR-1915	CLIP-seq
MIRT892133	hsa-miR-203	CLIP-seq
MIRT2200530	hsa-miR-3064-5p	CLIP-seq
MIRT892137	hsa-miR-3130-3p	CLIP-seq
MIRT2503276	hsa-miR-3135b	CLIP-seq
MIRT2200531	hsa-miR-3138	CLIP-seq
MIRT892138	hsa-miR-3157-3p	CLIP-seq
MIRT892139	hsa-miR-3173-5p	CLIP-seq
MIRT2503277	hsa-miR-3176	CLIP-seq
MIRT2503278	hsa-miR-3178	CLIP-seq
MIRT2503279	hsa-miR-3187-3p	CLIP-seq
MIRT892140	hsa-miR-3200-3p	CLIP-seq
MIRT892141	hsa-miR-3200-5p	CLIP-seq
MIRT892142	hsa-miR-331-3p	CLIP-seq
MIRT2503280	hsa-miR-338-3p	CLIP-seq
MIRT2503281	hsa-miR-3612	CLIP-seq
MIRT2503282	hsa-miR-3619-3p	CLIP-seq
MIRT2503283	hsa-miR-3622b-5p	CLIP-seq
MIRT1964396	hsa-miR-3670	CLIP-seq
MIRT892143	hsa-miR-3690	CLIP-seq
MIRT892144	hsa-miR-3918	CLIP-seq
MIRT2503284	hsa-miR-3922-3p	CLIP-seq
MIRT2503285	hsa-miR-3941	CLIP-seq
MIRT2503286	hsa-miR-3972	CLIP-seq
MIRT2503287	hsa-miR-3975	CLIP-seq
MIRT892146	hsa-miR-3978	CLIP-seq
MIRT2200533	hsa-miR-4277	CLIP-seq
MIRT1964397	hsa-miR-4293	CLIP-seq
MIRT892149	hsa-miR-4308	CLIP-seq
MIRT2503288	hsa-miR-4310	CLIP-seq
MIRT892150	hsa-miR-4320	CLIP-seq
MIRT2503289	hsa-miR-4423-5p	CLIP-seq
MIRT892152	hsa-miR-4426	CLIP-seq
MIRT2503290	hsa-miR-4443	CLIP-seq
MIRT2503291	hsa-miR-4486	CLIP-seq
MIRT892155	hsa-miR-4496	CLIP-seq
MIRT892156	hsa-miR-4512	CLIP-seq
MIRT2503292	hsa-miR-4529-5p	CLIP-seq
MIRT892158	hsa-miR-4638-3p	CLIP-seq
MIRT892159	hsa-miR-4647	CLIP-seq
MIRT2503293	hsa-miR-466	CLIP-seq
MIRT892160	hsa-miR-4662b	CLIP-seq
MIRT2503294	hsa-miR-4672	CLIP-seq
MIRT892161	hsa-miR-4685-5p	CLIP-seq
MIRT2200536	hsa-miR-4687-3p	CLIP-seq
MIRT2503295	hsa-miR-4713-3p	CLIP-seq
MIRT2503296	hsa-miR-4726-3p	CLIP-seq
MIRT892162	hsa-miR-4733-3p	CLIP-seq
MIRT2503297	hsa-miR-4738-3p	CLIP-seq
MIRT2503298	hsa-miR-4755-3p	CLIP-seq
MIRT892164	hsa-miR-4766-5p	CLIP-seq
MIRT2503299	hsa-miR-4776-5p	CLIP-seq
MIRT892165	hsa-miR-4782-5p	CLIP-seq
MIRT2200538	hsa-miR-4800-5p	CLIP-seq
MIRT892166	hsa-miR-4804-5p	CLIP-seq
MIRT2503300	hsa-miR-490-5p	CLIP-seq
MIRT892170	hsa-miR-516b	CLIP-seq
MIRT892171	hsa-miR-522	CLIP-seq
MIRT2503301	hsa-miR-548g	CLIP-seq
MIRT2503302	hsa-miR-619	CLIP-seq
MIRT2503303	hsa-miR-634	CLIP-seq
MIRT892175	hsa-miR-639	CLIP-seq
MIRT2503304	hsa-miR-650	CLIP-seq
MIRT2503305	hsa-miR-671-5p	CLIP-seq
MIRT892177	hsa-miR-711	CLIP-seq
MIRT892178	hsa-miR-767-5p	CLIP-seq
MIRT892180	hsa-miR-874	CLIP-seq
MIRT892181	hsa-miR-875-3p	CLIP-seq
MIRT2503272	hsa-miR-1202	CLIP-seq
MIRT2503273	hsa-miR-1246	CLIP-seq
MIRT2503274	hsa-miR-1287	CLIP-seq
MIRT892129	hsa-miR-1299	CLIP-seq
MIRT892130	hsa-miR-146b-3p	CLIP-seq
MIRT892132	hsa-miR-184	CLIP-seq
MIRT2503275	hsa-miR-1915	CLIP-seq
MIRT892133	hsa-miR-203	CLIP-seq
MIRT2200530	hsa-miR-3064-5p	CLIP-seq
MIRT892137	hsa-miR-3130-3p	CLIP-seq
MIRT2503276	hsa-miR-3135b	CLIP-seq
MIRT2200531	hsa-miR-3138	CLIP-seq
MIRT892138	hsa-miR-3157-3p	CLIP-seq
MIRT892139	hsa-miR-3173-5p	CLIP-seq
MIRT2503277	hsa-miR-3176	CLIP-seq
MIRT2503279	hsa-miR-3187-3p	CLIP-seq
MIRT2678158	hsa-miR-3195	CLIP-seq
MIRT892140	hsa-miR-3200-3p	CLIP-seq
MIRT892141	hsa-miR-3200-5p	CLIP-seq
MIRT892142	hsa-miR-331-3p	CLIP-seq
MIRT2503280	hsa-miR-338-3p	CLIP-seq
MIRT2503281	hsa-miR-3612	CLIP-seq
MIRT2503282	hsa-miR-3619-3p	CLIP-seq
MIRT2503283	hsa-miR-3622b-5p	CLIP-seq
MIRT1964396	hsa-miR-3670	CLIP-seq
MIRT892143	hsa-miR-3690	CLIP-seq
MIRT892144	hsa-miR-3918	CLIP-seq
MIRT2503284	hsa-miR-3922-3p	CLIP-seq
MIRT2503285	hsa-miR-3941	CLIP-seq
MIRT2503286	hsa-miR-3972	CLIP-seq
MIRT892146	hsa-miR-3978	CLIP-seq
MIRT2200533	hsa-miR-4277	CLIP-seq
MIRT1964397	hsa-miR-4293	CLIP-seq
MIRT892149	hsa-miR-4308	CLIP-seq
MIRT2503288	hsa-miR-4310	CLIP-seq
MIRT892150	hsa-miR-4320	CLIP-seq
MIRT2503289	hsa-miR-4423-5p	CLIP-seq
MIRT892152	hsa-miR-4426	CLIP-seq
MIRT2503290	hsa-miR-4443	CLIP-seq
MIRT892155	hsa-miR-4496	CLIP-seq
MIRT892156	hsa-miR-4512	CLIP-seq
MIRT2503292	hsa-miR-4529-5p	CLIP-seq
MIRT892158	hsa-miR-4638-3p	CLIP-seq
MIRT892159	hsa-miR-4647	CLIP-seq
MIRT2678159	hsa-miR-4648	CLIP-seq
MIRT2678160	hsa-miR-4650-5p	CLIP-seq
MIRT2678161	hsa-miR-4654	CLIP-seq
MIRT2503293	hsa-miR-466	CLIP-seq
MIRT892160	hsa-miR-4662b	CLIP-seq
MIRT2503294	hsa-miR-4672	CLIP-seq
MIRT892161	hsa-miR-4685-5p	CLIP-seq
MIRT2200536	hsa-miR-4687-3p	CLIP-seq
MIRT2503295	hsa-miR-4713-3p	CLIP-seq
MIRT2503296	hsa-miR-4726-3p	CLIP-seq
MIRT892162	hsa-miR-4733-3p	CLIP-seq
MIRT2503297	hsa-miR-4738-3p	CLIP-seq
MIRT2503298	hsa-miR-4755-3p	CLIP-seq
MIRT892164	hsa-miR-4766-5p	CLIP-seq
MIRT2678162	hsa-miR-4769-5p	CLIP-seq
MIRT2503299	hsa-miR-4776-5p	CLIP-seq
MIRT892165	hsa-miR-4782-5p	CLIP-seq
MIRT2678163	hsa-miR-4787-3p	CLIP-seq
MIRT2200538	hsa-miR-4800-5p	CLIP-seq
MIRT892166	hsa-miR-4804-5p	CLIP-seq
MIRT2503300	hsa-miR-490-5p	CLIP-seq
MIRT2678164	hsa-miR-513a-5p	CLIP-seq
MIRT892170	hsa-miR-516b	CLIP-seq
MIRT892171	hsa-miR-522	CLIP-seq
MIRT2503301	hsa-miR-548g	CLIP-seq
MIRT2503303	hsa-miR-634	CLIP-seq
MIRT892175	hsa-miR-639	CLIP-seq
MIRT2503304	hsa-miR-650	CLIP-seq
MIRT2503305	hsa-miR-671-5p	CLIP-seq
MIRT892177	hsa-miR-711	CLIP-seq
MIRT892178	hsa-miR-767-5p	CLIP-seq
MIRT892180	hsa-miR-874	CLIP-seq
MIRT892181	hsa-miR-875-3p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	ISS
GO:0000139	Component	Golgi membrane	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0005794	Component	Golgi apparatus	TAS	9478973
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007155	Process	Cell adhesion	TAS	9478973
GO:0007612	Process	Learning	IEA
GO:0007616	Process	Long-term memory	IEA
GO:0008146	Function	Sulfotransferase activity	IBA
GO:0008146	Function	Sulfotransferase activity	IDA	23269668, 32149355
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008146	Function	Sulfotransferase activity	TAS	9478973
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008209	Process	Androgen metabolic process	IDA	23269668
GO:0008210	Process	Estrogen metabolic process	IDA	23269668
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9478973
GO:0016051	Process	Carbohydrate biosynthetic process	IEA
GO:0016232	Function	HNK-1 sulfotransferase activity	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0030166	Process	Proteoglycan biosynthetic process	IBA

MIM	HGNC	e!Ensembl
606376	19650	ENSG00000115526

O43529

Protein name

Carbohydrate sulfotransferase 10 (EC 2.8.2.-) (HNK-1 sulfotransferase) (HNK-1ST) (HNK1ST) (HuHNK-1ST)

Protein function

Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03567	Sulfotransfer_2	111 → 349	Sulfotransferase family	Domain

Tissue specificity

TISSUE SPECIFICITY: In fetal tissues, it is predominantly expressed in brain, and weakly expressed in lung, kidney and liver. In adult, it is highly expressed in brain, testis, ovary, expressed at intermediate level in heart, pancreas, skeletal muscle, sp

Sequence

MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIP
EELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHK
ILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLK
TYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDF
VRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGID
HLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN

Sequence length

356

Interactions

View interactions

	KEGG		Reactome
	Mannose type O-glycan biosynthesis Metabolic pathways		Reactions specific to the complex N-glycan synthesis pathway

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24393480	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	19470764		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	20950796		★★★★★ ★☆☆☆☆ Found in Text Mining only

CHST10 (carbohydrate sulfotransferase 10)