Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	9477
Gene name	Mediator complex subunit 20
Gene symbol	MED20
Synonyms (NCBI Gene)	PRO0213SRB2TRFP
Chromosome	6
Chromosome location	6p21.1
Summary	This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activ

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Show/Hide all (217)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022390	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT1141219	hsa-miR-105	CLIP-seq
MIRT1141220	hsa-miR-1179	CLIP-seq
MIRT1141221	hsa-miR-1224-5p	CLIP-seq
MIRT1141222	hsa-miR-124	CLIP-seq
MIRT1141223	hsa-miR-1285	CLIP-seq
MIRT1141224	hsa-miR-1323	CLIP-seq
MIRT1141225	hsa-miR-1343	CLIP-seq
MIRT1141226	hsa-miR-146a	CLIP-seq
MIRT1141227	hsa-miR-146b-5p	CLIP-seq
MIRT1141228	hsa-miR-194	CLIP-seq
MIRT1141229	hsa-miR-1972	CLIP-seq
MIRT1141230	hsa-miR-202	CLIP-seq
MIRT1141231	hsa-miR-3157-5p	CLIP-seq
MIRT1141232	hsa-miR-3187-5p	CLIP-seq
MIRT1141233	hsa-miR-3545-3p	CLIP-seq
MIRT1141234	hsa-miR-3622a-5p	CLIP-seq
MIRT1141235	hsa-miR-3670	CLIP-seq
MIRT1141236	hsa-miR-3714	CLIP-seq
MIRT1141237	hsa-miR-3910	CLIP-seq
MIRT1141238	hsa-miR-3915	CLIP-seq
MIRT1141239	hsa-miR-3926	CLIP-seq
MIRT1141240	hsa-miR-4251	CLIP-seq
MIRT1141241	hsa-miR-4421	CLIP-seq
MIRT1141242	hsa-miR-4422	CLIP-seq
MIRT1141243	hsa-miR-4459	CLIP-seq
MIRT1141244	hsa-miR-4678	CLIP-seq
MIRT1141245	hsa-miR-4689	CLIP-seq
MIRT1141246	hsa-miR-4691-3p	CLIP-seq
MIRT1141247	hsa-miR-4700-3p	CLIP-seq
MIRT1141248	hsa-miR-4712-5p	CLIP-seq
MIRT1141249	hsa-miR-4716-5p	CLIP-seq
MIRT1141250	hsa-miR-4751	CLIP-seq
MIRT1141251	hsa-miR-4786-3p	CLIP-seq
MIRT1141252	hsa-miR-506	CLIP-seq
MIRT1141253	hsa-miR-5095	CLIP-seq
MIRT1141254	hsa-miR-516a-3p	CLIP-seq
MIRT1141255	hsa-miR-526b	CLIP-seq
MIRT1141256	hsa-miR-548o	CLIP-seq
MIRT1141257	hsa-miR-564	CLIP-seq
MIRT1141258	hsa-miR-589	CLIP-seq
MIRT1141259	hsa-miR-612	CLIP-seq
MIRT1141260	hsa-miR-770-5p	CLIP-seq
MIRT1141235	hsa-miR-3670	CLIP-seq
MIRT1141221	hsa-miR-1224-5p	CLIP-seq
MIRT1141229	hsa-miR-1972	CLIP-seq
MIRT2040008	hsa-miR-2467-5p	CLIP-seq
MIRT1141234	hsa-miR-3622a-5p	CLIP-seq
MIRT2040009	hsa-miR-3668	CLIP-seq
MIRT1141235	hsa-miR-3670	CLIP-seq
MIRT1141238	hsa-miR-3915	CLIP-seq
MIRT1141239	hsa-miR-3926	CLIP-seq
MIRT2040010	hsa-miR-4489	CLIP-seq
MIRT1141245	hsa-miR-4689	CLIP-seq
MIRT1141246	hsa-miR-4691-3p	CLIP-seq
MIRT2040011	hsa-miR-4693-3p	CLIP-seq
MIRT1141250	hsa-miR-4751	CLIP-seq
MIRT2040012	hsa-miR-511	CLIP-seq
MIRT1141255	hsa-miR-526b	CLIP-seq
MIRT2040013	hsa-miR-545	CLIP-seq
MIRT1141257	hsa-miR-564	CLIP-seq
MIRT2040014	hsa-miR-643	CLIP-seq
MIRT2040015	hsa-miR-802	CLIP-seq
MIRT2269870	hsa-miR-103a	CLIP-seq
MIRT2269871	hsa-miR-107	CLIP-seq
MIRT2269872	hsa-miR-1184	CLIP-seq
MIRT2269873	hsa-miR-1205	CLIP-seq
MIRT1141221	hsa-miR-1224-5p	CLIP-seq
MIRT1141222	hsa-miR-124	CLIP-seq
MIRT2269874	hsa-miR-1297	CLIP-seq
MIRT2269875	hsa-miR-1302	CLIP-seq
MIRT1141226	hsa-miR-146a	CLIP-seq
MIRT1141227	hsa-miR-146b-5p	CLIP-seq
MIRT2269876	hsa-miR-197	CLIP-seq
MIRT1141229	hsa-miR-1972	CLIP-seq
MIRT2269877	hsa-miR-214	CLIP-seq
MIRT2269878	hsa-miR-2682	CLIP-seq
MIRT2269879	hsa-miR-26a	CLIP-seq
MIRT2269880	hsa-miR-26b	CLIP-seq
MIRT2269881	hsa-miR-3158-5p	CLIP-seq
MIRT2269882	hsa-miR-3163	CLIP-seq
MIRT2269883	hsa-miR-34b	CLIP-seq
MIRT2269884	hsa-miR-3619-5p	CLIP-seq
MIRT1141234	hsa-miR-3622a-5p	CLIP-seq
MIRT2269885	hsa-miR-3622b-5p	CLIP-seq
MIRT2269886	hsa-miR-3662	CLIP-seq
MIRT1141236	hsa-miR-3714	CLIP-seq
MIRT1141237	hsa-miR-3910	CLIP-seq
MIRT2269887	hsa-miR-3919	CLIP-seq
MIRT2269888	hsa-miR-3921	CLIP-seq
MIRT1141239	hsa-miR-3926	CLIP-seq
MIRT1141240	hsa-miR-4251	CLIP-seq
MIRT2269889	hsa-miR-4291	CLIP-seq
MIRT2269890	hsa-miR-4298	CLIP-seq
MIRT2269891	hsa-miR-4428	CLIP-seq
MIRT2269892	hsa-miR-4465	CLIP-seq
MIRT2040010	hsa-miR-4489	CLIP-seq
MIRT2269893	hsa-miR-449c	CLIP-seq
MIRT2269894	hsa-miR-4517	CLIP-seq
MIRT2269895	hsa-miR-4653-5p	CLIP-seq
MIRT2269896	hsa-miR-4690-5p	CLIP-seq
MIRT1141246	hsa-miR-4691-3p	CLIP-seq
MIRT2040011	hsa-miR-4693-3p	CLIP-seq
MIRT1141248	hsa-miR-4712-5p	CLIP-seq
MIRT2269897	hsa-miR-4742-5p	CLIP-seq
MIRT1141250	hsa-miR-4751	CLIP-seq
MIRT2269898	hsa-miR-4803	CLIP-seq
MIRT2269899	hsa-miR-500a	CLIP-seq
MIRT1141252	hsa-miR-506	CLIP-seq
MIRT2269900	hsa-miR-544	CLIP-seq
MIRT2040013	hsa-miR-545	CLIP-seq
MIRT1141257	hsa-miR-564	CLIP-seq
MIRT1141258	hsa-miR-589	CLIP-seq
MIRT2269901	hsa-miR-630	CLIP-seq
MIRT2040014	hsa-miR-643	CLIP-seq
MIRT2269902	hsa-miR-661	CLIP-seq
MIRT2269903	hsa-miR-761	CLIP-seq
MIRT1141260	hsa-miR-770-5p	CLIP-seq
MIRT2269904	hsa-miR-940	CLIP-seq
MIRT2390785	hsa-miR-4768-5p	CLIP-seq
MIRT2568998	hsa-miR-101	CLIP-seq
MIRT2269870	hsa-miR-103a	CLIP-seq
MIRT2269871	hsa-miR-107	CLIP-seq
MIRT2269872	hsa-miR-1184	CLIP-seq
MIRT2269873	hsa-miR-1205	CLIP-seq
MIRT2568999	hsa-miR-1255a	CLIP-seq
MIRT2569000	hsa-miR-1255b	CLIP-seq
MIRT2569001	hsa-miR-1276	CLIP-seq
MIRT2569002	hsa-miR-144	CLIP-seq
MIRT2569003	hsa-miR-181a	CLIP-seq
MIRT2569004	hsa-miR-181b	CLIP-seq
MIRT2569005	hsa-miR-181c	CLIP-seq
MIRT2569006	hsa-miR-181d	CLIP-seq
MIRT2269877	hsa-miR-214	CLIP-seq
MIRT2269878	hsa-miR-2682	CLIP-seq
MIRT2569007	hsa-miR-3074-3p	CLIP-seq
MIRT2269881	hsa-miR-3158-5p	CLIP-seq
MIRT2569008	hsa-miR-3190	CLIP-seq
MIRT2269884	hsa-miR-3619-5p	CLIP-seq
MIRT2269885	hsa-miR-3622b-5p	CLIP-seq
MIRT2569009	hsa-miR-3664-3p	CLIP-seq
MIRT2569010	hsa-miR-3665	CLIP-seq
MIRT1141235	hsa-miR-3670	CLIP-seq
MIRT2569011	hsa-miR-3672	CLIP-seq
MIRT2569012	hsa-miR-384	CLIP-seq
MIRT2569013	hsa-miR-3911	CLIP-seq
MIRT2569014	hsa-miR-3914	CLIP-seq
MIRT2569015	hsa-miR-4262	CLIP-seq
MIRT2269893	hsa-miR-449c	CLIP-seq
MIRT2269894	hsa-miR-4517	CLIP-seq
MIRT2269896	hsa-miR-4690-5p	CLIP-seq
MIRT2269897	hsa-miR-4742-5p	CLIP-seq
MIRT2569016	hsa-miR-4761-5p	CLIP-seq
MIRT2569017	hsa-miR-4768-3p	CLIP-seq
MIRT2569018	hsa-miR-490-3p	CLIP-seq
MIRT2569019	hsa-miR-494	CLIP-seq
MIRT2569020	hsa-miR-513b	CLIP-seq
MIRT2569021	hsa-miR-515-5p	CLIP-seq
MIRT2269900	hsa-miR-544	CLIP-seq
MIRT2569022	hsa-miR-619	CLIP-seq
MIRT2569023	hsa-miR-649	CLIP-seq
MIRT2569024	hsa-miR-657	CLIP-seq
MIRT2269903	hsa-miR-761	CLIP-seq
MIRT2569025	hsa-miR-873	CLIP-seq
MIRT2269904	hsa-miR-940	CLIP-seq
MIRT2568998	hsa-miR-101	CLIP-seq
MIRT2269870	hsa-miR-103a	CLIP-seq
MIRT2269871	hsa-miR-107	CLIP-seq
MIRT2269872	hsa-miR-1184	CLIP-seq
MIRT2269873	hsa-miR-1205	CLIP-seq
MIRT2568999	hsa-miR-1255a	CLIP-seq
MIRT2569000	hsa-miR-1255b	CLIP-seq
MIRT2569001	hsa-miR-1276	CLIP-seq
MIRT2269874	hsa-miR-1297	CLIP-seq
MIRT2569002	hsa-miR-144	CLIP-seq
MIRT2569003	hsa-miR-181a	CLIP-seq
MIRT2569004	hsa-miR-181b	CLIP-seq
MIRT2569005	hsa-miR-181c	CLIP-seq
MIRT2569006	hsa-miR-181d	CLIP-seq
MIRT2269877	hsa-miR-214	CLIP-seq
MIRT2269878	hsa-miR-2682	CLIP-seq
MIRT2269879	hsa-miR-26a	CLIP-seq
MIRT2269880	hsa-miR-26b	CLIP-seq
MIRT2569007	hsa-miR-3074-3p	CLIP-seq
MIRT2269881	hsa-miR-3158-5p	CLIP-seq
MIRT2569008	hsa-miR-3190	CLIP-seq
MIRT2269884	hsa-miR-3619-5p	CLIP-seq
MIRT2269885	hsa-miR-3622b-5p	CLIP-seq
MIRT2569009	hsa-miR-3664-3p	CLIP-seq
MIRT2569010	hsa-miR-3665	CLIP-seq
MIRT2040009	hsa-miR-3668	CLIP-seq
MIRT1141235	hsa-miR-3670	CLIP-seq
MIRT2569011	hsa-miR-3672	CLIP-seq
MIRT2569012	hsa-miR-384	CLIP-seq
MIRT2569013	hsa-miR-3911	CLIP-seq
MIRT2569014	hsa-miR-3914	CLIP-seq
MIRT2569015	hsa-miR-4262	CLIP-seq
MIRT2269892	hsa-miR-4465	CLIP-seq
MIRT2269893	hsa-miR-449c	CLIP-seq
MIRT2269894	hsa-miR-4517	CLIP-seq
MIRT2269896	hsa-miR-4690-5p	CLIP-seq
MIRT2684794	hsa-miR-4703-3p	CLIP-seq
MIRT2269897	hsa-miR-4742-5p	CLIP-seq
MIRT2569016	hsa-miR-4761-5p	CLIP-seq
MIRT2569017	hsa-miR-4768-3p	CLIP-seq
MIRT2569018	hsa-miR-490-3p	CLIP-seq
MIRT2569019	hsa-miR-494	CLIP-seq
MIRT2569020	hsa-miR-513b	CLIP-seq
MIRT2569021	hsa-miR-515-5p	CLIP-seq
MIRT2269900	hsa-miR-544	CLIP-seq
MIRT2569022	hsa-miR-619	CLIP-seq
MIRT2684795	hsa-miR-648	CLIP-seq
MIRT2569023	hsa-miR-649	CLIP-seq
MIRT2569024	hsa-miR-657	CLIP-seq
MIRT2269903	hsa-miR-761	CLIP-seq
MIRT2569025	hsa-miR-873	CLIP-seq
MIRT2269904	hsa-miR-940	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003899	Function	DNA-directed RNA polymerase activity	NAS	9933582
GO:0005515	Function	Protein binding	IPI	14576168, 15175163, 24981860, 25281560, 25416956, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	24882805
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006351	Process	DNA-templated transcription	NAS	9933582
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9933582
GO:0006366	Process	Transcription by RNA polymerase II	TAS	9933582
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IEA
GO:0016592	Component	Mediator complex	NAS	9933582
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	11559591
GO:0032991	Component	Protein-containing complex	IEA
GO:0035914	Process	Skeletal muscle cell differentiation	IEA
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	NAS	11559591
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	NAS	11559591
GO:0070847	Component	Core mediator complex	IPI	24882805

MIM	HGNC	e!Ensembl
612915	16840	ENSG00000124641

Q9H944

Protein name

Mediator of RNA polymerase II transcription subunit 20 (Mediator complex subunit 20) (TRF-proximal protein homolog) (hTRFP)

Protein function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN

PDB

7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08612	Med20	1 → 198	TATA-binding related factor (TRF) of subunit 20 of Mediator complex	Family

Sequence

MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTG
KLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYC
DFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRH
DAVYGPADTMVQYMELFNKIRKQQQVPVAGIR

Sequence length

212

Interactions

View interactions

	Reactome
			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Brain atrophy	Brain atrophy	BEFREE	25446406		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	37511575	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35069777	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	BEFREE	25446406		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood Onset Dystonias	Dystonia	BEFREE	25446406		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	37511575	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24101134		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27179712		★★★★★ ★☆☆☆☆ Found in Text Mining only

MED20 (mediator complex subunit 20)